CN103976709A - Wearable array transducer probe and small animal brain function photoacoustic imaging system - Google Patents
Wearable array transducer probe and small animal brain function photoacoustic imaging system Download PDFInfo
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- CN103976709A CN103976709A CN201410166988.9A CN201410166988A CN103976709A CN 103976709 A CN103976709 A CN 103976709A CN 201410166988 A CN201410166988 A CN 201410166988A CN 103976709 A CN103976709 A CN 103976709A
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Abstract
The invention discloses a wearable array transducer probe and a small animal brain function photoacoustic imaging system. The wearable array transducer probe comprises a wrist-shaped outer casing, a top connector, a transducer array, a bottom sealing ring and a rubber buckle belt. The small animal brain function photoacoustic imaging system comprises the wearable array transducer probe, a composite cable, an integrated light source generator, a display and a host, wherein the composite cable comprises an optical signal line and a data line, a light beam expander of the wearing type array transducer probe is connected with the integrated light source generator through the optical signal line, and an adapter of the wearing type array transducer probe is connected with the host through the data line. The wearable array transducer probe overcomes the defects of the existing small animal brain function photoacoustic imaging system that the size is large, the cost is high, the special brain function imaging is not available, the small animals need to be anesthetized and fixed for observing, and the like.
Description
Technical field
The invention belongs to cerebral function imaging device field, particularly wearable array energy transducer probe and toy brain function photoacoustic imaging system.
Background technology
Brain is the organ of human spirit and intellectual activity, is the maincenter of mankind's activities, and whether its health is determining people's life and life quality thereof.Human brain be again so far known to the most complicated system, disclose human brain secret, improving brain function understanding is the urgent task of current scientific research and treatment, is also to natural science applied a major challenge.Over nearly 20 years, along with developing rapidly of modern physics, electronics and computer technology, cerebral function imaging technology has obtained significant progress, as: Magnetic resonance imaging technology (FMRI), positron emission computerized tomography technology (PET), single positron emission tomography scanning technique (SPECT), magneticencephalogram (MEG) and near infrared light spectral analysis technology (FNIRI), event related potential (ERP), electroencephalogram (EEG) etc.Cerebral function imaging adopts PET and FMRI more at present, and the main advantage of these two kinds of technology is: can be applied to human experimentation; Spatial resolution and temporal resolution are better; Can be used to draw full brain image.But the cost of equipment that it is high and huge volume restrictions its further universal and overall application.And the cerebral function imaging technology in many forward positions due to be subject to ethics and morals constraint also cannot be directly in human experimentation.
So-called photoacoustic imaging is a kind of harmless medical imaging method that development in recent years is got up, and it combines the multispectral functional imaging of optical imagery and the high-penetration depth characteristic of ultra sonic imaging, and tissue and the functional imaging of high-resolution and high contrast can be provided.At present, the equipment that adopts in the world photoacoustic imaging technology to carry out toy experiment mainly contains the Vevo LAZR toy photoacoustic imaging system of Canadian Visual Sonics company manufacture and the Nexus-128 photoacoustic imaging system that U.S. Enlight Biosciences subsidiary produces.But what current photoacoustic imaging device was mainly observed is the body imaging of toy, and without the specific function for brain imaging, and Vevo LAZR and Nexus-128 all adopt is that tunable pulsed laser device is as exciting light source, thereby equipment volume is large, involve great expense, the former is about 3,000,000 yuan/platform existing market price, approximately 2,500,000 yuan/platform of the latter, and this has also limited the universal and range of application of photoacoustic imaging device.In addition, Vevo LAZR and Nexus-128 system are when carrying out toy photoacoustic imaging, the same with most cerebral function imaging equipment, all need toy to anaesthetize and fix processing the deviation that toy limb motion is caused when preventing imaging.Although this is conducive to improve the stability of image quality, also contained that especially it,, when cerebral function imaging, observes the possibility of toy brain function under free movement state to photoacoustic imaging.
Summary of the invention
The problem existing in order to solve background technology, the present invention aims to provide wearable array energy transducer probe and the photoacoustic imaging system based on this probe, overcomes that existing toy opto-acoustic imaging devices volume is large, cost is high, without specially for brain function imaging and need the fixedly unfavorable factor such as toy observation of anesthesia.
In order to realize above-mentioned technical purpose, technical scheme of the present invention is:
Wearable array energy transducer probe, be worn on the brain of toy, comprise bowl-shape shell, top adapter, transducer array, bottom sealing ring and rubber cingulum, described top adapter is arranged on the top of bowl-shape shell, transducer array is evenly distributed on the inside of bowl-shape shell, bottom sealing ring is arranged on the bottom of bowl-shape shell, rubber cingulum is arranged on bottom sealing ring, described top adapter comprises beam expander and butt joint, butt joint connects transducer array, and beam expander guided laser uniform irradiation is at the brain of toy; Described transducer array can be launched ultrasound wave.
Wherein, above-mentioned rubber cingulum is fixed on bottom sealing ring by screw socket.
Wherein, above-mentioned bowl-shape shell and bottom sealing ring convergent-divergent in proportion.
The present invention also comprises the photoacoustic imaging system based on above-mentioned wearable array energy transducer probe, comprise aforesaid wearable array energy transducer probe, composite cable, integrated optical source generator, display and main frame, described composite cable comprises optical signal line and data wire, the beam expander of wearable array energy transducer probe is connected with integrated optical source generator through optical signal line, and the butt joint of wearable array energy transducer probe is connected with main frame through data wire; Operation wavelength and the pulse strength of described Selection of chiller integrated optical source generator, by optical signal line, laser being incided to wearable array energy transducer pops one's head in, make laser be irradiated to equably toy brain, the transducer array of wearable array energy transducer probe also can be independently to toy brain transmitting ultrasound wave, and utilize transducer array to survey the photoacoustic signal that toy brain produces, and through data wire, photoacoustic signal is sent to main frame, by the photoacoustic imaging software loading on main frame, completed the photoacoustic imaging of toy brain, and be finally presented on display.
Wherein, aforementioned display device, main frame and integrated optical source generator are loaded in movably on platform.
Wherein, above-mentioned optical signal line is fibre bundle, or optical signal line comprises single multimode fibre and optical fiber combiner, and integrated optical source generator is connected with single multimode fibre chain through optical fiber combiner.
Wherein, the semiconductor laser that above-mentioned integrated optical source generator comprises some different wave lengths, or the laser diode that comprises some different wave lengths, or the modulating pulse formula LED that comprises some different wave lengths, its wave-length coverage is between 650nm ~ 1250nm.
The beneficial effect that adopts technique scheme to bring is:
The present invention can carry out real-time non-intrusion measurement to toy, has that time precision is high, spatial resolution good, a multi-mode (photoacoustic imaging, ultra sonic imaging, the ultrasonic fusion of imaging of optoacoustic), the advantage such as radiationless, harmless, safe, flexible, easy-to-use.It is compared with existing cerebral function imaging technology, it is fixing without anesthesia when maximum difference is its zoopery, but adopt the wearable array energy transducer probe that comprises LASER Illuminator System to be fixed on the head of toy, can also to the brain of toy, carry out repeatedly photoacoustic imaging for a long time in real time with toy is freely movable, monitor it and cerebral vessels blood flow of various stimulations and condition, blood oxygen distribution and situation of change are understood the activity of brain below waking state, determine the function of brain zones of different.The present invention also can detect by the absorption distribution situation that toy carry out related brain functional diagnosis medicine, to the analysis of cerebral tumor new vessels high-resolution imaging etc.These features have an enormous advantage project development system tool in the large spatial scale research of cerebral activity, have wide scientific research and actual application prospect utilizing toy to carry out brain function imaging side mask.In addition, the present invention compares with existing apparatus, has the advantages such as volume is little, cost is low, easy and simple to handle.
Accompanying drawing explanation
Fig. 1 is the structural representation of the wearable array energy transducer probe of the present invention.
Fig. 2 is the structural representation of toy brain function photoacoustic imaging system of the present invention.
The specific embodiment
Below with reference to accompanying drawing, technical scheme of the present invention is elaborated.
The structural representation that the wearable array energy transducer of the present invention is popped one's head in as shown in Figure 1, it comprises bowl-shape shell, top adapter, transducer array, bottom sealing ring and rubber cingulum.Described top adapter is arranged on the top of bowl-shape shell, and transducer array is evenly distributed on the inside of bowl-shape shell, and bottom sealing ring is arranged on the bottom of bowl-shape shell, and rubber cingulum is arranged on bottom sealing ring.Described top adapter comprises beam expander and butt joint, and butt joint connects transducer array, and beam expander guided laser uniform irradiation is at the brain of toy.Described transducer array can be launched ultrasound wave.
In the present embodiment, rubber cingulum is fixed on bottom sealing ring by screw socket.Except wearable array energy transducer probe being fixed on the head of toy by rubber cingulum, bowl-shape shell and bottom sealing ring be convergent-divergent in proportion, the head of the toy of accomplishing to fit better.
The structural representation of toy brain function photoacoustic imaging system of the present invention as shown in Figure 2, it comprises wearable array energy transducer probe, composite cable, integrated optical source generator, display and main frame.Described composite cable comprises optical signal line and data wire, and the beam expander of wearable array energy transducer probe is connected with integrated optical source generator through optical signal line, and the butt joint of wearable array energy transducer probe is connected with main frame through data wire; Operation wavelength and the pulse strength of described Selection of chiller integrated optical source generator, by optical signal line, laser being incided to wearable array energy transducer pops one's head in, make laser be irradiated to equably toy brain, the transducer array of wearable array energy transducer probe also can be independently to toy brain transmitting ultrasound wave, and utilize transducer array to survey the photoacoustic signal that toy brain produces, and through data wire, photoacoustic signal is sent to main frame, by the photoacoustic imaging software loading on main frame, completed the photoacoustic imaging of toy brain, and be finally presented on display.
In the present embodiment, display, main frame and integrated optical source generator are all loaded in movably on platform, and to coordinate better toy to run on a large scale when surveying, this platform is provided with brake or brake unit is used for fixing this platform simultaneously.The laser that integrated optical source generator sends is narrow width pulse formula laser, so semiconductor laser that integrated optical source generator comprises some different wave lengths, or the semiconductor laser laser diode that comprises some different wave lengths, or the LED of the modulating pulse formula that comprises some different wave lengths, its wave-length coverage is covered as 650nm-1250nm.
Operation principle of the present invention is:
First by the control software on main frame, select operation wavelength and the pulse strength of integrated light source generator, by optical signal line, laser is incided in wearable array energy transducer probe, by the beam expander in probe, make it to be irradiated to equably the head of experimental animal, also can utilize the transducer array of Wearable array energy transducer probe to toy head transmitting ultrasound wave, recycling transducer array is surveyed the photoacoustic signal that toy brain produces, through data wire, photoacoustic signal is sent to main frame, by the photoacoustic imaging software loading on main frame, completed the photoacoustic imaging of toy brain, and be finally presented on display.In order to carry out optoacoustic brain blood oxygen, detect, need to use light sources more than at least two wavelength, in conjunction with near infrared light, in tissue, have better penetration performance, so system should adopt the near-infrared integrated optical source of 3～5 different wave lengths to meet with this needs of surveying.During detection, successively obtain the not photoacoustic signal under co-wavelength laser excitation of brain, derive the blood absorption coefficient of light under different wave length, extinction coefficient in conjunction with oxygenate/deoxyhemoglobin under different wave length, just can calculate blood oxygen saturation, and then draw out the blood oxygen distribution photoacoustic image of brain, realize the functional imaging to brain.
Above embodiment only, for explanation technological thought of the present invention, can not limit protection scope of the present invention with this, every technological thought proposing according to the present invention, and any change of doing on technical scheme basis, within all falling into protection domain of the present invention.
Claims (10)
1. wearable array energy transducer is popped one's head in, be worn on the brain of toy, it is characterized in that: comprise bowl-shape shell, top adapter, transducer array, bottom sealing ring and rubber cingulum, described top adapter is arranged on the top of bowl-shape shell, transducer array is evenly distributed on the inside of bowl-shape shell, bottom sealing ring is arranged on the bottom of bowl-shape shell, and rubber cingulum is arranged on bottom sealing ring; Described top adapter comprises beam expander and butt joint, and butt joint connects transducer array, and beam expander guided laser uniform irradiation is at the brain of toy; Described transducer array can be launched ultrasound wave.
2. wearable array energy transducer is popped one's head according to claim 1, it is characterized in that: described rubber cingulum is fixed on bottom sealing ring by screw socket.
3. wearable array energy transducer is popped one's head according to claim 1, it is characterized in that: described bowl-shape shell and bottom sealing ring be convergent-divergent in proportion.
4. the toy brain function photoacoustic imaging system based on wearable array energy transducer probe described in claim 1, it is characterized in that: comprise composite cable, integrated optical source generator, display, main frame and wearable array energy transducer probe as claimed in claim 1, described composite cable comprises optical signal line and data wire, the beam expander of wearable array energy transducer probe is connected with integrated optical source generator through optical signal line, and the butt joint of wearable array energy transducer probe is connected with main frame through data wire; Operation wavelength and the pulse strength of described Selection of chiller integrated optical source generator, by optical signal line, laser being incided to wearable array energy transducer pops one's head in, make laser be irradiated to equably toy brain, the transducer array of wearable array energy transducer probe also can be independently to toy brain transmitting ultrasound wave, and utilize transducer array to survey the photoacoustic signal that toy brain produces, and through data wire, photoacoustic signal is sent to main frame, by the photoacoustic imaging software loading on main frame, completed the photoacoustic imaging of toy brain, and be finally presented on display.
5. toy brain function photoacoustic imaging system according to claim 4, is characterized in that: described display, main frame and integrated optical source generator are all loaded in movably on platform.
6. toy brain function photoacoustic imaging system according to claim 4, is characterized in that: described optical signal line is fibre bundle.
7. toy brain function photoacoustic imaging system according to claim 4, is characterized in that: described optical signal line comprises single multimode fibre and optical fiber combiner, and integrated optical source generator is connected with single multimode fibre through optical fiber combiner.
8. according to toy brain function photoacoustic imaging system described in any one in claim 4 to 7, it is characterized in that: the semiconductor laser that described integrated optical source generator comprises some different wave lengths, its wave-length coverage is between 650nm ~ 1250nm.
9. according to toy brain function photoacoustic imaging system described in any one in claim 4 to 7, it is characterized in that: the laser diode that described integrated optical source generator comprises some different wave lengths, its wave-length coverage is between 650nm ~ 1250nm.
10. according to toy brain function photoacoustic imaging system described in any one in claim 4 to 7, it is characterized in that: the modulating pulse formula LED that described integrated optical source generator comprises some different wave lengths, its wave-length coverage is between 650nm ~ 1250nm.
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104568758A (en) * | 2014-12-12 | 2015-04-29 | 中国科学院苏州生物医学工程技术研究所 | LED-based photoacoustic imaging system |
| CN104545814A (en) * | 2014-12-31 | 2015-04-29 | 中国科学院深圳先进技术研究院 | Headset photoacoustic imaging device for animal |
| CN106037802A (en) * | 2016-06-27 | 2016-10-26 | 吉林大学 | System for positioning brain lesion area |
| WO2016198541A1 (en) | 2015-06-10 | 2016-12-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Detecting apparatus and associated kit and method |
| CN106473751A (en) * | 2016-11-25 | 2017-03-08 | 刘国栋 | Palm blood vessel imaging based on arrayed ultrasonic sensor and identifying device and its imaging method |
| CN107802372A (en) * | 2017-10-19 | 2018-03-16 | 中国科学院深圳先进技术研究院 | A kind of animal eyeball fixing device for photoacoustic imaging system |
| CN108464814A (en) * | 2018-02-27 | 2018-08-31 | 中国人民解放军陆军军医大学 | A kind of anti-dropout experimental animal is with wearable through sight stimulating apparatus |
| CN109497952A (en) * | 2018-12-24 | 2019-03-22 | 同济大学 | Photoacoustic ultrasound bimodal per rectum based endoscopic imaging device based on embedded LED |
| CN109998480A (en) * | 2019-02-01 | 2019-07-12 | 中国科学院苏州生物医学工程技术研究所 | Internal drug Vivo Studies on Screening system |
| CN110547788A (en) * | 2019-08-28 | 2019-12-10 | 李凯述 | Wearable animal photoacoustic combined electrocardiogram measuring system |
| CN110547789A (en) * | 2019-08-28 | 2019-12-10 | 李凯述 | Wearable animal cardiovascular measurement system |
| CN110876617A (en) * | 2019-08-28 | 2020-03-13 | 李凯述 | Charging system of cardiovascular measuring device |
| WO2023150077A1 (en) * | 2022-02-02 | 2023-08-10 | Trustees Of Boston University | Neural stimulation in vitro and in vivo by photoacoustic nanotransducers |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101828928A (en) * | 2010-04-01 | 2010-09-15 | 江西科技师范学院 | Three-dimensional optoacoustic mammary gland or brain non-destructive imaging system |
| CN102573621A (en) * | 2009-05-01 | 2012-07-11 | 视声公司 | System for photoacoustic imaging and related methods |
| US20130190595A1 (en) * | 2012-01-23 | 2013-07-25 | Alexander A. Oraevsky | Laser Optoacoustic Ultrasonic Imaging System (LOUIS) and Methods of Use |
-
2014
- 2014-04-24 CN CN201410166988.9A patent/CN103976709A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102573621A (en) * | 2009-05-01 | 2012-07-11 | 视声公司 | System for photoacoustic imaging and related methods |
| CN101828928A (en) * | 2010-04-01 | 2010-09-15 | 江西科技师范学院 | Three-dimensional optoacoustic mammary gland or brain non-destructive imaging system |
| US20130190595A1 (en) * | 2012-01-23 | 2013-07-25 | Alexander A. Oraevsky | Laser Optoacoustic Ultrasonic Imaging System (LOUIS) and Methods of Use |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104568758A (en) * | 2014-12-12 | 2015-04-29 | 中国科学院苏州生物医学工程技术研究所 | LED-based photoacoustic imaging system |
| CN104545814A (en) * | 2014-12-31 | 2015-04-29 | 中国科学院深圳先进技术研究院 | Headset photoacoustic imaging device for animal |
| WO2016198541A1 (en) | 2015-06-10 | 2016-12-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Detecting apparatus and associated kit and method |
| US11234677B2 (en) | 2015-06-10 | 2022-02-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Detecting apparatus and associated kit and method |
| CN106037802A (en) * | 2016-06-27 | 2016-10-26 | 吉林大学 | System for positioning brain lesion area |
| CN106037802B (en) * | 2016-06-27 | 2019-02-15 | 吉林大学 | A kind of positioning system in brain lesions region |
| CN106473751A (en) * | 2016-11-25 | 2017-03-08 | 刘国栋 | Palm blood vessel imaging based on arrayed ultrasonic sensor and identifying device and its imaging method |
| CN106473751B (en) * | 2016-11-25 | 2024-04-23 | 刘国栋 | Palm blood vessel imaging and identifying device based on array ultrasonic sensor and imaging method thereof |
| CN107802372A (en) * | 2017-10-19 | 2018-03-16 | 中国科学院深圳先进技术研究院 | A kind of animal eyeball fixing device for photoacoustic imaging system |
| CN108464814B (en) * | 2018-02-27 | 2021-02-02 | 中国人民解放军陆军军医大学 | Anti-drop experimental animals is with wearable eye stimulation device |
| CN108464814A (en) * | 2018-02-27 | 2018-08-31 | 中国人民解放军陆军军医大学 | A kind of anti-dropout experimental animal is with wearable through sight stimulating apparatus |
| CN109497952A (en) * | 2018-12-24 | 2019-03-22 | 同济大学 | Photoacoustic ultrasound bimodal per rectum based endoscopic imaging device based on embedded LED |
| CN109998480A (en) * | 2019-02-01 | 2019-07-12 | 中国科学院苏州生物医学工程技术研究所 | Internal drug Vivo Studies on Screening system |
| CN110876617A (en) * | 2019-08-28 | 2020-03-13 | 李凯述 | Charging system of cardiovascular measuring device |
| CN110547789A (en) * | 2019-08-28 | 2019-12-10 | 李凯述 | Wearable animal cardiovascular measurement system |
| CN110547788A (en) * | 2019-08-28 | 2019-12-10 | 李凯述 | Wearable animal photoacoustic combined electrocardiogram measuring system |
| WO2023150077A1 (en) * | 2022-02-02 | 2023-08-10 | Trustees Of Boston University | Neural stimulation in vitro and in vivo by photoacoustic nanotransducers |
| US11883344B2 (en) | 2022-02-02 | 2024-01-30 | Trustees Of Boston University | Neural stimulation in vitro and in vivo by photoacoustic nanotransducers |
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Application publication date: 20140813 |