CN103285949A - Micro-fluidic serum extracting chip - Google Patents
Micro-fluidic serum extracting chip Download PDFInfo
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- CN103285949A CN103285949A CN2013102036681A CN201310203668A CN103285949A CN 103285949 A CN103285949 A CN 103285949A CN 2013102036681 A CN2013102036681 A CN 2013102036681A CN 201310203668 A CN201310203668 A CN 201310203668A CN 103285949 A CN103285949 A CN 103285949A
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Abstract
The invention aims to provide a micro-fluidic serum extracting chip. The chip is formed by a blood sample introduction pool, a micro channel, a serum separation chamber and a sample collecting pool, wherein the interior of the serum separation chamber is filled with two kinds of micro balls with different hole diameters. The operating principle of the chip is as follows: the whole blood is added from a sample introduction port, the blood sample flows through the serum separation chamber along the micro channel under the action of surface tension or certain negative pressure, hemocytes are intercepted by a micro ball structure, and the serum flows out from ventages among the micro balls, and finally enters the sample collecting pool. The chip provided by the invention can be used for rapidly extracting the serum on line, the operation is simple and convenient, the separation efficiency is high, and the further integration with other operation units is easy to realize.
Description
Technical field
The present invention relates to a kind of micro-fluidic chip, particularly relate to a kind of serum and extract chip.
Background technology
Based on for example biochemical medicine detection of blood, urine and saliva of human body fluid, can provide the important information of reaction health of people state.At present, blood testing is pattern detection the most widely in biomedicine, clinical diagnosis, the health quarantine diagnosis, but there is very big interference in erythrocytic existence to the spectrum analysis in the blood testing, therefore how to isolate focus and difficult point problem that serum is blood testing research always quickly and easily from whole blood.
At present, most hospitals and laboratory also are to use large-scale centrifuge separation of serum and haemocyte, the method need extract the blood sample of ml vol in patient's body, and really for detection of sample tens of and even number microlitres only, cause a large amount of wastes of sample; And this type of centrifugation apparatus volume is big, complicated in mechanical structure, serum separation process and detection are separately independently to carry out, easily cause loss and the pollution of blood sample, be not suitable for the integrated of clinical diagnosis and miniature analytical system, can not satisfy the needs of micro-full analytical system development in the medical diagnosis, therefore be necessary to develop a kind of new differential from technology.
In recent years, the micro-fluidic chip technology had obtained in fields such as biology, chemistry, medical science to study widely and use.Because distinguishing feature such as have material cost and low processing cost, be fit to produce in batches, design philosophy is flexible and changeable, disposable micro-fluidic chip is highly suitable for medical instruments field.At present, on the micro-fluidic chip platform, low sample consumption, high flux, biochemical medical treatment detection have fast immediately been realized, if the functional unit that can further serum be separated is integrated on micro-fluidic chip, then can really bring into play the micro-fluidic chip micro-and the evaluating objects of " entirely ", this has extremely important science and application value for the realization of " chip lab ".
Summary of the invention
At the weak point of above-mentioned present serum separating and extracting process, the objective of the invention is to propose a kind of micro-fluidic serum and extract chip, this chip is made of blood sample inlet pool, microchannel, serum split cavity and sample collection pond.
Micro-fluidic serum provided by the present invention extracts chip, and the material that described serum extracts chip is glass, silicon, quartz, Merlon, polymethyl methacrylate, dimethyl silicone polymer etc.
Micro-fluidic serum provided by the present invention extracts chip, it is characterized in that, runs through connection by the microchannel between described blood sample inlet pool, serum split cavity and the sample collection pond.
Micro-fluidic serum provided by the present invention extracts chip, and described serum split cavity inside is filled with two kinds of microballoons of different pore sizes, and particle diameter is 10～200 microns.Micro-sphere material can be high molecular polymers such as Merlon, polyethylene, also can be inorganic compounds such as glass, silica.
Micro-fluidic serum provided by the present invention extracts chip, described microchannel width and the degree of depth are 50～500 microns, the microchannel width and the degree of depth that wherein connect serum split cavity downstream should be restricted in the serum split cavity to guarantee microballon less than the size of microballon.
Micro-fluidic serum provided by the present invention extracts chip, its principle is: whole blood is added from injection port, the blood sample serum split cavity of flowing through in surface tension or certain microchannel, suction function lower edge, haemocyte is held back by micro-sphere structure, serum then flows out from the hole between microballoon, enters the sample collection pond at last.
Micro-fluidic serum provided by the present invention extracts chip, can carry out the extraction of serum online, rapidly, and is easy and simple to handle, separative efficiency is high, be easy to realize and other operating unit further integrated.
Description of drawings
Fig. 1. a kind of micro-fluidic serum provided by the invention extracts the structural representation of chip.Wherein, A is injection port; B is the microchannel; C is the serum split cavity; D is the sample collection pond; E is the small particle diameter microballon; The big particle diameter microballon of F.
Specific embodiments
The following examples will give further instruction to the present invention in conjunction with Figure of description.
1 one kinds of polymethyl methacrylate serum of embodiment extract chip
As shown in Figure 1, a kind of serum provided by the invention extracts chip, is made up of sample inlet pool A, microchannel B, serum split cavity C, sample collection pond D, wherein is filled with two kinds of glass microballoons (particle diameter is respectively 20 μ m and 100 μ m) in the serum split cavity.Chip material is polymethyl methacrylate, adopts CNC Digit Control Machine Tool Precision Machining to go out each micro-structural, and the width of microchannel and the degree of depth are 80 μ m, and chip adopts pressure sintering to carry out involution at last.
The serum separating step is as follows: whole blood is added from sample inlet pool, and blood sample is at capillary force or necessarily the dirty menses sorting of suction function is from chamber, and haemocyte is trapped at front end, and serum then flows out from the hole between microballon, enters the sample collection pond at last.Use this serum to extract chip, can in 3min, be prepared into the blood serum sample of about 3 μ L.
2 one kinds of dimethyl silicone polymer serum of embodiment extract chip
As shown in Figure 1, a kind of serum provided by the invention extracts chip, is made up of sample inlet pool A, microchannel B, serum split cavity C, sample collection pond D, wherein is filled with two kinds of glass microballoons (particle diameter is respectively 15 μ m and 120 μ m) in the serum split cavity.Chip material is dimethyl silicone polymer, adopts and processes micro-structural based on photoetching die casting polymerization, and the width of microchannel and concentration are 100 μ m, adopt irreversible involution at last.
The serum separating step is as follows: whole blood is added from sample inlet pool, and blood sample is at capillary force or necessarily the dirty menses sorting of suction function is from chamber, and haemocyte is trapped at front end, and serum then flows out from the hole between microballon, enters the sample collection pond at last.Use this serum to extract chip, can in 3min, be prepared into the blood serum sample of about 5 μ L.
Adopt serum provided by the present invention to extract chip and carry out the extraction of serum, equipment is simple, easy and simple to handle, separative efficiency is high.And this device can integrate with follow-up biochemistry detection analysis at an easy rate, realizes full-automatic, high-throughout biochemistry detection, has extremely important practical value.
Claims (8)
1. a micro-fluidic serum extracts chip, it is characterized in that this micro-fluidic chip is made of blood sample inlet pool, microchannel, serum split cavity and sample collection pond.
2. extract chip according to the described a kind of micro-fluidic serum of claim 1, it is characterized in that the material that described serum extracts chip is glass, silicon, quartz, Merlon, polymethyl methacrylate, dimethyl silicone polymer etc.
3. extract chip according to the described a kind of micro-fluidic serum of claim 1, it is characterized in that, run through connection by the microchannel between described blood sample inlet pool, serum split cavity and the sample collection pond.
4. extract chip according to the described a kind of micro-fluidic serum of claim 1, it is characterized in that described serum split cavity inside is filled with two kinds of microballoons of different pore sizes, particle diameter is 10～200 microns.
5. extracting chip according to claim 1 and 4 described a kind of micro-fluidic serum, it is characterized in that described micro-sphere material can be high molecular polymers such as Merlon, polyethylene, also can be inorganic compounds such as glass, silica.
6. extract chip according to the described a kind of micro-fluidic serum of claim 1, it is characterized in that, described microchannel width and the degree of depth are 50～500 microns, the microchannel width and the degree of depth that wherein connect serum split cavity downstream should be restricted in the serum split cavity to guarantee microballon less than the size of microballon.
7. extract chip according to the described a kind of micro-fluidic serum of claim 1, it is characterized in that, described serum extracting method, its principle is: whole blood is added from injection port, the blood sample serum split cavity of flowing through in surface tension or certain microchannel, suction function lower edge, haemocyte is held back by micro-sphere structure, and serum then flows out from the hole between microballoon, enters the sample collection pond at last.
8. extract chip according to the described a kind of micro-fluidic serum of claim 1, can carry out the extraction of serum online, rapidly, easy and simple to handle, separative efficiency is high, be easy to realize and other operating unit further integrated.
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| CN2013102036681A CN103285949A (en) | 2013-05-27 | 2013-05-27 | Micro-fluidic serum extracting chip |
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