CN1720903A - Porous capsule and preparation process thereof - Google Patents
Porous capsule and preparation process thereof Download PDFInfo
- Publication number
- CN1720903A CN1720903A CN 200510026908 CN200510026908A CN1720903A CN 1720903 A CN1720903 A CN 1720903A CN 200510026908 CN200510026908 CN 200510026908 CN 200510026908 A CN200510026908 A CN 200510026908A CN 1720903 A CN1720903 A CN 1720903A
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- China
- Prior art keywords
- capsule
- holes
- aperture
- capsules
- merlon
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Abstract
The invention discloses a capsule with one or two small holes whose diameter is 50mn-6mm, wherein the small holes can be formed directly on a hollow capsule through a mechanical punching method or a laser punching method, or a hollow capsule with holes can be directly obtained through an injection molding method or a blow molding method. The capsule with holes can be filled by active constituents to obtain capsule preparations.
Description
Technical field
The present invention relates to a kind of capsule with holes and preparation method thereof, relate in particular to a kind of insoluble capsule of gastrointestinal with holes and preparation method thereof.
Background technology
The route of administration of medicine has a variety of, wherein oral administration accounts for more than 70% of medicine, mainly be because of its give prescription just, advantage such as little, the development of side effect, production cost be relatively low, peroral dosage form comprises tablet, capsule, granule, oral administration solution etc., wherein tablet, capsule quantity are many, oral sustained release, controlled release preparation come across the forties in last century, can play the slow or control drug release in the court of a feudal ruler, reduce administration number of times, reduce advantages such as side effect, be one of modern oral formulations developing direction.
Common oral sustained-release preparation has following several manufacture method: 1, activated medicine and hydrophilic gel material, insoluble skeleton material are made complex; 2, will there be active pharmaceutical compositions to coat the little or insoluble material of gastrointestinal solution dissolubility outward; 3, with medicine and ion exchange resin shape bond; 4, in flakes, the coated high molecular material is simultaneously opened an aperture therein with laser outside with the active pharmaceutical compositions compacting;
For the dissolution rate that makes active ingredient meets the treatment needs, said method need be done wide variety of materials, consumption screening experiment, and difficulty is big, the difficult control of dissolution rate, cladding process brings certain difficulty to large-scale production control, and tapping equipment requires height behind the tabletting, has high input.
Technology contents
Technical problem to be solved by this invention is to provide a kind of capsule with holes and preparation method thereof, to solve prior art Chinese medicine dissolution rate shortcoming rambunctious.
The invention provides a kind of capsule with holes, the aperture that it is 50nm-6mm that this capsule has 1-2 diameter.
The present invention also provides preparation above-mentioned capsular method with holes, with stomach, the insoluble acrylate copolymer of intestinal, ethyl cellulose, polrvinyl chloride, Merlon, polyvinyl fluoride, polypropylene, pectin with after dipping in the glue method and being prepared into Capsules, with mechanical punching method or laser boring method, open 1-2 aperture, aperture 50nm-6mm; Or polrvinyl chloride, Merlon, polyvinyl fluoride, polypropylene made capsulae vacuus with holes with injection moulding, blow moulding plastic uptake method, aperture 50nm-6mm, or Capsules open 1-2 aperture, aperture 50nm-6mm with Mechanical Method or laser method.
Active substance mixed with adjuvant be pressed into strip or make bulky grain shape compositions (opening small aperture in advance) greater than capsule, be filled in the Capsules of pre-drilled cavity, or two kinds of different activities materials are made the Capsules that small pieces are filled in pre-drilled cavity respectively, by changing pore size, control active matter rate of release is made slow release or controlled release capsule.Can be made into the different series of pore size slow, the controlled release Capsules with holes of the property opened in advance, be directly used in research and large-scale production.
This pharmaceutical dosage form is because of utilizing the Capsules of perforate, can select for use the perforate Capsules in different apertures to delay, controlled release research, the Capsules in both available this kind aperture is filled the active substance combination composition when determining to produce behind a kind of aperture, compare with general slow, controlled release oral dosage formulations, have development, produce easy, large-scale production steady quality, controlled.The perforate Capsules can be made by Capsules professional production enterprise, and pharmacy can directly be filled strip or bulky grain shape active compound matter with it.
Description of drawings
Fig. 1 is a Capsules perforate pre-structure sketch map with holes;
Fig. 2 is a structural representation after the Capsules perforate with holes;
Fig. 3 is a structural representation after the interior filling of the Capsules with holes strip active material compositions;
Fig. 4 is a structural representation behind the interior filler particles shape active compound of Capsules with holes;
Fig. 5 fills the active combination of two kinds of strips back structural representation in the Capsules with holes;
1 is aperture among Fig. 2,3,4,5, and 2 is the strip active compound composition among Fig. 3, and 3 is granule shape active compound composition among Fig. 4, and 4 is two kinds of active compound compositions among Fig. 5;
Specific embodiment
Embodiment 1
Stomach, the insoluble acrylate copolymer of intestinal, ethyl cellulose, polrvinyl chloride, Merlon, polyvinyl fluoride, polypropylene, pectin with after dipping in the glue method and being prepared into Capsules, are opened 1 aperture with the mechanical punching method, and the aperture is 50nm.
Embodiment 2
Polrvinyl chloride, Merlon, polyvinyl fluoride, polypropylene are directly made Capsules with holes with blow moulding, aperture 6mm.
Claims (3)
1. capsule with holes is characterized in that this capsule aperture that to have 1-2 diameter be 50nm-6mm.
2. one kind prepares the described capsular method with holes of claim 1, it is characterized in that stomach, the insoluble acrylate copolymer of intestinal, ethyl cellulose, polrvinyl chloride, Merlon, polyvinyl fluoride, polypropylene, pectin etc. with after dipping in the glue method and being prepared into Capsules, with mechanical punching method or laser boring method, open 1-2 aperture, aperture 50nm-6mm; Or usefulness injection moulding, blow moulding plastic uptake methods such as polrvinyl chloride, Merlon, polyvinyl fluoride, polypropylene made Capsules with holes, or open 1-2 aperture with Mechanical Method or laser method, aperture 50nm-6mm.
3, the application of the described capsule with holes of claim 1 in preparation capsule preparations medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510026908 CN1720903A (en) | 2005-06-20 | 2005-06-20 | Porous capsule and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510026908 CN1720903A (en) | 2005-06-20 | 2005-06-20 | Porous capsule and preparation process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1720903A true CN1720903A (en) | 2006-01-18 |
Family
ID=35911743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510026908 Pending CN1720903A (en) | 2005-06-20 | 2005-06-20 | Porous capsule and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1720903A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142466A (en) * | 2013-03-21 | 2013-06-12 | 青岛正大海尔制药有限公司 | Calcitriol gel and preparation method thereof |
| CN103315976A (en) * | 2013-06-13 | 2013-09-25 | 华南理工大学 | Preparation method for starch hard capsule shells |
| CN103874727A (en) * | 2011-10-12 | 2014-06-18 | 陶氏环球技术有限责任公司 | Injection-molded dosage form |
| CN105596215A (en) * | 2015-12-30 | 2016-05-25 | 新昌县捷奥激光制品有限公司 | Capsule punching equipment |
-
2005
- 2005-06-20 CN CN 200510026908 patent/CN1720903A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103874727A (en) * | 2011-10-12 | 2014-06-18 | 陶氏环球技术有限责任公司 | Injection-molded dosage form |
| CN103874727B (en) * | 2011-10-12 | 2016-05-11 | 陶氏环球技术有限责任公司 | The formulation of injection moulding |
| US9649278B2 (en) | 2011-10-12 | 2017-05-16 | Dow Global Technologies Llc | Injection-molded dosage form |
| CN103142466A (en) * | 2013-03-21 | 2013-06-12 | 青岛正大海尔制药有限公司 | Calcitriol gel and preparation method thereof |
| CN103315976A (en) * | 2013-06-13 | 2013-09-25 | 华南理工大学 | Preparation method for starch hard capsule shells |
| CN103315976B (en) * | 2013-06-13 | 2015-09-16 | 华南理工大学 | A kind of preparation method of starch hard capsule case |
| CN105596215A (en) * | 2015-12-30 | 2016-05-25 | 新昌县捷奥激光制品有限公司 | Capsule punching equipment |
| CN105596215B (en) * | 2015-12-30 | 2019-02-15 | 新昌县捷奥激光制品有限公司 | A kind of punch device of capsule |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |