CN103316093B - Chinese medicinal preparation for treating chemotherapy-induced superficial thrombophlebitis - Google Patents
Chinese medicinal preparation for treating chemotherapy-induced superficial thrombophlebitis Download PDFInfo
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- CN103316093B CN103316093B CN201210075492.1A CN201210075492A CN103316093B CN 103316093 B CN103316093 B CN 103316093B CN 201210075492 A CN201210075492 A CN 201210075492A CN 103316093 B CN103316093 B CN 103316093B
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Abstract
The invention relates to a Chinese medicine tincture for treating chemotherapy-induced superficial thrombophlebitis. The medicament compositions are: by weight, 28-32 g of strychnos nuxvomica, 28-32 g of baikal skullcap root, 14-18 g of raw rhubarb, 9-12 g of safflower, and 300 mL of 75% alcohol. The dosage form of the Chinese medicinal preparation is tincture, and the four medicines of strychnos nuxvomica, baikal skullcap root, raw rhubarb and safflower are placed into the alcohol and immersed for 5-7 days. Conformed by clinic application, the externally-applied effective rate for patients of the chemotherapy-induced superficial thrombophlebitis reaches 98% or more, and the cure rate in two weeks reaches 86.21%. The Chinese medicinal preparation has the advantages of being reliable in curative effect, low in price, simple in preparing process, convenient to apply and the like.
Description
Technical field
The present invention relates to one and treat the Chinese medicine preparation that superficial thrombophlebitis disease appears in chemotherapy rear section patient.
Two, background technology
Superficial thrombophlebitis is commonly encountered diseases clinically, falls ill at lower limb.Superficial thrombophlebitis is mainly with the great saphenous vein of lower limb, small saphenous vein and belong to; The cephalic vein of upper limb, thoracoepigastric veins can occur in breast superficial epigastric vein, and migrans superficial phlebitis etiology unknown is true, can alternately fall ill everywhere at human body to migrating property;
The position selection of superficial thrombophlebitis often because of venipuncture is improper, fixing is improper, the factor such as to puncture improper is brought out, when infusion chemotherapeutic because its cytotoxicity is large, large to the zest of blood vessel, and easily exosmose and cause immunoreation, its probability of bringing out superficial thrombophlebitis increases greatly.U.S.'s transfusion nurse association guide is pointed out, peripheral phlebitis incidence rate should lower than 5% or lower, but the incidence rate of adding up clinically is all considerably beyond this numeral, the phlebitis that the patients undergoing chemotherapy occurrence degree of about 50% ~ 80% is different.When infusion chemotherapeutic, though employ conventional preventive measure, still have the patient of 0.1% ~ 6.0% chemotherapeutics extravasation can occur, phlebitic incidence rate obviously raises.It is reported that infusion chemotherapeutics causes local phlebitis incidence rate and can reach 57.6%.Even during injection individual drugs, phlebitic incidence rate exceeds 93.3%, and after intravenous injection nvelbine, phlebitis occurs the patient of 87%.After there is superficial thrombophlebitis, not only greatly increase the misery of patient, also increased the weight of the treatment burden of patient, the method therefore finding the chemotherapeutic superficial thrombophlebitis of a kind of effective treatment is very important.
Three, summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of chemotherapeutic thrombosis superficial phlebitis, and curative effect is reliable, cheap, manufacturing process is simple, and application is convenient, is convenient to large-scale promotion and uses.
For achieving the above object, think that chemotherapeutic superficial thrombophlebitis is damp and hot heresy invasion and attack human body and then causes obstruction of collaterals by blood stasis according to theory of Chinese medical science, medicine should with clearing away heat-damp and promoting diuresis, and blood circulation promoting and blood stasis dispelling is main;
Therefore, medicine composition of the present invention by its weight ratio is:
Semen Strychni 28 ~ 32 grams, Radix Scutellariae 28 ~ 32 grams, Radix Et Rhizoma Rhei l4 ~ l8 gram, Flos Carthami 9 ~ l2 gram, 75% ethanol 300 milliliters.
Pharmaceutical dosage form of the present invention is tincture; Above-mentioned Semen Strychni, Radix Scutellariae, Radix Et Rhizoma Rhei, Flos Carthami 4 taste medicine are put into ethanol and soaked 5 ~ 7 days.
Usage and dosage: external.Getting and embrocate affected part in right amount, every day 3 ~ 4 times, 14 days is a course for the treatment of.Or get sterile gauze when using and soak rear soak in the red and swollen district of vein, 3 ~ 4 times/day, each 10 ~ 15min, scope exceeds inflammation scope 3cm.
Function: clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling.Cure mainly: chemotherapeutic superficial thrombophlebitis.
By modern medical theory, treatment of disease must aim at its pathogenesis.Damp and hot heresy is attacked human body and then is caused obstruction of collaterals by blood stasis, and medicine should with clearing away heat-damp and promoting diuresis, and blood circulation promoting and blood stasis dispelling is main.The chemotherapeutic superficial thrombophlebitis cause of disease is damp and hot, and controlling ought first clearing away heat-damp and promoting diuresis, and dispelling damp and hot heresy can subside a swelling.Pain system, caused by blood stasis, works as blood circulation promoting and blood stasis dispelling, and general rule is not bitterly.
Fang Zhong:
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication;
Radix Et Rhizoma Rhei: removing pathogenic heat from blood and toxic substance from the body, removing blood stasis removing mass, external is relieved inflammation or internal heat detumescence;
Flos Carthami: nourishing blood and promoting blood circulation, resolving depression pain relieving blood stasis removing;
Semen Strychni: mass dissipating and swelling eliminating, wind-expelling pain-stopping, relaxing muscles and tendons and activating QI and blood in the collateral.
Modern pharmacology confirms, Semen Strychni has anti-inflammatory and analgesic effect, and strychnine and NSC 118079 all have similar aspirin sample anticoagulant and anti-thrombosis function.Radix Scutellariae has antipyretic, calm, spasmolysis, and its Multiple components all can anticoagulant, and baicalin, baicalin also can suppress to be converted into fibrin by the fibronectin of thrombin induction, and can prevent by the diffusivity vascular blood coagulation of endotaxin induction.Radix Et Rhizoma Rhei can improve plasma osmotic pressure, makes to organize blood system to shift to Ink vessel transfusing, to supplement the blood volume of losing because losing blood greatly, reduces blood viscosity, is conducive to removing microcirculation disturbance.Flos Carthami directly or the effect of partial agonistic a-adrenoreceptor and distending the blood vessels, and has more weak direct vasoconstrictive effect, the platelet aggregation that Carthamus yellow can suppress ADP to cause, and can affect blood coagulation system in body and external simultaneously.
Prove that the effective percentage of medicine of the present invention to superficial thrombophlebitis reaches more than 98% through clinical trial, within two weeks, cure rate reaches 86.21%, and significantly can improve the clinical symptoms of patient, alleviates patient suffering.
Four, detailed description of the invention
Medicine composition of the present invention by its weight ratio is:
Semen Strychni 28 ~ 32 grams, Radix Scutellariae 28 ~ 32 grams, Radix Et Rhizoma Rhei l4 ~ l8 gram, Flos Carthami 9 ~ l2 gram, 75% ethanol 300 milliliters.
Pharmaceutical dosage form of the present invention is tincture; Above-mentioned Semen Strychni, Radix Scutellariae, Radix Et Rhizoma Rhei, Flos Carthami 4 taste medicine are put into ethanol and soaked 5 ~ 7 days.
Usage and dosage: external.Getting and embrocate affected part in right amount, every day 3-4 time, 14 days is a course for the treatment of.Or get 4 floor sterile gauze when using and soak rear soak in the red and swollen district of vein, 4 times/day, each 10 ~ 15min, scope exceeds inflammation scope 3cm.It within 14 days, is a course for the treatment of.
Clinical trial overview
After clinical 116 routine chemotherapy, superficial thrombophlebitis patient is divided into 2 groups at random, treatment group and each 58 examples of matched group." surgery of Chinese medicine disease Standardization of diagnosis and curative effect " that diagnostic criteria is formulated with reference to State Administration of Traditional Chinese Medicine; Clinical symptoms grade scale was with reference to new edition " infusion treatment nursing practice standard " in 2006; Statistical method adopts SPSS17.0 statistics software statistics.Confirm that the effective percentage of this therapy to superficial thrombophlebitis reaches more than 98%, within two weeks, cure rate reaches 86.21%, and significantly can improve the clinical symptoms of patient, alleviates patient suffering.
The features such as the present invention, in conjunction with theory of Chinese medical science and modern pharmacological research, has prepared a kind of preparation for the treatment of chemotherapeutic superficial thrombophlebitis, and prove through clinical research test, it is reliable that said preparation has curative effect, cheap, and manufacturing process is simple, and application is convenient.
Claims (2)
1. treat a Chinese medicine preparation for chemotherapeutic thrombosis superficial phlebitis, it is characterized in that: its medicine composition by its weight ratio is:
Semen Strychni 28 ~ 32 grams, Radix Scutellariae 28 ~ 32 grams, Radix Et Rhizoma Rhei l4 ~ l8 gram, Flos Carthami 9 ~ l2 gram, 75% ethanol 300 milliliters.
2. a preparation method for the Chinese medicine preparation of the chemotherapeutic thrombosis superficial phlebitis for the treatment of according to claim 1, is characterized in that: Semen Strychni, Radix Scutellariae, Radix Et Rhizoma Rhei, Flos Carthami 4 taste medicine are put into ethanol and soaked 5 ~ 7 days.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210075492.1A CN103316093B (en) | 2012-03-21 | 2012-03-21 | Chinese medicinal preparation for treating chemotherapy-induced superficial thrombophlebitis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210075492.1A CN103316093B (en) | 2012-03-21 | 2012-03-21 | Chinese medicinal preparation for treating chemotherapy-induced superficial thrombophlebitis |
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| CN103316093A CN103316093A (en) | 2013-09-25 |
| CN103316093B true CN103316093B (en) | 2014-12-17 |
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| CN201210075492.1A Expired - Fee Related CN103316093B (en) | 2012-03-21 | 2012-03-21 | Chinese medicinal preparation for treating chemotherapy-induced superficial thrombophlebitis |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101683394A (en) * | 2008-09-26 | 2010-03-31 | 天津市中宝制药有限公司 | Externally applied patch for treating phlebitis and method for producing the same |
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2012
- 2012-03-21 CN CN201210075492.1A patent/CN103316093B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101683394A (en) * | 2008-09-26 | 2010-03-31 | 天津市中宝制药有限公司 | Externally applied patch for treating phlebitis and method for producing the same |
Non-Patent Citations (2)
| Title |
|---|
| 复方黄芩涂膜剂治疗化疗药物所致静脉炎的疗效观察;赵华;《山东医学高等专科学校学报》;20081231;第30卷(第04期);263-265 * |
| 运用马钱子的体会;徐有全;《辽宁中医杂志》;19881231(第11期);19-20 * |
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