CN103272115B

CN103272115B - Preparation for treating purpura

Info

Publication number: CN103272115B
Application number: CN201310236040.1A
Authority: CN
Inventors: 张祺
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-06-17
Filing date: 2013-06-17
Publication date: 2014-07-09
Anticipated expiration: 2033-06-17
Also published as: CN103272115A

Abstract

The invention relates to a preparation for treating purpura. The preparation comprises substances in parts by weight as follows: 10-30 parts of radix rehmanniae, 10-30 parts of red peony roots, 1-20 parts of angelica sinensis, 10-30 parts of ligusticum wallichii, 10-30 parts of codonopsis pilosula, 10-30 parts of white atractylodes rhizome, 10-30 parts of poria cocos, 1-20 parts of liquorice, 10-30 parts of salvia miltiorrhiza, 1-20 parts of cortex moutan radicis, 10-30 parts of lithospermum, 10-30 parts of rhizoma dioscoreae nipponicae, 1-20 parts of pseudo-ginseng, 1-20 parts of periostracum cicada, 1-20 parts of bulbus fritillariae cirrhosae, 15-90 parts of honeysuckles, 10-30 parts of fructus kochiae and 10-30 parts of radix scrophulariae. The preparation for treating the purpura has the characteristics as follows: the cost is low, the preparation is easy to prepare, toxic and side effects are small, and the curative effect is remarkable.

Description

A kind of medicament for the treatment of purpura

Technical field

The present invention relates to tcm field, specifically, relate to a kind of medicament for the treatment of purpura.

Background technology

Henoch Schonlein purpura nephritis is the common type of anaphylactoid purpura, the doctor trained in Western medicine unified therapeutic scheme of nothing temporarily at present, although application glucocorticoid and immunosuppressant rear section case can obtain curative effect, and the little satisfaction of effect, and side effect is obvious.Therefore, actively seek this sick effective formula and drug of Chinese traditional treatment.Chinese medicine is by categories such as henoch Schonlein purpura nephritis ownership " purpura ", " hematuria ", " edema "; Heat is held the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, and the yin collaterals of burning is its main pathogenesis

Summary of the invention

The object of this invention is to provide a kind of medicament for the treatment of purpura.

In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of purpura, the material that it comprises following weight proportioning: Radix Rehmanniae 10-30 part, Radix Paeoniae Rubra 10-30 part, Radix Angelicae Sinensis 1-20 part, Rhizoma Chuanxiong 10-30 part, Radix Codonopsis 10-30 part, Rhizoma Atractylodis Macrocephalae 10-30 part, Poria 10-30 part, Radix Glycyrrhizae 1-20 part, Radix Salviae Miltiorrhizae 10-30 part, Cortex Moutan 1-20 part, Radix Arnebiae (Radix Lithospermi) 10-30 part, Rhizoma Dioscoreae Nipponicae 10-30 part, Radix Notoginseng 1-20 part, Periostracum Cicadae 1-20 part, Bulbus Fritillariae Cirrhosae 1-20 part, Flos Lonicerae 15-90 part, Fructus Kochiae 10-30 part and Radix Scrophulariae 10-30 part.

Preferably, the kit for the treatment of of the present invention purpura is containing the material of following weight proportioning: 15 parts of 15 parts, the Radix Rehmanniae, 15 parts of Radix Paeoniae Rubra, 9 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiongs, 15 parts of Radix Codonopsis, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts, Poria, 9 parts, Radix Glycyrrhizae, 15 parts of Radix Salviae Miltiorrhizaes, 6 parts of Cortex Moutans, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Rhizoma Dioscoreae Nipponicae, 9 parts of Radix Notoginseng, 9 parts of Periostracum Cicadaes, 5 parts of Bulbus Fritillariae Cirrhosaes, 60 parts of Flos Loniceraes, 15 parts of the Fructus Kochiae and Radix Scrophulariaes.

More preferably, the medicament for the treatment of of the present invention purpura also comprises the material of following weight proportioning: 5 parts of 5 parts of Fructus Broussonetiaes, 6 parts of 3 parts of, Herba Thlaspiss of RADIX PEUCEDANI, 5 parts of Rhizoma Smilacis Chinensiss, 7 parts of Herba Cichoriis, Rhizoma Dioscoreae Septemlobae 46 parts of Fen, Herba Siegesbeckiaes, 3 parts of Herba Gendarussaes, 5 parts of Cortex Syingae Amurensiss, 3 parts of Herba pterocephali, 3 parts of Nodus Nelumbinis Rhizomatis, 7 parts of Medulla Stachyuri (Medulla Helwingiae)s, 4 parts of Flos Bombacis Malabaricis, 5 parts of Concha Arcaes, 3 parts of Caulis Mahoniaes, 6 parts of Folium Sauropis, 7 parts of Semen Lablab Albums, 3 parts of Retinervus Luffae Fructuss, 5 parts of Herba Polygoni cymosis, 3 parts of Semen Celosiae and Fructus Litseae.

More preferably, described medicament can be tablet, dispersible tablet, powder or capsule.

The medicament for the treatment of purpura of the present invention has the advantages that cost is low, preparation is easy, toxic and side effects is little, curative effect is showing.

The specific embodiment

Embodiment 1:

Take 150 grams of 150 grams, the Radix Rehmanniae, 150 grams of Radix Paeoniae Rubra, 90 grams of Radix Angelicae Sinensis, 150 grams of Rhizoma Chuanxiongs, 150 grams of Radix Codonopsis, 150 grams of the Rhizoma Atractylodis Macrocephalaes, 150 grams, Poria, 90 grams, Radix Glycyrrhizae, 150 grams of Radix Salviae Miltiorrhizaes, 60 grams of Cortex Moutans, 150 grams of Radix Arnebiae (Radix Lithospermi)s, 150 grams of Rhizoma Dioscoreae Nipponicae, 90 grams of Radix Notoginseng, 90 grams of Periostracum Cicadaes, 50 grams of Bulbus Fritillariae Cirrhosaes, 600 grams of Flos Loniceraes, 150 grams of the Fructus Kochiae and Radix Scrophulariaes, pulverize, cross 80 mesh sieves.Add 340 grams of sucrose, mix homogeneously, then divides and installs in 100 bags, obtains powder of the present invention.

Embodiment 2:

Take 150 grams, the Radix Rehmanniae, 150 grams of Radix Paeoniae Rubra, 90 grams of Radix Angelicae Sinensis, 150 grams of Rhizoma Chuanxiongs, 150 grams of Radix Codonopsis, 150 grams of the Rhizoma Atractylodis Macrocephalaes, 150 grams, Poria, 90 grams, Radix Glycyrrhizae, 150 grams of Radix Salviae Miltiorrhizaes, 60 grams of Cortex Moutans, 150 grams of Radix Arnebiae (Radix Lithospermi)s, 150 grams of Rhizoma Dioscoreae Nipponicae, 90 grams of Radix Notoginseng, 90 grams of Periostracum Cicadaes, 50 grams of Bulbus Fritillariae Cirrhosaes, 600 grams of Flos Loniceraes, 150 grams of the Fructus Kochiae, 150 grams of Radix Scrophulariaes, 50 grams of Fructus Broussonetiaes, 30 grams of RADIX PEUCEDANI, 60 grams of Herba Thlaspiss, 50 grams of Rhizoma Smilacis Chinensiss, 70 grams of Herba Cichoriis, 40 grams of Rhizoma Dioscoreae Septemlobaes, 60 grams of Herba Siegesbeckiaes, 30 grams of Herba Gendarussaes, 50 grams of Cortex Syingae Amurensiss, 30 grams of Herba pterocephali, 30 grams of Nodus Nelumbinis Rhizomatis, 70 grams of Medulla Stachyuri (Medulla Helwingiae)s, 40 grams of Flos Bombacis Malabaricis, 50 grams of Concha Arcaes, 30 grams of Caulis Mahoniaes, 60 grams of Folium Sauropis, 70 grams of Semen Lablab Albums, 30 grams of Retinervus Luffae Fructuss, 50 grams of Herba Polygoni cymosis, 50 grams of 30 grams of Semen Celosiae and Fructus Litseae, pulverize, cross 80 mesh sieves.Add 540 grams of sucrose, mix homogeneously, then divides and installs in 100 bags, obtains powder of the present invention.

Experimental example

40 examples are in my institute and are in hospital and out-patient, make a definite diagnosis according to nineteen ninety-five Second China National nephropathy meeting diagnostic criteria, except acute glomerulonephritis, lupus nephritis, acute pyelonephritis.Wherein male 20 examples, female's 20 examples; Age 16-56 year, 34 years old mean age; Course of disease 0.5-24 month, average 9.25 months; All there is skin purpura history; There are stomachache person's 5 examples, arthralgia person's 7 examples, edema of pair of lower extremities person 3 examples; Henoch Schonlein purpura nephritis time of occurrence is after purpura occurs, 1 thoughtful 2 months, and average 1.33 months; Urine protein+arriving +++, the full visual field of R-RBC 1-/HP, person's 3 examples that have cast.Be divided into two groups, every group of 20 routine patients, two groups are conveniently compared there was no significant difference (P > 0.05) in sex, age, the course of disease, state of an illness scoring etc., have comparability.

First group of powder prepared by the oral embodiment 1 of patient, every day three times, each oral 2 bags, treating 60 days is 1 course for the treatment of, treats 1 course for the treatment of.

Second group of powder prepared by the oral embodiment 2 of patient, every day three times, each oral 2 bags, treating 60 days is 1 course for the treatment of, treats 1 course for the treatment of.

Formulate criterion of therapeutical effect with reference to " guideline of clinical investigations of new Chinese medicine treatment chronic nephritis " in 2002 " new Chinese medicine guideline of clinical investigations " as follows:

Clinic control: urine protein turn out cloudy or twenty-four-hour urine protein quantification normal; 25/μ of Urine sediments analyzer RBC counting < l;

Effective: urine protein is turned out cloudy, twenty-four-hour urine protein quantification is normal; Or twenty-four-hour urine protein quantification reduces >=50%, Urine sediments analyzer RBC count check minimizing >=50%;

Effective: twenty-four-hour urine protein quantification reduces >=30% but < 50%; Urine sediments analyzer RBC counts minimizing >=30% but < 50%;

Invalid: clinical manifestation and lab testing improvement all do not reach effective standard or add severe one.

Therapeutic outcome

In first group of patient, clinic control: 8 examples, effective 7 examples, effective 5 examples; In second group of patient, clinic control: 16 examples, effective 4 examples.In observation, do not occur serious adverse reaction, after treatment finishes, two groups of patients' blood, urine, stool routine and hepatic and renal function inspection are showed no extremely.

Claims

1. treat the powder of purpura for one kind, it is characterized in that it makes by following method: take 150 grams, the Radix Rehmanniae, 150 grams of Radix Paeoniae Rubra, 90 grams of Radix Angelicae Sinensis, 150 grams of Rhizoma Chuanxiongs, 150 grams of Radix Codonopsis, 150 grams of the Rhizoma Atractylodis Macrocephalaes, 150 grams, Poria, 90 grams, Radix Glycyrrhizae, 150 grams of Radix Salviae Miltiorrhizaes, 60 grams of Cortex Moutans, 150 grams of Radix Arnebiae (Radix Lithospermi)s, 150 grams of Rhizoma Dioscoreae Nipponicae, 90 grams of Radix Notoginseng, 90 grams of Periostracum Cicadaes, 50 grams of Bulbus Fritillariae Cirrhosaes, 600 grams of Flos Loniceraes, 150 grams of 150 grams of the Fructus Kochiae and Radix Scrophulariaes, pulverize, cross 80 mesh sieves, add 340 grams of sucrose, mix homogeneously, then divide and install in 100 bags, obtain described powder, described powder every day three times, each oral 2 bags, treat 60 days is 1 course for the treatment of, treat 1 course for the treatment of.