CN1735393A - Soluble oral patch with collagen and interlaced active ingredients - Google Patents
Soluble oral patch with collagen and interlaced active ingredients Download PDFInfo
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- CN1735393A CN1735393A CN 200380108321 CN200380108321A CN1735393A CN 1735393 A CN1735393 A CN 1735393A CN 200380108321 CN200380108321 CN 200380108321 CN 200380108321 A CN200380108321 A CN 200380108321A CN 1735393 A CN1735393 A CN 1735393A
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Abstract
A soft, adherent, soluble oral patch for delivering topical medication in the mouth including a hydrophilic polymer that is liquid at human mouth temperatures. Preferably, the hydrophilic polymer gels to a solid at temperatures just below human mouth temperatures. The structure of the oral patch is formed with a porous network that remains solid at human mouth temperatures and slowly dissolves in saliva. In some embodiments, the network is elasto-plastic and in some cases it is hydrophilic. The hydrophilic polymer is located within pores of the network, along with a desired medication. The oral patch is formed by mixing and hydrating the ingredients, bringing them to a hot temperature just below boiling, and cooling them to form a gel. The hot mixture may be poured into molds and the mold may also serve as packaging for delivery. The packaging may comprise a germ barrier moisture passing film which allows the oral patch to dry out or become re-hydrated without growing mold.
Description
Priority
The application requires to be filed in the U.S. Patent application 10/287 on November 5th, 2002,843 priority, the latter is to be filed in JIUYUE in 2002 4 days 10/236 in the U.S., 289 part continuation application (CIP), and requirement is filed in the priority of 28 days U.S. Patent application of calendar year 2001 December 60/344,577.
Background of invention
Since a lot of centuries, in order to treat the health problem of oral cavity or throat, people's buccal in the oral cavity comprises the compositions of medical herbs or other medicines, is used for topical application.The most ancient title of this compositions, is called " tablet " in the past from Greek from Latin language.The recent model of tablet is a cough drop, and why so name is because it is to form like this: the confection based on sugar of the viscosity of heat " is dripped " onboard or in the mould, therein its cooling formation tablet.The another kind of recent model of tablet is throat " lozenge ", and why so name is because its shape is rhombus (resembling playing card), just the meaning of word " lozenge ".The architectural feature of the tablet of these types depends on their primary structure composition, and these compositions typically are corn syrup or sugar, comprise sugar alcohol.These tablets have only medium viscosity to tooth, and gingiva, buccal or lip are not had significant viscosity.
For the higher drug level of sending than tablet in the ad-hoc location acquisition in oral cavity of drug level, developed adherent oral patch.Buccal bioadhesive tablet typically comprises one or more layers incomplete dissolved flexible layer, as by people such as Anthony invention, be disclosed in United States Patent (USP) 5,713, those of 852.Another example of buccal bioadhesive tablet is DentiPatch, and it comprises one or more layers insoluble thermoplastic layers and lignocaine, and by Noven Pharmaceuticals, Inc. offers for sale.When being used for this paper, word " patch " is not included in the oral cavity and moves and do not rest on the preparation of a position, as cough drop, throat lozenge or other tablet.It does not comprise following dosage form yet: when putting into the oral cavity, can not keep together as single body, as powder, liquid, paste, viscous liquid gel or can be broken into the tablet of powder or paste or the preparation of tablet when chewing or being placed in the saliva.
Most important difference is between the topical preparation of the mouth cavity medicine that is used for buccal bioadhesive tablet of the present invention and other form such as tablet, buccal bioadhesive tablet is designed to: (1) is in the long relatively time period, as in 30 minutes or longer time period, discharge medicine to the oral cavity, (2) has medium at least viscosity, thereby it can be placed on preferred positions, can be and come off because of gravity or slight motion, (3) remain single body in the oral cavity, can not spread to a plurality of positions in oral cavity simultaneously.
The preparation that comprises the medicine that is delivered locally to the oral cavity serves many purposes.Under many treatment situations, to compare with allowing preparation mobile in the oral cavity (as when talking), a position that allows preparation be retained in the oral cavity is useful.Authorize the United States Patent (USP) 6,139,861 of Mark Friedman and investigated the known method that slow dissolved drug is bonded at position in the oral cavity.These methods comprise the adherent soluble patches of two kinds of forms, are called " but etch tablet of mucosal adhesive " by Friedman.These tablets form with polymers carboxymethylcellulo,e, hydroxy methocel, polyacrylic acid and carbopol-934.Do not have in these polymer a kind ofly under human mouth temperatures, to be molten into liquid.
Summary of the invention
The present invention is the adherent oral patch that is included under the human mouth temperatures to the hydrophilic polymer of liquid.Buccal bioadhesive tablet is made up of two kinds of key components.
First component is the porous molecular network that is shaped to single solid structure, and it is solid-state that this network keeps under human mouth temperatures, rather than frangible, neither stick with paste.Preferred network is hydrophilic, thereby even it is when being placed on the wet mucomembranous surface in oral cavity, it also can absorb moisture and become adhesion from mucomembranous surface.Preferably, network is slowly dissolving in saliva, thereby patch is only dissipated in time, needn't shift out this patch from the oral cavity.
Second component is to be the hydrophilic polymer of liquid under human mouth temperatures.Distribution of polymer is in the institute of network is porose.Because polymer is hydrophilic, and be liquid under human mouth temperatures, it can stick on the intraoral wet surface effectively, and particularly soft, and this provides comfort for any sensitive organization such as aphtha.Preferred second component is the collagen of partial hydrolysis, and Tathagata is from the proteinic gelatin of animal.
Needn't be the at first dry saliva of coming self-organizing of user just can be bonded at buccal bioadhesive tablet on tooth, gingiva, buccal, lip or the tongue.If the patient only is placed on buccal bioadhesive tablet in the his or her oral cavity, and it was pressed 10 to 40 seconds in desired location, patch will be bonded at its position contacting and not move, even those tissues wet.With before placing adherent oral patch, need at first tissue to be dried to compare with towel, this uses convenient for the patient.If the patient thinks using buccal bioadhesive tablet in the lip or under the tongue, when talking, buccal bioadhesive tablet can be shifted out easily, do not use towel or mirror just can easily it be placed once more then.
With hydrophilic polymer, required medicine also is positioned at the hole of network.
Network component can be made up of the heat-sensitive gel that fusion temperature is higher than human mouth temperatures.Preferably, heat-sensitive gel is plastoelastic, as being dissolved in hot water by the mixture with hydrogels konjac gum and xanthan gum, cooling off then to form the elastoplasticity gel and forms.Perhaps, network can be formed by complex carbohydrate such as cellulose, pectin, maltodextrin or from the starch of Rhizoma Solani tuber osi, rice, corn or Semen Tritici aestivi.And network can be made up of hydrogel, and the fusion temperature of this hydrogel is higher than the temperature in the human mouth, is made up of aminoacid such as peptide.
In preferred embodiments, hydrophilic polymer gelling at room temperature is a solid.This permission is shifted out buccal bioadhesive tablet from the oral cavity, be placed on smooth surface such as the plastic bag.Can handle with finger because hydrophilic gel gelling afterwards, buccal bioadhesive tablet become once more, sending it back to oral cavity, and can be too not sticking so that can not handle, or on finger or plastic bag, stay residue.In such embodiment, hydrophilic polymer is the protein gel (collagen) that obtains from animal tissue, and it solidifies when just being lower than oral temperature, even still keeps solid-state under the temperature of pocket, therefore can not melt in pocket.
On the other hand, the present invention is the method for preparing adherent oral patch.In the method, composition, hydrophilic polymer molecule, drug molecule, the He Shui of formation porous network are mixed together.Before composition is added in together, perhaps after they are added in together, heating blends is with the dissolving all the components, then mixture is cooled off, thereby cause that the composition that is used to form network forms the porous network as single solid structure, comprises medicine and hydrophilic polymer in the hole of this porous network.Before heat of cooling mixture, it can be deposited in the mould with suitable shape, to form preferred single solid structure.Mould can form in powdered starch, and this is known in the confection manufacturing industry that forms gum sugar.Perhaps, mould can be formed by rigid material such as metal or plastics.If mould is thin plastics or aluminum, it also can be used as the packing that buccal bioadhesive tablet is passed to consumer.
The accompanying drawing summary
Fig. 1 a has shown the side view of softish adherent, soluble oral patch.
Fig. 1 b has shown the vertical view of same oral patch.
Fig. 2 has shown the structure of solid porous network with the representative form, and this network comprises the hole.
Detailed Description Of The Invention
Fig. 1 has shown the preferable shape of buccal bioadhesive tablet.It makes by slow dissolving hydrocolloid, and is at least one to six hours thereby it is typically kept in the oral cavity.Patch can lamellar or rhombus or oblate or other any desirable shape formation.Preferred shape is thin lenticular shaped, as shown in Figure 1a.
Fig. 2 has shown the solid porous network structure of (comprising the hole) with the representative form.In order to implement the present invention, be that it keeps solid-state under human mouth temperatures to a requirement of network, and do not melt.Thereby buccal bioadhesive tablet can slowly corrode, and network should constitute by have the material that is low to moderate moderate rate of disintegration in warm saliva.If network is etch fast enough, medicine can shed from network quickly than network etch, thereby although the part of buccal bioadhesive tablet still is retained in the oral cavity, it no longer discharges medicine.Hydrophilic polymer is full of the hole of network with water and medicine, helps to slow down medicine from the internal loss of network hole.As polymer, its molecule is very long, and they tend to be enwinded by network.In turn, polymer molecule trends towards twining drug molecule with network structure.In order to obtain more winding, drug molecule can with hydrophilic polymer molecule or network molecule or with both faintly chemistry link, as by crosslinked.
For recently understand by class by the porous network that under human mouth temperatures, is full of for the polymer of liquid how to become very sticking can disintegrate, the fishnet bag that imagination is full of by linguini alfredo (linguiniAlfredo).When linguini alfredo is cold, when for example just having taken out from refrigerator, the beans flavoring agent of suckling in vain is frozen, and total is not very sticking.Imagine that it heats in microwave oven.White milk beans sauce melts also becomes very sticking.Individually, the fishnet bag cannot not be sticking.But the hole is enough big, thereby can be expanded outside the hole by the lasagne thigh that flavoring agent covers.When warm, if total is thrown to wall, this structure may be stuck, but bag still keeps it certainly as a monoblock.The lasagne thigh is just as the long molecule that is the polymer of liquid under oral temperature.Their length makes them be difficult for coming off from the fishnet bag.
Can use many different compositionss to form network.For the ease of producing,, then be easily if network is formed by the heat-sensitive gel that fusion temperature is higher than human mouth temperatures.This allows whole mixture to be liquid under far above the temperature of human mouth temperatures, by cooling mixture, makes heat-sensitive gel form required network by gelatinization, thereby allows to form network.If the temperature that gel melts once more is higher than human body temperature, the temperature of gel formation can be lower than human mouth temperatures so.
The material of being convenient to obtain that forms this gel comprises various forms of agar, carrageenin, its most of form, particularly kappa carrageenan, Konjac glucomannan, locust bean gum and xanthan gum.The heat-sensitive gel that all these materials all can form abundant elasticity or plasticity or have two kinds of character when network during by abundant hydration, makes its soft feel in human mouth.If dry removing anhydrated from network, its meeting hardening can produce sense of discomfort when placement contacts with sensitive organization such as aphtha.In order to prevent that network from becoming dry, can with the hermetic seal device package it, perhaps add nonvolatile plasticizer such as glycerol (glycerol).But the glycerol of adding is many more, and the viscosity of buccal bioadhesive tablet is low more.
Synthetic hydrogel can be used for the liquid polymers of under oral temperature infusible network or viscosity.Usually use the protein that extracts from natural origin to prepare protein-based hydrogels, but they also can be synthesized, as using
Diblock copolypeptide amphiphiles, as by people such as Nowak at " Rapidly Recovering Hydrogel Scaffolds From Self-Assembling DiblockCopolypeptide Amphiphiles " .Nowak, A.P.; Breedveld, V.; Pakstis, L.; Ozbas, B.; Pine, D.J.; Pochan, D.; Deming, T.J.
Nature, 2002,417, the 424-428 instruction.The use of synthetic material allows to adjust the chain length and the composition of copolymer.Synthetic hydrogel also can prepare from polysaccharide and synthetic block copolymer, they form thermoreversible gel, allow the solubilising dewatering medicament and sustained release, as Williams, PA, at the Centrefor Water Soluble Polymers, North East Wales Institute, Plas Coch, MoldRoad, Wrexham, the Wales instruction.
Replacement forms network with true hydrogel, can form network with complex carbohydrate such as cellulose, pectin, starch, maltodextrin or other polysaccharide.The network structure that forms hydration from this material is known in the confection manufacturing industry of preparation chewing gum (gummy candy).Perhaps can be with the network that is combined to form of true hydrogel and complex carbohydrate.
In the adherent oral patch most important composition be under human mouth temperatures for liquid, be positioned at the hydrophilic polymer in network hole.The gelatin of tropocollagen molecule as obtaining from animal protein (as from pig or Corii Bovis seu Bubali or from fish), very good as this composition.Tropocollagen molecule trends towards very well being bonded at the tissue of the inside, oral cavity, and these tissues itself also are tropocollagen molecules.Tropocollagen molecule can be partial hydrolysis, so that they are shorter and molecular weight is lower, they are the form of commercially available gelatin.
The hydrolytic collagen of hydration helps the Wound healing of human body skin.The inventor finds that when being used for the oral cavity by buccal bioadhesive tablet, it can reduce pain, helps to cure wound and other damage in the oral cavity.In the time of will being used to reduce the short term pain of aphthous ulcer according to the buccal bioadhesive tablet test that does not contain other active component of the present invention preparation, its success rate equates with the commercially available topical therapeutic thing that does not contain anesthetics.Tests for speeding of healing of oral wounds shows very little but significant the improvement.
Commercially available gelatin is according to " bloom strength (bloom strength) " classification, and bloom strength is meant the intensity of the gel that forms.Gelatin (with long tropocollagen molecule preparation) with higher bloom strength is preferred to adherent oral patch, because it also has higher viscosity when liquid form.The high viscosity of liquid form prevents that the disengaging of gelatin molecule from network is faster than the etch of network, and high viscosity can keep medicine better with slow release.The highest commercial bloom strength 250 is preferred.
Adherent oral patch is fit to and the United States Patent (USP) 6 of authorizing Friedman, 139, all medicines of mentioning in 861 use together, and these medicines comprise steroidal such as sugared cortex steroidal and nonsteroidal anti-inflammatory agent such as naproxen sodium, ibuprofen, acetaminophen and ketoprofen.Medicine also can be that antibacterial is as being used for the treatment of the antifungal agent of candida organisms (thrush), as nystatin, clotrimazole, miconazole or fluconazol.Medicine can be used for the treatment of aphtha (aphthous ulcer), comprise pharmaceutical antibiotics such as tetracycline, penicillin or amoxicillin, or any form of other aphtha medicine such as amlexanox or Radix Glycyrrhizae extract, comprise (DGL) or the Radix Glycyrrhizae that carries out enzyme modification with glucuronidase of separating the Radix Glycyrrhizae sweet taste.
If network is formed by aforesaid hydrogel, then buccal bioadhesive tablet can be according to known method preparation in the confection manufacturing industry.This method is to be higher than activation temperature and to be lower than the mixture that forms well-hydrated under the temperature of boiling temperature of water, thus water can not vaporize, but hydrogel is fully activated and gelling when product cools off.In the method, network can form by following combination: the combination of true hydrogel such as xanthan gum and locust bean gum or Konjac glucomannan and complex carbohydrate such as cellulose or pectin or starch.For medication licorice root extract, effectively weight ratio is that 56% water, 16% gelatin, 11% Radix Glycyrrhizae extract, 10% cellulose, 4.8% glycerol and 2.2% glue such as kappa carrageenan or xanthan gum add locust bean gum or Konjac glucomannan, is heated to 130 to 200 °F.Water can increase to up to 75%, and this can increase required subsequently exsiccant amount.
Hot mixt is introduced into or sprays into mould.Mould can be the chunk that comprises flat, or closed molds.Chunk can form like this: stopper is pressed in powdered starch such as the corn starch, or forms in tray, be used to pack the laminated material of colding pressing that the PVC of product such as thermoforming or PET or aluminum and PVC and skim are used for the polyamide of intensity.Closed molds can be used for as injection molding machine.Mould can be lining with plastics, and plastics have become the part of final packaging in this case.The appropriate amount of pouring each buccal bioadhesive tablet of mould into is 0.8 gram.
If buccal bioadhesive tablet is deposited in the powdered starch, then starch can absorb some redundant moisture, buccal bioadhesive tablet before from starch, being shifted out in hothouse by further dry, packaged in the hermetic seal device, pressurize with gamma-rays or at the distillator internal heating and to sterilize.
If buccal bioadhesive tablet is deposited in the mould that forms in the tray, then tray is kept in the hothouse, lose the moisture of appropriate amount until buccal bioadhesive tablet.Appropriate method at the tray inner drying is they to be exposed 3 days without convection current or exposing 24 hours to flowing down under indoor temperature and humidity.In dry run, buccal bioadhesive tablet reduces by about 47% weight, thereby is that 0.8 buccal bioadhesive tablet that restrains has become 0.42 gram when beginning to pour mould into.In order to routine heat-sealing adherent thin film of technology or paper tinsel lid tray is sealed then, pressurize whole packaging sterilizing with gamma-rays or at the distillator internal heating.
Use for great majority, it is the extremely exsiccant of medium dry that most of user are preferred buccal bioadhesive tablet.By this initial drying, it is more tacky more complete that buccal bioadhesive tablet becomes, so they can talk or take out during feed, and then put back to.This exsiccant unique shortcoming is buccal bioadhesive tablet hardening when drying, and the comfort of buccal bioadhesive tablet is reduced.Its compliance is also relatively poor, therefore can not be bonded at well on crust such as gingiva and the tooth.When the oral cavity patch was placed in delicate tissue such as big aphtha, it was moist and softish that most of user are preferred buccal bioadhesive tablet.Therefore, the preferred film that allows moisture penetration that uses is packed buccal bioadhesive tablet, thereby does not need buccal bioadhesive tablet is taken out from packing, and moisture just can be added on the buccal bioadhesive tablet easily, or removes from buccal bioadhesive tablet.If packaging film is the barrier of pathogenic bacteria, this just allows buccal bioadhesive tablet to keep aseptic, even they are moist also grow mold not.Effectively film is cellophane, polystyrene, polybutadiene, polyamide, Tyvek (entanglement (matted) formal wire) and expanded film such as Goretex.Thickness is that the polyamide of Mill, 0.7 Mill to 1.0 is effective.When on the packaging small quantity of water droplets being arranged, allow this packing to place one to two day, this is enough to the buccal bioadhesive tablet of hydration the inside.On the contrary, allow to be packaged on the shelf in the hothouse and placed one to three day, this is enough to make buccal bioadhesive tablet to become dry.
Though described specific embodiments of the present invention above, scope of the present invention should not limited by top description, and is only limited by following claims.
Claims (45)
1. adherent oral patch of delivering drugs in time in human mouth, this patch comprises:
(a) be shaped to single solid structure, in saliva, have the porous network that is low to moderate moderate rate of disintegration, it keeps solid-state under human mouth temperatures;
(b) be positioned at the drug molecule in network hole; With
(c) under human mouth temperatures, be hydrophilic polymer molecule liquid, that be positioned at the network hole.
2. buccal bioadhesive tablet as claimed in claim 1, wherein network is hydrophilic.
3. buccal bioadhesive tablet as claimed in claim 1, wherein network is made up of the heat-sensitive gel that fusion temperature is higher than human mouth temperatures.
4. buccal bioadhesive tablet as claimed in claim 3, wherein heat-sensitive gel is plastoelastic.
5. buccal bioadhesive tablet as claimed in claim 4, wherein heat-sensitive gel is the mixture of Konjac glucomannan and xanthan gum, and it is dissolved in hot water, and cooling then is to form the elastoplasticity gel.
6. buccal bioadhesive tablet as claimed in claim 2, wherein network is made up of at least a hydrogel that is selected from Konjac glucomannan, xanthan gum, locust bean gum, agar and the carrageenin.
7. buccal bioadhesive tablet as claimed in claim 1, wherein network is made up of complex carbohydrate.
8. buccal bioadhesive tablet as claimed in claim 7, wherein network is made up of cellulose.
9. buccal bioadhesive tablet as claimed in claim 7, wherein network is made up of at least a complex carbohydrate that is selected from pectin, potato starch, rice starch, corn starch, wheaten starch or the maltodextrin.
10. buccal bioadhesive tablet as claimed in claim 1, wherein network is made up of aminoacid.
11. buccal bioadhesive tablet as claimed in claim 10, wherein aminoacid is the peptide based aquagel.
12. buccal bioadhesive tablet as claimed in claim 1, wherein hydrophilic polymer has formed the Thermoreversibly gel, and this gel at room temperature is a gel, is liquid under human mouth temperatures.
13. buccal bioadhesive tablet as claimed in claim 12, wherein hydrophilic polymer is the gelatin that obtains from animal tissue.
14. buccal bioadhesive tablet as claimed in claim 1, wherein hydrophilic polymer is made up of protein.
15. buccal bioadhesive tablet as claimed in claim 14, wherein hydrophilic polymer is a collagen.
16. buccal bioadhesive tablet as claimed in claim 1, its Chinese medicine are steroidal.
17. buccal bioadhesive tablet as claimed in claim 16, wherein steroidal is sugared cortex steroidal.
18. buccal bioadhesive tablet as claimed in claim 1, its Chinese medicine are nonsteroidal anti-inflammatory agent.
19. buccal bioadhesive tablet as claimed in claim 1, its Chinese medicine are antibiotic.
20. buccal bioadhesive tablet as claimed in claim 19, its Chinese medicine are antifungal agent.
21. buccal bioadhesive tablet as claimed in claim 1, its Chinese medicine are licorice root extract.
22. buccal bioadhesive tablet as claimed in claim 21, its Chinese medicine are the licorice root extract of enzyme modification.
23. buccal bioadhesive tablet as claimed in claim 1, the packaging material institute that is contained pathogenic bacteria barrier moisture penetration film around.
24. one kind prepares the method for sending the adherent oral patch of topical drug in human mouth in time, this method comprises:
(a) mix the mixture comprise following material: medicine, be used to form and in saliva, have the composition that is low to moderate moderate rate of disintegration and under human mouth temperatures, keeps solid-state hydrophilic porous network, under human mouth temperatures, be the hydrophilic polymer molecule of liquid, He Shui;
(b) heat this mixture; With
(c) cool off this mixture, thereby be used in the hydrophilic porous network of the composition formation of formation network, contain medicine and hydrophilic polymer in the hole of this network as single solid structure.
25. method as claimed in claim 24, wherein network forms by the gelatinization due to the cooling step.
26. method as claimed in claim 24, wherein in cooling procedure, hydrophilic polymer has formed the Thermoreversibly gel, and this gel at room temperature is a gel, is viscous liquid under human mouth temperatures.
27. method as claimed in claim 24, wherein hydrophilic polymer is made up of protein.
28. method as claimed in claim 27, wherein hydrophilic polymer is the gelatin that obtains from animal tissue.
29. method as claimed in claim 24 also comprises: between heating steps and cooling step, hot mixt is deposited in the mould, when mixture is in mould, carries out cooling step.
30. method as claimed in claim 29, wherein mould forms in powdered starch.
31. method as claimed in claim 29, wherein mould is the plastic plate of flat rigid.
32. method as claimed in claim 25, also comprise with buccal bioadhesive tablet be packaged in contain pathogenic bacteria barrier moisture penetration film around in the material.
33. the adjustable buccal bioadhesive tablet through packing of moisture comprises:
(a) packaging material that contained pathogenic bacteria barrier moisture penetration film around buccal bioadhesive tablet.
34. the buccal bioadhesive tablet through packing as claimed in claim 33, wherein film is selected from a class pathogenic bacteria barrier moisture penetration film, the expanded film that it comprises cellophane, polystyrene, polybutadiene, polyamide, Tyvek (formal wire of entanglement) and comprises Goretex.
35. the buccal bioadhesive tablet through packing as claimed in claim 33, wherein film is a polyamide.
36. send the lozenge of collagen to oral injury place for one kind, comprising:
(a) be shaped to the porous network of single solid structure;
(b) be positioned at the tropocollagen molecule in network hole.
37. lozenge as claimed in claim 36, wherein collagen is partial hydrolysis.
38. lozenge as claimed in claim 36, wherein collagen is the gelatin from animal protein.
39. lozenge as claimed in claim 36, wherein network is hydrophilic.
40. lozenge as claimed in claim 36, wherein network is made up of the heat-sensitive gel that fusion temperature is higher than human mouth temperatures.
41. lozenge as claimed in claim 36, wherein network is made up of at least a hydrogel that is selected from Konjac glucomannan, xanthan gum, locust bean gum, agar and the carrageenin.
42. lozenge as claimed in claim 36, wherein network is made up of complex carbohydrate.
43. lozenge as claimed in claim 36, wherein heat-sensitive gel is the mixture of Konjac glucomannan and xanthan gum, and it is dissolved in hot water, and cooling then is to form the elastoplasticity gel.
44. lozenge as claimed in claim 36, wherein network is made up of cellulose.
45. lozenge as claimed in claim 36, wherein network is made up of aminoacid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/287,843 US20030124178A1 (en) | 2001-12-28 | 2002-11-05 | Soft, adherent, soluble oral patch |
| US10/287,843 | 2002-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1735393A true CN1735393A (en) | 2006-02-15 |
Family
ID=34312015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200380108321 Pending CN1735393A (en) | 2002-11-05 | 2003-10-29 | Soluble oral patch with collagen and interlaced active ingredients |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1567102A2 (en) |
| JP (1) | JP2006505614A (en) |
| CN (1) | CN1735393A (en) |
| AU (1) | AU2003287313A1 (en) |
| CA (1) | CA2505126A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101138541B (en) * | 2006-09-06 | 2010-10-06 | 上海医药工业研究院 | Amlexanox partial film forming gel composition and uses thereof |
| CN105873572A (en) * | 2013-11-14 | 2016-08-17 | 首尔制药株式会社 | Orally disintegrating porous film comprising pharmacological active ingredient and method for preparing same |
| CN111688111A (en) * | 2012-06-28 | 2020-09-22 | 汉高股份有限及两合公司 | Method for manufacturing composite insert |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070243238A1 (en) * | 2006-04-13 | 2007-10-18 | Haley Jeffrey T | Treating mouth sores with patches adhered to teeth |
| US10603252B2 (en) | 2015-09-09 | 2020-03-31 | Lg Household & Health Care Ltd. | Tooth-attachable patch capable of being removed by tooth brushing |
| JP7039461B2 (en) | 2015-10-06 | 2022-03-22 | エルジー ハウスホールド アンド ヘルスケア リミテッド | Toothpaste patch that can be removed by brushing |
-
2003
- 2003-10-29 EP EP03781546A patent/EP1567102A2/en not_active Withdrawn
- 2003-10-29 AU AU2003287313A patent/AU2003287313A1/en not_active Abandoned
- 2003-10-29 CN CN 200380108321 patent/CN1735393A/en active Pending
- 2003-10-29 JP JP2004551629A patent/JP2006505614A/en not_active Withdrawn
- 2003-10-29 CA CA002505126A patent/CA2505126A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101138541B (en) * | 2006-09-06 | 2010-10-06 | 上海医药工业研究院 | Amlexanox partial film forming gel composition and uses thereof |
| CN111688111A (en) * | 2012-06-28 | 2020-09-22 | 汉高股份有限及两合公司 | Method for manufacturing composite insert |
| CN105873572A (en) * | 2013-11-14 | 2016-08-17 | 首尔制药株式会社 | Orally disintegrating porous film comprising pharmacological active ingredient and method for preparing same |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2505126A1 (en) | 2004-05-27 |
| EP1567102A2 (en) | 2005-08-31 |
| AU2003287313A1 (en) | 2004-06-03 |
| JP2006505614A (en) | 2006-02-16 |
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