CN107802372A - A kind of animal eyeball fixing device for photoacoustic imaging system - Google Patents
A kind of animal eyeball fixing device for photoacoustic imaging system Download PDFInfo
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- CN107802372A CN107802372A CN201710975694.4A CN201710975694A CN107802372A CN 107802372 A CN107802372 A CN 107802372A CN 201710975694 A CN201710975694 A CN 201710975694A CN 107802372 A CN107802372 A CN 107802372A
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- animal
- pressing plate
- fixing device
- imaging system
- photoacoustic imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
The embodiment of the present invention is applied to technical field of photoacoustic, there is provided a kind of animal eyeball fixing device for photoacoustic imaging system.The animal eyeball fixing device includes base, regulation fixation kit and pressing plate, fixation kit is adjusted to be arranged on base, the both ends of pressing plate are fixed on regulation fixation kit, there is the receiving space for being used for clamping animal head between pressing plate and base, at least one through hole for being used to be arranged animal eyeball is offered in the middle part of pressing plate.The present invention convenient and swift can carry out noninvasive fixation by the through hole on pressing plate to animal eyeball, effectively eliminate the adverse effect that animal breath and Rotation of eyeball come to imaging belt, make photoacoustic imaging system more precise sharpness, and animal eyeball blood vessel and its disease can be observed steadily in the long term.
Description
Technical field
The invention belongs to technical field of photoacoustic, more particularly to a kind of animal eyeball for photoacoustic imaging system to fix
Device.
Background technology
Photoacoustic imaging is a kind of a kind of breakthrough Novel noninvasive biomedical imaging for having optics and ultrasonic imaging advantage concurrently
Technology, its principle are that pulse laser is imported into biological tissue, organize, because transient thermal growths produce ultrasonic signal, to pass through detection
This signal obtains the light absorbs information of tissue, so as to provide the contrast mechanism based on optical absorption characteristics for imaging.In biological tissue
Hemoglobin is different to the degree of absorption of different wavelengths of light, and the photoacoustic signal degree of strength being inspired is also different, and selection is high
The Single wavelength of absorption is scanned to blood vessel, can direct imaging, without injecting any contrast medium；And multi-wavelength is selected to be swept
Retouch, then can obtain the parameter such as oxygen saturation, oxygen metabolism rate in blood by calculating, this is to research Tumor Angiongesis and research and development
Cancer therapy drug has great significance.
Because ultrasonic wave is decayed very greatly in atmosphere, in order to detect caused ultrasonic signal, in biological tissue and probe
Between must have couplant (be usually water or medical ultrasonic coupling agent), generally ultrasonic probe is placed in tank, tank bottom
Lower perforate and layer overlay optical thin film, will be close on optical thin film on biological sample surface smear after couplant.Work as pulse
Laser is imported into biological tissue inspire ultrasonic wave after, ultrasonic signal is spread out of from tissue, by couplant, film and water,
Finally received by ultrasonic probe.
In the optoacoustic system of current non-array formula, limited by ultrasonic probe quantity and mechanical scanning speed, when it is to one
The long period is needed during individual large area imaging, the remains stationary state therefore it is required that testee is tried one's best during scanning.Optoacoustic
System at present can to mouse ear blood vessel, go the cerebral vessels of epidermis to carry out blur-free imaging, but for rat anterior ocular segment blood
Pipe always can not blur-free imaging, its reason be animal breath motion influence its trunk entirety undulatory motion, the measured object in motion
Body easily causes imaging artefacts.And a large amount of adhesive tapes of generally use fix animal eyeball at present, there are many drawbacks in the fixed form,
It is too loose to cause larger shake as fixation can tightly cause very much its ischemic, experiment generally require by repeatedly it is fixed can be only achieved compared with
Good fixed effect, and even if fixing successfully, the animal eyeball also can not be by stably long-term observation.
The content of the invention
Technical problem to be solved of the embodiment of the present invention is to provide a kind of animal eyeball for photoacoustic imaging system
Fixing device, it is intended to solve fixed inconvenience and animal breath and eyeball present in animal eyeball fixed form of the prior art
Rotation causes the problem of imaging artefacts.
The embodiment of the present invention, which is achieved in that, provides a kind of animal eyeball fixing device for photoacoustic imaging system,
It includes base, regulation fixation kit and pressing plate, and the regulation fixation kit is arranged on the base, and the two of the pressing plate
End is fixed on the regulation fixation kit, has the receiving for being used to clamp animal head empty between the pressing plate and the base
Between, at least one through hole for being used to be arranged animal eyeball is offered in the middle part of the pressing plate.
Further, the pressing plate is plastic plate or plank.
Further, the through hole has several, and the size of each through hole is.
Further, the through hole is circular hole.
Further, rubber ring is equipped with the through hole.
Further, the outer peripheral edge of the rubber ring has groove, and the groove is removably connected in the through hole
On inwall.
Further, the regulation fixation kit includes fixed block, briquetting and screw；Wear successively one end of the screw
The briquetting, pressing plate and fixed block are crossed, and is anchored on the base.
Further, the screw is butterfly screws.
Further, the both ends of the pressing plate offer U-type groove, and the butterfly screws are located in the U-type groove.
Further, the material of the briquetting and fixed block is metal.
Compared with prior art, beneficial effect is the embodiment of the present invention：The present invention is by the way that the animal of anesthesia is positioned over
On base, and its head is clamped between pressing plate and base, while by the pressure of pressing plate, animal eyeball is pressurized and protrude from
In the through hole of pressing plate, noninvasive fixation is carried out to animal eyeball so as to convenient and swift, animal breath is effectively eliminated and eyeball turns
The dynamic adverse effect come to imaging belt, makes photoacoustic imaging system more precise sharpness, and can observe animal eyeball blood steadily in the long term
Pipe and its disease.
Brief description of the drawings
Fig. 1 is the animal eyeball fixture structure schematic diagram provided in an embodiment of the present invention for photoacoustic imaging system；
Fig. 2 is the animal eyeball fixing device decomposition texture schematic diagram shown in Fig. 1；
Fig. 3 is the pressure plate structure schematic diagram in Fig. 1；
Fig. 4 is the rubber ring structural representation in Fig. 1；
Fig. 5 is the working state schematic representation of the animal eyeball fixing device shown in Fig. 1.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
As shown in Figures 1 to 5, it is that a kind of animal eyeball for photoacoustic imaging system provided in an embodiment of the present invention is fixed
Device.The animal eyeball fixing device includes 1, two regulation fixation kit 2 of base and pressing plate 3, two regulation fixation kits 2
On base 1, and it is oppositely arranged, for pressing plate 3 between two regulation fixation kits 2, its both ends is separately fixed at tune
Save on fixation kit 2, there is the receiving space for being used for clamping animal head, between pressing plate 3 and base 1 between pressing plate 3 and base 1
Distance can be adjusted by adjusting the height of fixation kit 2.Offered at the middle part of pressing plate 3 at least one dynamic for being arranged
The through hole 30 of thing eyeball so that when animal head is pressed on base 1 by pressing plate 3, by animal eyeball aligned through holes 30, so that will be dynamic
Thing eyeball is protruded from through hole 30.In the present embodiment, through hole 30 is circular hole, and has several, the face of each through hole 30
Product size, is arranged with the fixation adapted to respectively to different size of animal eyeball.
In above-mentioned implementation, rubber ring 4 is equipped with through hole 30, specifically, the outer peripheral edge of rubber ring 4 has groove 40,
Groove 40 is removably connected on the inwall of through hole 30, so as to increase the elastic and flexible of the position of through hole 30 on pressing plate 3, is avoided
Animal eyeball is crushed, and the frictional force of clamping animal head can be strengthened.
In above-described embodiment, regulation fixation kit 2 includes fixed block 21, briquetting 22 and screw 23.One end of screw 23
Briquetting 22, pressing plate 3 and fixed block 21 are sequentially passed through, and is connected through a screw thread and is anchored on base 1, makes the equal energy in both ends of pressing plate 3
Enough it is locked between fixed block 21 and briquetting 22.In the present embodiment, the screw 23 is butterfly screws, is easy to locking and pine
Pressing plate 3 is driven, and can be according to the size of animal head, by suitably adjusting butterfly screws, so as to the elastic of pressing plate 3
Degree is adjusted, and on the one hand can stablize and push down animal head, on the other hand also will not transition compress and cause eyeball ischemic and shadow
Ring photoacoustic imaging effect.
In above-described embodiment, the material of briquetting 22 and fixed block 21 is metal, and pressing plate 3 is plastic plate or plank.At this
Briquetting 22 and fixed block 21 in embodiment use piece of stainless steel, and pressing plate 3 uses plastic plate, and the material of the plastic plate is using durable
PC (Polycarbonate makrolon) plastics, it has certain elasticity, and is water white transparency, in order to the energy of pressing plate 3
It is enough stable to push down animal head, and animal eyeball easily can be directed at belling in the through hole 30 on pressing plate 3, with right
Animal eyeball is fixed.U-type groove 31 is offered at the both ends of pressing plate 3, butterfly screws 23 are located in U-type groove 31, make pressure
Plate 3 can be adjusted suitably in its longitudinal direction, be easy to the through hole 30 on pressing plate 3 to be directed at animal eyeball.
In summary, the animal eyeball fixing device for photoacoustic imaging system of the invention can easily fix animal
Eyeball, effectively eliminate the eyes caused by animal breath and shake the influence brought to photoacoustic imaging, make photoacoustic imaging system more accurate
Clearly with observing animal eyeball blood vessel and its disease steadily in the long term, and experiment terminates rear animal survival and its eyeball does not have
There is any wound；Meanwhile the animal eyeball is fixed in the fixing device by noninvasive, its top hides without other any mechanical parts
Gear, enough spaces are provided for optoacoustic system imaging probe, be advantageous to high-resolution probe close to image space.The present invention's is dynamic
Thing eyeball fixture is applicable not only to the fixation of the animal eyeballs such as rat, rabbit, is easy to photoacoustic imaging system observation imaging, also
It can be suitably used for animal brain being fixed observation imaging.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement made within refreshing and principle etc., should be included in the scope of the protection.
Claims (10)
1. a kind of animal eyeball fixing device for photoacoustic imaging system, it is characterised in that including base, regulation fixation kit
And pressing plate, the regulation fixation kit are arranged on the base, the both ends of the pressing plate are fixed on the fixed group of the regulation
There is the receiving space for being used for clamping animal head on part, between the pressing plate and the base, opened up in the middle part of the pressing plate
There is at least one through hole for being used to be arranged animal eyeball.
2. it is used for the animal eyeball fixing device of photoacoustic imaging system as claimed in claim 1, it is characterised in that the pressing plate
For plastic plate or plank.
3. it is used for the animal eyeball fixing device of photoacoustic imaging system as claimed in claim 1, it is characterised in that the through hole
With several, the size of each through hole is.
4. it is used for the animal eyeball fixing device of photoacoustic imaging system as claimed in claim 1, it is characterised in that the through hole
For circular hole.
5. it is used for the animal eyeball fixing device of photoacoustic imaging system as claimed in claim 1, it is characterised in that the through hole
It is upper to be equipped with rubber ring.
6. it is used for the animal eyeball fixing device of photoacoustic imaging system as claimed in claim 5, it is characterised in that the rubber
The outer peripheral edge of ring has groove, and the groove is removably connected on the inwall of the through hole.
7. the animal eyeball fixing device for photoacoustic imaging system as described in any one in claim 1 to 6, its feature
It is, the regulation fixation kit includes fixed block, briquetting and screw；One end of the screw sequentially pass through the briquetting,
Pressing plate and fixed block, and be anchored on the base.
8. it is used for the animal eyeball fixing device of photoacoustic imaging system as claimed in claim 7, it is characterised in that the screw
For butterfly screws.
9. it is used for the animal eyeball fixing device of photoacoustic imaging system as claimed in claim 7, it is characterised in that the pressing plate
Both ends offer U-type groove, the butterfly screws are located in the U-type groove.
10. it is used for the animal eyeball fixing device of photoacoustic imaging system as claimed in claim 7, it is characterised in that the pressure
The material of block and fixed block is metal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710975694.4A CN107802372A (en) | 2017-10-19 | 2017-10-19 | A kind of animal eyeball fixing device for photoacoustic imaging system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710975694.4A CN107802372A (en) | 2017-10-19 | 2017-10-19 | A kind of animal eyeball fixing device for photoacoustic imaging system |
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| Publication Number | Publication Date |
|---|---|
| CN107802372A true CN107802372A (en) | 2018-03-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710975694.4A Pending CN107802372A (en) | 2017-10-19 | 2017-10-19 | A kind of animal eyeball fixing device for photoacoustic imaging system |
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| CN (1) | CN107802372A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110236729A (en) * | 2019-07-08 | 2019-09-17 | 温州医科大学附属眼视光医院 | A kind of size-adjustable lagophthalmos ball fixing device based on eyeball dislocation method |
Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2549946Y (en) * | 2002-06-13 | 2003-05-14 | 复旦大学附属眼耳鼻喉科医院 | Eyeball fixer for surgical operation |
| CN201710373U (en) * | 2010-06-22 | 2011-01-19 | 中国人民解放军第三军医大学第一附属医院 | Eye ball fixing device |
| CN202821706U (en) * | 2012-09-21 | 2013-03-27 | 天津市天津医院 | Experimental animal operating table |
| CN203169839U (en) * | 2013-04-15 | 2013-09-04 | 舒长和 | Electromagnetic treatment loop of acoustics-electromagnetism combined therapeutic instrument |
| CN203220457U (en) * | 2013-03-25 | 2013-10-02 | 中国人民解放军第三军医大学第一附属医院 | Eyeball fixing device |
| CN203220456U (en) * | 2013-03-25 | 2013-10-02 | 中国人民解放军第三军医大学第一附属医院 | Pop-up eyeball fixing device |
| CN103340697A (en) * | 2013-07-18 | 2013-10-09 | 深圳先进技术研究院 | Fixing device used for fixing back skin of experimental animal |
| CN103976709A (en) * | 2014-04-24 | 2014-08-13 | 中国科学院苏州生物医学工程技术研究所 | Wearable array transducer probe and small animal brain function photoacoustic imaging system |
| CN204092265U (en) * | 2014-10-23 | 2015-01-14 | 中国人民解放军总医院 | A kind of animal spinal cord living imaging Orientation observation device |
| CN104274157A (en) * | 2014-09-24 | 2015-01-14 | 深圳先进技术研究院 | Fixing device and photoacoustic tomography system with same |
| CN204181735U (en) * | 2014-09-10 | 2015-03-04 | 中国辐射防护研究院 | Toy arc irradiation fixture |
| CN105193520A (en) * | 2015-09-30 | 2015-12-30 | 无锡市第二人民医院 | Method for fixing eyeball of living mouse |
| CN106137529A (en) * | 2016-07-27 | 2016-11-23 | 苏州贝尔锋医疗器械有限公司 | Open eyelid and eyeball fixture |
| CN205698116U (en) * | 2016-04-20 | 2016-11-23 | 复旦大学 | A kind of living animal head window for two-photon laser imaging maintains and fixing device |
| CN106551753A (en) * | 2015-09-30 | 2017-04-05 | 张进 | A kind of brake for operation on eyeball |
| CN208725936U (en) * | 2017-10-19 | 2019-04-12 | 中国科学院深圳先进技术研究院 | A kind of animal eyes ball fixing device for photoacoustic imaging system |
-
2017
- 2017-10-19 CN CN201710975694.4A patent/CN107802372A/en active Pending
Patent Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2549946Y (en) * | 2002-06-13 | 2003-05-14 | 复旦大学附属眼耳鼻喉科医院 | Eyeball fixer for surgical operation |
| CN201710373U (en) * | 2010-06-22 | 2011-01-19 | 中国人民解放军第三军医大学第一附属医院 | Eye ball fixing device |
| CN202821706U (en) * | 2012-09-21 | 2013-03-27 | 天津市天津医院 | Experimental animal operating table |
| CN203220457U (en) * | 2013-03-25 | 2013-10-02 | 中国人民解放军第三军医大学第一附属医院 | Eyeball fixing device |
| CN203220456U (en) * | 2013-03-25 | 2013-10-02 | 中国人民解放军第三军医大学第一附属医院 | Pop-up eyeball fixing device |
| CN203169839U (en) * | 2013-04-15 | 2013-09-04 | 舒长和 | Electromagnetic treatment loop of acoustics-electromagnetism combined therapeutic instrument |
| CN103340697A (en) * | 2013-07-18 | 2013-10-09 | 深圳先进技术研究院 | Fixing device used for fixing back skin of experimental animal |
| CN103976709A (en) * | 2014-04-24 | 2014-08-13 | 中国科学院苏州生物医学工程技术研究所 | Wearable array transducer probe and small animal brain function photoacoustic imaging system |
| CN204181735U (en) * | 2014-09-10 | 2015-03-04 | 中国辐射防护研究院 | Toy arc irradiation fixture |
| CN104274157A (en) * | 2014-09-24 | 2015-01-14 | 深圳先进技术研究院 | Fixing device and photoacoustic tomography system with same |
| CN204092265U (en) * | 2014-10-23 | 2015-01-14 | 中国人民解放军总医院 | A kind of animal spinal cord living imaging Orientation observation device |
| CN105193520A (en) * | 2015-09-30 | 2015-12-30 | 无锡市第二人民医院 | Method for fixing eyeball of living mouse |
| CN106551753A (en) * | 2015-09-30 | 2017-04-05 | 张进 | A kind of brake for operation on eyeball |
| CN205698116U (en) * | 2016-04-20 | 2016-11-23 | 复旦大学 | A kind of living animal head window for two-photon laser imaging maintains and fixing device |
| CN106137529A (en) * | 2016-07-27 | 2016-11-23 | 苏州贝尔锋医疗器械有限公司 | Open eyelid and eyeball fixture |
| CN208725936U (en) * | 2017-10-19 | 2019-04-12 | 中国科学院深圳先进技术研究院 | A kind of animal eyes ball fixing device for photoacoustic imaging system |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110236729A (en) * | 2019-07-08 | 2019-09-17 | 温州医科大学附属眼视光医院 | A kind of size-adjustable lagophthalmos ball fixing device based on eyeball dislocation method |
| CN110236729B (en) * | 2019-07-08 | 2021-07-06 | 温州医科大学附属眼视光医院 | Rabbit eyeball fixing device with adjustable size based on eyeball dislocation method |
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Application publication date: 20180316 |