CN103313707A - 二苯基-胺衍生物的用途、合成方法及药物组合物 - Google Patents
二苯基-胺衍生物的用途、合成方法及药物组合物 Download PDFInfo
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- CN103313707A CN103313707A CN2011800654202A CN201180065420A CN103313707A CN 103313707 A CN103313707 A CN 103313707A CN 2011800654202 A CN2011800654202 A CN 2011800654202A CN 201180065420 A CN201180065420 A CN 201180065420A CN 103313707 A CN103313707 A CN 103313707A
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
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- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
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- C07D473/32—Nitrogen atom
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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| EP10382314.2 | 2010-11-23 | ||
| EP10382314A EP2465498A1 (en) | 2010-11-23 | 2010-11-23 | Diphenyl-amine derivatives: uses, process of synthesis and pharmaceutical compositions |
| PCT/EP2011/070620 WO2012069442A1 (en) | 2010-11-23 | 2011-11-22 | Diphenyl-amine derivatives: uses, process of synthesis and pharmaceutical compositions |
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| CN103313707A true CN103313707A (zh) | 2013-09-18 |
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| WO2007117399A2 (en) | 2006-03-31 | 2007-10-18 | Janssen Pharmaceutica N.V. | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| JP6038882B2 (ja) * | 2011-04-20 | 2016-12-07 | マッパー・リソグラフィー・アイピー・ビー.ブイ. | 光ファイバの構成体及びこのような構成体を形成する方法 |
| PT2964229T (pt) | 2013-03-06 | 2020-03-23 | Janssen Pharmaceutica Nv | Moduladores de piridina benzimidazol-2-ilo do recetor h4 de histamina |
| KR101694318B1 (ko) * | 2014-10-02 | 2017-01-09 | 한국과학기술연구원 | 신규한 퓨린 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
Citations (1)
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| US7320993B1 (en) * | 1997-12-17 | 2008-01-22 | Astellas Deutschland Gmbh | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents |
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| GB682160A (en) * | 1948-10-18 | 1952-11-05 | Wellcome Found | Improvements in and relating to the preparation of substituted aminoalcohols, alkenylamines, aminoalkanes and quaternary salts thereof |
| CA2166100A1 (en) * | 1993-06-23 | 1995-01-05 | Richard A. Glennon | Sigma receptor ligands and the use thereof |
| US5795756A (en) | 1995-12-11 | 1998-08-18 | Johnson; Roger A. | Method and compounds for the inhibition of adenylyl cyclase |
| JP2000503315A (ja) * | 1996-01-20 | 2000-03-21 | ブラッドフォード・ユニバーシティ | タモキシフェンおよびその同族体 |
| RU2280645C2 (ru) | 2001-04-05 | 2006-07-27 | Сумитомо Кемикал Компани, Лимитед | Способ получения 2,6-дигалогенпурина |
| WO2005009348A2 (en) | 2003-06-25 | 2005-02-03 | Ariad Pharmaceuticals, Inc. | Substituted purine derivatives |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7320993B1 (en) * | 1997-12-17 | 2008-01-22 | Astellas Deutschland Gmbh | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents |
Non-Patent Citations (3)
| Title |
|---|
| ANDREA KRAGLER,ET AL.: "Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》 * |
| FULVIO GUALTIERI,ET AL.: "SAR Studies in the Field of Calcium(I1) Antagonists. Effect of Modifications at the Tetrasubstituted Carbon of Verapamil-like Compounds", 《J.MED.CHEM.》 * |
| P CALDIROLA,ET AL.: "New prenylamine-analogues:investigations of their influence on calcium-dependent biological systems", 《EUR J MED CHEM》 * |
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| US20130296346A1 (en) | 2013-11-07 |
| CL2013001445A1 (es) | 2014-03-28 |
| SA111320943B1 (ar) | 2014-12-09 |
| MA34746B1 (fr) | 2013-12-03 |
| WO2012069442A1 (en) | 2012-05-31 |
| JP2014505662A (ja) | 2014-03-06 |
| ZA201303692B (en) | 2014-07-30 |
| RU2013128602A (ru) | 2014-12-27 |
| CO6771413A2 (es) | 2013-10-15 |
| EP2465498A1 (en) | 2012-06-20 |
| KR20130121888A (ko) | 2013-11-06 |
| BR112013012665A2 (pt) | 2016-09-06 |
| EP2642987A1 (en) | 2013-10-02 |
| MX2013005761A (es) | 2013-09-26 |
| UY33745A (es) | 2012-06-29 |
| AU2011333887A1 (en) | 2013-07-04 |
| CA2818842A1 (en) | 2012-05-31 |
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