CN103316165A - 一种治疗盆腔炎性包块的中药灌肠剂 - Google Patents
一种治疗盆腔炎性包块的中药灌肠剂 Download PDFInfo
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Abstract
本发明公开了一种治疗盆腔炎性包块的中药灌肠剂。盆腔炎性包块属“腹痛”、“带下”、“不孕”等病症范畴，其病理特点多为虚实夹杂之证。“虚”多因久病气虚耗伤，抗病能力低下；“实”则因久病瘀血内阻，痰湿内蕴，气机阻滞，不通则痛。本发明选择中药白蔹、铜锤草、鱼腥草、雪三七、西红花、珍珠菜、肿节风、草香附、赤芍、曼陀茄根、小茴香，制成灌肠剂，经临床试验，总有效率95.5％，明显优于对照组，值得临床推广应用。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗盆腔炎性包块的中药灌肠剂。
背景技术
盆腔炎性包块是盆腔炎性疾病后遗症，大多是急性盆腔炎未经彻底正规有效的治疗而使病程迁延所致。其主要临床表现为月经紊乱、白带增多、腰腹疼痛及不孕等，如已形成慢性附件炎，则可触及肿块。许多女性因盆腔炎症而造成输卵管阻塞不能受孕，或导致宫外孕，严重影响妇女的身心健康，病情迁延难愈，严重者甚至会继发真菌感染引起病情恶化，长期使用抗生素可产生各种并发症。目前西医在治疗上采用抗菌谱广，对需氧菌和厌氧菌都有杀灭作用的广谱抗生素，长此以往造成细菌的耐药，导致治疗效果欠佳；中药灌肠治疗可通过直肠粘膜吸收，因直肠与子宫、附件相邻，通过直肠给药，使药物直达病所，减少破坏，且生物利用度高，能促进盆腔局部血液循环，改善组织营养状态，提高新陈代谢，协助炎性反应的吸收及消退，使粘连松解，包块消散，迅速起到治疗作用。
发明内容
本发明的目的是提供一种治疗盆腔炎性包块的中药灌肠剂。盆腔炎性包块，属“腹痛”、“带下”、“瘕”、“不孕”等病症范畴。其病理特点多为虚实夹杂之证。“虚”多因久病气虚耗伤，抗病能力低下；“实”则因久病瘀血内阻，痰湿内蕴，气机阻滞，不通则痛。
本发明的目的是通过以下技术方案实现的，该治疗慢性盆腔炎的中药制剂由以下重量份的中药制成：白蔹15-20份、铜锤草20-35份、鱼腥草10-15份、雪三七12-18份、西红花9-15份、珍珠菜40-50份、肿节风10-30份、草香附7-15份、赤芍13-16份、曼陀茄根3-5份、小茴香14-22份。
优选的，白蔹17份、铜锤草28份、鱼腥草13份、雪三七15份、西红花12份、珍珠菜45份、肿节风20份、草香附11份、赤芍15份、曼陀茄根4份、小茴香18份。
制备方法将上述中药加清水1500～2000mL，浸泡40～50min，浓煎得120～160mL药汁，保持38～40℃灌肠。
方中：白蔹、铜锤草、鱼腥草清热解毒，消痈散结，散瘀消肿，利尿通淋；雪三七、西红花、珍珠菜活血止血，消炎止痛，活血化瘀，散瘀开结，活血调经，利水消肿；肿节风抗菌消炎，祛风通络，活血散结；赤芍清热凉血，散瘀止痛；曼陀茄根、小茴香、草香附温中散寒，理气止痛，调经活血。
临床资料
1、一般资料 所选本院确诊为盆腔炎性包块的住院患者120例，随机分成两组，治疗组60例，年龄20-45岁，平均35±0.5岁；每日晨6时体温36.5℃-39.5℃；彩超示包块大小3.5cm×2.4cm-12.6cm×6.8cm，平均6.22cm×5.28cm。对照组60例，年龄23-55岁，平均36±0.9岁，每日晨6时体温36.0℃-39.3℃；彩超示包块大小为3.6cm×2.8cm-10.2cm×7.0cm，平均5.86cm×5.03cm。两组年龄分布、体温、妇科检查及彩超显示包块大小等情况差异无统计学意义。
2、诊断标准 临床表现：下腹坠胀疼痛、腰酸、痛经、不孕等症。妇科检查：可触到单侧或双侧附件炎性包块或囊性包块，活动受限压痛。B超提示：子宫后方包块(4-5cm)43例，双侧附件包块(4-5cm)32例，单侧附件包块(4-5cm)45例。
3、治疗方法 治疗组患者使用本发明所述的中药灌肠剂，即称取白蔹25g、铜锤草28g、鱼腥草13g、雪三七15g、西红花12g、珍珠菜45g、肿节风20g、草香附23g、赤芍15g、曼陀茄根4g、小茴香18g，将上述中药加清水1500～2000mL，浸泡40～50min，浓煎得150mL药汁；使用方法：将浓煎的150mL中药灌肠剂，药温38～40℃灌肠，嘱患者排空大小便后，取左侧卧位，双膝屈曲，将12号一次性吸痰管头蘸少许润滑液，自肛门徐徐插入直至深度15～20cm，约10～15min药液滴注完毕后将灌肠管缓慢拔出，嘱病人保留4个小时以上。在月经干净3d后应用，每天1次；对照组则用理疗、口服中药等综合治疗，两组均10d为1个疗程，连续治疗3个疗程。
4、疗效标准 治愈：腹痛消失，白带正常，体温正常，妇检及彩超检查盆腔包块消失；有效：腹痛消失或减轻，白带正常或接近正常，妇检及彩超检查盆腔包块明显缩小；无效：治疗前后症状及体征无变化。
5、治疗结果 治疗组患者60例，治疗第一个疗程后治愈42例(70.0％)，其中疗程最短的为7天，最长两个疗程；有效15例(25％)，无效3例(5.0)，总有效率为95.5％，对照组治疗第一个疗程治愈3例，第二个疗程后治愈16例，总治愈率为31.7％，有效23例(38.3)，无效18例(30.0)总有效率为70.0％；两组比较，治疗组的治愈率、总有效率明显优于对照组，比较差异有统计学意义。P＜0.05。
具体实施方式
实施例一：称取白蔹25g、铜锤草28g、鱼腥草13g、雪三七15g、西红花12g、珍珠菜45g、肿节风20g、草香附23g、赤芍15g、曼陀茄根4g、小茴香18g。将上述中药加清水1500～2000mL，浸泡40～50min，浓煎得120～160mL药汁，保持38～40℃灌肠。
实施例二：称取白蔹20g、铜锤草35g、鱼腥草10g、雪三七18g、西红花9g、珍珠菜50g、肿节风10g、草香附25g、赤芍13g、曼陀茄根5g、小茴香22g。将上述中药加清水1500～2000mL，浸泡40～50min，浓煎得120～160mL药汁，保持38～40℃灌肠。
实施例三：称取白蔹30g、铜锤草20g、鱼腥草15g、雪三七12g、西红花15g、珍珠菜40g、肿节风30g、草香附20g、赤芍16g、曼陀茄根3g、小茴香14g。将上述中药加清水1500～2000mL，，浸泡40～50min，浓煎得120～160mL药汁，保持38～40℃灌肠。
Claims (2)
1.一种治疗盆腔炎性包块的中药灌肠剂，其特征在于该中药制剂由以下重量份的中药制成：白蔹15-20份、铜锤草20-35份、鱼腥草10-15份、雪三七12-18份、西红花9-15份、珍珠菜40-50份、肿节风10-30份、草香附7-15份、赤芍13-16份、曼陀茄根3-5份、小茴香14-22份。
2.根据权利要求1所述的一种治疗盆腔炎性包块的中药灌肠剂，其特征在于该中药制剂由以下重量份的中药制成：白蔹17份、铜锤草28份、鱼腥草13份、雪三七15份、西红花12份、珍珠菜45份、肿节风20份、草香附11份、赤芍15份、曼陀茄根4份、小茴香18份。
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|---|---|---|---|---|
| CN102600429A (zh) * | 2012-03-29 | 2012-07-25 | 常熟市常福有机复合肥有限公司 | 治疗气滞血瘀型慢性盆腔炎中药组合物及制备方法 |
| CN102641426A (zh) * | 2012-02-17 | 2012-08-22 | 王传梅 | 一种治疗盆腔炎性包块的中药灌肠剂 |
| CN103110847A (zh) * | 2013-02-20 | 2013-05-22 | 艾白媛 | 一种治疗子宫内膜移位症的中药制剂 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102641426A (zh) * | 2012-02-17 | 2012-08-22 | 王传梅 | 一种治疗盆腔炎性包块的中药灌肠剂 |
| CN102600429A (zh) * | 2012-03-29 | 2012-07-25 | 常熟市常福有机复合肥有限公司 | 治疗气滞血瘀型慢性盆腔炎中药组合物及制备方法 |
| CN103110847A (zh) * | 2013-02-20 | 2013-05-22 | 艾白媛 | 一种治疗子宫内膜移位症的中药制剂 |
Non-Patent Citations (2)
| Title |
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| 张慧: "中药保留灌肠治疗湿热瘀结型慢性盆腔炎的临床研究", <<山东中医药大学硕士学位论文>> * |
| 郭兴萍等: "中药灌肠治疗盆腔炎性包块的临床观察", <<中医药研究>> * |
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