CN103315976A - Preparation method for starch hard capsule shells - Google Patents
Preparation method for starch hard capsule shells Download PDFInfo
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- CN103315976A CN103315976A CN2013102335984A CN201310233598A CN103315976A CN 103315976 A CN103315976 A CN 103315976A CN 2013102335984 A CN2013102335984 A CN 2013102335984A CN 201310233598 A CN201310233598 A CN 201310233598A CN 103315976 A CN103315976 A CN 103315976A
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Abstract
The invention discloses a preparation method for starch hard capsule shells. The preparation method comprises the following steps of:, placing the following raw materials in parts by mass of 20-30 parts of deionized water, 60-80 parts of starch or starch blend, 2-10 parts of an edible plasticizer, and 0.1-2 parts of an edible lubricant in a high-speed mixer, and stirring and mixing; extruding and granulating the mixed materials by a double-screw reaction-type extruder; preparing the granules into sheets by a single-screw extruder; adjusting the die temperature of a plastic suction forming machine to 50-100 DEG C, and preheating; fixing the starch sheets on the heating table of the plastic suction forming machine, and softening; vacuumizing a plastic suction die, and adsorbing the softened sheets above the die, so as to obtain the starch hard capsule shells. According to the preparation method disclosed by the invention, the problems of long drying time, high energy consumption, low production efficiency, instable product quality, and the like during the preparation for starch hard capsule shells, of the traditional soaking forming method, are effectively solved; the prepared starch hard capsule shells is free from a drying process, short in production cycle, uniform in the wall thicknesses of the capsule shells, and stable in size.
Description
Technical field
The present invention relates to a kind of capsule shells, particularly relate to a kind of novel preparation method of starch hard capsule case, this starch hard capsule case is used for medicine and health food packing material.
Background technology
Hard capsule means makes uniform powder or granule with a certain amount of medicine and suitable adjuvant, loads in empty hard capsule and makes.In the modern Chinese medicine preparation was produced, hard capsule can be isolated the advantages such as bad smell of medicine effectively because technical process is relatively simple, taking convenience, rapid-action, is widely used in recent years.
On the current market hard capsule product mainly with gelatin as softgel shell, the gelatine capsule production technology is simple, but working condition is harsh, and is strict to the temperature and humidity of Workplace, finished product grow drying time and energy consumption large.Also there are some performance issues in capsule product, as to wet and the protective effect of oxygen sensitive medicaments is poor, easily in the esophagus adhesion, the phenomenons such as prolonged disintegration and drug dissolution reduction are arranged in storage.The physicochemical property of gelatin itself and the complexity in source, resistance to control have determined that there is the defective of many performances that is difficult to overcome and secure context in product, and simultaneously the people is for mixing or the artificial pollution reason causes heavy metals exceeding standard to be difficult to effect a radical cure.Because the factor of defects, religion and the vegetarianism of gelatine capsule, the driving of market profit, many scientific research institutions and enterprise all begin active development novel plant capsule.
Along with the progress of expanding economy and science and technology, conserve energy, reduce energy consumption, reducing production costs becomes the inexorable trend of capsule industry development, this area in the urgent need to develop new non-gelatin, vegetative hard capsule casing material and production technology thereof.Starch is renewable plant resources macromolecule, have the advantages such as wide material sources, pollution-free, low price, the lifting that can accelerate China's capsule adjuvant industry technology level with succeeding in developing of vacuum suction moulding multiple techniques is extruded in the reaction of starch (base) hard capsule case, improves the product quality class of China's pharmaceutic adjuvant industry.
Summary of the invention
The objective of the invention is to overcome the shortcoming of prior art, provide a kind of energy-conservation, low-cost, production efficiency is high, adapt to the novel method of wide preparation starch (base) hard capsule case.
For reaching goal of the invention, the technology used in the present invention measure one is:
A kind of preparation method of starch hard capsule case comprises the steps:
1) in mass fraction, with 20 ?30 parts of deionized waters, 60 ?80 parts of starch or starch blend, 2 ?10 parts of edible plasticizers and 0.1 ?2 parts of edible lubricants put into high-speed mixer, temperature be controlled at 50 ?under 60 ° of C conditions, mix 1 ?5 minutes, get mixture; Described edible plasticizer is one or more in glycerol, Sorbitol, ethylene glycol, Glycerine 1,3-diacetate, mannitol, monoacetin and the polypropylene glycol; Described edible lubricant is stearic acid, edible fat acid glyceride or its combination; Described starch is one or more in potato starch, corn starch, wheaten starch, rice starch, the tapioca; Or described starch is for by in etherificate, esterification, cross-linking modified potato starch, corn starch, wheaten starch, rice starch and the tapioca one or more; Described starch blend is the blend of starch and gelatin or edible fiber; By percentage to the quality, in the starch blend starch account for 30 ?70%; Gelatin or edible fiber account for 70 ?30%;
2) use twin screw response type extruder mixed material extruding pelletization;
3) use single screw extrusion machine that pellet is prepared into sheet material;
4) mold temperature of plastic suction forming apparatus is adjusted to 50 ?100 ℃, preheating 8 ?12 minutes;
5) the starch sheet material is fixed on the warm table of plastic suction forming apparatus softening, heating-up temperature be 115 ?125 ℃, the time be 1.5 ?3 seconds;
6) mould has made progress and has rushed and the startup vacuum system, to the plastics suction mould evacuation, makes softening sheet material be adsorbed on the mould top, obtains the starch hard capsule case.
Preferably, the speed that mixes of described high-speed mixer be 1500 ?2000 rev/mins.The operative temperature of described double screw extruder be 90 ?160 ℃, screw speed be 75 ?300r/min.Described single screw extrusion machine operative temperature be 100 ?170 ℃, screw speed be 60 ?300r/min.The vacuum pressure of described evacuation be 0.5 ?2.0Mpa.
With respect to prior art, the present invention has following advantage:
The preparation technology of the starch capsule of 1) having reported at present is most and gelatine capsule is similar, adopt traditional dip forming method, but this technique faces insufficient strength and the too high problem of starch solution viscosity of starch material, can't flow in the glue groove, wayward thickness and carry out automated production.The present invention is applied to the processing of traditional plastic extrusion and plastics sucking moulding technology in the research of starch capsule after improvement, not only broken through the yoke that traditional method prepares the starch capsule, reduced simultaneously raw material and processing cost, is convenient to the promotion development of product.
2) the present invention adopts the method for extruding processing and plastics sucking moulding coupling to prepare starch (base) hard capsule case first, a kind of new capsule shells production method is provided, this technology can take full advantage of existing plastics-production equipment, improves the production efficiency of amylan softgel shell, reduces production costs.
3) starch (base) the hard capsule case good forming effect of preparation, capsule softgel shell wall thickness uniformity, dimensionally stable is to meet the need of market.
The specific embodiment
Below in conjunction with embodiment technical scheme of the present invention is further described, but the scope of protection of the invention is not limited to the scope of embodiment statement.Operating environment temperature: room temperature.
Embodiment 1
The preparation method of a kind of starch (base) hard capsule case comprises the steps:
1) in mass fraction, 25 parts of deionized waters, 70 parts of corn starchs, 4.8 parts of glycerol and 0.2 part of stearic acid are put into high-speed mixer (mixing speed is 1600 rev/mins, and temperature is controlled at 60 ° of C) mix 2 minutes, get mixture;
2) use twin screw response type extruder (screw slenderness ratio is 40:1) mixed material extruding pelletization, twin screw response type extruder is divided into delivery area, admittedly molten mixed zone to the melt Conveying district from the charging aperture to the head, totally 8 intervals, 8 interval temperature are respectively 45 ℃, 70 ℃, 120 ℃, 150 ℃, 150 ℃, 130 ℃, 120 ℃ and 105 ℃, and screw speed is 140r/min;
3) use single screw extrusion machine (screw slenderness ratio is 30:1) that pellet is prepared into sheet material simultaneously, the temperature of extruder piecewise interval is respectively 45 ℃, 70 ℃, 120 ℃, 150 ℃, 150 ℃, 130 ℃, 120 ℃ and 105 ℃, screw speed is 140r/min, the starch sheet material that obtains is wide to be 1.2 meters, and thickness is 0.3MM; After testing, the stretch modulus of starch sheet material is 1400MPa, and hot strength is 25Mpa.
4) open plastic suction forming apparatus (HSC ?5105570 types, the mechanical plastic cement company limited of the grand China in Zhejiang) on and off switch and adjusting hard capsule Die and mould plate temperature, the Die and mould plate length and width are respectively 50CM X60CM, on dismountable cylindrical shape hard capsule medicated cap or body pin are arranged, be applicable to the capsule shaping that model is 0#, 1#, 2#, 3#, 4#, one-time formed quantity is 300, and mold temperature is adjusted to 80 ℃, preheating 10 minutes;
5) the corn starch sheet material is fixed on the warm table of plastic suction forming apparatus softeningly, heating-up temperature is 140 ℃, and the time is 2 seconds;
6) mould has made progress and has rushed and the startup vacuum system, to the plastics suction mould evacuation, vacuum pressure reaches 1.2Mpa, make softening sheet material be adsorbed on the mould top, (hard capsule is cylindrical, two supporting joints, i.e. medicated cap and body about minute to obtain hard capsule case, both have separately groove and wedge, closely overlap integrator).
7) cool off after 3 seconds, the rapidly demoulding, and side cut is rested and reorganized, cover synthesizes hollow starch hard capsule case.The starch hard capsule case of gained is transparent, free from extraneous odour.Through hot analytical test, moisture is lower than 15%; The time that is dissolved in pH value 7 water under stirring at a slow speed is less than 15 minutes.The starch hard capsule standby with adopting traditional dip forming legal system compared, and adopts the tensile strength of material of extrusion molding preparation can improve 20%.The capsule of gained was reduced to 1 minute from 5 hours drying time, had improved production efficiency and had reduced production cost.
Embodiment 2
A kind of preparation method of starch hard capsule case comprises the steps:
1) in mass fraction, 20 parts of deionized waters, 60 parts of potato starch, 20 parts of gelatin, 3 parts of glycerol, 0.5 part of Sorbitol, 0.5 part of stearic acid are put into high-speed mixer, and (mixing speed is 1500 rev/mins, temperature is controlled at 55 ° of C) mix 5 minutes, get mixture;
2) use twin screw response type extruder (screw slenderness ratio is 40:1) mixed material extruding pelletization, twin screw response type extruder is divided into delivery area, admittedly molten mixed zone to the melt Conveying district from the charging aperture to the head, totally 8 intervals, 8 interval temperature are respectively 50 ℃, 75 ℃, 125 ℃, 145 ℃, 155 ℃, 135 ℃, 125 ℃ and 115 ℃, and screw speed is 180r/min;
3) use single screw extrusion machine (screw slenderness ratio is 30:1) that pellet is prepared into sheet material simultaneously, the temperature of extruder piecewise interval is respectively 45 ℃, 70 ℃, 120 ℃, 150 ℃, 150 ℃, 130 ℃, 120 ℃ and 105 ℃, screw speed is 200r/min, the starch sheet material that obtains is wide to be 1.2 meters, and thickness is 0.2MM; After testing, the stretch modulus of starch base sheet material is 1700MPa, and hot strength is 20Mpa.
4) open plastic suction forming apparatus (HSC ?5105570 types, the mechanical plastic cement company limited of the grand China in Zhejiang) on and off switch and adjusting hard capsule Die and mould plate temperature, the Die and mould plate length and width are respectively 50CM X60CM, on dismountable cylindrical shape hard capsule medicated cap or body pin are arranged, be applicable to the capsule shaping that model is 0#, 1#, 2#, 3#, 4#, one-time formed quantity is 300, and mold temperature is adjusted to 70 ℃, preheating 8 minutes;
5) the starch base sheet material is fixed on the warm table of plastic suction forming apparatus softeningly, heating-up temperature is 145 ℃, and the time is 2 seconds;
6) mould has made progress and has rushed and the startup vacuum system, to the plastics suction mould evacuation, vacuum pressure reaches 0.9Mpa, make softening sheet material be adsorbed on the mould top, (hard capsule is cylindrical, two supporting joints, i.e. medicated cap and body about minute to obtain hard capsule case, both have separately groove and wedge, closely overlap integrator).
7) cool off after 3 seconds, the rapidly demoulding, and side cut is rested and reorganized, cover synthesizes hollow starch hard capsule case.The starch base hard capsule case of gained is transparent, free from extraneous odour.Through hot analytical test, moisture is lower than 17%; The time that is dissolved in pH value 7 water under stirring at a slow speed is less than 15 minutes.The starch hard capsule standby with adopting traditional dip forming legal system compared, and adopts the tensile strength of material of extrusion molding preparation can improve 30%.
Embodiment 3
A kind of preparation method of starch hard capsule case comprises the steps:
1) in mass fraction, with 30 parts of deionized waters, 80 parts of hydroxypropyl corn starch (substitution value is 0.03), 5 parts of glycerol, 1 part of monoacetin and 1 part of ethylene glycol, (mixing speed is 2000 rev/mins to put into high-speed mixer, temperature is controlled at 55 ° of C,) mix 1.5 minutes, get mixture;
2) use twin screw response type extruder (screw slenderness ratio is 40:1) mixed material extruding pelletization, twin screw response type extruder is divided into delivery area, admittedly molten mixed zone to the melt Conveying district from the charging aperture to the head, totally 8 intervals, 8 interval temperature are respectively 45 ℃, 70 ℃, 110 ℃, 125 ℃, 145 ℃, 135 ℃, 115 ℃ and 110 ℃, and screw speed is 180r/min;
3) use single screw extrusion machine (screw slenderness ratio is 30:1) that pellet is prepared into sheet material simultaneously, the temperature of extruder piecewise interval is respectively 45 ℃, 70 ℃, 110 ℃, 130 ℃, 130 ℃, 110 ℃, 100 ℃ and 95 ℃, screw speed is 220r/min, the starch sheet material that obtains is wide to be 1.2 meters, and thickness is 0.2MM; After testing, the stretch modulus of starch sheet material is 2300MPa, and hot strength is 19Mpa;
4) open plastic suction forming apparatus (HSC ?5105570 types, the mechanical plastic cement company limited of the grand China in Zhejiang) on and off switch and adjusting hard capsule Die and mould plate temperature, the Die and mould plate length and width are respectively 50CM X60CM, on dismountable cylindrical shape hard capsule medicated cap or body pin are arranged, be applicable to the capsule shaping that model is 0#, 1#, 2#, 3#, 4#, one-time formed quantity is 300, and mold temperature is adjusted to 75 ℃, preheating 10 minutes;
5) the starch sheet material is fixed on the warm table of plastic suction forming apparatus softeningly, heating-up temperature is 130 ℃, and the time is 2 seconds;
6) mould has made progress and has rushed and the startup vacuum system, to the plastics suction mould evacuation, vacuum pressure reaches 0.9Mpa, make softening sheet material be adsorbed on the mould top, (hard capsule is cylindrical, two supporting joints, i.e. medicated cap and body about minute to obtain hard capsule case, both have separately groove and wedge, closely overlap integrator).
7) cool off after 2 seconds, the rapidly demoulding, and side cut is rested and reorganized, cover synthesizes hollow starch hard capsule case.The starch hard capsule case of gained is transparent, free from extraneous odour.Through hot analytical test, moisture is lower than 15%; The time that is dissolved in pH value 7 water under stirring at a slow speed is less than 15 minutes.
Embodiment 4
A kind of preparation method of starch hard capsule case comprises the steps:
1) in mass fraction, 2 parts of 25 parts of deionized waters, 70 parts of corn starchs, 10 parts of soybean dietary fibers, 5 parts of glycerol and Polyethylene Glycol are put into high-speed mixer, and (mixing speed is 1800 rev/mins, temperature is controlled at 50 ° of C) mix 5 minutes, get mixture;
2) use twin screw response type extruder (screw slenderness ratio is 40:1) mixed material extruding pelletization, twin screw response type extruder is divided into delivery area, admittedly molten mixed zone to the melt Conveying district from the charging aperture to the head, totally 8 intervals, 8 interval temperature are respectively 75 ℃, 110 ℃, 130 ℃, 150 ℃, 150 ℃, 130 ℃, 120 ℃ and 105 ℃, and screw speed is 150r/min;
3) use single screw extrusion machine (screw slenderness ratio is 30:1) that pellet is prepared into sheet material simultaneously, the temperature of extruder piecewise interval is respectively 70 ℃, 90 ℃, 120 ℃, 150 ℃, 150 ℃, 130 ℃, 120 ℃ and 110 ℃, screw speed is 170r/min, the starch sheet material that obtains is wide to be 1.2 meters, and thickness is 0.3MM; After testing, the stretch modulus of starch sheet material is 2800MPa, and hot strength is 18Mpa.
4) open plastic suction forming apparatus (HSC ?5105570 types, the mechanical plastic cement company limited of the grand China in Zhejiang) on and off switch and adjusting hard capsule Die and mould plate temperature, the Die and mould plate length and width are respectively 50CM X60CM, on dismountable cylindrical shape hard capsule medicated cap or body pin are arranged, be applicable to the capsule shaping that model is 0#, 1#, 2#, 3#, 4#, one-time formed quantity is 300, and mold temperature is adjusted to 90 ℃, preheating 7 minutes;
5) the starch base sheet material is fixed on the warm table of plastic suction forming apparatus softeningly, heating-up temperature is 120 ℃, and the time is 2 seconds;
6) mould has made progress and has rushed and the startup vacuum system, to the plastics suction mould evacuation, vacuum pressure reaches 1.0Mpa, make softening sheet material be adsorbed on the mould top, (hard capsule is cylindrical, two supporting joints, i.e. medicated cap and body about minute to obtain hard capsule case, both have separately groove and wedge, closely overlap integrator).
7) cool off after 5 seconds, the rapidly demoulding, and side cut is rested and reorganized, cover synthesizes hollow starch hard capsule case.The starch hard capsule case of gained is transparent, free from extraneous odour.Through hot analytical test, moisture is lower than 15%; The time that is dissolved in pH value 7 water under stirring at a slow speed is less than 15 minutes.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize above-mentioned technology contents to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (5)
1. the preparation method of a starch hard capsule case is characterized in that comprising the steps:
1) in mass fraction, with 20 ?30 parts of deionized waters, 60 ?80 parts of starch or starch blend, 2 ?10 parts of edible plasticizers and 0.1 ?2 parts of edible lubricants put into high-speed mixer, temperature be controlled at 50 ?under 60 ° of C conditions, mix 1 ?5 minutes, get mixture; Described edible plasticizer is one or more in glycerol, Sorbitol, ethylene glycol, Glycerine 1,3-diacetate, mannitol, monoacetin and the polypropylene glycol; Described edible lubricant is stearic acid, edible fat acid glyceride or its combination; Described starch is one or more in potato starch, corn starch, wheaten starch, rice starch, the tapioca; Or described starch is for by in etherificate, esterification, cross-linking modified potato starch, corn starch, wheaten starch, rice starch and the tapioca one or more; Described starch blend is the blend of starch and gelatin or edible fiber; By percentage to the quality, in the starch blend starch account for 30 ?70%; Gelatin or edible fiber account for 70 ?30%;
2) use twin screw response type extruder mixed material extruding pelletization;
3) use single screw extrusion machine that pellet is prepared into sheet material;
4) mold temperature of plastic suction forming apparatus is adjusted to 50 ?100 ℃, preheating 8 ?12 minutes;
5) the starch sheet material is fixed on the warm table of plastic suction forming apparatus softening, heating-up temperature be 115 ?125 ℃, the time be 1.5 ?3 seconds;
6) mould has made progress and has rushed and the startup vacuum system, to the plastics suction mould evacuation, makes softening sheet material be adsorbed on the mould top, obtains the starch hard capsule case.
2. the preparation method of starch hard capsule case according to claim 1 is characterized in that: the speed that described high-speed mixer mixes be 1500 ?2000 rev/mins.
3. the preparation method of starch hard capsule case according to claim 1 is characterized in that: the operative temperature of described double screw extruder be 90 ?160 ℃, screw speed be 75 ?300r/min.
4. the preparation method of starch hard capsule case according to claim 1 is characterized in that: described single screw extrusion machine operative temperature be 100 ?170 ℃, screw speed be 60 ?300r/min.
5. the preparation method of starch hard capsule case according to claim 1 is characterized in that: the vacuum pressure of described evacuation be 0.5 ?2.0Mpa.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104224749A (en) * | 2014-10-10 | 2014-12-24 | 青岛澳海生物有限公司 | Novel non-gelatin soft capsule and preparation method thereof |
| CN105232493A (en) * | 2015-10-29 | 2016-01-13 | 华南理工大学 | Gelatin/hydroxypropyl starch blended hard capsule as well as preparation method thereof |
| CN105832698A (en) * | 2016-04-19 | 2016-08-10 | 常州市蓝勖化工有限公司 | Method for preparing hollow capsule shells by using ocentyl succinic anhydride taro starch ester |
| CN107550737A (en) * | 2017-08-25 | 2018-01-09 | 贵州盛茂白芨开发有限公司 | A kind of preparation method of bletilla polysaccharide capsule |
| CN113842372A (en) * | 2021-09-30 | 2021-12-28 | 南京财经大学 | Starch-based capsule coat and preparation method and application thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224749A (en) * | 2014-10-10 | 2014-12-24 | 青岛澳海生物有限公司 | Novel non-gelatin soft capsule and preparation method thereof |
| CN104224749B (en) * | 2014-10-10 | 2016-03-02 | 青岛澳海生物有限公司 | A kind of novel non-gelatin soft capsule and preparation method thereof |
| CN105232493A (en) * | 2015-10-29 | 2016-01-13 | 华南理工大学 | Gelatin/hydroxypropyl starch blended hard capsule as well as preparation method thereof |
| CN105832698A (en) * | 2016-04-19 | 2016-08-10 | 常州市蓝勖化工有限公司 | Method for preparing hollow capsule shells by using ocentyl succinic anhydride taro starch ester |
| CN107550737A (en) * | 2017-08-25 | 2018-01-09 | 贵州盛茂白芨开发有限公司 | A kind of preparation method of bletilla polysaccharide capsule |
| CN107550737B (en) * | 2017-08-25 | 2020-05-05 | 贵州盛茂白芨开发有限公司 | Method for preparing bletilla striata polysaccharide capsule |
| CN113842372A (en) * | 2021-09-30 | 2021-12-28 | 南京财经大学 | Starch-based capsule coat and preparation method and application thereof |
| CN113842372B (en) * | 2021-09-30 | 2023-02-24 | 南京财经大学 | Starch-based capsule coat and preparation method and application thereof |
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