CN103314871A - Visual target active attention training system for sober rats/mice - Google Patents
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Abstract
The invention discloses a visual target active attention training system for sober rats/mice. The visual target active attention training system comprises a master control unit, a behavior restricting high table, a visual stimulation display unit, an infrared eye movement monitoring unit, a basic controller, a water feeding rewarding unit and a video monitoring unit. The visual target active attention training system has the advantages that active attention of the tested animals to visual targets can be effectively improved, the conditioned reflex time of the tested rats/mice from generating the attention to the visual targets to behavior feedback is shortened, and the duration of the active attention of the tested rats/mice to the visual targets is prolonged in experimental procedures; the visual target active attention training system supports various visual cognition experimental paradigms, and is easy to extent and high in universality; the visual target active attention training system has important application value and high experimental demands in research fields of coding of neurons of vision systems, brain cognition functions, drug evaluation, plasticity of neural networks and the like.
Description
Technical field
The present invention relates to neuro-physiology and cognitive behavior and learn the field, especially relate to greatly clear-headed/mouse sensation target and initiatively pay close attention to training system.
Background technology
Greatly/mouse is the most frequently used model animal in the research of visual system function and visual cognition behavioral function, in experimentation, usually all need tested large/mouse can carry out active concern to the visual stimulus target.In the visual system functional study, how neuron is encoded to characterize to visual stimulus and is had important value, needs in the experiment to guarantee that visual stimulus is in geostationary position in the visual field of animal subject.At present for narcose large/the existing very deeply widely research of mouse Neurons In Visual System encoding characteristics, but the neuron encoding characteristics can be subject to the adjusting of more perceptional factors under the waking state, have larger researching value, therefore be subject to showing great attention to of domestic and international researcher.At present, in greatly clear-headed/mouse Neurons In Visual System encoding characteristics research, the main fixing method of animal subject head that adopts, use the implanted iron plate that large/mouse head is fixed on the stereotaxic instrument, health is forced to be strapped in the fixing constraint cylinder of shape or four limbs place on the rotatable spheroid.Although these methods can guarantee the head of animal, the visual field and all be in geostationary position, easily animal are produced physiology and psychic influence in the experimentation, as cause animal struggle, agitation, pain etc.; This experimental state that allows animal " passive " carry out the sensation target perception can cause other cortexes to the neururgic complex modulation of visual cortex simultaneously, makes to analyze the larger bias of Neurons In Visual System visual stimulus encoding characteristics existence that obtains.
In addition, adopting large/mouse to carry out in the research of visual cognition behavioral function, usually utilize certain visual cues to strengthen the specific selection behavior of animal subject, animal subject focuses on plan to the active of sensation target and induces in operation behavior (schedule-induced operant) task and play a key effect, and at first needs to train animal subject to carry out active concern to sensation target in the visual cognition behavioral experiment.
At present, to greatly/mouse visual cognition behavioral experiment device in the experimental boxs that adopt narrow spaces more, to reduce to be in the animal subject space exploration time of free movement state and the interference of other perception factors, but this method is difficult to guarantee that animal " sees " when sensation target occurs on the one hand, cause a large amount of invalid examinations inferior, and animal subject is paid close attention to the training time prolongation of screen; On the other hand, become this field main flow trend in conjunction with implantation micro-electrode having collection analysis nerve signal when adopting at present large/mouse to carry out the research of visual cognition behavioral experiment, but allow animal subject free activity in the experimental box body of narrow space be easy to the clashing and breaking electrode, simultaneously, animal subject is also longer from the time-histories of paying close attention to visual cues, the behavior of making is fed back, rewarded to final acquisition, is difficult to the state of determining which time window is just carrying out the sensation target cognition corresponding to animal subject in nerve signal.
Therefore, the needs development is a kind of can either to make the tested large/mouse that regains consciousness be in a kind of nature in experimentation, can also effectively limit its activity space, being convenient to train animal subject that sensation target is carried out active pays close attention to, shorten the automation training system of Time Created of conditioned reflex between sensation target and the behavior response, but yet there are no the report of all relevant this respects.
Summary of the invention
The object of the invention is to provide a kind of large/mouse sensation target of regaining consciousness initiatively to pay close attention to training system, reaching the tested rat of Effective Raise pays close attention to the active of sensation target, shorten tested rat and set up the time of paying close attention to conditioned reflex between sensation target and the behavior feedback, tested rat is to the time of initiatively paying close attention to of sensation target in the prolongation experimentation.
For achieving the above object, the present invention takes following technical proposals:
Large/mouse the sensation target of regaining consciousness of the present invention is initiatively paid close attention to training system, comprises that main control unit, behavior limit high platform, visual stimulus display unit, infrared eye movement monitoring unit, basic controller, feedwater award unit, video monitoring unit; Described behavior limits high platform and is comprised of telescope support and the food dish, the microswitch that are arranged on the upper shed groove at its top and be arranged in the described upper shed groove; Described visual stimulus display unit is the display screen that is disposed on upper shed groove one side stand; Described infrared eye movement monitoring unit is to be arranged on the infrared video watch-dog that upper shed groove front upper place is used for the action of monitoring rat eyes; Described video monitoring unit is to be arranged on the video monitor that the back upper place, training place is used for global monitoring; It is the water-storing bottle that is arranged on upper shed groove top that the unit is rewarded in described feedwater, and the outlet pipe of described water-storing bottle extends to described food dish position, is provided with electrically-controlled valve at described outlet pipe; Described main control unit video inputs is connected with infrared video watch-dog, video monitor output respectively; The main control unit video output terminals is connected with display screen; The main control unit communication interface is connected with described basic controller; Main control unit control inputs, output interface are connected with described microswitch, electrically-controlled valve drive circuit control end respectively.
The upper shed groove that described behavior limits high platform is deep-slotted chip breaker, described food dish is arranged on an end of upper shed arc groove, described microswitch is arranged on the place ahead of food dish, and the upper shed groove adopts the insertion slot type structure to be fixed on the supporting plate of high flexible adjustable telescopic support.
The invention has the advantages that the Effective Raise animal subject is to the active concern of sensation target, shorten tested large/mouse sets up the time of paying close attention to conditioned reflex between sensation target and the behavior feedback, prolong in the experimentation tested greatly/mouse is to time of initiatively paying close attention to of sensation target.Simultaneously the present invention supports multiple visual cognition experimental paradigm, is easy to expansion, highly versatile.The present invention has great using value and experiment demand in research fields such as Neurons In Visual System coding, brain cognitive function, assessing drug actions, neutral net plasticity.
Description of drawings
Fig. 1 is structural representation of the present invention.
Fig. 2 is control circuit theory diagram of the present invention.
Embodiment
As shown in Figure 1, 2, large/mouse the sensation target of regaining consciousness of the present invention is initiatively paid close attention to training system, comprises that main control unit 12, behavior limit high platform, visual stimulus display unit, infrared eye movement monitoring unit, basic controller 11, feedwater award unit, video monitoring unit; Described behavior limit high platform utilization large/mouse " steep cliff is walked quickly and kept away " effect restriction large/make it in the raw in the mouse activity space, effectively reduce the interference of other perception informations.Described behavior limits high platform by the adjustable telescope support of high flexible 1 and is inserted into the upper shed groove 2 of arcuate structure on its top bracket 13, and the food dish 3, the microswitch that are arranged on ends in the described upper shed groove 2 form; Described microswitch is arranged on the place ahead of food dish 3.Described visual stimulus display unit is the display screen 5 that is disposed on upper shed groove 2 one side stands 4; Described infrared eye movement monitoring unit is the infrared video watch-dog 6 that is arranged on upper shed groove 2 tops, be used for synchronous recording analyze visual cognition action learning training experiment process tested large/the eye movement state of mouse, whether watch the conditional information of expectation target image attentively for main control unit provides animal subject.Described video monitoring unit is the video monitor 7 that is arranged on the top, training place, consisted of by low-light high-definition camera and data acquisition unit, be connected the experimentation playback when being used for the monitoring of animal subject visual cognition action learning training process or unmanned with main control unit.It is the water-storing bottle 8 that is arranged on upper shed groove 2 tops that the unit is rewarded in described feedwater, and the outlet pipe 9 of described water-storing bottle 8 extends to described food and coils 3 positions, is provided with for the electrically-controlled valve 10 that supplies water at described outlet pipe 9; The psychological need of unit by using " water deprivation " animal subject to water rewarded in feedwater, reward and adopt the electrically-controlled valve feedwater, confluent is easy to control and is not easy to occur executing agency block, and simultaneously feedwater is rewarded and can not caused undergo training animal habituation and negative effect, improves accuracy rate and the training speed of training.Described main control unit video inputs is connected with infrared video watch-dog 6, video monitor 7 outputs respectively; The main control unit video output terminals is connected with display screen 5; The main control unit communication interface is connected with described basic controller 11; Main control unit control inputs, output interface are connected with described microswitch, electrically-controlled valve drive circuit control end respectively.
The image that main control unit is mainly used to infrared eye movement video monitoring unit is passed back (per second〉30 frames) carries out pupil location, eye movement analysis and training data to be processed.Pupil location and trajectory track algorithm are adopted in data analysis, and when eye movement displacement during less than setting threshold, main control unit arranges the eye movement status signal for effective, otherwise is invalid.Data analysis is also carried out statistical analysis to the inferior detection data of each experiment examination simultaneously, calculate the indexs such as behavior response latent period, touching accuracy, when tested reaching gives the experimenter voice suggestion when training requirement maybe can't be finished training, automatically finish whole training process.
Training method of the present invention is summarized as follows:
Animal subject is initiatively paid close attention to sensation target and is trained the incremental following three phases that is divided into, and the training goal in each stage, training mode and award controlled condition arrange as follows:
Phase I: reward training
Training goal: tested large/mouse adapts to high platform and do not fall, and association touches microswitch and obtains feedwater and reward.
Training mode:
1, the high platform environment of tested adaptation guarantees not fall, and this stage visual stimulus display unit stimulates and the encouraging pattern that uniformly-spaced feeds water without vision;
2, tested control water is placed on behavior and limits on the high platform, and the complete grey screen display of this stage visual stimulus display unit is shown, applying feedwater and rewarding when triggering microswitch.
Reward controlled condition: trigger microswitch and think that namely behavior response is correct, award;
Second stage: the visual attention location reflection is set up
Training goal: set up the conditioned reflex of when image occurring on the display screen, touching the microswitch behavior.
Training mode: visual stimulus presents image after for examination time beginning, surpass image stimulate present duration after display screen ash screen display show.
Reward controlled condition: it is inferior that whole examination time interior touchless microswitch behavior is considered as invalid examination.Effectively in the examination time, synchronous recording was analyzed tested eye movement state during image presented within the examination time cycle, if pay close attention to screen in the display image period and switch to ash after the screen period touching microswitch then award.
Claims (2)
1. greatly clear-headed/mouse sensation target is initiatively paid close attention to training system, be it is characterized in that: comprise that main control unit (12), behavior limit high platform, visual stimulus display unit, infrared eye movement monitoring unit, basic controller (11), feedwater award unit, video monitoring unit; Described behavior limits high platform by telescope support (1) and is arranged on the upper shed groove (2) at its top and is arranged on described upper shed groove (2) interior food dish (3), microswitch and forms; Described visual stimulus display unit is for being disposed on the display screen (5) on upper shed groove (2) one side stands (4); Described infrared eye movement monitoring unit is used for the infrared video watch-dog (6) of monitoring rat eyes action for being arranged on upper shed groove (2) front upper place; Described video monitoring unit is to be arranged on the video monitor (7) that the back upper place, training place is used for the training place monitoring; Described feedwater is rewarded the unit for being arranged on the water-storing bottle (8) above the upper shed groove (2), and the outlet pipe (9) of described water-storing bottle (8) extends to described food dish (3) position, is provided with electrically-controlled valve (10) at described outlet pipe (9); Described main control unit video inputs is connected with infrared video watch-dog (6), video monitor (7) output respectively; The main control unit video output terminals is connected with display screen (5); The main control unit communication interface is connected with described basic controller (11); Basic controller (11) input, output interface are connected with described microswitch, electrically-controlled valve drive circuit control end respectively.
2. large/mouse the sensation target of regaining consciousness according to claim 1 is initiatively paid close attention to training system, it is characterized in that: the upper shed groove (2) that described behavior limits high platform is deep-slotted chip breaker, described food dish (3) is arranged on an end of upper shed arc groove, described microswitch is arranged on the place ahead of food dish (3), and upper shed groove (2) adopts the insertion slot type structure to be fixed on the supporting plate (13) of transferring telescope support (1).
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| CN106719082A (en) * | 2016-12-28 | 2017-05-31 | 华东师范大学 | A kind of experimental provision for detecting small birds cognitive function |
| CN107041322A (en) * | 2017-05-02 | 2017-08-15 | 中国人民解放军军事医学科学院基础医学研究所 | Non-human primates vision and Cognitive Function Research system |
| CN107411762A (en) * | 2017-08-31 | 2017-12-01 | 杭州极智医疗科技有限公司 | Cognitive disorder diagnostic equipment |
| CN109011655A (en) * | 2018-08-18 | 2018-12-18 | 胡绍富 | A kind of flying squirrel gliding performance system |
| CN111024934A (en) * | 2019-12-27 | 2020-04-17 | 苏州溢博伦光电仪器有限公司 | Vibration reduction type microscopic observation method |
| CN112715415A (en) * | 2021-03-01 | 2021-04-30 | 河南省轻工业学校 | Bird visual cognition behavior training system and method |
| CN113796335A (en) * | 2021-08-26 | 2021-12-17 | 五邑大学 | Control method, device and equipment of mouse behavior training system and storage medium |
| CN115226648A (en) * | 2022-07-18 | 2022-10-25 | 陕西师范大学 | Small-sized automatic animal behavior training system and training method |
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| CN115226648B (en) * | 2022-07-18 | 2023-09-22 | 陕西师范大学 | Small-sized automatic animal behavior training system and training method |
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