CN107041322A - Non-human primates vision and Cognitive Function Research system - Google Patents
Non-human primates vision and Cognitive Function Research system Download PDFInfo
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- CN107041322A CN107041322A CN201710301055.XA CN201710301055A CN107041322A CN 107041322 A CN107041322 A CN 107041322A CN 201710301055 A CN201710301055 A CN 201710301055A CN 107041322 A CN107041322 A CN 107041322A
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- 238000011160 research Methods 0.000 title claims abstract description 30
- 230000003920 cognitive function Effects 0.000 title claims abstract description 26
- 241000288906 Primates Species 0.000 title description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 230000000007 visual effect Effects 0.000 claims abstract description 9
- 230000002452 interceptive effect Effects 0.000 claims abstract description 8
- 230000004424 eye movement Effects 0.000 claims description 5
- 210000001508 eye Anatomy 0.000 abstract description 27
- 241001465754 Metazoa Species 0.000 abstract description 26
- 238000010171 animal model Methods 0.000 abstract description 10
- 238000012360 testing method Methods 0.000 abstract description 8
- 210000005252 bulbus oculi Anatomy 0.000 abstract description 6
- 230000010354 integration Effects 0.000 abstract description 5
- 230000003993 interaction Effects 0.000 abstract description 5
- 230000003930 cognitive ability Effects 0.000 abstract description 4
- 239000000284 extract Substances 0.000 abstract description 3
- 230000001149 cognitive effect Effects 0.000 description 7
- 230000008859 change Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000006399 behavior Effects 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000282575 Gorilla Species 0.000 description 1
- 241000282553 Macaca Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000036992 cognitive tasks Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000006886 spatial memory Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K29/00—Other apparatus for animal husbandry
- A01K29/005—Monitoring or measuring activity, e.g. detecting heat or mating
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- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Biophysics (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Eye Examination Apparatus (AREA)
Abstract
The invention discloses a kind of non-human primates vision and Cognitive Function Research system.The non-human primates vision and Cognitive Function Research system include：Fixing seat, including：Seat, collar fixed system, waist restriction plate and touch panel device portal frame；Water supply system, including：Bucket, electronics water valve and NI capture cards；Touch panel device, with the visual stimulus touch-screen that acoustic stimuli and presentation image are carried out for can play sound；Eye tracker device, including：Infrared camera and infrared lamp, eye tracker body and interactive module；And control device, including：NI collections card module, touch screen module, eye tracker module and task module.The non-human primates vision and Cognitive Function Research system result in stable animal position, and then extract the characteristic vector and experimental animal cognitive ability parameter of the animal eyeball direction of motion, and interaction dimension is high, integration degree is high, and test accuracy and efficiency are high.
Description
Technical field
The present invention relates to animal vision and Cognitive Function Research method field, more particularly to a kind of non-human primates vision and
Cognitive Function Research system.
Background technology
Brain vision and cognitive function are always the emphasis of Neuroscience Research.And non-human primate as with the mankind
Immediate experimental animal has been widely used in Related Research Domain.Although central nervous system and the people of this kind of experimental animal
Class is very much like, but can not understand language due to them or be experienced with language performance, how to confirm its actual impression, clearly stimulates
Response effect is always masty problem.
Touch-screen early has been used for human cognitive research field.For example, the 5-CSRTT tasks based on tablet personal computer by with
In the diagnosis of alzheimer cognitive function of patients.Due to its exact controllability, integrate stimulation and present with reacting record etc.
Feature, with wide clinic and research application prospect.Meanwhile, have been reported is used for rodent, macaque, gorilla by touch-screen
Deng experimental animal Cognitive Function Research.For example, monkey CANTAB touch screen cognitive system, cognitive, interior or exterior space can set to reinforcing
The Cognitive tasks such as of short duration identification and nonrecognition, spatial memory of the change with visual discrimination, to showing symbol are put to test.
But most animals Cognitive Study system allows animal freely activity before instrument, it is impossible to limit animal behavior.This
Kind design cause animal make a response before and after be in relatively uncontrolled state, therefore can not be used for study limb motion, eye
Dynamic or record brain neural signal.With the development of scientific research, the requirement to assay reproducibility, accuracy and data dimension is got over
Come higher.Exploitation is accomplished by a kind of with the Cognitive Study system of substantially stationary non-human primates body position to be easy to limbs
Motion, eye be dynamic or record of brain neural signal.
The information for being disclosed in the background section is merely intended to understanding of the increase to the general background of the present invention, without answering
When the prior art for being considered as recognizing or implying the information structure in any form well known to persons skilled in the art.
The content of the invention
It is an object of the invention to provide a kind of simple and reasonable non-human primates vision and Cognitive Function Research system
System, the non-human primates vision and Cognitive Function Research system result in stable animal position, and then extract animal eyeball
The characteristic vector and experimental animal cognitive ability parameter of the direction of motion, interaction dimension is high, integration degree is high, test accuracy and effect
Rate is high.
To achieve the above object, the invention provides a kind of non-human primates vision and Cognitive Function Research system, including：
Fixing seat, including：Seat, collar fixed system, waist restriction plate and touch panel device portal frame, the collar fix system
System is arranged on above the seat of the seat, and the waist restriction plate is arranged in the middle part of the backrest of seat；The touch panel device
Portal frame is arranged in front of the backrest of seat；Water supply system, including：Bucket, electronics water valve and NI capture cards, the bucket lead to
The side that support is arranged on the fixed seat is crossed, the electronics water valve is arranged on the delivery port of the bucket, for controlling to give
Water and water；Touch panel device, with sound carries out acoustic stimuli and the visual stimulus of presentation image is touched for can play
Screen；Eye tracker device, including：Infrared camera and infrared lamp, eye tracker body and interactive module, wherein, infrared camera and
Infrared lamp is connected as eye tracker collection terminal with eye tracker body, and infrared camera and infrared lamp are used to detect ocular movemeut；
Eye tracker body is used for the eye movement for controlling, recording and exporting；And control device, including：NI collections card module, touch-screen
The NI capture cards of module, eye tracker module and task module, the NI collection card modules and water supply system are connected；The touch-screen
Module is connected with touch panel device；The eye tracker module is connected with the interactive module of eye tracker device；The task module point
It is not connected with NI collections card module, touch screen module and eye tracker module.
Preferably, in above-mentioned technical proposal, fixing seat also includes：It is arranged on the closure fence of the seat the week side of boss.
Preferably, in above-mentioned technical proposal, the delivery port of bucket is connected with the metallic water pipe of anti-bite, anti-suction.
Preferably, in above-mentioned technical proposal, control device also includes：As a result output module, for recording experimental result.
Compared with prior art, the present invention has the advantages that：The non-human primates vision and Cognitive Function Research
System results in stable animal position, and then extracts the characteristic vector and the cognitive energy of experimental animal of the animal eyeball direction of motion
Force parameter, interaction dimension is high, integration degree is high, and test accuracy and efficiency are high.
Brief description of the drawings
Fig. 1 is the non-human primates vision of the present invention and the structure chart of Cognitive Function Research system.
Fig. 2 is the non-human primates vision of the present invention and the schematic diagram of Cognitive Function Research system.
Fig. 3 is the non-human primates vision of the present invention and the operational flowchart of Cognitive Function Research system.
Fig. 4 is the flow chart of the non-human primates vision and Cognitive Function Research system of the present invention.
Embodiment
Below in conjunction with the accompanying drawings, the embodiment to the present invention is described in detail, it is to be understood that the guarantor of the present invention
Shield scope is not limited by embodiment.
Explicitly indicated that unless otherwise other, otherwise in entire disclosure and claims, term " comprising " or its change
Change such as "comprising" or " including " etc. and will be understood to comprise stated element or part, and do not exclude other members
Part or other parts.
As shown in figure 1, according to the non-human primates vision of the specific embodiment of the invention and Cognitive Function Research system bag
Include：Fixing seat 1, water supply system, touch panel device 3, eye tracker device 4 and control device 5.Wherein, fixing seat 1 is used for solid
Determine neck neck, waist and belly and the head of non-human primate 6；Water supply system is used to give the drinking-water prize of non-human primate 6
Encourage；Touch panel device 3 is used to vision and acoustic stimuli is presented to non-human primate, and can perceive animal touch location；Eye
Dynamic instrument apparatus 4 is used to follow the trail of and records the eye movement of non-human primate bilateral and blink information；Control device 5 is used to set
Visual stimulus relevant parameter is simultaneously recorded to touch-screen result.The non-human primates vision and Cognitive Function Research system can
Stable animal position, and then the characteristic vector and experimental animal cognitive ability parameter of the extraction animal eyeball direction of motion are obtained,
Interaction dimension is high, integration degree is high.
Specifically, fixing seat 1 includes：Seat, collar fixed system, waist restriction plate, portal frame and closure are enclosed
Column.Wherein, the height adjustable of seat, the sitting posture for coordinating non-human primate；Collar fixed system is arranged on seat
Above seat, the neck for fixing non-human primate, its height adjustable, it is adaptable to which different building shape non-human primates are tested
Animal；Waist restriction plate is arranged in the middle part of the backrest of seat, and leg or mobile waist are lifted for limiting non-human primate；
Portal frame is arranged in front of the backrest of seat, and it is retractable structure, the touch-screen for placing touch panel device 3；Closure
Fence is arranged on the week side of boss of seat, for preventing non-human primate from touching the non-human primates vision and Cognitive Function Research
The circuit of system.
Water supply system includes：Bucket, electronics water valve 21, metallic water pipe and NI capture cards 22.Wherein, bucket is set up by branch
Put in the side of fixing seat 1, for storing water, the delivery port of bucket is connected with the metallic water pipe of anti-bite, anti-suction；Electronics water valve
21 are arranged on the delivery port of bucket, for controlling feedwater and water.
Touch panel device 3, which has, to be used to can play sound progress acoustic stimuli and the visual stimulus touch of image is presented
Screen, the visual stimulus touch-screen is subjected to animal and touches feedback.Touch panel device 3 is arranged on the 50cm apart from the positive front upper place of animal
Place, sample frequency is 120Hz.
Eye tracker device 4 includes：Infrared camera and infrared lamp, eye tracker body and interactive module, wherein, infrared photography
Head and infrared lamp are connected as eye tracker collection terminal with eye tracker body, and infrared camera and infrared lamp are used to detect that eyeball is lived
Dynamic；Eye tracker body is used for the eye movement for controlling, recording and exporting；Interactive module is used to interact with control device 5.
With reference to Fig. 2 as can be seen that control device 5 includes：NI collections card module, touch screen module, eye tracker module, task
Module and result output module, wherein, the NI capture cards 22 of NI collection card modules and water supply system are connected, for NI capture card numbers
According to collection and control；Touch screen module is connected with touch panel device 3, the touch of the touch-screen for obtaining touch panel device 3
Position and state；Eye tracker module is connected with the interactive module of eye tracker device 4, collection for eye movement data, is calibrated and is chased after
Track；Task module is connected with NI collections card module, touch screen module and eye tracker module respectively, for controlling vision or cognitive
Business, the task module can show that touch location, eye move position in real time during system use in second piece of display split screen display available
Put and the information such as experiment number；As a result output module is used to record experimental result, and the result output module can be by the row that recorded
It is output to learn result with txt forms in specified path file.
As shown in figure 3, in use, suitable position will be adjusted to for the touch panel device that visual stimulus is presented to animal
Put, it is fixed.
In this example, the refreshing frequency of the visual stimulus touch-screen of touch panel device 3 is 60Hz, and target goes out active context
Color is black, and aiming pip is white, and brightness decays from center to surrounding in Gaussian curve.It is real in the other application of the system
In example, screen color and color of object can change according to practical study purpose.Screen display other colors, size, time
Length is also understood to belong to scope of protection of the present invention.
Experimental animal is positioned in fixing seat, neck is fixed, seat position is adjusted according to animal size.Fixed waist
Restriction plate, limitation animal lift leg.
As shown in Figure 4：
S1, open system, into program.
Entrance program in S1 includes, and opens master control programme, opens eye tracker module.
S2, opening front end, front end is mainly used in primate touch screen and used.
S3, into parameter selection, the adjustment grey screen time is 1 second, and delay is 1 second after touch screen, and 1 radius of point is set to 0.3, point 2
Radius 0.1~0.5, the feedwater time of brightness range 1~240 is 0.1 second, and it is successfully to choose size the greater.
S4, it can be carried out selecting bright spot comparison pattern in different model selections, this example according to test mission.
Parameter, which preserves to finish, exits into beginning experimental stage S5, experimentation as shown in Figure 4.
Experimental stage can provide different training modes according to different patterns, while Background control interface can show correspondence
The closing situation and pull bar state of the state of hardware system, such as magnet valve water system be up and down or left and right status information,
To adapt to the otherness of different experiments animal cognition ability, all parameters can be adjusted, and such as increase 2 sizes
Otherness shortens grey screen time etc..
In experimentation, it should be noted that avoid the influence to animal attraction such as the artificial sound, motion as far as possible, so as to reduce and be
System service efficiency.
S6, the total degree of middle control software display training and success rate, all results can generate .txt formatted files
It is stored in specified path；Finally termination test can be selected according to the demand of tested number, switch new pattern.
After S6, end experiment, experimental result is recorded, and by between experimental animal taking-up return raising, complete test process.
Above-mentioned experiment model can determine that the luminous point that subject animal vision is perceived is big using Animal Behavior Science detection mode
Small and position, is that the scientific research of non-human primates visually-perceptible proposes important evidence.
To sum up, the non-human primates vision and Cognitive Function Research system result in stable animal position, Jin Erti
The characteristic vector and experimental animal cognitive ability parameter of the animal eyeball direction of motion are taken, interaction dimension is high, integration degree is high, examination
Test precision and efficiency is high.
It is foregoing to the present invention specific illustrative embodiment description be in order to illustrate and illustration purpose.These descriptions
It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to above-mentioned teaching, can be much changed
And change.The purpose of selecting and describing the exemplary embodiment is that explaining that the certain principles and its reality of the present invention should
With so that those skilled in the art can realize and using the present invention a variety of exemplaries and
A variety of selections and change.The scope of the present invention is intended to be limited by claims and its equivalents.
Claims (4)
1. a kind of non-human primates vision and Cognitive Function Research system, it is characterised in that including：
Fixing seat, including：Seat, collar fixed system, waist restriction plate and touch panel device portal frame, the collar are consolidated
Determine system to be arranged on above the seat of the seat, the waist restriction plate is arranged in the middle part of the backrest of seat；The touch-screen
Device portal frame is arranged in front of the backrest of seat；
Water supply system, including：Bucket, electronics water valve and NI capture cards, the bucket are arranged on the fixed seat by support
Side, the electronics water valve is arranged on the delivery port of the bucket, for controlling feedwater and water；
Touch panel device, with the visual stimulus touch-screen that acoustic stimuli and presentation image are carried out for can play sound；
Eye tracker device, including：Infrared camera and infrared lamp, eye tracker body and interactive module, wherein, infrared camera and
Infrared lamp is connected as eye tracker collection terminal with eye tracker body, and infrared camera and infrared lamp are used to detect ocular movemeut；
Eye tracker body is used for the eye movement for controlling, recording and exporting；And
Control device, including：NI collections card module, touch screen module, eye tracker module and task module, the NI gather snap gauge
Block and the NI capture cards of water supply system are connected；The touch screen module is connected with touch panel device；The eye tracker module and eye
The interactive module connection of dynamic instrument apparatus；The task module gathers card module, touch screen module and eye tracker module with NI respectively
Connection.
2. non-human primates vision according to claim 1 and Cognitive Function Research system, it is characterised in that the fixation
Seat also includes：It is arranged on the closure fence of the seat the week side of boss.
3. non-human primates vision according to claim 1 and Cognitive Function Research system, it is characterised in that the bucket
Delivery port be connected with the metallic water pipe of anti-bite, anti-suction.
4. non-human primates vision according to claim 1 and Cognitive Function Research system, it is characterised in that the control
Device also includes：As a result output module, for recording experimental result.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710301055.XA CN107041322A (en) | 2017-05-02 | 2017-05-02 | Non-human primates vision and Cognitive Function Research system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710301055.XA CN107041322A (en) | 2017-05-02 | 2017-05-02 | Non-human primates vision and Cognitive Function Research system |
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| Publication Number | Publication Date |
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| CN107041322A true CN107041322A (en) | 2017-08-15 |
Family
ID=59546228
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710301055.XA Pending CN107041322A (en) | 2017-05-02 | 2017-05-02 | Non-human primates vision and Cognitive Function Research system |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107411762A (en) * | 2017-08-31 | 2017-12-01 | 杭州极智医疗科技有限公司 | Cognitive disorder diagnostic equipment |
| CN109566447A (en) * | 2018-12-07 | 2019-04-05 | 中国人民解放军军事科学院军事医学研究院 | The research system of non-human primate movement and cognitive function based on touch screen |
| CN109924982A (en) * | 2017-12-19 | 2019-06-25 | 深圳先进技术研究院 | Eye movement detects cage |
| CN113439682A (en) * | 2021-06-07 | 2021-09-28 | 中国人民解放军军事科学院军事医学研究院 | Training device and method for intercepting three-dimensional moving target of primate |
| CN113519411A (en) * | 2020-04-13 | 2021-10-22 | 中国科学院脑科学与智能技术卓越创新中心 | Experiment or training device for magnetic resonance imaging of primates |
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| CN113519411B (en) * | 2020-04-13 | 2023-11-03 | 中国科学院脑科学与智能技术卓越创新中心 | Experimental or training device for primate magnetic resonance imaging |
| CN113439682A (en) * | 2021-06-07 | 2021-09-28 | 中国人民解放军军事科学院军事医学研究院 | Training device and method for intercepting three-dimensional moving target of primate |
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