CN107550737B - Method for preparing bletilla striata polysaccharide capsule - Google Patents
Method for preparing bletilla striata polysaccharide capsule Download PDFInfo
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- CN107550737B CN107550737B CN201710743619.5A CN201710743619A CN107550737B CN 107550737 B CN107550737 B CN 107550737B CN 201710743619 A CN201710743619 A CN 201710743619A CN 107550737 B CN107550737 B CN 107550737B
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Abstract
The invention relates to the technical field of capsule processing, and discloses a method for preparing bletilla striata polysaccharide capsules, which comprises capsule shell molding, medicine charging and packaging, wherein the capsule shell molding comprises the following steps: A. arranging a forming die, wherein the forming die comprises a die cavity, a first convex tooth is arranged on the wall of the die cavity, an interlayer is arranged in the wall of the die cavity, a pipeline is taken and inserted into the interlayer, a first through hole is formed in the side wall of the interlayer, a second convex tooth is arranged on the side wall of the die cavity, and a second through hole is formed in the second convex tooth; B. filling bletilla striata mucilage, and filling the bletilla striata mucilage into the interlayer through a pipeline; C. coating bletilla striata polysaccharide, and coating the bletilla striata polysaccharide on the second convex teeth; D. filling glue for molding, namely filling glue for preparing the capsule into a mold cavity; E. and taking out the capsule shell, pressurizing the interlayer, sliding the second convex teeth to enable the second convex teeth to collide with the first convex teeth, and taking out the capsule shell after the capsule shell is molded. By the method of the present invention, a capsule can be produced which avoids adhesion to the throat area.
Description
Technical Field
The invention relates to the technical field of capsule processing, in particular to a method for preparing bletilla striata polysaccharide capsules.
Background
Some medicines for treating diseases have certain irritation on esophagus and gastric mucosa, or the medicines have poor taste, are easy to volatilize, are easy to be decomposed by saliva in oral cavity and are easy to be inhaled into trachea, and in order to ensure the curative effect of the medicines and improve the treatment effect, the medicines are filled into capsules when being processed. The capsule shell not only protects the medicine property from being damaged, but also protects digestive organs and respiratory tract. Removal of the capsule shell may result in loss of the drug, waste of the drug, reduced efficacy, etc.
The capsule shell surface of current capsule is smooth surface, and capsule shell itself is colloidal substance, has certain viscidity, and when the patient took capsule-like medicine, can cause the capsule adhesion at the throat position because of drinking water less or other reasons sometimes to arouse patient's vomiting or other uncomfortable symptoms, influence the patient and take medicine, be unfavorable for patient's recovery.
Disclosure of Invention
The invention aims to provide a preparation method of a bletilla striata polysaccharide capsule, which is used for producing a capsule capable of avoiding being adhered to a throat part, is beneficial to a patient to take medicine and promotes the rehabilitation of the patient.
In order to achieve the purpose, the basic technical scheme of the invention is as follows: a method for preparing bletilla striata polysaccharide capsules comprises capsule shell molding, medicine charging and packaging, wherein the capsule shell molding step comprises the following operation steps:
A. arranging a forming die, taking the forming die of the capsule shell, wherein the forming die comprises a die cavity, a first convex tooth protruding towards the center of the die cavity is arranged on the cavity wall of the die cavity, an interlayer is arranged in the cavity wall of the die cavity, a section of pipeline is taken, one end of the pipeline extends into the interlayer, the other end of the pipeline is positioned outside the forming die, a first through hole is arranged on the side wall of the interlayer facing the inner side of the die cavity, an L-shaped second convex tooth is arranged on the side wall of the die cavity, the second convex tooth comprises a transverse plate, a second through hole is arranged on the transverse plate, the first through hole is communicated with the die cavity through the second through hole, and a longitudinal plate is connected on the transverse plate in a sliding;
B. filling bletilla striata mucilage, sliding the transverse plate, staggering the first through hole and the second through hole, taking the bletilla striata, and filling the bletilla striata into the interlayer through a pipeline;
C. coating bletilla striata polysaccharide, dipping the bletilla striata polysaccharide by a brush, and coating the bletilla striata polysaccharide on the second convex teeth;
D. filling glue for molding, namely filling the glue solution for preparing the capsule into a mold cavity to mold a capsule shell;
E. and taking out the capsule shell, pressurizing the interlayer by a pipeline, sliding the longitudinal plate to enable the longitudinal plate to collide with the first convex teeth, and taking out the capsule shell from the forming die after the capsule shell is formed.
The principle and the advantages of the scheme are as follows: when filling tuber of hyacinth bletilla viscose, the horizontal board that slides makes second through-hole and first through-hole stagger to can block up first through-hole, prevent that the tuber of hyacinth bletilla viscose from spilling from first through-hole. The first and second raised teeth are provided on the mold cavity such that the resulting adhesive surface has a fold. When sliding the horizontal board to first dogtooth, first through-hole and second through-hole can align, the tuber of hyacinth bletilla mucus in the interlayer flows to the capsule shell on the pressure effect to thereby pressure makes the capsule shell just sunken to the center of capsule shell to the position of first through-hole form concave part, when first dogtooth and vertical board collision, will extrude the both sides border of concave part and paste tightly, and because scribble tuber of hyacinth bletilla polysaccharide on the second dogtooth, make the both sides border of concave part glue together, thereby wrap up the tuber of hyacinth bletilla mucus in concave part. The capsule shell is used for packaging medicines, when a patient takes the capsule, the bletilla striata polysaccharide at the concave part is dissolved by water, so that the two side edges of the concave part which are attached to each other are separated, and the bletilla striata mucus in the concave part can flow out, so that the oral cavity or throat part is lubricated, the capsule is prevented from being adhered to the oral cavity or throat part, discomfort of the patient is avoided, and the treatment effect is improved. And the bletilla striata mucus can lubricate the throat of a patient, and reduce the stimulation of the medicament to the throat of the patient. The bletilla striata polysaccharide on the capsule shell simultaneously makes the capsule have sweet taste, weakens the plastic taste of the capsule and makes the capsule suitable for patients to take. Meanwhile, bletilla striata has the effects of reducing phlegm and relieving cough, diminishing inflammation and stopping bleeding, and has a health-care effect on patients.
Preferably, as an improvement, in the step B, when the interlayer is filled with the bletilla striata mucus through the pipeline, the bletilla striata mucus is sucked by using a needle, and the pipeline is injected through the needle for filling. Because the tuber of hyacinth bletilla mucus is thick form, directly pour into by the pipeline and lead to the unable pipeline that gets into of tuber of hyacinth bletilla mucus easily, use the syringe needle, then can directly inject the tuber of hyacinth bletilla mucus into the pipeline, the pressure through the syringe needle promotes the tuber of hyacinth bletilla mucus and flows fast, has avoided the unable problem that gets into the pipeline of tuber of hyacinth bletilla mucus, prevents simultaneously that the tuber of hyacinth bletilla mucus from flowing slowly and taking place the phenomenon of pipe blockage in the pipeline.
Preferably, as an improvement, in step B, the bletilla striata liquid used is a sticky powder extracted from bletilla striata liquid. Therefore, the storage and transportation of the capsule can be facilitated, and when a patient takes the capsule, the viscous powder leaks out and is dissolved in water after the bletilla striata polysaccharide is dissolved in water, so that the oral cavity and the throat of the patient are lubricated.
Preferably, as an improvement, in the step C, the bletilla striata polysaccharide is decocted into thick syrup, and the syrup is smeared by using a brush after being cooled to 10-15 ℃. Because the viscosity of the sticky syrup is higher, the fixing effect on the concave part of the capsule shell is good, the concave part is favorably formed, and the bletilla striata mucus is prevented from leaking.
Preferably, as an improvement, step E is followed by step F, wherein step F is a shell surface treatment, the capsule shell formed in step E is placed on a plane, a pressing plate is used to press the capsule shell, and the pressing plate is pushed back and forth to roll and rub the capsule shell. During the forming process of the capsule shell or after the bletilla striata polysaccharide is adhered to the capsule shell, water caltrops are easy to generate on the surface of the capsule shell, and the water caltrop parts of the capsule shell can be smooth by rolling and rubbing the capsule shell by the pressing plate, so that the water caltrop parts can be prevented from stabbing the oral cavity, throat, intestines and stomach of a patient.
Preferably, as an improvement, a cavity is arranged inside the pressing plate, and the cavity is filled with hot air at the temperature of 10-15 ℃. The temperature of the hot air can shape the colloid material of the capsule shell or the bletilla striata polysaccharide on the capsule shell, thereby facilitating the water caltrop of the capsule shell to become smooth.
Preferably, as an improvement, the cavity is communicated with a hot air blower. The hot air blower can keep the temperature of the pressing plate, and is beneficial to forming the capsule shell.
Drawings
Fig. 1 is a sectional view of a molding die used in an embodiment of the present invention.
Fig. 2 is a structural view of a second tooth in the embodiment.
FIG. 3 is a block diagram of a capsule made by the process of the present invention.
Detailed Description
The present invention will be described in further detail below by way of specific embodiments:
reference numerals in the drawings of the specification include: the capsule comprises a die cavity 1, a first convex tooth 2, a second convex tooth 3, an interlayer 4, a first through hole 5, a second through hole 6, a pipeline 7, a capsule shell 8, a concave part 9, a transverse plate 10 and a longitudinal plate 11.
A preparation method of rhizoma bletilla polysaccharide capsule comprises:
1. forming a capsule shell:
A. arranging a forming die, taking the forming die of a capsule shell, wherein the forming die comprises a die cavity 1, a plurality of first convex teeth 2 protruding towards the center of the die cavity 1 are arranged on the cavity wall of the die cavity 1, an interlayer 4 is arranged in the cavity wall of the die cavity 1, a section of pipeline 7 is taken, one end of the pipeline 7 extends into the interlayer 4, the other end of the pipeline 7 is positioned at the outer side of the forming die, a first through hole 5 is arranged on the side wall of the interlayer 4 facing the inner side of the die cavity 1, an L-shaped second convex tooth 3 is arranged between two adjacent first convex teeth 2, the plurality of second convex teeth 3 are connected together through a connecting frame, as shown in figure 2, each second convex tooth 3 comprises a transverse plate 10, a second through hole 6 is arranged on each transverse plate 10, each first through hole 5 is communicated with the die cavity 1 through each second through hole 6, and each transverse plate 10 is connected with a longitudinal plate 11 in a sliding manner;
B. filling bletilla striata, sliding the transverse plate 10, staggering the first through hole 5 and the second through hole 6, taking the bletilla striata, extracting the bletilla striata into viscous powder, sucking the viscous powder by using a needle head, and injecting the viscous powder into the interlayer 4 from the pipeline 7 through the needle head for filling;
C. coating bletilla striata polysaccharide, decocting the bletilla striata polysaccharide into thick syrup, cooling the syrup to 10-15 ℃, dipping the bletilla striata polysaccharide with a brush, and coating the bletilla striata polysaccharide on the second convex teeth 3;
D. filling glue for molding, namely filling glue for preparing the capsule into the die cavity 1 to mold the capsule shell 8;
E. taking out the capsule shell 8, pressurizing the interlayer 4 by the pipeline 7, sliding the longitudinal plate 11 to make the longitudinal plate 11 collide with the first convex teeth 2, and taking out the capsule shell 8 from the forming die after the capsule shell 8 is formed;
F. processing the shell surface, namely placing the capsule shell 8 formed in the step E on a plane, pressing the capsule shell 8 by using a pressing plate, pushing the pressing plate back and forth to roll and rub the capsule shell 8, wherein a cavity is arranged in the pressing plate, hot air at the temperature of 10-15 ℃ is filled in the cavity, and the cavity is communicated with a hot air blower;
2. loading the powder into capsule shell 8 to obtain capsule shown in figure 3;
3. and (4) packaging, namely hermetically packaging the capsule, and performing freezing storage and transportation at low temperature.
The first convex tooth 2 and the second convex tooth 3 form a plurality of bulges in the die cavity 1, so that after the capsule shell 8 is formed, the surface has a plurality of wrinkles, when the transverse plate 10 slides towards the first convex tooth 2, the first through hole 5 and the second through hole 6 are aligned, pressure applied to the partition layer 4 extrudes viscous powder in the partition layer 4 and sprays the viscous powder onto the capsule shell 8, the spraying force enables the part, opposite to the second through hole 6, on the capsule shell 8 to be sunken towards the center of the capsule shell 8, so that a concave part 9 is formed, the viscous powder falls into the concave part 9, meanwhile, the longitudinal plate 11 collides with the first convex tooth 2, and the bletilla striata on the second convex tooth 3 adheres two side edges of the concave part 9 together, seals the concave part 9 and prevents the viscous powder from leaking.
The water caltrops on the capsule shell 8 can be smooth by the rolling and rubbing processing, and the water caltrops are prevented from scratching mucous membranes of oral cavities, throats, intestines and stomach and the like.
The capsule produced by the method of the present invention has a surface with a plurality of folds as shown in fig. 3. When the capsule is taken by patients, the bletilla striata polysaccharide in the fold part is melted by water, the viscous powder sealed in the fold leaks out and lubricates the surface of the capsule, thereby preventing the capsule from adhering to the oral cavity and throat parts, and being suitable for patients to take. The rhizoma bletilla polysaccharide is dissolved in water, and can also reduce plastic flavor of the capsule, and prevent discomfort of the user.
The foregoing is merely an example of the present invention and common general knowledge in the art of designing and/or characterizing particular aspects and/or features is not described in any greater detail herein. It should be noted that, for those skilled in the art, without departing from the technical solution of the present invention, several variations and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.
Claims (4)
1. The preparation method of the bletilla striata polysaccharide capsule comprises the steps of capsule shell molding, medicine charging and packaging, and is characterized in that: the capsule shell forming step comprises the following operation steps:
A. arranging a forming die, taking the forming die of the capsule shell, wherein the forming die comprises a die cavity, a first convex tooth protruding towards the center of the die cavity is arranged on the cavity wall of the die cavity, an interlayer is arranged in the cavity wall of the die cavity, a section of pipeline is taken, one end of the pipeline extends into the interlayer, the other end of the pipeline is positioned outside the forming die, a first through hole is arranged on the side wall of the interlayer facing the inner side of the die cavity, an L-shaped second convex tooth is arranged on the side wall of the die cavity, the second convex tooth comprises a transverse plate, a second through hole is arranged on the transverse plate, the first through hole is communicated with the die cavity through the second through hole, and a longitudinal plate is connected on the transverse plate in a sliding;
B. filling bletilla striata mucilage, sliding the transverse plate, staggering the first through hole and the second through hole, taking the bletilla striata, and filling the bletilla striata into the interlayer through a pipeline; when bletilla striata mucus is filled into the interlayer from the pipeline, the bletilla striata mucus is sucked by using a needle head, and the bletilla striata mucus is injected into the pipeline through the needle head for filling;
C. coating bletilla striata polysaccharide, decocting the bletilla striata polysaccharide into thick syrup, cooling the syrup to 10-15 ℃, dipping the bletilla striata polysaccharide with a brush, and coating the bletilla striata polysaccharide on the second convex teeth;
D. filling glue for molding, namely filling the glue solution for preparing the capsule into a mold cavity to mold a capsule shell;
E. and taking out the capsule shell, pressurizing the interlayer by a pipeline, sliding the longitudinal plate to enable the longitudinal plate to collide with the first convex teeth, and taking out the capsule shell from the forming die after the capsule shell is formed.
2. The method for preparing bletilla striata polysaccharide capsule according to claim 1, wherein the method comprises the following steps: and F, after the step E, processing the shell surface, namely placing the capsule shell formed in the step E on a plane, pressing the capsule shell on the capsule shell by using a pressing plate, and pushing the pressing plate back and forth to roll and rub the capsule shell.
3. The preparation method of bletilla striata polysaccharide capsule according to claim 2, wherein the preparation method comprises the following steps: a cavity is arranged in the pressing plate, and hot air at 10-15 ℃ is filled in the cavity.
4. The preparation method of bletilla striata polysaccharide capsule according to claim 3, wherein the preparation method comprises the following steps: the cavity is communicated with an air heater.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710743619.5A CN107550737B (en) | 2017-08-25 | 2017-08-25 | Method for preparing bletilla striata polysaccharide capsule |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710743619.5A CN107550737B (en) | 2017-08-25 | 2017-08-25 | Method for preparing bletilla striata polysaccharide capsule |
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| CN107550737A CN107550737A (en) | 2018-01-09 |
| CN107550737B true CN107550737B (en) | 2020-05-05 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0102832A2 (en) * | 1982-09-02 | 1984-03-14 | R.P. Scherer Corporation | Hard shell gelatin capsule dipping apparatus and method |
| EP0773858A1 (en) * | 1995-06-05 | 1997-05-21 | Gs Technologies, Inc. | Method and apparatus for the manufacture or pharmaceutical cellulose capsules |
| CN1164386A (en) * | 1996-05-03 | 1997-11-12 | 泉州市第一医院 | Common bletilla tuber hellow capsule |
| CN103315976A (en) * | 2013-06-13 | 2013-09-25 | 华南理工大学 | Preparation method for starch hard capsule shells |
| CN104248514A (en) * | 2014-07-15 | 2014-12-31 | 浙江海迪森胶丸有限公司 | Film-blowing-type uniform-thickness capsule shell forming machine |
| CN204352208U (en) * | 2014-11-25 | 2015-05-27 | 浙江宏辉胶丸有限公司 | A kind of mold for empty capsule |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104905967B (en) * | 2015-05-23 | 2019-04-16 | 浙江益立胶囊股份有限公司 | Production mould for the double-deck enteric hollow capsule |
| CN205659156U (en) * | 2016-02-26 | 2016-10-26 | 汤臣倍健股份有限公司 | Pelleting mould and pellet press |
-
2017
- 2017-08-25 CN CN201710743619.5A patent/CN107550737B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0102832A2 (en) * | 1982-09-02 | 1984-03-14 | R.P. Scherer Corporation | Hard shell gelatin capsule dipping apparatus and method |
| EP0773858A1 (en) * | 1995-06-05 | 1997-05-21 | Gs Technologies, Inc. | Method and apparatus for the manufacture or pharmaceutical cellulose capsules |
| CN1164386A (en) * | 1996-05-03 | 1997-11-12 | 泉州市第一医院 | Common bletilla tuber hellow capsule |
| CN103315976A (en) * | 2013-06-13 | 2013-09-25 | 华南理工大学 | Preparation method for starch hard capsule shells |
| CN104248514A (en) * | 2014-07-15 | 2014-12-31 | 浙江海迪森胶丸有限公司 | Film-blowing-type uniform-thickness capsule shell forming machine |
| CN204352208U (en) * | 2014-11-25 | 2015-05-27 | 浙江宏辉胶丸有限公司 | A kind of mold for empty capsule |
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| CN107550737A (en) | 2018-01-09 |
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