CN107550737A - A kind of preparation method of bletilla polysaccharide capsule - Google Patents
A kind of preparation method of bletilla polysaccharide capsule Download PDFInfo
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- CN107550737A CN107550737A CN201710743619.5A CN201710743619A CN107550737A CN 107550737 A CN107550737 A CN 107550737A CN 201710743619 A CN201710743619 A CN 201710743619A CN 107550737 A CN107550737 A CN 107550737A
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- capsule
- bletilla
- double wedge
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- mucus
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Abstract
The present invention relates to capsule processing technique field, discloses a kind of preparation method of bletilla polysaccharide capsule, including capsule casing forming, powder charge and packaging, capsule casing forming include：Mould is set, and mould includes die cavity, the first double wedge is set in the cavity wall of die cavity A, interlayer is set in cavity wall, takes pipeline, pipeline is stretched into interlayer, first through hole is opened up in the side wall of interlayer, and the second double wedge is set in the side wall of die cavity, the second through hole is set on the second double wedge；B, filling bletilla striata mucus, it is by pipeline that bletilla striata mucus is filling in interlayer；C, bletilla polysaccharide is smeared, bletilla polysaccharide is applied on the second double wedge；D, encapsulating is molded, and the glue for preparing capsule is poured into die cavity；E, capsule shells are taken out, are pressurizeed into interlayer, and slide the second double wedge, the second double wedge and the first double wedge is collided, after capsule casing forming, is drawn off.A kind of capsule for avoiding being adhered to throat can be produced by the inventive method.
Description
Technical field
The present invention relates to capsule processing technique field, and in particular to a kind of preparation method of bletilla polysaccharide capsule.
Background technology
The medicines of some treatment diseases, have certain excitant to esophagus and gastric mucosa, or medicine mouthfeel itself is bad, easy
In volatilization, easily decomposed in the oral cavity by saliva, and easily suck tracheal strips, the effect of in order to ensure these medicines, improve treatment
Effect, when processing medicine, these medicines can be loaded in capsule.Capsule shells both protected medicine property of medicine not to be destroyed, and also protected
Digestive organs and respiratory tract.Remove capsule shells and be then likely to result in drug wastage, drug waste, drug effect reduction etc..
The capsule shells surface of existing capsule is smooth surface, and capsule shells sheet has certain glue as colloid substance
Property, patient is when taking the medicine into capsule shape, sometimes because of the less or other reasonses that drink water, causes capsule to be adhered to bottleneck throat
Position, so as to cause the vomiting of patient or other malaise symptoms, patient's medication is influenceed, is unfavorable for the rehabilitation of patient.
The content of the invention
The invention is intended to provide a kind of preparation method of bletilla polysaccharide capsule, can avoid being adhered to throat to produce one kind
The capsule at position, taken medicine beneficial to patient, promote Rehabilitation.
To reach above-mentioned purpose, basic technology scheme of the invention is as follows：A kind of preparation method of bletilla polysaccharide capsule, bag
Capsule casing forming, powder charge and packaging are included, capsule shells forming step includes following operating procedure：
Mould is set, take the mould of capsule shells A, mould includes die cavity, set in the cavity wall of die cavity to mould
First double wedge of chamber center protrusion, sets interlayer in the cavity wall of die cavity, takes one section of pipeline, one end of pipeline is stretched into interlayer
Interior, the other end of pipeline is located at the outside of mould, in interlayer towards opening up first through hole in the side wall on the inside of die cavity, and
Second double wedge of L-type is set in the side wall of die cavity, the second double wedge includes transverse plate, sets the second through hole on transverse plate, and second
Through hole connects first through hole with die cavity, and be slidably connected longitudinal plate on transverse plate；
B, filling bletilla striata mucus, transverse plate is slided, first through hole and the second through hole are staggered, take bletilla striata mucus, and will by pipeline
Bletilla striata mucus is filling in interlayer；
C, bletilla polysaccharide is smeared, dips bletilla polysaccharide with brush, and be applied on the second double wedge；
D, encapsulating is molded, and the glue for preparing capsule, which is poured into die cavity, makes capsule casing forming；
E, capsule shells are taken out, are pressurizeed from pipeline into interlayer, and slide longitudinal plate, longitudinal plate and the first double wedge is collided, treats glue
After softgel shell shaping, capsule shells are taken out from mould.
The principle and advantage of this programme be：During filling bletilla striata mucus, transverse plate is slided, makes the second through hole and first through hole wrong
Open, so as to which first through hole is blocked, prevent bletilla striata mucus from being spilt from first through hole.Set on die cavity the first double wedge and
Second double wedge so that manufactured gluing surface has fold.When sliding transverse plate to the first double wedge, first through hole and second is led to
Hole is alignd, and the bletilla striata mucus in interlayer is flow in capsule shells under pressure, and pressure causes capsule shells face
The position of one through hole, so as to form matrix portion, when the first double wedge and longitudinal plate collision, will extrude to the central concave of capsule shells
The both sides edge in matrix portion is adjacent to, and due to being coated with bletilla polysaccharide on the second double wedge so that the both sides edge in matrix portion is bonded at
Together, so that bletilla striata mucus is wrapped in matrix portion.The capsule shells are used for the packaging of medicine, when patient takes the capsule
When, the bletilla polysaccharide at matrix portion is by water-solubleization so that the both sides edge that matrix portion is affixed is separated from each other, the bletilla striata in matrix portion
Mucus is flowed out, and so as to lubricate oral cavity or throat, is prevented capsule to be adhered to oral cavity or throat, is avoided causing trouble
The discomfort of person, improve therapeutic effect.And bletilla striata mucus can be lubricated the throat of patient, reduce thorn of the medicine to patient throat
Swash.Bletilla polysaccharide in capsule shells causes capsule to have sweet taste simultaneously, weakens the plastic cement taste of capsule, is adapted to patient and takes.
The bletilla striata has the effect of preventing phlegm from forming and stopping coughing, anti-inflammation hemostasia in itself simultaneously, with health role to patient.
Preferably, as an improvement, in step B, during filling bletilla striata mucus, needle aspirate is used into interlayer from pipeline
Bletilla striata mucus, and injected into pipeline by syringe needle carry out it is filling.Because bletilla striata mucus is in thick, appearance is directly poured into by pipeline
It is easily caused bletilla striata mucus to cannot be introduced into pipeline, using syringe needle, then bletilla striata mucus can be injected directly into pipeline, passes through syringe needle
Pressure promote bletilla striata mucus quickly flow, avoid the problem of bletilla striata mucus cannot be introduced into pipeline, while prevent bletilla striata mucus
Flowed slowly in pipeline and the phenomenon of line clogging occurs.
Preferably, as an improvement, in step B, used bletilla striata mucus is the viscosity extracted from bletilla striata mucus
Powder.It so, it is possible to be easy to the accumulating of capsule, and when patient takes capsule, bletilla polysaccharide is by after water-solubleization, cohesive powders leakage
Go out and soluble in water, so as to lubricate the oral cavity of patient and throat.
Preferably, as an improvement, in step C, bletilla polysaccharide is brewed into sticky syrup, treats that syrup is cooled to
At 10-15 degrees Celsius, reuse brush and smeared.Because thick syrup stickiness is higher, to capsule shells matrix position
Good fixing effect, it is molded beneficial to matrix position, prevents bletilla striata mucus from spilling.
Preferably, as an improvement, after step E, also step F, step F are shell surface processing, by what is be molded in step E
Capsule shells are placed in plane, are pressed in using pressing plate in capsule shells, promote pressing plate back and forth, and rolling stranding is carried out to capsule shells.Capsule shells exist
In forming process or after bletilla polysaccharide is bonded in capsule shells, water caltrop easily is produced on capsule shells surface, by pressing plate to capsule
The rolling of shell is rubbed with the hands, can make the water caltrop position of capsule shells become round and smooth, prevents water caltrop position from piercing the oral cavity of patient, throat or stomach etc.
Wound.
Preferably, as an improvement, cavity is provided with inside pressing plate, 10-15 degrees Celsius of hot blast is filled with cavity.Heat
It is moulding that the temperature of wind can have the bletilla polysaccharide on the colloidal materials or capsule shells of capsule shells, so as to the water chestnut beneficial to capsule shells
Angle becomes round and smooth.
Preferably, as an improvement, cavity is communicated with air-heater.Air-heater can keep the temperature of pressing plate, beneficial to glue
Softgel shell is molded.
Brief description of the drawings
Fig. 1 is the sectional view of the mould used in the embodiment of the present invention.
Fig. 2 is the structure chart of the second double wedge in embodiment.
The structure chart of capsule made of Fig. 3 the inventive method.
Embodiment
Below by embodiment, the present invention is further detailed explanation：
Reference in Figure of description includes：Die cavity 1, the first double wedge 2, the second double wedge 3, interlayer 4, first through hole 5, second
Through hole 6, pipeline 7, capsule shells 8, matrix portion 9, transverse plate 10, longitudinal plate 11.
A kind of preparation method of bletilla polysaccharide capsule, including：
1st, capsule casing forming：
Mould is set, take the mould of capsule shells, mould is as shown in figure 1, including die cavity 1, in the chamber of die cavity 1 A,
Multiple the first double wedges 2 protruded to the center of die cavity 1 are set on wall, interlayer 4 is set in the cavity wall of die cavity 1, takes one section of pipeline 7,
One end of pipeline 7 is stretched into interlayer 4, the other end of pipeline 7 is located at the outside of mould, in interlayer 4 towards the inner side of die cavity 1
Side wall on open up first through hole 5, and the second double wedge 3 of L-type is set between two the first adjacent double wedges 2, several second
Linked together by link between double wedge 3, as shown in Fig. 2 the second double wedge 3 includes transverse plate 10, set on transverse plate 10
The second through hole 6 is put, the second through hole 6 connects first through hole 5 with die cavity 1, and longitudinal plate 11 is slidably connected on transverse plate 10；
B, filling bletilla striata mucus, transverse plate 10 is slided, the through hole 6 of first through hole 5 and second is staggered, bletilla striata mucus is taken, by the bletilla striata
Mucus is extracted into cohesive powders, using needle aspirate cohesive powders, and is injected and is filled into interlayer 4 from pipeline 7 by syringe needle
Dress；
C, bletilla polysaccharide is smeared, bletilla polysaccharide is brewed into sticky syrup, when syrup is cooled to 10-15 degrees Celsius, with brush
Son dips bletilla polysaccharide, and is applied on the second double wedge 3；
D, encapsulating is molded, and the glue for preparing capsule, which is poured into die cavity 1, is molded capsule shells 8；
E, capsule shells 8 are taken out, are pressurizeed from pipeline 7 into interlayer 4, and slide longitudinal plate 11, touch the double wedge 2 of longitudinal plate 11 and first
Hit, after the shaping of capsule shells 8, capsule shells 8 are taken out from mould；
F, shell surface is handled, and the capsule shells 8 being molded in step E are placed in plane, are pressed in using pressing plate in capsule shells 8, to push back
Dynamic pressure plate, capsule shells 8 are carried out with rolling stranding, cavity is provided with inside pressing plate, 10-15 degrees Celsius of hot blast, cavity are filled with cavity
It is communicated with air-heater；
2nd, powder charge, load medicinal powder in capsule shells 8, capsule as shown in Figure 3 is made；
3rd, pack, capsule is packed, freezing accumulating is carried out using low temperature.
First double wedge 2 and the second double wedge 3 form multiple projections in die cavity 1 so that after capsule shells 8 are molded, surface has
Multiple folds, when sliding transverse plate 10 to the first double wedge 2, the through hole 6 of first through hole 5 and second is alignd, now to interlayer 4
The pressure of interior application extrudes the cohesive powders in interlayer 4, and is sprayed onto in capsule shells 8, and the blowing force promotes the face of the second through hole 6
Position in capsule shells 8 is to the central concave of capsule shells 8, and so as to form matrix portion 9, cohesive powders are fallen into matrix portion 9, simultaneously
Longitudinal plate 11 is collided with the first double wedge 2, and the bletilla polysaccharide on the second double wedge 3 sticks together two sides in matrix portion 9, will be recessed
Type portion 9 seals, and prevents cohesive powders from spilling.
Processing is rubbed in rolling, which with the hands, can make the water caltrop in capsule shells 8 round and smooth, prevent the positions such as water caltrop scratch oral cavity, throat, stomach
Mucous membrane.
Using capsule made of the inventive method as shown in figure 3, surface has multiple folds.When patient takes the capsule
When, the bletilla polysaccharide at fold position is melted by water, and the cohesive powders sealed in fold are spilt, and capsule surface is lubricated, so as to
Prevent capsule to be adhered to oral cavity and throat, enter clothes suitable for patient.Bletilla polysaccharide is soluble in water, additionally it is possible to mitigates the modeling of capsule
Glue taste, it is uncomfortable to prevent that user from producing.
Above-described is only embodiments of the invention, the general knowledge such as known concrete technical scheme and/or characteristic in scheme
Do not describe excessively herein.It should be pointed out that for those skilled in the art, before technical solution of the present invention is not departed from
Put, several modifications and improvements can also be made, these should also be considered as protection scope of the present invention, and these are all without influence sheet
Invent the effect and practical applicability implemented.The scope of protection required by this application should be based on the content of the claims,
The records such as the embodiment in specification can be used for the content for explaining claim.
Claims (7)
1. a kind of preparation method of bletilla polysaccharide capsule, including capsule casing forming, powder charge and packaging, it is characterised in that：The glue
Softgel shell forming step includes following operating procedure：
Mould is set, take the mould of capsule shells A, mould includes die cavity, set in the cavity wall of die cavity to mould
First double wedge of chamber center protrusion, sets interlayer in the cavity wall of die cavity, takes one section of pipeline, one end of pipeline is stretched into interlayer
Interior, the other end of pipeline is located at the outside of mould, in interlayer towards opening up first through hole in the side wall on the inside of die cavity, and
Second double wedge of L-type is set in the side wall of die cavity, the second double wedge includes transverse plate, sets the second through hole on transverse plate, and second
Through hole connects first through hole with die cavity, and be slidably connected longitudinal plate on transverse plate；
B, filling bletilla striata mucus, transverse plate is slided, first through hole and the second through hole are staggered, take bletilla striata mucus, and will by pipeline
Bletilla striata mucus is filling in interlayer；
C, bletilla polysaccharide is smeared, dips bletilla polysaccharide with brush, and be applied on the second double wedge；
D, encapsulating is molded, and the glue for preparing capsule, which is poured into die cavity, makes capsule casing forming；
E, capsule shells are taken out, are pressurizeed from pipeline into interlayer, and slide longitudinal plate, longitudinal plate and the first double wedge is collided, treats glue
After softgel shell shaping, capsule shells are taken out from mould.
A kind of 2. preparation method of bletilla polysaccharide capsule according to claim 1, it is characterised in that：In the step B, by
Pipeline during filling bletilla striata mucus, using needle aspirate bletilla striata mucus, and is injected into pipeline by syringe needle and filled into interlayer
Dress.
A kind of 3. preparation method of bletilla polysaccharide capsule according to claim 2, it is characterised in that：In the step B, institute
The bletilla striata mucus used is the cohesive powders extracted from bletilla striata mucus.
A kind of 4. preparation method of bletilla polysaccharide capsule according to claim 3, it is characterised in that：, will in the step C
Bletilla polysaccharide is brewed into sticky syrup, when syrup is cooled to 10-15 degrees Celsius, reuses brush and is smeared.
A kind of 5. preparation method of bletilla polysaccharide capsule according to claim 4, it is characterised in that：After the step E, also
It is shell surface processing to have step F, step F, and the capsule shells being molded in step E are placed in plane, are pressed in using pressing plate in capsule shells,
Pressing plate is promoted back and forth, and rolling stranding is carried out to capsule shells.
A kind of 6. preparation method of bletilla polysaccharide capsule according to claim 5, it is characterised in that：Set inside the pressing plate
There is cavity, 10-15 degrees Celsius of hot blast is filled with cavity.
A kind of 7. preparation method of bletilla polysaccharide capsule according to claim 6, it is characterised in that：The cavity is communicated with
Air-heater.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710743619.5A CN107550737B (en) | 2017-08-25 | 2017-08-25 | Method for preparing bletilla striata polysaccharide capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710743619.5A CN107550737B (en) | 2017-08-25 | 2017-08-25 | Method for preparing bletilla striata polysaccharide capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107550737A true CN107550737A (en) | 2018-01-09 |
| CN107550737B CN107550737B (en) | 2020-05-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710743619.5A Active CN107550737B (en) | 2017-08-25 | 2017-08-25 | Method for preparing bletilla striata polysaccharide capsule |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0102832A2 (en) * | 1982-09-02 | 1984-03-14 | R.P. Scherer Corporation | Hard shell gelatin capsule dipping apparatus and method |
| EP0773858A1 (en) * | 1995-06-05 | 1997-05-21 | Gs Technologies, Inc. | Method and apparatus for the manufacture or pharmaceutical cellulose capsules |
| CN1164386A (en) * | 1996-05-03 | 1997-11-12 | 泉州市第一医院 | Common bletilla tuber hellow capsule |
| CN103315976A (en) * | 2013-06-13 | 2013-09-25 | 华南理工大学 | Preparation method for starch hard capsule shells |
| CN104248514A (en) * | 2014-07-15 | 2014-12-31 | 浙江海迪森胶丸有限公司 | Film-blowing-type uniform-thickness capsule shell forming machine |
| CN204352208U (en) * | 2014-11-25 | 2015-05-27 | 浙江宏辉胶丸有限公司 | A kind of mold for empty capsule |
| CN104905967A (en) * | 2015-05-23 | 2015-09-16 | 浙江益立胶囊股份有限公司 | Production mold for double-layer enteric hollow capsule |
| CN205659156U (en) * | 2016-02-26 | 2016-10-26 | 汤臣倍健股份有限公司 | Pelleting mould and pellet press |
-
2017
- 2017-08-25 CN CN201710743619.5A patent/CN107550737B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0102832A2 (en) * | 1982-09-02 | 1984-03-14 | R.P. Scherer Corporation | Hard shell gelatin capsule dipping apparatus and method |
| EP0773858A1 (en) * | 1995-06-05 | 1997-05-21 | Gs Technologies, Inc. | Method and apparatus for the manufacture or pharmaceutical cellulose capsules |
| CN1164386A (en) * | 1996-05-03 | 1997-11-12 | 泉州市第一医院 | Common bletilla tuber hellow capsule |
| CN103315976A (en) * | 2013-06-13 | 2013-09-25 | 华南理工大学 | Preparation method for starch hard capsule shells |
| CN104248514A (en) * | 2014-07-15 | 2014-12-31 | 浙江海迪森胶丸有限公司 | Film-blowing-type uniform-thickness capsule shell forming machine |
| CN204352208U (en) * | 2014-11-25 | 2015-05-27 | 浙江宏辉胶丸有限公司 | A kind of mold for empty capsule |
| CN104905967A (en) * | 2015-05-23 | 2015-09-16 | 浙江益立胶囊股份有限公司 | Production mold for double-layer enteric hollow capsule |
| CN205659156U (en) * | 2016-02-26 | 2016-10-26 | 汤臣倍健股份有限公司 | Pelleting mould and pellet press |
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| CN107550737B (en) | 2020-05-05 |
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