CN103316161B - Acne cream and preparing process thereof - Google Patents

Abstract

The invention discloses a Chinese patent medicine for treating acnes and in particular relates to an acne cream for treating acnes and a preparing process thereof. The acne cream comprises the following components: 0.2-0.5g of bezoar, 3-10g of radix angelicae, 5-10g of radix ampelopsis, 15-30g of fructus cnidii, 10-20g of honeysuckle, 10-15g of isatis roots, 3-10g of frankincense and 3-10g of myrrh, wherein the weight unit is not limited to gram. The preparing process comprises the following steps: respectively grinding the bezoar, the radix angelicae and the radix ampelopsis into micro powder; respectively grinding the fructus cnidii, the honeysuckle, the isatis roots, the frankincense and the myrrh into superfine powder, soaking and filtering the powder by using 95 percent of ethanol to obtain liquid medicine and dregs, concentrating the liquid medicine to prepare clear cream, decocting the dregs twice, and filtering and concentrating to prepare the clear cream; uniformly mixing and stirring the clear cream and the micro powder to prepare the acne cream. The acne cream is exact in curative effect and clear in acting mechanism, does not have a toxic effect or side effect, does not have adverse reaction and has a multi-target curative effect. The acne cream has the five effects of killing various pathogenic bacteria and viruses, clearing heat, removing damp and detoxifying, promoting blood circulation to remove blood stasis and dredging channels, relieving itching and sterilizing and moistening skin, beautifying and restoring endocrine disorder of a body to be normal.

Description

Acne ointment and processing technology

Technical field

The present invention is a kind of Chinese patent medicine for the treatment of acne, particularly a kind of to curing that acne have determined curative effect, clear mechanism, have no side effect, have no adverse reaction, the acne ointment of Mutiple Targets curative effect and processing technology.

Background technology

The formal name used at school of acne is acne, be commonly called as " comedo ", be again pimples, whelk, skin sore etc., it is a kind of chronic dermatosis because hair follicle and the inflammation of sebaceous gland obstruction cause, usually be apt to occur in teenager face, cervical region, chest and back, shoulder and upper arm, clinical manifestation is mainly Whiteheads, blackhead, inflamed papules, pustule, tuberosity, cyst etc.This disease adolescence is common, often naturally can cure, but all leave scar after adolescence.Although acne are a kind of diseases with age with spontaneous recovery tendency, acne patient face all leaves scar, and serious harm children in adolescence face, affects patients ' life quality, causes patient mental's pressure and financial burden.About there is disease of pimples patient 8,000 ten thousand people in China.And increase progressively with 3% ascendant trend every year, the teen-age physical and mental health of serious harm.At present, there is no the medicine of curing acne both at home and abroad.

The treatment of acne comprises external used medicine, oral drugs and naturopathy.External used medicine comprises tretinoin medicines, as adapalene gel, also topical antibiotic can carry out antimicrobial therapy, as lincomycin, benzoyl peroxide etc.; Oral drugs comprise antibiotic, as minocycline, azithromycin, Tai Ersi etc.; Naturopathy comprises red blue light photoradiation therapy and photodynamic therapy, and the latter is that first external photosensitizer uses red light irradiation again.External used medicine is easy to use, but curative effect is slow, DeGrain; Although oral drugs have certain curative effect, side effect is large, easily produces drug-induced disease.As: skin mucosa is dry, and particularly women at fertile age has a certain impact to fertility after taking medicine; Naturopathy controls inflammation curative effect rapidly, but needs repeatedly to treat, and can only take stopgap measures, and can not effect a permanent cure, costly easily recur.

Summary of the invention

The object of the invention is to overcome that existing acne therapy DeGrain, side effect are large, the easy defect such as recurrence, inventing a kind of determined curative effect, clear mechanism, having no side effect, acne ointment and the processing technology of the Mutiple Targets curative effect that has no adverse reaction, has.

The object of the invention is to realize as follows:

Described acne ointment, is mixed formed by Calculus Bovis, the Radix Angelicae Dahuricae, Radix Ampelopsis, Fructus Cnidii, Flos Lonicerae, Radix Isatidis, Olibanum, Myrrha, by Chinese materia medica weight proportion be:

The processing technology of described acne ointment, be make in the ratio of the above each component, it comprises the following steps:

One. Calculus Bovis, the Radix Angelicae Dahuricae, Radix Ampelopsis are worn into micropowder respectively, crosses 300 mesh sieves, make the cell grade micropowder that particle diameter is less than 48 μm, it is for subsequent use that loading vial is placed on calorstat;

Two. Fructus Cnidii, Flos Lonicerae, Radix Isatidis, Olibanum, Myrrha are worn into coarse powder respectively, crosses 150 mesh sieves, then wear into micropowder respectively, cross 300 mesh sieves, make the cell grade micropowder that particle diameter is less than 48 μm; Soaking 10-12 hour by putting into the ethanol that its weight 10 is doubly 95% to the concentration of micropowder after above-mentioned micropowder mixing, then filtering and obtaining medicinal liquid and medicinal residues;

Three. the medicinal liquid that step 2 is made, through concentrated, make one-level clear paste, be in store for; Medicinal residues step 2 made decoct 2 times, add weight 6 doubly to the water of medicinal residues at every turn, and each decoction 30 minutes, merges twice decoction liquor, filters, obtains decocting liquid, refiltered by decocting liquid, then through concentrated, makes secondary clear paste, is in store for; Described clear paste, comprising effective ingredient is: cnidium monnieri phenol (cnidimol), luteolin (luteolin), indirubin (indinbin), boswellic acid (alpha-beta-boswellieacid) and r-myrrholic acid (alpha-beta-r-comiphoricacid);

Four. Calculus Bovis step one made, the Radix Angelicae Dahuricae, Radix Ampelopsis cell grade micropowder, the one-level secondary clear paste made with step 3 mixes, and stirs, namely makes acne ointment, loads in bottle.

Therapeutic effect of the present invention is as follows:

The present invention uses the methods of production such as modern pharmacology, pharmacodynamics, pharmacokinetics, toxicology, illustrates herbal pharmacology, the property of medicine, drug action mechanism, develops " acne ointment ".The present invention's " acne ointment " treats acne, determined curative effect, clear mechanism clinically, has no side effect, has no adverse reaction, and to acne patient, disease belongs to interior-heat, damp and hot, endocrine disturbance person, all has good curative effect, and mild is cured for two weeks, and serious symptom is cured for three weeks; The present invention has Mutiple Targets curative effect, the various pathogenic bacteria virus of primary antibodie, two removing damp-heat removing toxic substances, three blood circulation promoting and blood stasis dispelling, dredging the meridian, four itch-stopping bactericidals, and skin moistening skin care, five can make person endocrine dysfunction recover normal.

Detailed description of the invention

Described acne ointment: be made up of Calculus Bovis, the Radix Angelicae Dahuricae, Radix Ampelopsis, Fructus Cnidii, Flos Lonicerae, Radix Isatidis, Olibanum, Myrrha, each component is chosen best weight of implementing and is:

Calculus Bovis 0.2g

Radix Angelicae Dahuricae 10g

Radix Ampelopsis 10g

Fructus Cnidii 30g

Flos Lonicerae 15g

Radix Isatidis 10g

Olibanum 10g

Myrrha 10g

Described unit of weight is not limited to g.

Described acne ointment, be make by the weight of the above each component, its manufacture method is as follows:

One. top grade crude drug Calculus Bovis, the Radix Angelicae Dahuricae, the Radix Ampelopsis super micron mill of type WK-150 are pulverized, crosses 300 mesh sieves, make the cell grade micropowder that particle diameter should be less than 48 μm, it is for subsequent use that loading vial is placed on calorstat.

Two. crude drug Fructus Cnidii, Flos Lonicerae, Radix Isatidis, Olibanum, Myrrha Chinese medicine of the five flavours are pulverized with the Universalpulverizer of type WT-130 respectively, cross 150 mesh sieves, pulverize with the super micron mill of type WK-150 respectively again, cross 300 mesh sieves, make particle diameter and be less than 48 μm of cell grade superfine powder, add the soak with ethanol 12 hours that its weight 10 to the concentration of micropowder is doubly 95% after mixing, then filter and obtain medicinal liquid and medicinal residues.

Three. make one-level clear paste by concentrated for the multi-functional extraction concentration and recovery unit of medicinal liquid type TNF-0.5, put into calorstat and be in store for; Above-mentioned two medicinal residues are decocted 2 times more respectively, adds the water that its amount weighs 6 times, each decoction 30 minutes at every turn, merge twice decoction liquor, filter, obtain decocting liquid, then make secondary clear paste with the multi-functional extraction concentration and recovery unit of type TNP-0.5 is concentrated, put into calorstat and be in store for.Described clear paste comprises effective ingredient: cnidium monnieri phenol (cnidimol); Luteolin (luteolin); Indirubin (indinbin); Boswellic acid (alpha-beta-boswellieacid); R-myrrholic acid (alpha-beta-r-comiphoricacid).

Four. by Calculus Bovis, the Radix Angelicae Dahuricae, Radix Ampelopsis cell grade micropowder, with one-level secondary clear paste, to stir obtained ointment with the ointment agitator of type WB-3, then use the ointment filling machine of type WDG-1, ointment is poured in bottle, makes " acne ointment ".

Select acne patient 120 example clinically, be divided into treatment group and matched group at random, treatment group 60 example, matched group 60 example.

1. diagnosed SARS case inclusive criteria:

According to " acne diagnostic criteria ", select in clinical case diagnosis, include case in and be mainly facial skin from the beginning of the pityriasis rubra rubella for grain of rice size or for Whiteheads, or be blackhead, white or faint yellow fat bolt can be extruded, because little pus head can appear in the little papular top of patient infection's laking.Severe patient becomes Acne conglobata, and infection site is comparatively dark, occurs aubergine tuberosity, abscess, cyst, and even ulceration forms sinus tract and cicatrix.Include acne patient in for two groups, by " Pillsburv " classification method, I degree (gently), II degree (in), III degree (weight) classifies.Through statistical disposition on sex, age, the course of disease and cicatrix depth degree, without significant difference (P > 0.05), there is comparability, there is statistical significance.

2. Chinese medical discrimination diagnostic criteria:

Disease belongs to (1) lung stomach disorder due to wind pathogen heat, has pus born of the same parents, sufferings, red tongue, yellow and thin fur, wiry and frequent pulse depending on Blushing; (2) damp-heat in the spleen and stomach body fluid deficiency, taste are with placed in the middle burnt, and be qi-blood-body fluid the source of vital function, heat accumulates stasis, send out as acne.Patient Duo Yin surfeit is pungent, the product of seafood, depending on body of the tongue in vain dry, tongue is yellowish, deep-thready pulse; (3) blood stasis phlegm-damp, stasis blocking meridians, send out as pus born of the same parents, tuberosity, cyst, cicatrix, have ecchymosis, thick and greasy fur, stringy and rolling pulse depending on tongue is dark violet.

3. case selection:

Select disease of pimples patient 120 example, be divided into treatment group and matched group at random.Treatment group 60 example, man 13 example, female 47 example, the age 16-30 year, the mean age is 21.8 years old, course of disease 0.6-8, average course of disease 2.8 years.Onset acne patient 18 example, old acne patient 42 example (face leaves scar).Matched group 60 example, man 12 example, female 48 example, the age 16-30 year, the mean age is 21.2 years old, course of disease 0.6-8, average course of disease 2.7 years.Onset acne patient 19 example, old acne patient 41 example (face leaves scar).

4. administrated method:

Treatment group is coated with Langfang outward and contains " acne ointment " every night that Xiang Chinese medicine study researches and develops and smear acne position once, and face is cleaned by Tu Qianxian clear water, then uses cotton swab that " acne ointment " is smeared affected part, and face is cleaned with clear water by the next morning.Matched group is smeared " Xinfu Manling ointment ", and (the healthy medicine company limited in Shandong produces, and the accurate word of traditional Chinese medicines (Z20027830), every day smears face sooner or later at twice.

5. observation index:

Treating phase every day entry for two groups, the pityriasis rubra rubella of facial skin grain of rice shape is how many, and Whiteheads is how many, and blackhead is how many, with or without extruding white or faint yellow fat bolt, sufferings number of times, persistent period, symptom treatment effect.

6. efficacy evaluation:

According to " acne efficacy assessment standard ", two groups of therapeutic effect are evaluated.Symptom efficacy assessment standard: effective: the symptom such as sufferings, Whiteheads, blackhead, red tuberosity, abscess, cyst is cured.Effective: the symptom such as sufferings, Whiteheads, blackhead, red tuberosity, abscess, cyst alleviates or substantially disappears.Invalid: the symptom such as sufferings, Whiteheads, blackhead, red tuberosity, abscess, cyst is without change or exacerbation of symptoms.

7. therapeutic outcome:

Two groups of clinical symptoms therapeutic outcomes compare: the results are shown in Table 1.Treatment group and matched group total effective rate have highly significant difference (P < 0.001), and treatment group is better than matched group.

Table 1

Treatment group and matched group * * * P < 0.001

As can be seen from Table 1, treatment group and matched group total effective rate have highly significant difference (P < 0.001), and treatment group total effective rate is 100%, and matched group total effective rate is 65%, and treatment group is obviously better than matched group.

8. typical case:

(1) Ma Rongyi, female, 30 years old, cadre, face had red scar, and on January 9th, 2010 goes to a doctor.Patient's readme: face's acne have more than ten years medical history, leave red scar, redness is itched sometimes, rhabdion is had to occur now and then white pus head, have a strong impact on oneself face, used the medicine of multiple treatment acne and invalid to Duo Jia clinic, hospitalize, patient loses treatment confidence.Through outer painting " acne ointment " after three weeks, patient makes a phone call to chief Liu: " my face acne is cured! The red scar of face shoals, and also not red and swollenly itches, and white pus head also disappears! The free administration of chief Liu is thanks to cure my face acne for many years ".Follow up a case by regular visits to after 2 years and do not recur, patient facial region is fair and clear does not stay next scar.

(2) all color phoenix, female, 24 years old, student, patient facial region had multiple acne and adularescent pus head.On January 17th, 2010 goes to a doctor.Patient's readme: from middle school, chin and forehead starts to occur Whiteheads, does not go down for a long time, develops into afterwards and occurs white pus head on the face successively, and itch and feel bad, and does not restrain to scratch through conventional hands to leave scar.Sometimes also have white pus, make my mood very worried.Use for oral administration and outer painting multiple treatment acne drug ineffective, I has lost treatment confidence.Substantially disappear through outer painting " acne ointment " one week rear face acne, white pus head disappears substantially, and face is not also itched! Patient heart is much better.Two weeks rear face acne, white pus head and scar disappear, and face is fair and clear, and patient's disease of pimples is cured.Follow up a case by regular visits to after 2 years and do not recur, the fair and clear gloss of patient face.Very happy the saying of patient heart: " thank Liu old thick moral to benefit mankind, my disease of pimples is cured in free administration ".

(3) Dou Jianxia, female, 30 years old, financial accounting, patient's face had multiple acne white pus head, and leaves black purple scar, and on February 4th, 2010 goes to a doctor.Patient's readme: face acne has 13 years, has once been Tianjin, Beijing Duo Jia hospitalize face acne is invalid, sometimes arrives public arena oneself panesthesia face too ugly depressed very large.Face acne 5,6 at least, tens at most, sufferings feel bad to grab with hands and leave black purple scar sometimes, facial skin is dark yellow, tarnish.Through outer painting " acne ointment " after two weeks, patient facial region's acne disappear substantially, and face sufferings alleviate.After three weeks, patient's face acne disappears, and scar shoals, and face is fair and clear glossy, and patient facial region's acne are cured.Follow up a case by regular visits to after 2 years and do not recur, patient heart is very happy.

(4) Chen Jian, female, 28 years old, civil servant, suffer from acne for many years, face left scar, and on April 28th, 2010 goes to a doctor.A patient's readme: I has more than ten years by facial comedo! Once used the medicine for external use of various treatment comedo to fail to respond to any medical treatment, after eating maror, comedo increases the weight of and tingle, and nose is red and swollen.Top all adularescents pus head of small pox, squeeze with hands and all leave red scar print, my mood is quite unhappy.Through outer painting " acne ointment " after one week, face acne reduce, and scar print shoals, and nose redness disappears.Coating is after two weeks, and facial comedo all disappears, and scar flattens, and face is fair and clear glossy, and comedo is cured.Follow up a case by regular visits to after 2 years and do not recur.Patient says: I am as a televised report, and disease of pimples Liu cures to me always, makes my mood very good.

(5) Liu Wei, female, 23 years old, student, had acne below forehead face, and has aubergine pox, and on July 6th, 2010 goes to a doctor.Patient's readme: be all acne below forehead, face and leave aubergine pox, corse sweat pore, fuel-displaced, sufferings are felt bad.Through treatment in a few years, used multiple ointment, also ate multi-medicament, take a lot of money and fail to respond to any medical treatment really, small pox always emerges in an endless stream, and allows be full of worry my time in youth.Through outer painting " acne ointment " after one week red pox diminished, skin on the face also becomes moist, and face bleaches a lot, and the symptom of corse sweat pore have also been smaller.Medication is after two weeks, and below forehead face, acne are all cured, and aubergine pox disappears, and facial skin becomes fair and clear glossy.Fuel-displaced symptom does not have finally without, forehead, small pox on the face today yet! This makes me very delight, worry for many years finally without.Follow up a case by regular visits to after 2 years and do not recur.Patient says: " I thanks the old noble medical ethics and atmosphere of Liu, cures my comedo.”

(6) Zhang Fengnan, man, 23 years old, student, patient's whole face was comedo, and face both sides leave red scar.On August 16th, 2010 goes to a doctor.Patient's readme: from I 18 years old face be all small pox, have blackhead, and have red pimple, sufferings catch existing red scar with hands unbearably, and small pox increases gradually, and whole face was all small pox afterwards, and especially chin is even more serious, and adularescent pus head and red tuberosity.I am to hospital of too much family, spend more than 50,000 yuan of money treatment all invalid, make me lose the confidence for the treatment of.Through outer painting " acne ointment " after one week on the face small pox see few, sufferings symptom alleviates.Coating is after two weeks, and face's acne all disappear, and sufferings sense does not have yet! Red tuberosity and scar flatten, and face is fair and clear, and disease of pimples is cured.Follow up a case by regular visits to after 2 years and do not recur.Patient heart joyfully says: " in the past, I had also never heard, and had the doctor which country free administration is cured the disease in the world.The People's Republic of China (PRC) of our greatness is only had to have doctor that is sincere like this, that present with all respect unselfishly.Here it is to me freely cures the Liu Guiyuan chief of comedo.”

Claims (2)

1. an acne ointment, is characterized in that: it is made up of Calculus Bovis, the Radix Angelicae Dahuricae, Radix Ampelopsis, Fructus Cnidii, Flos Lonicerae, Radix Isatidis, Olibanum, Myrrha, by Chinese materia medica weight proportion is:

。

2. the processing technology of acne ointment according to claim 1, is characterized in that: by described Chinese materia medica weight proportion Calculus Bovis 0.2-0.5; Radix Angelicae Dahuricae 3-10; Radix Ampelopsis 5-10; Fructus Cnidii 15-30; Flos Lonicerae 10-20; Radix Isatidis 10-15; Olibanum 3-10; Myrrha 3-10 makes, and it comprises the following steps:

(1) Calculus Bovis, the Radix Angelicae Dahuricae, Radix Ampelopsis are worn into micropowder respectively, cross 300 mesh sieves, make the cell grade micropowder that particle diameter is less than 48 μm, it is for subsequent use that loading vial is placed on calorstat;

(2) Fructus Cnidii, Flos Lonicerae, Radix Isatidis, Olibanum, Myrrha are worn into coarse powder respectively, cross 150 mesh sieves, then wear into micropowder respectively, cross 300 mesh sieves, make the cell grade micropowder that particle diameter is less than 48 μm; Soaking 10-12 hour by putting into the ethanol that its weight 10 is doubly 95% to the concentration of micropowder after above-mentioned micropowder mixing, then filtering and obtaining medicinal liquid and medicinal residues;

(3) medicinal liquid step 2 made, through concentrated, make one-level clear paste, is in store for; Medicinal residues step 2 made decoct 2 times, add weight 6 doubly to the water of medicinal residues at every turn, and each decoction 30 minutes, merges twice decoction liquor, filters, obtains decocting liquid, refiltered by decocting liquid, then filtering and concentrating, make secondary clear paste, be in store for; Described clear paste, comprising effective ingredient is: cnidium monnieri phenol, luteolin, indirubin, boswellic acid and r-myrrholic acid;

(4) Calculus Bovis step one made, the Radix Angelicae Dahuricae, Radix Ampelopsis cell grade micropowder, the one-level secondary clear paste made with step 3 mixes, and stirs, namely makes acne ointment, loads in bottle.