CN103417510A - Tamarind gum plant capsule and preparation method thereof - Google Patents
Tamarind gum plant capsule and preparation method thereof Download PDFInfo
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- CN103417510A CN103417510A CN2013103132741A CN201310313274A CN103417510A CN 103417510 A CN103417510 A CN 103417510A CN 2013103132741 A CN2013103132741 A CN 2013103132741A CN 201310313274 A CN201310313274 A CN 201310313274A CN 103417510 A CN103417510 A CN 103417510A
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Abstract
The invention provides a tamarind gum plant capsule and a preparation method thereof. The capsule comprises the following components in percentage by mass: 0.3-5.0% of tamarind gum, 0.1-1.0% of gelata, 0.1-0.3% of coagulant aid, 0.1-0.6% of humectant, 0.1-0.3% of pigment and purified water in balancing amount. Through addition of the tamarind gum plant raw material and the gelata, the viscosity of solution is improved, the film forming property of gum liquid of the tamarind gum plant capsule is better, the solution temperature is 70-90 DEG C, and the gum temperature is 55-75 DEG C; certain complexation exists between the coagulant aid and the gelata, the coagulant aid and the gelata have excellent emulsifying and stabilizing effects on tamarind gum and increase the disintegration speed of the plant capsule, and a certain of humectant is added to improve the toughness of the plant capsule and be conducive to reducing the friability of conventional plant capsules.
Description
Technical field
Present technique is to belong to medicinal hollow capsule, relates to particularly a kind of plant capsule.
Background technology
Traditional Capsules softgel shell is to consist of materials such as gelatin, G & Ws, current domestic pharmaceutical producing enterprise, the Capsules of the uses such as health food enterprise is all to take animal gelatin as raw material, and animal gelatin is mainly hide glue, the osseocolla extracted in the animal osteoderm, belong to protein matter, be widely used in pharmaceutical field.Because gelatine capsule exists the dehydration sclerosis, water suction is softening, meet the aldehydes quality defects such as cross-linking and curing reaction, easy breed bacteria mycete easily occur, therefore the unsuitable easy moisture absorption of filling, easy-weathering and the content that reacts with softgel shell, as the material that contains aldehyde radical etc.Its water content is higher, hygroscopicity is strong, and may be transferred to the content medicine to the moisture content absorbed, and makes the medicine moisture absorption rotten, causes off quality and effect duration to shorten; Cross-linking reaction easily occurs, and causes the defects such as capsule disintegrate prolongation or dissolution reduction.Along with people in recent years use being on the rise of hormone and abuse medicine phenomenon in a large number in aquaculture, people more and more suspect to some extent to the safety of animal product, and " bovine spongiform encephalopathy " that sweep across Europe just once caused certain impact to traditional gelatine capsule market.The development of vegetarianism and the impact that is subject to the factors such as religion, so pure natural, vegetal capsule product will become the dominant direction of capsule product development.
Summary of the invention
The object of the invention is to provide the quickly disintegrated plant capsule of a kind of energy;
In order to reach the purpose solved the problems of the technologies described above, technical scheme of the present invention is:
The plant capsule that a kind of tamarind gum is main material, capsule shells is composed of the following components, wherein each constituent mass percentage ratio is:
Tamarind gum 0.3%～5.0%,
Gel 0.1%～1.0%,
Flocculation aid 0.1%～0.3%,
Wetting agent 0.1%～0.6%,
Or pigment 0.1～0.3%;
Surplus is purified water
The molecular weight of tamarind gum is 1.0 * 10
4～2.0 * 10
5, viscosity is 300～500mpa.s
Gel is one or more in carrageenan, xanthan gum, gellan gum or pectin;
Flocculation aid is one or more in potassium chloride, calcium chloride, potassium citrate or potassium acetate;
Wetting agent is glycerol;
Pigment is selected from titanium dioxide, carmine, lemon yellow or light blue.
A kind of preparation method of tamarind gum plant capsule, its step is as follows:
A chooses raw material according to the mass percent of said components;
B is by the tamarind gum raw material, and gel, flocculation aid, wetting agent or pigment join in the purified water of corresponding proportion, stir, and makes its dissolving, and then add and be warmed up to 70～90 ℃, after dissolving fully, under 55～75 ℃ standing 2～4 hours, heat preservation for standby use;
C is the glue of having stablized, and then advances to dip in glue, drying and moulding, the demoulding, cutting, fit and is prepared into Capsules; 20～40 ℃ of baking temperatures, relative humidity remains on 30%～60%, and be 2～4 hours drying time.
The present invention compared with prior art has the following advantages and good effect:
By adding the tamarind gum plant material, the tamarind gum plant material is with respect to other glue plant material, better water solublity etc. is arranged, the viscometric properties of solution that added gel to improve, make the glue film property of tamarind gum Capsules better, 70～90 ℃ of solution temperatures, 55～75 ℃ of viscose glue temperature, the better effects if of dipping in glue at this temperature; Add between flocculation aid and gel certain complexing is arranged, with tamarind gum, good emulsion stabilizing effect is arranged, improved the disintegration rate of Capsules, the disintegration time of the hollow plant capsule of Sargassum polysaccharides is 10min, and the tamarind gum plant capsule disintegration time be to be less than or equal to 8min; Add certain wetting agent and improve the toughness of plant capsule, be conducive to reduce the friability of existing plant capsule.
The specific embodiment
Embodiment 1
30 kilograms of the tamarind gums that to get viscosity be 300mpa.s, 1 kilogram, 3 kilograms of K type carrageenans and potassium chloride, 2 kilograms of glycerol, join more than 70 ℃ in the purified water of 950 kilograms, stirring and dissolving 2 hours, temperature is down to 70 ℃, stirs, stable remove bubble after, standing 3 hours, dip in glue, under the relative humidity of the temperature of 35 ℃ and 50%, drying and moulding, the demoulding, cutting, cover synthesize transparent Capsules, can be used for the relevant medicine of filling.
Embodiment 2
40 kilograms of the tamarind gums that to get viscosity be 400mpa.s, 2 kilograms of xanthan gum, 2 kilograms of glycerol, 2 kilograms of the scattered titanium dioxides of 1 kilogram of appropriate pigment lemon yellow and high shear, join more than 70 ℃ in the purified water of 900 kilograms, stirring and dissolving 3 hours, temperature is down to 65 ℃, stir, stable remove bubble after, standing 2 hours, dip in glue, under the relative humidity of the temperature of 30 ℃ and 50%, drying and moulding, the demoulding, cutting, cover synthesize transparent Capsules, can be used for the relevant medicine of filling.
Embodiment 3
25 kilograms of the tamarind gums that to get viscosity be 500mpa.s, 1.5 kilograms, 4 kilograms of K type carrageenans and potassium chloride, 3 kilograms of glycerol, join more than 70 ℃ in the purified water of 960 kilograms, stirring and dissolving 4 hours, temperature is down to 70 ℃, stirs, stable remove bubble after, standing 4 hours, dip in glue, under the relative humidity of the temperature of 35 ℃ and 45%, drying and moulding, the demoulding, cutting, cover synthesize transparent Capsules, can be used for the relevant medicine of filling.
Embodiment 4
50 kilograms of the tamarind gums that to get viscosity be 300mpa.s, 8 kilograms of 3 kilograms of K type carrageenans and pectin, 2 kilograms, 1 kilogram, potassium chloride and calcium chloride, 6 kilograms of glycerol, join more than 70 ℃ in the purified water of 850 kilograms, stirring and dissolving 2 hours, temperature is down to 70 ℃, stir, stable remove bubble after, standing 3 hours, dip in glue, under the relative humidity of the temperature of 40 ℃ and 60%, drying and moulding, the demoulding, cutting, cover synthesize transparent Capsules, can be used for the relevant medicine of filling.
Embodiment 5
3 kilograms of the tamarind gums that to get viscosity be 400mpa.s, 1 kilogram of xanthan gum, 1 kilogram, calcium chloride, 1 kilogram of glycerol, 1 kilogram of pigment light blue, join more than 70 ℃ in the purified water of 980 kilograms, stirring and dissolving 3 hours, temperature is down to 65 ℃, stirs, stable remove bubble after, standing 2 hours, dip in glue, under the relative humidity of the temperature of 20 ℃ and 30%, drying and moulding, the demoulding, cutting, cover synthesize transparent Capsules, can be used for the relevant medicine of filling.
Disintegration time embodiment
Get 6 of above-mentioned capsule shells, fill Pulvis Talci, according to the method inspection under inspection technique disintegration (two appendix XA of Pharmacopoeia of the People's Republic of China version in 2010) capsule item, except leaving over a small amount of softgel shell, each all should all disintegrates in 8min.If any 1 all disintegrate, should separately get 6 retrials, all should be up to specification
| Start disintegration time | Whole disintegration times | After eight minutes, change |
| 5′11〞 | 6′23〞 | A little fragment |
Target level of product quality and technical specification
The plant capsule Comparison of standards
The above, be only preferred embodiment of the present invention, not the present invention done the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away from, to any modification made for any of the above embodiments, equivalent variations and remodeling, still belong to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (2)
1. a tamarind gum plant capsule, is characterized in that capsule shells is composed of the following components, and each constituent mass percentage ratio is:
Tamarind gum 0.3%～5.0%,
Gel 0.1%～1.0%,
Flocculation aid 0.1%～0.3%,
Wetting agent 0.1%～0.6%,
Or pigment 0.1～0.3%;
Surplus is purified water;
The molecular weight of described tamarind gum is 1.0 * 10
4～2.0 * 10
5, viscosity is 300～500mpa.s;
Described gel is one or more in carrageenan, xanthan gum, gellan gum or pectin;
Described flocculation aid is one or more in potassium chloride, calcium chloride, potassium citrate or potassium acetate;
Described wetting agent is glycerol;
Described pigment is selected from titanium dioxide, carmine, lemon yellow or light blue.
2. the preparation method of a tamarind gum plant capsule comprises that step is as follows:
A,Component according to claim 1 is chosen raw material by mass percentage;
B,By the tamarind gum raw material, gel, flocculation aid, wetting agent or pigment join in the purified water of corresponding proportion, stir, and make its dissolving, and then add and be warmed up to 70～90 ℃, after dissolving fully, under 55～75 ℃ standing 2～4 hours, heat preservation for standby use;
C,By the glue of having stablized, then advance to dip in glue, drying and moulding, the demoulding, cutting, fit and be prepared into Capsules; 20～40 ℃ of described baking temperatures, be 2～4 hours described drying time; When described capsule is dry, relative humidity remains on 30%～60%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310313274.1A CN103417510B (en) | 2013-07-24 | 2013-07-24 | Tamarind gum plant capsule and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310313274.1A CN103417510B (en) | 2013-07-24 | 2013-07-24 | Tamarind gum plant capsule and preparation method thereof |
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| CN103417510A true CN103417510A (en) | 2013-12-04 |
| CN103417510B CN103417510B (en) | 2015-02-25 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104522297A (en) * | 2014-12-31 | 2015-04-22 | 朱勤 | Coated puffed feed processing method |
| CN105250234A (en) * | 2015-09-10 | 2016-01-20 | 李厚山 | Capsule shell and preparation method therefor |
| CN109400925A (en) * | 2018-09-29 | 2019-03-01 | 四川农业大学 | A method of degradable packaging film is made with tamarind seeds |
| CN111467318A (en) * | 2020-05-12 | 2020-07-31 | 湖北人福药用辅料股份有限公司 | Tamarind gum plant enteric empty capsule and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961495A (en) * | 2010-09-28 | 2011-02-02 | 北京航洋胶囊技术有限公司 | Plant soft capsule material and preparation method thereof |
| CN103127029A (en) * | 2013-03-21 | 2013-06-05 | 上海理工大学 | Plant empty capsule and preparation method thereof |
-
2013
- 2013-07-24 CN CN201310313274.1A patent/CN103417510B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961495A (en) * | 2010-09-28 | 2011-02-02 | 北京航洋胶囊技术有限公司 | Plant soft capsule material and preparation method thereof |
| CN103127029A (en) * | 2013-03-21 | 2013-06-05 | 上海理工大学 | Plant empty capsule and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104522297A (en) * | 2014-12-31 | 2015-04-22 | 朱勤 | Coated puffed feed processing method |
| CN105250234A (en) * | 2015-09-10 | 2016-01-20 | 李厚山 | Capsule shell and preparation method therefor |
| CN105250234B (en) * | 2015-09-10 | 2018-08-07 | 李厚山 | A kind of capsule shells and preparation method thereof |
| CN109400925A (en) * | 2018-09-29 | 2019-03-01 | 四川农业大学 | A method of degradable packaging film is made with tamarind seeds |
| CN111467318A (en) * | 2020-05-12 | 2020-07-31 | 湖北人福药用辅料股份有限公司 | Tamarind gum plant enteric empty capsule and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103417510B (en) | 2015-02-25 |
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