CN105232493A - Gelatin/hydroxypropyl starch blended hard capsule as well as preparation method thereof - Google Patents
Gelatin/hydroxypropyl starch blended hard capsule as well as preparation method thereof Download PDFInfo
- Publication number
- CN105232493A CN105232493A CN201510727101.3A CN201510727101A CN105232493A CN 105232493 A CN105232493 A CN 105232493A CN 201510727101 A CN201510727101 A CN 201510727101A CN 105232493 A CN105232493 A CN 105232493A
- Authority
- CN
- China
- Prior art keywords
- gelatin
- starch
- hard capsule
- hydroxypropyl starch
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of a gelatin/hydroxypropyl starch blended hard capsule. The preparation method comprises the following steps: (1) weighing the raw materials in percentage by weight: 8.7-14.5% of gelatin, 0.5-6.3% of hydroxypropyl starch, 0.8-4.5% of a plasticizer, 0.5-1.5% of a gel, and the balance of water; and (2) mixing the raw materials weighed in the step (1), and preparing the gelatin/hydroxypropyl starch blended hard capsule according to a conventional capsule preparation technology. The preparation method of the gelatin/hydroxypropyl starch blended hard capsule has low energy consumption and high production efficiency, and the prepared gelatin/hydroxypropyl starch blended hard capsule is low in price, wide in application range, and high in stability.
Description
Technical field
The present invention relates to the preparation field of capsule, particularly blended hard capsule of a kind of gelatin/hydroxypropyl starch and preparation method thereof.
Background technology
Hard capsule means makes uniform powder or granule by a certain amount of medicine and suitable adjuvant, loads and makes in empty hard capsule.In modern Chinese medicine preparation is produced, hard capsule because technical process is relatively simple, taking convenience, rapid-action, can effectively isolate the advantages such as the bad smell of medicine, be widely used in recent years.
Capsule product is main mainly with gelatin in the market, and its processing technique does not change over more than 100 year substantially.Gelatin is obtained through being hydrolyzed by the bone of animal, skin, belongs to protein matter, has good bio-compatibility and physicochemical property, be widely used in field of medicaments.Gelatine capsule production technology is simple, but working condition is harsh, and require strict to the temperature and humidity of Workplace, Product processing energy consumption is large, and gelatine starting material is expensive simultaneously, causes product price higher.In addition; also there are some performance issues in gelatine capsule product; as to wet and the protective effect of oxygen sensitive medicaments is poor, easily in esophagus adhesion, be easy to be cross-linked with medicines such as containing aldehyde, reducing sugar base class compound and vitamin C, cause the phenomenons such as the delay of capsule shells disintegrate and capsule 's content stripping.Therefore, many scientific research institutions and enterprise all start active development Novel capsule material.
Existing a lot of scientific research institution reports the research of plant capsule and patent in the world, but rarely plant capsule successful commercialization.The input of the production equipment that its main cause is new and the processing conditions of complexity cause the price of new product higher.Therefore, utilize existing equipment to develop the blended capsule of cheap gelatin-based and there is obvious science and commercial significance.Starch is renewable plant resources macromolecule, is that a kind of cost is lower and have the raw material of good filming, can be used as a kind of blend components and apply in gelatin product, reduce production cost.
Summary of the invention
In order to overcome the above-mentioned shortcoming of prior art with not enough, the object of the present invention is to provide the preparation method of the blended hard capsule of a kind of gelatin/hydroxypropyl starch, low energy consumption, high efficiency, the blended hard capsule of gelatin/hydroxypropyl starch prepared is cheap, widely applicable, stability is high.
Another object of the present invention is to the blended hard capsule of gelatin/hydroxypropyl starch providing the preparation method of the blended hard capsule of above-mentioned gelatin/hydroxypropyl starch to prepare, effectively alleviate while greatly can reducing production cost and eliminate the performance issue existed in current gelatine capsule product.
Object of the present invention is achieved through the following technical solutions:
A preparation method for the blended hard capsule of gelatin/hydroxypropyl starch, comprises the following steps:
(1) by following percentage by weight raw materials weighing:
(2) step (1) is weighed the raw material mixing obtained, adopt the conventional technique preparing capsule to prepare the blended hard capsule of gelatin/hydroxypropyl starch.
Step (1) described plasticizer is more than one in glycerol, Polyethylene Glycol, sorbitol, propylene glycol, fatty acid or fatty acid ester.
Step (1) described gel is more than one in carrageenan, gellan gum, pectin, agar, natural gum, arabic gum, Konjac glucomannan or xanthan gum.
Step (1) described hydroxypropyl starch, its starch source is more than one in tapioca, wheaten starch, potato starch, sweet potato starch, corn starch, bean starch, rice starch.
Step (1) described hydroxypropyl starch, its starch source prioritizing selection high amylose starches.
Step (1) described gelatin is 20 DEG C time, and concentration is the viscosity that the aqueous solution of the gelatin of 2wt% has 0.3-2mpa.s.
The blended hard capsule of gelatin/hydroxypropyl starch, is prepared by the preparation method of the described blended hard capsule of gelatin/hydroxypropyl starch.
Compared with prior art, the present invention has the following advantages and beneficial effect:
(1) the present invention by adding appropriate hydroxypropyl starch in gelatin substrate, utilize its reactionlessness under low moisture condition and hydrophilic, reduce and delay the impact of the internal bag thing of moisture and stop the generation of chemical reaction between capsule material and content, thus improving the stability of the blended hard capsule of gelatin/hydroxypropyl starch.Because starch is renewable plant resources macromolecule, wide material sources and cheap, after modifying and decorating process, there is good film property and physical and chemical stability, effectively alleviate while greatly can reducing production cost and eliminate the performance issue existed in current gelatine capsule product.
(2) the blended hard capsule of gelatin/hydroxypropyl starch of the present invention, due to the existence of hydroxypropyl starch, makes the viscosity of blending ingredients increase, is easy to molding, product stability, reduce the sensitivity of process of manufacture Raw to production environment.
(3) preparation method of the blended hard capsule of gelatin/hydroxypropyl starch of the present invention, utilizes existing instrument and equipment, prepares the blended hard capsule of gelatin-based of a kind of low cost, low energy consumption, high efficiency.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited thereto.
Embodiment 1
By (20 DEG C, the gelatin of 10wt%, the solution viscosity of 2wt% is 1mpa.s), the hydroxypropyl corn starch of 5wt% (20 DEG C, the solution viscosity of 15wt% is 20000mpa.s), the glycerol of 2wt%, the carrageenan of 0.8wt% and the water mixing of surplus, obtain the compositions for the preparation of the blended hard capsule of gelatin/hydroxypropyl starch.
Utilize the compositions that above-mentioned steps obtains, adopt and traditional dip in adhesive process, add in machine gelatin dipping tray by dissolving the glue reaching certain viscosity and temperature, after the mould of oiling dips in glue, the operations such as air channel oven dry, the demoulding, otch, fit of passing on prepare the blended hard capsule of gelatin/hydroxypropyl starch.The blended hard capsule of gelatin/hydroxypropyl starch of gained is transparent, free from extraneous odour.Through thermal analyses test, moisture is lower than 15%; Under stirring at a slow speed, the time be dissolved in pH value 7 water is less than 15 minutes.
Embodiment 2
By 12wt% gelatin (20 DEG C, the solution viscosity of 2wt% is 1mpa.s), the hydroxypropyl potato starch (20 DEG C, the solution viscosity of 15wt% is 15000mpa.s) of 3wt%, the Polyethylene Glycol of 2wt%; The arabic gum of 2wt% and the water mixing of surplus, obtain the compositions for the preparation of the blended hard capsule of gelatin/hydroxypropyl starch.
Utilize the compositions that above-mentioned steps obtains, adopt and traditional dip in adhesive process, add in machine gelatin dipping tray by dissolving the glue reaching certain viscosity and temperature, after the mould of oiling dips in glue, pass on operations such as air channel oven dry, the demoulding, otch, fit-prepare the blended hard capsule of gelatin/hydroxypropyl starch.The blended hard capsule of gelatin/hydroxypropyl starch of gained is transparent, free from extraneous odour.Through thermal analyses test, moisture is lower than 15%; Under stirring at a slow speed, the time be dissolved in pH value 7 water is less than 15 minutes.
Embodiment 3
By (20 DEG C, 13wt% gelatin, the solution viscosity of 2wt% is 1mpa.s), (weight ratio of hydroxypropyl corn starch and hydroxypropyl potato starch is 1:1 for the hydroxypropyl corn starch of 2wt% and hydroxypropyl potato starch, 20 DEG C, the solution viscosity of 15wt% is 20000mpa.s, 20 DEG C, the solution viscosity of 15wt% is 15000mpa.s), the Polyethylene Glycol of 1.5wt% and glycerol (weight ratio is 1:1), the water mixing of the pectin of 2wt% and xanthan gum (weight ratio is 1:1) and surplus, obtain the compositions for the preparation of the blended hard capsule of gelatin/hydroxypropyl starch.
Utilize the compositions that above-mentioned steps obtains, adopt and traditional dip in adhesive process, add in machine gelatin dipping tray by dissolving the glue reaching certain viscosity and temperature, after the mould of oiling dips in glue, the operations such as air channel oven dry, the demoulding, otch, fit of passing on prepare the blended hard capsule of gelatin/hydroxypropyl starch.The blended hard capsule of gelatin/hydroxypropyl starch of gained is transparent, free from extraneous odour.Through thermal analyses test, moisture is lower than 15%; Under stirring at a slow speed, the time be dissolved in pH value 7 water is less than 15 minutes.
Above-described embodiment is the present invention's preferably embodiment, but embodiments of the present invention are not limited by the examples, as plasticizer also can be more than one in glycerol, Polyethylene Glycol, sorbitol, propylene glycol, fatty acid or fatty acid ester; Gel also can be in carrageenan, gellan gum, pectin, agar, natural gum, arabic gum, Konjac glucomannan or xanthan gum more than one; Hydroxypropyl starch, its starch source can be in tapioca, wheaten starch, potato starch, sweet potato starch, corn starch, bean starch, rice starch more than one, preferred high amylose starches; Change, the modification done under other any does not deviate from spirit of the present invention and principle, substitute, combine, simplify, all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (7)
1. a preparation method for the blended hard capsule of gelatin/hydroxypropyl starch, is characterized in that, comprise the following steps:
(1) by following percentage by weight raw materials weighing:
(2) step (1) is weighed the raw material mixing obtained, adopt the technique preparing capsule to prepare the blended hard capsule of gelatin/hydroxypropyl starch.
2. the preparation method of the blended hard capsule of gelatin/hydroxypropyl starch according to claim 1, is characterized in that, step (1) described plasticizer is more than one in glycerol, Polyethylene Glycol, sorbitol, propylene glycol, fatty acid or fatty acid ester.
3. the preparation method of the blended hard capsule of gelatin/hydroxypropyl starch according to claim 1, it is characterized in that, step (1) described gel is more than one in carrageenan, gellan gum, pectin, agar, natural gum, arabic gum, Konjac glucomannan or xanthan gum.
4. the preparation method of the blended hard capsule of gelatin/hydroxypropyl starch according to claim 1, it is characterized in that, step (1) described hydroxypropyl starch, its starch source is more than one in tapioca, wheaten starch, potato starch, sweet potato starch, corn starch, bean starch, rice starch.
5. the preparation method of the blended hard capsule of gelatin/hydroxypropyl starch according to claim 1, is characterized in that, step (1) described hydroxypropyl starch, and its starch source is high amylose starches.
6. the preparation method of the blended hard capsule of gelatin/hydroxypropyl starch according to claim 1, is characterized in that, step (1) described gelatin is 20 DEG C time, and concentration is the viscosity that the aqueous solution of the gelatin of 2wt% has 0.3-2mpa.s.
7. the blended hard capsule of gelatin/hydroxypropyl starch, is characterized in that, is prepared by the preparation method of the blended hard capsule of gelatin/hydroxypropyl starch described in any one of claim 1 ~ 6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510727101.3A CN105232493A (en) | 2015-10-29 | 2015-10-29 | Gelatin/hydroxypropyl starch blended hard capsule as well as preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510727101.3A CN105232493A (en) | 2015-10-29 | 2015-10-29 | Gelatin/hydroxypropyl starch blended hard capsule as well as preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105232493A true CN105232493A (en) | 2016-01-13 |
Family
ID=55030496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510727101.3A Pending CN105232493A (en) | 2015-10-29 | 2015-10-29 | Gelatin/hydroxypropyl starch blended hard capsule as well as preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105232493A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006004418A2 (en) * | 2004-07-05 | 2006-01-12 | Laabakk Erik | Encapsulated tobacco smoke |
| CN101245157A (en) * | 2007-02-17 | 2008-08-20 | 长春大成特用玉米变性淀粉开发有限公司 | Film-forming agent composition and starchiness vegetable adhesive containing the composition |
| CN103315976A (en) * | 2013-06-13 | 2013-09-25 | 华南理工大学 | Preparation method for starch hard capsule shells |
-
2015
- 2015-10-29 CN CN201510727101.3A patent/CN105232493A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006004418A2 (en) * | 2004-07-05 | 2006-01-12 | Laabakk Erik | Encapsulated tobacco smoke |
| CN101245157A (en) * | 2007-02-17 | 2008-08-20 | 长春大成特用玉米变性淀粉开发有限公司 | Film-forming agent composition and starchiness vegetable adhesive containing the composition |
| CN103315976A (en) * | 2013-06-13 | 2013-09-25 | 华南理工大学 | Preparation method for starch hard capsule shells |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101406704B (en) | Novel plant capsule film material and method for producing the same | |
| CN103830736B (en) | Production method of starch empty capsule | |
| CN104721170B (en) | A kind of epoxy glue masticatory pattern soft capsule and preparation method thereof | |
| EP2223685A1 (en) | Non-gelatin enteric hard capsule shell and preparation method thereof | |
| CN108498478B (en) | Preparation method of starch-based hard capsules | |
| CN111454490B (en) | Composition for preparing edible plant plasma membrane and application thereof | |
| CN105395513B (en) | A kind of method that modified starch prepares hard shell capsules | |
| CN104721167A (en) | Starch soft capsules | |
| CN104800186B (en) | A kind of starch hollow capsule and its preparation technology | |
| CN104840447A (en) | Preparation method of pulullan vacant capsules | |
| CN105456226A (en) | Hydroxypropyl methyl cellulose/hydroxypropyl starch plant empty capsule and preparation method | |
| CN111040256A (en) | Raw material composition for preparing starch matrix hollow capsule and starch matrix hollow capsule | |
| CN101347145A (en) | Egg antistaling agent and method of preparing the same | |
| CN104784148A (en) | Film formation composition for preparing plant capsules and preparation method of film formation composition | |
| CN107889882A (en) | A kind of betel nut table glue compounding fruit glaze agent and its application | |
| CN105232493A (en) | Gelatin/hydroxypropyl starch blended hard capsule as well as preparation method thereof | |
| CN101279096B (en) | Pullulan polysaccharide Vc coating combination | |
| CN105285897B (en) | A kind of allotment type lenthionine and preparation method thereof | |
| CN103417510A (en) | Tamarind gum plant capsule and preparation method thereof | |
| CN103933009A (en) | Composition used for preparing cellulose hard capsule and application thereof | |
| CN109908102A (en) | The method for being used to prepare the shelling composition of soft capsule and preparing soft capsule | |
| CN104922089A (en) | Preparation method of high-performance starch capsule | |
| CN103554279B (en) | The composite modified starch of alternative gelatin and application | |
| CN105250235A (en) | Carrageenan plant soft capsule material and application thereof | |
| CN101439028A (en) | Hypromellose composition and application thereof in preparing plant base medicinal capsule |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160113 |
|
| RJ01 | Rejection of invention patent application after publication |