CN105832698A - Method for preparing hollow capsule shells by using ocentyl succinic anhydride taro starch ester - Google Patents
Method for preparing hollow capsule shells by using ocentyl succinic anhydride taro starch ester Download PDFInfo
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- CN105832698A CN105832698A CN201610242685.XA CN201610242685A CN105832698A CN 105832698 A CN105832698 A CN 105832698A CN 201610242685 A CN201610242685 A CN 201610242685A CN 105832698 A CN105832698 A CN 105832698A
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- taros
- ocentyl succinic
- capsule
- mass fraction
- starch ester
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Abstract
The invention discloses a method for preparing hollow capsule shells by using ocentyl succinic anhydride taro starch ester, and belongs to the field of capsule shells. According to the method, the ocentyl succinic anhydride taro starch ester is prepared from taro starch and ocentyl succinic anhydride under an alkaline condition, and is mixed with a plasticizer and lubricating oil, and the mixture is subjected to extrusion granulation and capsule forming to obtain capsule shells. According to the method disclosed by the invention, the ocentyl succinic anhydride taro starch ester is used as a matrix material for preparing hollow capsule shells, and is biodegradable, and the prepared capsule shells have good protectiveness for drugs, cannot be adhered to esophagus easily, are good in uniformity and high in strength, and can reduce the probability of the appearance of holes and breakage, so that the hollow capsule shells can be widely applied to the industries of medicines, health products and foods.
Description
Technical field
The invention discloses a kind of method utilizing ocentyl succinic taros'starch ester to prepare Capsules shell, belong to capsule shells field.
Background technology
Medicinal hollow capsule prepared by the gelatin utilizing the collagen protein in the skin of animal, osseous tissue to obtain after hydrolysis, there is long history, owing to the ingredient of Capsules parcel can avoid the medicine sensory stimulation to human body itself, and reaching medicine slow release effect in vivo, the Capsules with gelatin as raw material is widely used at medicine, field of food for a long time.As medicine and the main encapsulating material of health product, its defect is also recognized by everybody.Protein such as self is easily affected by acid, alkali, limits the use of some drugs.Gelatin molecule is contained within more active group, it is easy to react with the medicine contacted, thus changes the character of medicine.Have again environment is dried, the moist and sensitivity of variations in temperature, have impact on quality and the use of capsule.
Starch based capsule product is a kind of novel non-gelatin class capsule, has a safety non-toxic, cheap and easy to get, the advantage such as biodegradable.The production method of tradition snap fit capsule is to be added in machine gelatin dipping tray by the glue of certain viscosity and temperature, after the mould of oiling dips in glue, transfers the operations such as air channel drying, the demoulding, otch, fit and makes.But, art methods utilizes the capsule lack of homogeneity that multiple starch material is manufactured experimently, and there is the shortcoming that fragility is big, intensity is little all the time.
Summary of the invention
nullThe technical problem that present invention mainly solves: there are some performances with gelatin for Capsules prepared by raw material for tradition，To wet and oxygen sensitive medicaments protective effect is poor、Easily in esophagus adhesion、The phenomenon such as prolonged disintegration and drug dissolution reduction is had in storage，But capsule lack of homogeneity prepared by starch material，And it is big to there is fragility all the time、The problem of the shortcoming that intensity is little，Provide a kind of method utilizing ocentyl succinic taros'starch ester to prepare Capsules shell，The present invention uses taros'starch and octenyl succinic acid anhydride to be prepared into ocentyl succinic taros'starch ester in the basic conditions，By itself and plasticizer、Lubricating oil mixes，By mixture extruding pelletization、Capsule shaping must be by softgel shell，The present invention utilizes ocentyl succinic taros'starch ester as the host material preparing Capsules，The most biodegradable，And the capsule shells that is prepared into is good to medicament protection，It is difficult in esophagus adhesion，Uniformity is good，Intensity is big，Reduce and hole and broken probability occur，Can be widely used for medicine、Health product and food service industry.
In order to solve above-mentioned technical problem, the technical solution adopted in the present invention is:
(1) 200～400g taros'starchs are weighed, it is added thereto to 50～100mL deionized waters, stirring mixes to obtain taros'starch slurry, it is 5.5～6.0 with mass fraction 5% sodium hydroxide solution regulation taros'starch slurry pH, move it into after regulation in water-bath, arranging temperature is 60～80 DEG C, in taros'starch, 30～50mL mass fraction 15% anhydride ethanol solution it are slowly added dropwise at a temperature of keeping this, control to be added dropwise to complete in 10～15min, dropping limit, limit is stirred, continuing stirring reaction 50～60min after dripping off, reaction is cooled to room temperature after terminating；
(2) drip mass fraction 5% citric acid solution in above-mentioned reactant regulating its pH is 7.0, after regulation, product is mixed with mass fraction 80% ethanol solution by solid-to-liquid ratio 1:3, after stirring mixing, sucking filtration obtains filtering residue, filtering residue is cleaned 2～3 times with mass fraction 60% ethanol and deionized water respectively, filtrate after cleaning is put in baking oven, being dried 5～6h at 60～80 DEG C, crushed after being dried, sieve to obtain 80～100 mesh powder, ocentyl succinic taros'starch ester powder；
(3) in parts by weight, choose 25～35 parts of deionized waters respectively, 60～70 parts of above-mentioned ocentyl succinic taros'starch ester powder, 4～6 parts of ethylene glycol and 1～3 part of edible fat acid glyceride, first ocentyl succinic taros'starch ester powder and deionized water are mixed, at 50～70 DEG C, stir gelatinizing 1～2h, in gelatinizing thing, add ethylene glycol, keep continuing at a temperature of this stirring 1～2h, filter after stirring filtering residue put into baking oven is dried to water content be 35～40%；
(4) above-mentioned dried filtering residue employing double screw rod extruder is carried out extruding pelletization, extruder rotating speed is 120～250r/min, and head temperature is 110～120 DEG C, puts in mould after pelletize, use automatic Capsules manufacture machine be shaped, Capsules shell.
The application process of the present invention: first the present invention is prepared the capsule cap of capsule shells, capsule status is opened, capsule body inserts in capsule board hole, regulation levels distance, make capsule mouth equal with plate face, drug particles is laid on plate face, vibrate capsule board gently, drug particles is made to fill uniformly, after filling up capsule, plate face excess particles is cleared away, jack-up capsule body, fit capsule cap, take out capsule, obtain, the capsules weight that the present invention prepares is 24.0～26.0mg, wherein filler particles weight is 21.0～22.5mg, capsule shells weight 3.0～3.5mg, capsule crushing strength 8～12N, can easily crush and with loud and clear with finger, and the most still enbrittle.
The invention has the beneficial effects as follows:
(1) present invention utilize ocentyl succinic taros'starch ester as preparing the host material of Capsules, the most biodegradable, and good to the protectiveness of medicine after using, be difficult in esophagus adhesion；
(2) the capsule shells uniformity that the present invention prepares is good, and intensity is big, reduces and hole and broken probability occurs, can be widely used for medicine, health product and food service industry；
(3) present invention prepares capsule softgel shell uniform wall thickness unanimously, dimensionally stable, and preparation technology is simple and convenient to operate, preparation condition temperature.
Detailed description of the invention
First 200～400g taros'starchs are weighed, it is added thereto to 50～100mL deionized waters, stirring mixes to obtain taros'starch slurry, it is 5.5～6.0 with mass fraction 5% sodium hydroxide solution regulation taros'starch slurry pH, move it into after regulation in water-bath, arranging temperature is 60～80 DEG C, in taros'starch, 30～50mL mass fraction 15% anhydride ethanol solution it are slowly added dropwise at a temperature of keeping this, control to be added dropwise to complete in 10～15min, dropping limit, limit is stirred, continuing stirring reaction 50～60min after dripping off, reaction is cooled to room temperature after terminating；Dripping mass fraction 5% citric acid solution in above-mentioned reactant and regulating its pH is 7.0, after regulation, product is mixed with mass fraction 80% ethanol solution by solid-to-liquid ratio 1:3, after stirring mixing, sucking filtration obtains filtering residue, filtering residue is cleaned 2～3 times with mass fraction 60% ethanol and deionized water respectively, filtrate after cleaning is put in baking oven, being dried 5～6h at 60～80 DEG C, crushed after being dried, sieve to obtain 80～100 mesh powder, ocentyl succinic taros'starch ester powder；In parts by weight, choose 25～35 parts of deionized waters respectively, 60～70 parts of above-mentioned ocentyl succinic taros'starch ester powder, 4～6 parts of ethylene glycol and 1～3 part of edible fat acid glyceride, first ocentyl succinic taros'starch ester powder and deionized water are mixed, at 50～70 DEG C, stir gelatinizing 1～2h, in gelatinizing thing, add ethylene glycol, keep continuing at a temperature of this stirring 1～2h, filter after stirring filtering residue put into baking oven is dried to water content be 35～40%；Above-mentioned dried filtering residue employing double screw rod extruder is carried out extruding pelletization, extruder rotating speed is 120～250r/min, and head temperature is 110～120 DEG C, puts in mould after pelletize, use automatic Capsules manufacture machine be shaped, Capsules shell.
Example 1
First 200g taros'starch is weighed, it is added thereto to 50mL deionized water, stirring mixes to obtain taros'starch slurry, is 5.5 with mass fraction 5% sodium hydroxide solution regulation taros'starch slurry pH, moves it in water-bath after regulation, arranging temperature is 60 DEG C, being slowly added dropwise 30mL mass fraction 15% anhydride ethanol solution at a temperature of keeping this wherein, control to be added dropwise to complete in 10min, dropping limit, limit is stirred, continuing stirring reaction 50min after dripping off, reaction is cooled to room temperature after terminating；Dripping mass fraction 5% citric acid solution in above-mentioned reactant and regulating its pH is 7.0, after regulation, product is added in mass fraction 80% ethanol solution by solid-to-liquid ratio 1:3, after stirring mixing, sucking filtration obtains filtering residue, filtering residue is cleaned 2 times with mass fraction 60% ethanol and deionized water respectively, filtrate after cleaning is put in baking oven, being dried 5h at 60 DEG C, crushed after being dried, sieve to obtain 80 mesh powder, ocentyl succinic taros'starch ester powder；In parts by weight, choose 25 parts of deionized waters respectively, 60 parts of above-mentioned ocentyl succinic taros'starch ester powder, 4 parts of ethylene glycol and 1 part of edible fat acid glyceride, first mix ocentyl succinic taros'starch ester powder and deionized water, stirs gelatinizing 1h at 50 DEG C, ethylene glycol is added in gelatinizing thing, keep continuing stirring 1h at a temperature of this, filter after stirring, obtain filtering residue put into baking oven is dried to water content be 35%；Above-mentioned dried filtering residue employing double screw rod extruder is carried out extruding pelletization, and extruder rotating speed is 20r/min, and head temperature is 110 DEG C, puts in mould after pelletize, uses automatic Capsules to manufacture machine and is shaped, Capsules shell.
First the present invention is prepared the capsule cap of capsule shells, capsule status is opened, capsule body inserts in capsule board hole, regulation levels distance, make capsule mouth equal with plate face, drug particles is laid on plate face, vibrate capsule board gently, drug particles is made to fill uniformly, after filling up capsule, plate face excess particles is cleared away, jack-up capsule body, fit capsule cap, take out capsule, obtain, the capsules weight that the present invention prepares is 24.0mg, wherein filler particles weight is 21.0mg, capsule shells weight 3.0mg, capsule crushing strength 8N, can easily crush and with loud and clear with finger, and the most still enbrittle.
Example 2
First 300g taros'starch is weighed, it is added thereto to 75mL deionized water, stirring mixes to obtain taros'starch slurry, is 5.7 with mass fraction 5% sodium hydroxide solution regulation taros'starch slurry pH, moves it in water-bath after regulation, arranging temperature is 70 DEG C, being slowly added dropwise 40mL mass fraction 15% anhydride ethanol solution at a temperature of keeping this wherein, control to be added dropwise to complete in 13min, dropping limit, limit is stirred, continuing stirring reaction 55in after dripping off, reaction is cooled to room temperature after terminating；Dripping mass fraction 5% citric acid solution in above-mentioned reactant and regulating its pH is 7.0, after regulation, product is added in mass fraction 80% ethanol solution by solid-to-liquid ratio 1:3, after stirring mixing, sucking filtration obtains filtering residue, filtering residue is cleaned 2 times with mass fraction 60% ethanol and deionized water respectively, filtrate after cleaning is put in baking oven, being dried 5.5h at 70 DEG C, crushed after being dried, sieve to obtain 90 mesh powder, ocentyl succinic taros'starch ester powder；In parts by weight, choose 30 parts of deionized waters respectively, 65 parts of above-mentioned ocentyl succinic taros'starch ester powder, 5 parts of ethylene glycol and 2 parts of edible fat acid glycerides, first mix ocentyl succinic taros'starch ester powder and deionized water, stirs gelatinizing 1.5h at 60 DEG C, ethylene glycol is added in gelatinizing thing, keep continuing stirring 1.5h at a temperature of this, filter after stirring, obtain filtering residue put into baking oven is dried to water content be 38%；Above-mentioned dried filtering residue employing double screw rod extruder is carried out extruding pelletization, and extruder rotating speed is 25r/min, and head temperature is 115 DEG C, puts in mould after pelletize, uses automatic Capsules to manufacture machine and is shaped, Capsules shell.
First the present invention is prepared the capsule cap of capsule shells, capsule status is opened, capsule body inserts in capsule board hole, regulation levels distance, make capsule mouth equal with plate face, drug particles is laid on plate face, vibrate capsule board gently, drug particles is made to fill uniformly, after filling up capsule, plate face excess particles is cleared away, jack-up capsule body, fit capsule cap, take out capsule, obtain, the capsules weight that the present invention prepares is 25.0mg, wherein filler particles weight is 21.7mg, capsule shells weight 3.3mg, capsule crushing strength 10N, can easily crush and with loud and clear with finger, and the most still enbrittle.
Example 3
First 400g taros'starch is weighed, it is added thereto to 100mL deionized water, stirring mixes to obtain taros'starch slurry, is 6.0 with mass fraction 5% sodium hydroxide solution regulation taros'starch slurry pH, moves it in water-bath after regulation, arranging temperature is 80 DEG C, being slowly added dropwise 50mL mass fraction 15% anhydride ethanol solution at a temperature of keeping this wherein, control to be added dropwise to complete in 15min, dropping limit, limit is stirred, continuing stirring reaction 60min after dripping off, reaction is cooled to room temperature after terminating；Dripping mass fraction 5% citric acid solution in above-mentioned reactant and regulating its pH is 7.0, after regulation, product is added in mass fraction 80% ethanol solution by solid-to-liquid ratio 1:3, after stirring mixing, sucking filtration obtains filtering residue, filtering residue is cleaned 3 times with mass fraction 60% ethanol and deionized water respectively, filtrate after cleaning is put in baking oven, being dried 6h at 80 DEG C, crushed after being dried, sieve to obtain 100 mesh powder, ocentyl succinic taros'starch ester powder；In parts by weight, choose 35 parts of deionized waters respectively, 70 parts of above-mentioned ocentyl succinic taros'starch ester powder, 6 parts of ethylene glycol and 3 parts of edible fat acid glycerides, first mix ocentyl succinic taros'starch ester powder and deionized water, stirs gelatinizing 2h at 70 DEG C, ethylene glycol is added in gelatinizing thing, keep continuing stirring 2h at a temperature of this, filter after stirring, obtain filtering residue put into baking oven is dried to water content be 40%；Above-mentioned dried filtering residue employing double screw rod extruder is carried out extruding pelletization, and extruder rotating speed is 30r/min, and head temperature is 120 DEG C, puts in mould after pelletize, uses automatic Capsules to manufacture machine and is shaped, Capsules shell.
First the present invention is prepared the capsule cap of capsule shells, capsule status is opened, capsule body inserts in capsule board hole, regulation levels distance, make capsule mouth equal with plate face, drug particles is laid on plate face, vibrate capsule board gently, drug particles is made to fill uniformly, after filling up capsule, plate face excess particles is cleared away, jack-up capsule body, fit capsule cap, take out capsule, obtain, the capsules weight that the present invention prepares is 26.0mg, wherein filler particles weight is 22.5mg, capsule shells weight 3.5mg, capsule crushing strength 12N, can easily crush and with loud and clear with finger, and the most still enbrittle.
Claims (1)
1. one kind utilizes the method that ocentyl succinic taros'starch ester prepares Capsules shell, it is characterised in that concrete preparation process is:
(1) 200～400g taros'starchs are weighed, it is added thereto to 50～100mL deionized waters, stirring mixes to obtain taros'starch slurry, it is 5.5～6.0 with mass fraction 5% sodium hydroxide solution regulation taros'starch slurry pH, move it into after regulation in water-bath, arranging temperature is 60～80 DEG C, in taros'starch, 30～50mL mass fraction 15% anhydride ethanol solution it are slowly added dropwise at a temperature of keeping this, control to be added dropwise to complete in 10～15min, dropping limit, limit is stirred, continuing stirring reaction 50～60min after dripping off, reaction is cooled to room temperature after terminating；
(2) drip mass fraction 5% citric acid solution in above-mentioned reactant regulating its pH is 7.0, after regulation, product is mixed with mass fraction 80% ethanol solution by solid-to-liquid ratio 1:3, after stirring mixing, sucking filtration obtains filtering residue, filtering residue is cleaned 2～3 times with mass fraction 60% ethanol and deionized water respectively, filtrate after cleaning is put in baking oven, being dried 5～6h at 60～80 DEG C, crushed after being dried, sieve to obtain 80～100 mesh powder, ocentyl succinic taros'starch ester powder；
(3) in parts by weight, choose 25～35 parts of deionized waters respectively, 60～70 parts of above-mentioned ocentyl succinic taros'starch ester powder, 4～6 parts of ethylene glycol and 1～3 part of edible fat acid glyceride, first ocentyl succinic taros'starch ester powder and deionized water are mixed, at 50～70 DEG C, stir gelatinizing 1～2h, in gelatinizing thing, add ethylene glycol, keep continuing at a temperature of this stirring 1～2h, filter after stirring filtering residue put into baking oven is dried to water content be 35～40%；
(4) above-mentioned dried filtering residue employing double screw rod extruder is carried out extruding pelletization, extruder rotating speed is 120～250r/min, and head temperature is 110～120 DEG C, puts in mould after pelletize, use automatic Capsules manufacture machine be shaped, Capsules shell.
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| CN201610242685.XA CN105832698A (en) | 2016-04-19 | 2016-04-19 | Method for preparing hollow capsule shells by using ocentyl succinic anhydride taro starch ester |
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| CN201610242685.XA CN105832698A (en) | 2016-04-19 | 2016-04-19 | Method for preparing hollow capsule shells by using ocentyl succinic anhydride taro starch ester |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716489A (en) * | 2012-05-31 | 2012-10-10 | 浙江中同科技有限公司 | Modified starch composition plant capsule and preparation method thereof |
| CN103044557A (en) * | 2013-01-04 | 2013-04-17 | 钦州学院 | Preparation method of octenyl succinic acid modified starch ester |
| CN103242457A (en) * | 2013-05-02 | 2013-08-14 | 宁波大学 | Method for extracting taro starch and application of taro starch |
| CN103315976A (en) * | 2013-06-13 | 2013-09-25 | 华南理工大学 | Preparation method for starch hard capsule shells |
-
2016
- 2016-04-19 CN CN201610242685.XA patent/CN105832698A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716489A (en) * | 2012-05-31 | 2012-10-10 | 浙江中同科技有限公司 | Modified starch composition plant capsule and preparation method thereof |
| CN103044557A (en) * | 2013-01-04 | 2013-04-17 | 钦州学院 | Preparation method of octenyl succinic acid modified starch ester |
| CN103242457A (en) * | 2013-05-02 | 2013-08-14 | 宁波大学 | Method for extracting taro starch and application of taro starch |
| CN103315976A (en) * | 2013-06-13 | 2013-09-25 | 华南理工大学 | Preparation method for starch hard capsule shells |
Non-Patent Citations (5)
| Title |
|---|
| 吴克刚 等编著: "《食品微胶囊技术》", 31 July 2006 * |
| 张燕萍 主编: "《变性淀粉制造与应用》", 31 July 2007 * |
| 曹余 等: "淀粉基植物胶囊研究现状与发展前景", 《淀粉基植物胶囊研究现状与发展前景》 * |
| 许凤 等: "辛烯基琥珀酸芋艿淀粉酯制备及性质研究", 《中国食品学报》 * |
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