CN105233073B - Chinese medicinal enema and preparation method thereof for cooling - Google Patents
Chinese medicinal enema and preparation method thereof for cooling Download PDFInfo
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- CN105233073B CN105233073B CN201510805727.1A CN201510805727A CN105233073B CN 105233073 B CN105233073 B CN 105233073B CN 201510805727 A CN201510805727 A CN 201510805727A CN 105233073 B CN105233073 B CN 105233073B
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Abstract
The present invention relates to a kind of Chinese medicine heat-clearing enemas for cooling, it is made of the raw material of following mass ratio, 5 10 parts of the coptis, 5 10 parts of radix scutellariae, 5 10 parts of Cortex Phellodendri, 5 10 parts of Radix Ophiopogonis, 5 10 parts of the leaf of bamboo, 5 10 parts of Chinese violet, 5 10 parts of honeysuckle, 10 20 parts of gypsum, 10 20 parts of radix bupleuri.First the principle active component for being easy to volatilization in radix bupleuri is extracted using distillation and extraction method, second extraction then is carried out to radix bupleuri according still further to traditional Chinese medicine decocting method, takes full advantage of whole active components of the medicine.Said preparation has significant effect, and safety is good, the feature small to animal injury.The mode that rectally can be used enables effective ingredient directly through intestinal wall absorbed into serum, to have rapid-action, simple operation and other advantages small to animal irritation.
Description
Technical field
The invention belongs to Chinese veterinarian's medicine field, specifically a kind of Chinese medicinal enema for treating animal fever.
Background technology
Fever is common reflection of a variety of diseases in body, but while generating heat excessive can then cause body dehydration, soda acid flat
The problems such as weighing apparatus imbalance, shock, entail dangers to life when serious.To fever, there are many effective treatment hands for the development of present medical technology
Section, such as use antibacterial therapy, sweating cooling, cold compress cooling the methods of, but these methods treatment animal adstante febre more have inconvenience,
Either gastric infusion or drug administration by injection are required to certain technology and necessary instrument, and slightly misoperation may can cause
The damage of animal.
Invention content
The invention solves a technical problem be to provide it is a kind of for cooling Chinese medicine heat-clearing enema, said preparation tool
Effective notable, safety is good, the feature small to animal injury.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
A kind of Chinese medicine heat-clearing enema for cooling is made, 5-10 parts of the coptis, radix scutellariae 5- of the raw material of following mass ratio
10 parts, 5-10 parts of Cortex Phellodendri, Radix Ophiopogonis 5-10 part, 5-10 parts of the leaf of bamboo, 5-10 parts of Chinese violet, 5-10 parts of honeysuckle, gypsum 10-20
Part, 10-20 parts of radix bupleuri.
Heat-clearing enema prescription of the present invention selects clearing heat and detoxicating China's tradition, the Chinese medicinal composition of Yin-nourishing and body fluid promoting, vegetable liver and qi,
The coptis, radix scutellariae, Cortex Phellodendri bitter cold in side, clearing heat-fire are monarch drug in a prescription；Radix Ophiopogonis, nourishing Yin and clearing heat, the aquatic Tianjin of profit, is ministerial drug at the leaf of bamboo；It is purple
Flower Chinese violet, honeysuckle, gypsum are clearing heat and detoxicating, antibacterial anti-inflammatory, are adjutant；Radix bupleuri liver-smoothing, qi-regulating, relieving the exterior syndrome with drugs pungent in flavor and cool in property, to make medicine.It is all
Medicine phases close, jointly generate clearing heat-fire, removing toxic substances promote the production of body fluid, anti-inflammatory antipyretic the effect of, it is significant in efficacy.
The present invention also provides the preparation method of the above-mentioned Chinese medicine heat-clearing enema for cooling, including step simultaneously
（1）Extraction radix bupleuri first is distilled with water, collects radix bupleuri distillate and radix bupleuri residue；
（2）Then radix bupleuri residue and the coptis, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, the leaf of bamboo, Chinese violet, honeysuckle and gypsum are closed
And boiled and extracted with boiling, collect extracting solution；
（3）Finally extracting solution is merged with radix bupleuri distillate.
Step as a preferred technical solution,（1）In, radix bupleuri is soaked, and every gram of radix bupleuri adds water 6-8ml, is subsequently placed in
It distills and heats distillation in collection device, the volume for collecting radix bupleuri distillate is equivalent to the 100% of raw material gross mass.Further preferably
Scheme be radix bupleuri impregnate 2 hours.
Step as a preferred technical solution,（2）In, first in the coptis, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, the leaf of bamboo, Chinese violet, gold
It is soaked in honeysuckle flower and gypsum, every gram of above raw material adds water 5-10ml, after immersion, radix bupleuri residue is added, heating, which is boiled, to be carried
It takes, the volume for collecting extracting solution is equivalent to the 100% of raw material gross mass.
Further preferred scheme is that the coptis, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, the leaf of bamboo, Chinese violet, honeysuckle and gypsum add
It is impregnated 2 hours after water；Extraction 2 times, every time 120 minutes is boiled in heating.
Medicament fully takes into account the extraction of various medicinal material active components in Study on Preparation, using distillation and extraction method elder generation
The principle active component for being easy to volatilization in radix bupleuri is extracted, then radix bupleuri is carried out according still further to traditional Chinese medicine decocting method secondary
Extraction, takes full advantage of whole active components of the medicine.Remaining Chinese medicine by boiling extraction, make various water solubilitys in medicinal material at
Get the proposition method for meeting traditional Chinese medicine fully to propose.Through filtering and impurity removing, sterilizing is sealed after concentration, can effectively reduce medicine
The loss of object active ingredient, ensure that medication effect.
Heat-clearing enema of the present invention enables effective ingredient to be directly absorbed into through intestinal wall by the way of rectally
Blood has rapid-action, simple operation and other advantages small to animal irritation.It is administered simultaneously the discharge for also helping enteral place excrement, energy
The absorption for reducing enterogenous endotoxin, is also beneficial to the more preferable performance of antipyretic effect, is suitable for the treatment of various medium and small animals.
Specific implementation mode
Embodiment 1
Coptis 10g, radix scutellariae 10g, Cortex Phellodendri 10g, Radix Ophiopogonis 10g, leaf of bamboo 10g, Chinese violet 10g, honeysuckle 10g, raw stone
Cream 20g, radix bupleuri 20g.
It takes radix bupleuri to be placed in distillation extractor, adds deionized water 120ml, impregnate 120 minutes, collected after heating distillation extraction
Radix bupleuri distillate 110ml.
Add deionized water 450ml in the coptis, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, the leaf of bamboo, Chinese violet, honeysuckle and gypsum,
Impregnate 120 minutes after, be added radix bupleuri residue, heating boil extraction it is secondary, 120 minutes every time, collect extracting solution, filtered through gauze,
Filtrate water-bath is concentrated to 110ml.
Extracting solution after concentration merges with radix bupleuri distillate, total 220ml.Then it is distributed into bottle, is sealed, high pressure sterilization,
It is spare.
Embodiment 2
Coptis 5g, radix scutellariae 5g, Cortex Phellodendri 5g, Radix Ophiopogonis 5g, leaf of bamboo 5g, Chinese violet 5g, honeysuckle 5g, gypsum 10g,
Radix bupleuri 10g.
It takes radix bupleuri to be placed in distillation extractor, adds deionized water 60ml, impregnate 120 minutes, collected after heating distillation extraction
Radix bupleuri distillate 55ml.
Add deionized water 270ml in the coptis, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, the leaf of bamboo, Chinese violet, honeysuckle and gypsum,
Impregnate 120 minutes after, be added radix bupleuri residue, heating boil extraction it is secondary, 120 minutes every time, collect extracting solution, filtered through gauze,
Filtrate water-bath is concentrated to 55ml.
Extracting solution after concentration merges with radix bupleuri distillate, total 110ml.Then it is distributed into bottle, is sealed, high pressure sterilization,
It is spare.
Embodiment 3
Coptis 10g, radix scutellariae 10g, Cortex Phellodendri 10g, Radix Ophiopogonis 10g, leaf of bamboo 10g, Chinese violet 10g, honeysuckle 10g, raw stone
Cream 20g, radix bupleuri 20g.
It takes radix bupleuri to be placed in distillation extractor, adds deionized water 160ml, impregnate 120 minutes, collected after heating distillation extraction
Radix bupleuri distillate 110ml.
Add deionized water 630ml in the coptis, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, the leaf of bamboo, Chinese violet, honeysuckle and gypsum,
Impregnate 120 minutes after, be added radix bupleuri residue, heating boil extraction it is secondary, 120 minutes every time, collect extracting solution, filtered through gauze,
Filtrate water-bath is concentrated to 110ml.
Extracting solution after concentration merges with radix bupleuri distillate, total 220ml.Then it is distributed into bottle, is sealed, high pressure sterilization,
It is spare.
Embodiment 4
Coptis 6g, radix scutellariae 8g, Cortex Phellodendri 7g, Radix Ophiopogonis 9g, leaf of bamboo 5g, Chinese violet 8g, honeysuckle 6g, gypsum 15g,
Radix bupleuri 16g.
It takes radix bupleuri to be placed in distillation extractor, adds deionized water 112ml, impregnate 120 minutes, collected after heating distillation extraction
Radix bupleuri distillate 80ml.
Add deionized water 512ml in the coptis, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, the leaf of bamboo, Chinese violet, honeysuckle and gypsum,
Impregnate 120 minutes after, be added radix bupleuri residue, heating boil extraction it is secondary, 120 minutes every time, collect extracting solution, filtered through gauze,
Filtrate water-bath is concentrated to 80ml.
Extracting solution after concentration merges with radix bupleuri distillate, total 160ml.Then it is distributed into bottle, is sealed, high pressure sterilization,
It is spare.
Embodiment 5
Coptis 8g, radix scutellariae 6g, Cortex Phellodendri 10g, Radix Ophiopogonis 5g, leaf of bamboo 8g, Chinese violet 7g, honeysuckle 9g, gypsum
12g, radix bupleuri 15g.
It takes radix bupleuri to be placed in distillation extractor, adds deionized water 90ml, impregnate 120 minutes, collected after heating distillation extraction
Radix bupleuri distillate 80ml.
Add deionized water 585ml in the coptis, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, the leaf of bamboo, Chinese violet, honeysuckle and gypsum,
Impregnate 120 minutes after, be added radix bupleuri residue, heating boil extraction it is secondary, 120 minutes every time, collect extracting solution, filtered through gauze,
Filtrate water-bath is concentrated to 80ml.
Extracting solution after concentration merges with radix bupleuri distillate, total 160ml.Then it is distributed into bottle, is sealed, high pressure sterilization,
It is spare.
Embodiment 6
Coptis 5g, radix scutellariae 10g, Cortex Phellodendri 8g, Radix Ophiopogonis 7g, leaf of bamboo 7g, Chinese violet 6g, honeysuckle 7g, gypsum
12g, radix bupleuri 18g.
It takes radix bupleuri to be placed in distillation extractor, adds deionized water 144ml, impregnate 120 minutes, collected after heating distillation extraction
Radix bupleuri distillate 80ml.
Add deionized water 620ml in the coptis, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, the leaf of bamboo, Chinese violet, honeysuckle and gypsum,
Impregnate 120 minutes after, be added radix bupleuri residue, heating boil extraction it is secondary, 120 minutes every time, collect extracting solution, filtered through gauze,
Filtrate water-bath is concentrated to 80ml.
Extracting solution after concentration merges with radix bupleuri distillate, total 160ml.Then it is distributed into bottle, is sealed, high pressure sterilization,
It is spare.
Content illustrates the technique effect of the present invention by taking the Chinese medicine heat-clearing enema that embodiment 1 obtains as an example below.
1. experiment material
The Chinese medicine heat-clearing enema that embodiment 1 is prepared.Aspirin effervescent tablet, lot number：1211048, AstraZeneca
Pharmaceutical Co. Ltd produces, and when use is made into the solution of debita spissitudo with water for injection.Angel high activity dried yeast, lot number：
20120903, Angel Yeast Co., Ltd's production.Escherichia coli endotoxin, 109k4076, sigma Products.
The Omrons detecting instrument MC-246 electronic thermometer, the production of Omron Trade Co., Ltd..
2. experimental animal
SPF grades of SD rats 80, half male and half female, weight body 180-200g, the limited public affairs of tonneau China's experimental animal technology are tieed up in Beijing
Department's production, credit number：SCXK（Capital）2012-0001.Regular grade Japan white big ear rabbit 60, it is dynamic purchased from the experiment of Beijing Longan
Object cultivates center, credit number：SCXK（Capital）2009-0005.Animal uses credit number：SYXK（Shanxi）2012-0001.Experiment
21 DEG C ± 1 DEG C, relative humidity 40%-60%, 10-15 times/h of rate of ventilation of room temperature, light application time 12h/12h light and shades alternating.It is real
Drinking-water is freely eaten in each group animal during testing, and animal is managed by same experimenter.
3. experimental method
3.1 dosage
Rat experiment sets high, medium and low three dosage groups, and dosage is respectively 20g/kg, 10g/ by crude drug content calculation
kg、5g/kg；Rabbit experiment sets high, medium and low three dosage groups, and dosage is respectively 10g/kg, 5g/ by crude drug content calculation
kg、2.5g/kg。
3.2 pairs of yeast cause the influence of rat fever
Multiple Fundamentals of Measurement body temperature, makes rat to body temperature measurement operating habit before the experiment of SD rats.Choose Temperature changing width
Small rat 60 is spent, 6 groups, respectively control group, model group, positive group are equally divided into（Aspirin group）, heat-clearing enema
High dose, middle dosage, low dose group.Based on the average of the basal body temperature measured by last time, each group rat body is observed
The variation of temperature.
After each group rat test 0h Fundamentals of Measurement body temperature, in addition to control group, remaining each group rat is subcutaneously injected 5%
Physiological saline yeast soln 1ml/100g weight modelings.The Temperature changing of rat is monitored after modeling.5h after modeling, each dosage group are big
Bowel lavage gives the heat-clearing enema fluid of corresponding dosage to mouse respectively, and aspirin group gavage gives 125mg/kg aspirin aqueous solutions,
Control group, model group bowel lavage give the physiological saline of same volume.The liquid that all bowel lavage are given is pre- by liquid before administration
Heat is to 38 DEG C.1 after administration, 2,3,4,5h when measure animal body temperature, calculate administration after each time point each group rat body
Temperature and the difference of basal body temperature and the detemperature rate of each administration group rat：Detemperature rate=model cell mean-administration cell mean/mould
Type cell mean.
3.3 induced by endotoxin cause the influence of fever in rabbits
Multiple Fundamentals of Measurement body temperature before 40 rabbit experiments makes animal custom anus temperature measurement operation.The grouping same day measures house
Rabbit basal body temperature, 36 rabbit stochastic averaginas that Thermal preference is moderate, Temperature changing amplitude is small are divided into 6 groups, every group 6.Respectively
For control group, model group, positive group（Aspirin group）And heat-clearing enema high dose, middle dosage, low dose group.Each group is dynamic
Object gives corresponding drug respectively after experimental day Fundamentals of Measurement body temperature.High, medium and low dosage group bowel lavage is tested to give accordingly
The heat-clearing enema fluid of dosage, control group and model group bowel lavage give normal saline, and aspirin group gavage gives 62.5mg/
Kg liquids.In addition to control group, auricular vein injects 250ng/kg escherichia coli endotoxins to remaining each group rabbit simultaneously.Measure modeling
Afterwards 1,2,3,4, when 5h each group animal body temperature, calculate the difference of each time point animal heat and basal body temperature after administration and respectively give
Medicine group detemperature rate.
3.4 data processing
Using SPSS11.5 softwares, one-way analysis of variance handles data, and t is examined between group.
4. result
4.1 pairs of yeast cause the influence of rat fever model
Administration high dose group is continued until that 5h generates apparent cooling effect since 1h, compared with model group, drop
Temperature effect is notable；Middle dose group produces significant cooling effect in 4h, 5h.Low dose group animal heat also shows to drop
Low trend, but there was no significant difference compared with model group.Aspirin group is compared with model group, and 1h is generated apparent after administration
Cooling effect, but since 2h, cooling effect occurs as soon as the trend gradually weakened, and heat-clearing enema high dose group is then from 2h
Start to 5h, cooling effect shows apparent enhancing trend, and in 5h, detemperature rate reaches 58.5%, shows persistently good
Cooling-down effect illustrates that heat-clearing enema increases with significant inhibiting effect rat temperature caused by yeast.It the results are shown in Table 1, table 2
。
4.2 induced by endotoxin cause the influence of fever in rabbits
Compared with the control group, model group animal body temperature after giving endotoxin is significantly raised, and peak occurs in 1h, 3h
The characteristics of being worth, preferably embodying 2 peak values of model.Compared with model group, 1h is after the administration of heat-clearing enema high dose group
Significant cooling effect is produced, and reaches maximum cooling-down effect in 5h, shows rabbit caused by good inhibition endotoxin
The raised effect of body temperature；In, low dosage heat-clearing enema group also show certain cooling trend, but without aobvious compared with model group
Sex differernce is write, only middle dose group produces significant difference in 5h.Aspirin group animal only 1h animal heats upon administration
Conspicuousness reduce, since 2h until from end have not seen significant cooling effect.It can be seen that heat-clearing enema high dose group
Rabbit body temperature caused by endotoxin can be significantly inhibited to increase, and reach 85.4% detemperature rate in 5h, produce good cooling effect
Fruit.It the results are shown in Table 3, table 4.
The experiment classical model that fever animal model is technology maturation, the caused fever of saccharomycete is due to injection site
Whole body caused by the inflammatory reaction of thalline generates heat, the heating paresthesia under energy preferably simulation pathological state.Animal pattern institute table
The symptom revealed is similar to clinical symptoms, is adapted to the refrigeration function of verification antipyretic.Bacterial endotoxin acts on animal body
Or human body, mononuclear macrophage release endogenous pyrogen TNF-a and IL-1 etc. can be induced, TNF-a is by directly stimulating down
Thalamus heat-regulating centers and macrophage discharge IL-1, and IL-1 promotes mononuclear macrophage to discharge PGE2 again, under stimulation
Thalamus heat-regulating centers causes to generate heat.Each model shows distinctive heat-producing characteristics in experimentation, shows that experiment is made
Animal fever model has reached the requirement of experimental design.
1 heat-clearing enema of table causes yeast the influence of rat fever difference（X ± s, n=10）
Note：Compared with the control group, ##P<0.01;Compared with model group, * P<0.05, **P<0.01.
2 heat-clearing enema of table causes yeast the influence of rat fever detemperature rate（X ± S, n=10）
The influence of fever in rabbits difference caused by 3 heat-clearing enema induced by endotoxin of table（X ± S, n=6）
Note：Compared with the control group, #P<0.05, ##P<0.01;Compared with model group, * P<0.05.
4 heat-clearing enema induced by endotoxin of table causes the influence of fever in rabbits detemperature rate（X±S, n=6）
Claims (7)
1. a kind of Chinese medicine heat-clearing enema for cooling, it is characterised in that：It is made of the raw material of following parts by weight, coptis 5-10
Part, 5-10 parts of radix scutellariae, 5-10 parts of Cortex Phellodendri, Radix Ophiopogonis 5-10 part, 5-10 parts of the leaf of bamboo, 5-10 parts of Chinese violet, 5-10 parts of honeysuckle, life
10-20 parts of gypsum, 10-20 parts of radix bupleuri.
2. the method for preparing the Chinese medicine heat-clearing enema for cooling as described in claim 1, it is characterised in that：Including step
Suddenly：
（1）Extraction radix bupleuri first is distilled with water, collects radix bupleuri distillate and radix bupleuri residue；
（2）Then radix bupleuri residue is merged with the coptis, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, the leaf of bamboo, Chinese violet, honeysuckle and gypsum,
It is boiled and is extracted with boiling, collect extracting solution；
（3）Finally extracting solution is merged with radix bupleuri distillate.
3. according to the method described in claim 2, it is characterized in that：Step（1）In, radix bupleuri is soaked, and every gram of radix bupleuri adds water
6-8ml is subsequently placed in distillation collection device and heats distillation, calculated with ml/g, and the volume for collecting radix bupleuri distillate is equivalent to Huang
Company, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, the leaf of bamboo, Chinese violet, honeysuckle, gypsum, radix bupleuri gross mass 100%.
4. according to the method described in claim 3, it is characterized in that：Step（2）In, first in the coptis, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, bamboo
It is soaked in leaf, Chinese violet, honeysuckle and gypsum, every gram of above raw material adds water 5-10ml, and after immersion, it is residual that radix bupleuri is added
Slag, heating are boiled extraction, are calculated with ml/g, the volume for collecting extracting solution is equivalent to the coptis, radix scutellariae, Cortex Phellodendri, Radix Ophiopogonis, the leaf of bamboo, purple
Flower Chinese violet, honeysuckle, gypsum, radix bupleuri gross mass 100%.
5. according to the method described in claim 3, it is characterized in that：It soaks 2 hours.
6. according to the method described in claim 4, it is characterized in that：Step（2）It soaks 2 hours.
7. according to the method described in claim 6, it is characterized in that：Extraction 2 times, every time 120 minutes is boiled in heating.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101879273A (en) * | 2010-07-07 | 2010-11-10 | 贾瑞飞 | Medicament for treating cold by enema method |
| CN102935136A (en) * | 2012-11-28 | 2013-02-20 | 重庆开洲九鼎牧业科技开发有限公司 | Heat-clearing and toxicity-removing composition and feed for livestock as well as preparation method and application thereof |
| CN104398650A (en) * | 2014-11-12 | 2015-03-11 | 成都乾坤动物药业有限公司 | Preparation method of pharmaceutical composition for treating swine febrile disease |
-
2015
- 2015-11-20 CN CN201510805727.1A patent/CN105233073B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101879273A (en) * | 2010-07-07 | 2010-11-10 | 贾瑞飞 | Medicament for treating cold by enema method |
| CN102935136A (en) * | 2012-11-28 | 2013-02-20 | 重庆开洲九鼎牧业科技开发有限公司 | Heat-clearing and toxicity-removing composition and feed for livestock as well as preparation method and application thereof |
| CN104398650A (en) * | 2014-11-12 | 2015-03-11 | 成都乾坤动物药业有限公司 | Preparation method of pharmaceutical composition for treating swine febrile disease |
Non-Patent Citations (2)
| Title |
|---|
| 刘铁军治疗"发热"经验;王亚红等;《辽宁中医杂志》;20100318;第37卷(第3期);第417-418页 * |
| 复方银黄微型灌肠剂对发热大鼠下丘脑中COX-1、COX-2 mRNA表达的影响;刘华钢等;《华西药学杂志》;20070220(第1期);第15页左栏倒数第1段，右栏倒数第1段 * |
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