CN103316353B - Ice laser treatment device carrier liquid and preparation method thereof - Google Patents
Ice laser treatment device carrier liquid and preparation method thereof Download PDFInfo
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- CN103316353B CN103316353B CN201310168674.8A CN201310168674A CN103316353B CN 103316353 B CN103316353 B CN 103316353B CN 201310168674 A CN201310168674 A CN 201310168674A CN 103316353 B CN103316353 B CN 103316353B
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- deionized water
- cellulose
- hydroxyethyl
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- carrier fluid
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Abstract
The invention relates to an ice laser treatment device carrier liquid and a preparation method thereof, wherein the ice laser treatment device carrier liquid comprises, by weight, 0.5-5% of hydroxyethyl cellulose, 0.005-0.015% of methylchloroisothiazolinone, and the balance of deionized water. According to the present invention, hydroxyethyl cellulose is adopted as a film forming agent, and has advantages of simple component, rapid film forming, good water retention performance and high stability compared with the film forming agent formed by carrying out a reaction of more than two different substances in the prior art; and the ice laser treatment device carrier liquid adopting deionized water and hydroxyethyl cellulose as main components is added with methylchloroisothiazolinone and/or 2-methyl-4-isothiazolin-3-one, such that the ice laser treatment device carrier liquid has a sterilization and sterilization function.
Description
Technical field
The present invention relates to one and have that film forming speed is fast, water retention property good, stability is high, and there is disinfection function, ice laser therapeutic apparatus carrier fluid being used as drug carrier system and preparation method thereof.
Background technology
Ice laser therapeutic apparatus carrier fluid as drug carrier system needs to possess the basic characteristics that film forming speed is fast, water retention property good, stability is high usually, for the ice laser therapeutic apparatus carrier fluid as drug carrier system of high-quality, also need to possess, under the effect of luminous energy, electric energy or acoustic energy, there is not easily decomposability and the feature not disruptive to the pharmaceutical compositions be dissolved in wherein.
At present, ice laser therapeutic apparatus carrier fluid as drug carrier system is that two or more different materials reacts generation under certain condition mostly, modal is react with PHOSPHATIDYL ETHANOLAMINE and polysaccharide, the reactant generated, as adopted PHOSPHATIDYL ETHANOLAMINE and hyaluronic reaction product, or adopt the reaction product etc. of PHOSPHATIDYL ETHANOLAMINE and carboxymethyl cellulose.Thisly react generated product under certain condition by two or more different materials, when its ice laser therapeutic apparatus carrier fluid as drug carrier system uses, under the effect of luminous energy, electric energy or acoustic energy, its interatomic bond makes a concerted effort to there is destroyed danger, thus causing when the effect of luminous energy, electric energy or acoustic energy, molecule is destroyed and make gel lose coagulation force.In addition, the product required for generating with the reaction of two or more different materials, needs extra work flow, have also increased dramatically cost of material, can weaken the market competitiveness.
Summary of the invention
The object of the invention is for the problems referred to above, provide to society that film forming speed is fast, water retention property good, stability is high, and ice laser therapeutic apparatus carrier fluid with disinfection function and preparation method thereof.
Technical scheme of the present invention is: provide a kind of ice laser therapeutic apparatus carrier fluid, comprise the following component of percentage by weight:
Hydroxyethyl-cellulose 0.5-5%; Methylchloroisothiazandnone 0.005%-0.015%; Surplus is deionized water.
As improvement of the present invention, the present invention also comprises MIT 0.001%-0.009%.
The present invention also provides a kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight
Hydroxyethyl-cellulose 0.5-5%; MIT 0.002%-0.01%; Surplus is deionized water.
The present invention also provides the method preparing above-mentioned ice laser therapeutic apparatus carrier fluid, respectively hydroxyethyl-cellulose, methylchloroisothiazandnone and deionized water are weighed in proportion, then methylchloroisothiazandnone is dissolved in deionized water, then, then by hydroxyethyl-cellulose dissolve in when constantly stirring in the deionized water containing methylchloroisothiazandnone.
The present invention also provides another to prepare the method for above-mentioned ice laser therapeutic apparatus carrier fluid, respectively hydroxyethyl-cellulose, methylchloroisothiazandnone, MIT and deionized water are weighed in proportion, then methylchloroisothiazandnone and MIT are dissolved in deionized water, then, then by hydroxyethyl-cellulose dissolve in when constantly stirring in the deionized water containing methylchloroisothiazandnone and MIT.
The present invention also provides the third to prepare the method for above-mentioned ice laser therapeutic apparatus carrier fluid, respectively hydroxyethyl-cellulose, MIT and deionized water are weighed in proportion, then MIT is dissolved in deionized water, then, then by hydroxyethyl-cellulose dissolve in when constantly stirring in the deionized water containing MIT.
The present invention only adopts hydroxyethyl-cellulose as film former, and the two or more different materials adopted in itself and prior art react raw film former, have the advantage that composition is simple, film forming speed is fast, water retention property is good, stability is high; Dried up with in the ice laser therapeutic apparatus carrier liquid of hydroxyethyl-cellulose to go, add methylchloroisothiazandnone or/and MIT, make ice laser therapeutic apparatus carrier liquid have the function of sterilizing.
Detailed description of the invention
Embodiment 1
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 0.5%; Methylchloroisothiazandnone 0.005%; Surplus is deionized water.
Embodiment 2
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 1.5%; Methylchloroisothiazandnone 0.007%; Surplus is deionized water.
Embodiment 3
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 2.5%; Methylchloroisothiazandnone 0.01%; Surplus is deionized water.
Embodiment 4
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 3.5%; Methylchloroisothiazandnone 0.012%; Surplus is deionized water.
Embodiment 5
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 4.5%; Methylchloroisothiazandnone 0.015%; Surplus is deionized water.
Embodiment 6
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 5%; Methylchloroisothiazandnone 0.01%; Surplus is deionized water.
Embodiment 7
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 0.5%; Methylchloroisothiazandnone 0.005%; MIT 0.001%; Surplus is deionized water.
Embodiment 8
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 1.5%; Methylchloroisothiazandnone 0.007%; MIT 0.003%; Surplus is deionized water.
Embodiment 9
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 2.5%; Methylchloroisothiazandnone 0.01%; MIT 0.005%; Surplus is deionized water.
Embodiment 10
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 3.5%; Methylchloroisothiazandnone 0.012%; MIT 0.007%; Surplus is deionized water.
Embodiment 11
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 4.5%; Methylchloroisothiazandnone 0.015%; MIT 0.009%; Surplus is deionized water.
Embodiment 12
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 5%; Methylchloroisothiazandnone 0.01%; MIT 0.009%; Surplus is deionized water.
Embodiment 13
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 0.5%; MIT 0.002%; Surplus is deionized water.
Embodiment 14
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 1.5%; MIT 0.004%; Surplus is deionized water.
Embodiment 15
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 2.5%; MIT 0.006%; Surplus is deionized water.
Embodiment 16
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 3.5%; MIT 0.008%; Surplus is deionized water.
Embodiment 17
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 4.5%; MIT 0.01%; Surplus is deionized water.
Embodiment 18
A kind of ice laser therapeutic apparatus carrier fluid, comprises the following component of percentage by weight: hydroxyethyl-cellulose 5%; MIT 0.01%; Surplus is deionized water.
In the present invention, the method preparing enforcement 1 to embodiment 6 is, respectively hydroxyethyl-cellulose, methylchloroisothiazandnone and deionized water are weighed in proportion, then methylchloroisothiazandnone is dissolved in deionized water, then, then by hydroxyethyl-cellulose dissolve in when constantly stirring in the deionized water containing methylchloroisothiazandnone.
In the present invention, the method preparing enforcement 7 to embodiment 12 is, respectively hydroxyethyl-cellulose, methylchloroisothiazandnone, MIT and deionized water are weighed in proportion, then methylchloroisothiazandnone and MIT are dissolved in deionized water, then, then by hydroxyethyl-cellulose dissolve in when constantly stirring in the deionized water containing methylchloroisothiazandnone and MIT.
In the present invention, the method preparing enforcement 13 to embodiment 18 is, respectively hydroxyethyl-cellulose, MIT and deionized water are weighed in proportion, then MIT is dissolved in deionized water, then, then by hydroxyethyl-cellulose dissolve in when constantly stirring in the deionized water containing MIT.
Preserve under ice laser therapeutic apparatus carrier fluid in the present invention needs low temperature, after with the addition of medicine, before use should in freezing to solid-state, and painting is touched at human body therapy skin area, coordinate electromagenetic wave radiation (preferably laser emission again, but be not with restriction) or acoustic radiation (preferably Ultrasonic Radiation, but be not with restriction) just can will easily medicine be entered in human body through human body skin, and ice laser therapeutic apparatus carrier fluid itself can not be destroyed, because in ice laser therapeutic apparatus carrier fluid, itself contains antibacterial and anti-inflammation functions, also can not infect because of the effect of laser or sound wave at human body therapy skin area.
The weight average molecular weight indefinite of the hydroxyethyl-cellulose (HEC, C2H602-X) in the present invention, but be preferably below more than 20,000 dalton 1,500,000 dalton, be more preferably below more than 50,000 dalton 600,000 dalton.
In the present invention, because hydroxyethyl-cellulose (HEC) is a kind of white or faint yellow, tasteless, nontoxic threadiness or pulverulent solids, it is prepared through etherification reaction by alkali cellulose and oxirane (or 2-chloroethyl alcohol), belongs to nonionic soluble fiber element ethers.Therefore, hydroxyethyl-cellulose (HEC) has good thickening, suspension, dispersion, emulsifying, bonding, film forming, protection moisture and provides the characteristics such as protecting colloid.Hydroxyethyl-cellulose (HEC) dissolves in hot water or cold water, and high temperature or boil does not precipitate, and makes it have large-scale dissolubility and viscosity characteristics, and non-thermal gelation; Hydroxyethyl-cellulose (HEC) itself is nonionic, can with other interior on a large scale water-soluble polymers, and surfactant, salt coexist, and is a kind of excellent colloidal thickener containing high concentration electrolyte solution; Hydroxyethyl-cellulose (HEC) water holding capacity exceeds one times than methylcellulose, has good flow adjustment; It is the poorest that the dispersibility of hydroxyethyl-cellulose (HEC) and the methylcellulose of generally acknowledging and hydroxypropyl emthylcellulose compares dispersibility, but protecting colloid ability is the strongest.
Methylchloroisothiazandnone is a kind of high-effective broad-spectrum fungicide, water soluble, has good effect for suppression microbial growth, can anti-bacteria, fungus, mycete and mycete growth.
Similarly, Methylisothiazolinone (MIT) is also a kind of efficient germicide, has good effect for suppression microbial growth, can anti-bacteria, fungus, mycete and mycete growth.
By methylchloroisothiazandnone and Methylisothiazolinone used in combination by a certain percentage, its effect is better.
Claims (7)
1. an ice laser therapeutic apparatus carrier fluid, is characterized in that: the following component comprising percentage by weight:
The hydroxyethyl-cellulose 0.5-5% of weight average molecular weight between 50,000 dalton and 600,000 dalton; Methylchloroisothiazandnone 0.005%-0.015%; Surplus is deionized water.
2. ice laser therapeutic apparatus carrier fluid as claimed in claim 1, is characterized in that: also comprise MIT 0.001%-0.009%.
3. ice laser therapeutic apparatus carrier fluid as claimed in claim 1 or 2, is characterized in that: described ice laser therapeutic apparatus carrier fluid exists in the solid-state form after being frozen.
4. an ice laser therapeutic apparatus carrier fluid, is characterized in that: the following component comprising percentage by weight:
The hydroxyethyl-cellulose 0.5-5% of weight average molecular weight between 50,000 dalton and 600,000 dalton; MIT 0.002%-0.01%; Surplus is deionized water.
5. ice laser therapeutic apparatus carrier fluid as claimed in claim 4, is characterized in that: described ice laser therapeutic apparatus carrier fluid exists in the solid-state form after being frozen.
6. prepare the method for ice laser therapeutic apparatus carrier fluid according to claim 1, it is characterized in that: respectively the hydroxyethyl-cellulose of weight average molecular weight between 50,000 dalton and 600,000 dalton, methylchloroisothiazandnone and deionized water are weighed in proportion, then methylchloroisothiazandnone is dissolved in deionized water, then, then by hydroxyethyl-cellulose dissolve in when constantly stirring in the deionized water containing methylchloroisothiazandnone.
7. prepare the method for ice laser therapeutic apparatus carrier fluid according to claim 2, it is characterized in that: respectively the hydroxyethyl-cellulose of weight average molecular weight between 50,000 dalton and 600,000 dalton, methylchloroisothiazandnone, MIT and deionized water are weighed in proportion, then methylchloroisothiazandnone and MIT are dissolved in deionized water, then, then by hydroxyethyl-cellulose dissolve in when constantly stirring in the deionized water containing methylchloroisothiazandnone and MIT.
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