CN111228443A

CN111228443A - Traditional Chinese medicine composition for treating purpura and preparation method thereof

Info

Publication number: CN111228443A
Application number: CN202010226040.3A
Authority: CN
Inventors: 林志武
Original assignee: Chengdu Southwest Traditional Chinese Medicine Hospital Co Ltd
Current assignee: Chengdu Southwest Traditional Chinese Medicine Hospital Co Ltd
Priority date: 2020-03-26
Filing date: 2020-03-26
Publication date: 2020-06-05

Abstract

The invention provides a traditional Chinese medicine composition for treating purpura and a preparation method thereof, and the composition is prepared from the following raw materials: 10 g of codonopsis pilosula, 15 g of astragalus membranaceus, 10 g of fried bighead atractylodes rhizome, 3 g of amber powder, 20 g of poria cocos, 10 g of angelica sinensis, 10 g of red peony root, 20 g of Chinese yam, 10 g of ligusticum wallichii, 10 g of lithospermum, 20 g of madder, 10 g of cornus officinalis, 10 g of cortex moutan, 20 g of salvia miltiorrhiza, 10 g of periostracum cicada, 10 g of radix curcumae, 15 g of radix rehmanniae, 15 g of pseudo-ginseng, 30g of lalang grass rhizome, 30g of cornu bubali, 15 g of cat claw, 15 g of schisandra chinensis, 20 g of agrimony, 20 g of field thistle, 10 g of raw hawthorn, 15 g of medicinal cyathula root, 6 g of prepared rhubarb, 30g of perfoliate knotweed, 10 g of pyrrosia leaf, 10 g of crinis carbonisatus. The traditional Chinese medicine is prepared from a plurality of traditional Chinese medicines, and has the advantages of mild drug effect, small side effect, safety, health, good curative effect and low price.

Description

Traditional Chinese medicine composition for treating purpura and preparation method thereof

Technical Field

The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating purpura and a preparation method thereof.

Background

Purpura, also known as purpura, is characterized by bleeding of blood under the skin and mucous membrane to produce ecchymosis. Purpura including allergic purpura and thrombocytopenic purpura of western medicine; the age of allergic purpura is 3-14 years, especially the school age is common for children, more men than women and more diseases in spring; the age of the thrombocytopenic purpura is 2-5 years old, the male and female diseases are not different, the mortality rate is about 1 percent, the main lethal factor is intracranial hemorrhage, the disease is more acute, and the bleeding is the main disease of the disease. Except purpura appearing on skin and mucosa, it is often accompanied by epistaxis, gingival hemorrhage, hematemesis, hematochezia, hematuria, etc. In severe bleeding, blood deficiency symptoms such as pale complexion, and even collapse can be seen. The existing medicines for treating purpura are not obvious enough in efficacy, and the medicines have large side effects, so that the health of people is harmed, and the purpura cannot be effectively treated.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide the traditional Chinese medicine composition for treating purpura and the preparation method thereof.

According to one aspect of the invention, the traditional Chinese medicine composition for treating purpura is characterized by comprising the following raw materials: 10 g of codonopsis pilosula, 15 g of astragalus membranaceus, 10 g of fried bighead atractylodes rhizome, 3 g of amber powder, 20 g of poria cocos, 10 g of angelica sinensis, 10 g of red peony root, 20 g of Chinese yam, 10 g of ligusticum wallichii, 10 g of lithospermum, 20 g of madder, 10 g of cornus officinalis, 10 g of cortex moutan, 20 g of salvia miltiorrhiza, 10 g of periostracum cicada, 10 g of radix curcumae, 15 g of radix rehmanniae, 15 g of pseudo-ginseng, 30g of lalang grass rhizome, 30g of cornu bubali, 15 g of cat claw, 15 g of schisandra chinensis, 20 g of agrimony, 20 g of field thistle, 10 g of raw hawthorn, 15 g of medicinal cyathula root, 6 g of prepared rhubarb, 30g of perfoliate knotweed, 10 g of pyrrosia leaf, 10 g of crinis carbonisatus.

The invention also provides a preparation method of the traditional Chinese medicine composition for treating purpura, which is characterized by comprising the following steps: weighing the raw material medicines according to a prescription, leaching with clear water to remove impurities, drying, grinding the dried raw material medicines into fine powder, uniformly mixing, adding a common carrier, and forming a preparation to obtain the pill.

Compared with the prior art, the invention has the following beneficial effects: the traditional Chinese medicine is prepared from a plurality of traditional Chinese medicines, has mild drug effect, small side effect, safety, health, good curative effect and low price, has obvious advantages in the aspects of consolidating the curative effect and reducing the toxic and side effect, and obtains more satisfactory effect clinically.

Detailed Description

The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.

The traditional Chinese medicine composition for treating purpura is prepared from the following raw materials: 10 g of codonopsis pilosula, 15 g of astragalus membranaceus, 10 g of fried bighead atractylodes rhizome, 3 g of amber powder, 20 g of poria cocos, 10 g of angelica sinensis, 10 g of red peony root, 20 g of Chinese yam, 10 g of ligusticum wallichii, 10 g of lithospermum, 20 g of madder, 10 g of cornus officinalis, 10 g of cortex moutan, 20 g of salvia miltiorrhiza, 10 g of periostracum cicada, 10 g of radix curcumae, 15 g of radix rehmanniae, 15 g of pseudo-ginseng, 30g of lalang grass rhizome, 30g of cornu bubali, 15 g of cat claw, 15 g of schisandra chinensis, 20 g of agrimony, 20 g of field thistle, 10 g of raw hawthorn, 15 g of medicinal cyathula root, 6 g of prepared rhubarb, 30g of perfoliate knotweed, 10 g of pyrrosia leaf, 10 g of crinis carbonisatus. The raw material medicaments used by the invention can be purchased from common traditional Chinese medicine stores, and the specification of the raw material medicaments meets the national traditional Chinese medicine standard.

The pharmacological analysis is as follows:

codonopsis pilosula: has effects of invigorating spleen, replenishing qi, invigorating spleen, and benefiting lung. Has effects in invigorating spleen, replenishing qi, quenching thirst, invigorating spleen, tonifying lung, nourishing blood, and promoting salivation. Can be used for treating deficiency of spleen-lung qi, anorexia, listlessness, cough, asthma, deficiency of qi and blood, sallow complexion, palpitation, short breath, thirst due to body fluid consumption, and internal heat.

Astragalus root: sweet in nature and taste, slightly warm in nature, and entering spleen and lung meridians, it is the key herb for tonifying qi.

Frying the bighead atractylodes rhizome: warm in nature, bitter and sweet in taste. To invigorate the spleen, replenish qi, dry dampness and induce diuresis.

Amber powder: tranquilizing, promoting urination, and promoting blood circulation.

Tuckahoe, poria cocos: sweet, bland and mild. It enters heart, lung, spleen and kidney meridians. Induce diuresis and drain dampness, benefit spleen and stomach, invigorate spleen and calm heart.

Chinese angelica: the book materia Medica is as follows: dang Gui is sweet and heavy in flavor, so it can tonify blood, and its qi is light and pungent, so it can also move blood, tonify middle energizer and move middle energizer, and is good at qi in blood and holy herb in blood.

Red peony root: bitter and slightly astringent taste and cool nature. Antibacterial, antiinflammatory, qi regulating, blood circulation promoting, blood cooling, hemostasis, tranquilizing, spasmolytic, and analgesic effects.

Chinese yam: sweet in flavor and neutral in nature. It enters spleen, lung and kidney meridians. Has effects in invigorating spleen and stomach, tonifying lung and kidney, invigorating spleen and replenishing qi, invigorating spleen, tonifying deficiency, invigorating kidney, replenishing vital essence, and tranquilizing mind.

Ligusticum wallichii: pungent flavor and warm nature. It enters liver, gallbladder and pericardium meridians. Promote blood circulation and move qi, dispel wind and alleviate pain.

Lithospermum: cold in nature, sweet and salty in flavor. It is used for cooling blood, promoting blood circulation, removing toxic substance and promoting eruption. Can be used for treating blood heat and toxic materials, macula purple black, measles without adequate eruption, pyocutaneous disease, eczema, and scald due to hot water and fire.

Madder root: is cold in nature and bitter in taste, enters heart and liver channels, and has the effects of promoting blood circulation, stopping bleeding, clearing and activating the channels and collaterals, relieving cough and eliminating phlegm.

Cornus officinalis: tonify liver and kidney, astringe essence and qi, and strengthen deficiency.

Cortex moutan: tranquilizing, cooling, antipyretic, analgesic, spasmolytic, and anti-atherosclerosis, diuresis, and antiulcer effects.

Red sage root: promoting blood circulation, dispelling blood stasis, dredging meridians, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood, and eliminating carbuncle.

Cicada shell: disperse wind-heat, promote eruption, relieve sore throat, remove nebula, improve eyesight, dispel wind and stop convulsion.

Turmeric root-tuber: pungent, bitter and cold. It enters liver, heart and lung meridians. Promoting blood circulation to arrest pain, promoting qi circulation to relieve depression, clearing away heart-fire, cooling blood, promoting bile flow, and eliminating jaundice.

Coptis chinensis: clear heat and dry dampness, purge fire and remove toxicity.

Gardenia: bitter, cold and non-toxic. Purging pathogenic fire and relieving restlessness; clearing heat and promoting diuresis; cool blood and remove toxicity.

Scutellaria baicalensis: contains baicalin and baicalein, has wide antibacterial spectrum, and has inhibitory effect on various bacteria, dermatophytes, leptospira, etc.

Radix rehmanniae: cold in nature, has the functions of cooling blood, clearing heat, nourishing yin, tonifying kidney, promoting the production of body fluid and quenching thirst.

Pseudo-ginseng: stopping bleeding, removing blood stasis, relieving inflammation and pain, and tonifying body.

Cogongrass rhizome: cool blood to stop bleeding, clear heat and induce diuresis.

Buffalo horn: clear heat, cool blood, arrest convulsion and remove toxicity.

Radix ranunculi ternati: detoxification; resolve phlegm and dissipate nodulation.

Schisandra chinensis: astringe lung, nourish kidney, promote fluid production, astringe sweat and astringe essence.

Agrimony: astringing to stop bleeding, diminishing inflammation, stopping dysentery, removing toxic substance, killing parasite, invigorating qi and tonifying heart.

Herba Cirsii: hemostasis, blood coagulation, antibacterial, anti-inflammatory and cardiovascular effects.

Raw hawthorn: promote digestion, invigorate stomach, promote qi circulation and dissipate blood stasis.

Radix cyathulae: dispel stasis, dredge meridians, dredge joints, induce diuresis and treat stranguria.

Preparing rhubarb: promoting diuresis, removing jaundice, clearing heat, relaxing bowels, removing toxic substance, and resolving carbuncle.

The lever plate is divided into: clear heat and remove toxicity, induce diuresis to alleviate edema, and relieve cough.

And (3) reed: induce diuresis to treat stranguria, clear lung-heat to relieve cough, cool blood to stop bleeding.

Carbonized human hair: astringe to stop bleeding, resolve blood stasis, induce diuresis.

Earthworm: clearing away heat, arresting convulsion, dredging meridians, relieving asthma, and promoting urination.

Charred lotus root and mustard: astringe to stop bleeding.

Charring the fineleaf schizonepeta herb: astringe to stop bleeding.

The preparation method comprises the following steps: weighing the raw materials according to a prescription, leaching with clear water to remove impurities, drying, grinding the dried raw materials into fine powder, uniformly mixing, adding a common carrier, and forming to obtain the pill. The taking method and the dosage of the invention are as follows: the dosage of the drug depends on the specific dosage form, and factors such as age, weight and health condition of the patient. And (3) use guidance: the pill is prepared by taking a dose of the medicines and preparing the pills, and 7 days is 1 course of treatment. It is preferably administered after heating or warming. Fishy and spicy taste is avoided during administration.

The composition of the invention is subjected to a large number of animal acute toxicity tests, animal long-term toxicity tests and a large number of clinical tests for treating diseases, and provides scientific and objective basis for the links of using the composition for treating diseases. The test method and the test result are respectively as follows:

1) animal acute toxicity tests were performed on the pills prepared in accordance with the present invention:

medicine preparation: the raw material medicaments used by the invention are purchased from a common traditional Chinese medicine store, and the specification of the raw material medicaments accords with the national traditional Chinese medicine standard.

Test animals: mice, weighing around 50g, were randomly selected for males and females and purchased from the market.

The method and the result are as follows: taking 50 mice, starving for about 20 hours, feeding 6 pills for each mouse per day for one week continuously, observing for 10 days, and ensuring that the mice normally move without toxic reaction and death. The oral liquid has no acute toxicity and safe clinical dosage.

2) Animal long-term toxicity tests were performed on the pills prepared according to the invention:

test animals: the white rats with the body weight of 120-130g were randomly selected and purchased from the market.

The method and the result are as follows: 20 rats are taken and divided into 2 groups, each group comprises 10 rats, wherein the 1 st group is taken as an administration group, 4 rats are fed with pills each day, the 2 nd group is normally fed as a control group, the rats are fed once a day and continuously fed for 90 days, the body weight is measured, the rats are killed after being broken 24 hours after the last administration, the blood, urine, liver and kidney functions are measured, the heart, kidney and other internal organs are taken, the change of tissue morphology is observed, the effect of dosage is observed, the change of diet and activity is observed, and experiments prove that the administration group and the control group have no obvious change and have no toxic reaction, so the rat liver-kidney-nourishing oral liquid is a safe medicine.

And (3) clinical diagnosis: allergic constitution or more certain allergen triggering; punctate or plaque bleeding can be seen on the whole body or limbs, and the bleeding attacks are repeated; or the bleeding spots are slightly higher than the skin, and the color is bright red or dark red, and the skin is slightly itchy and can be accompanied with symptoms of abdominal pain or joint pain and the like; headache, coma, hematochezia and hematuria can occur in severe cases. The treatment method comprises the following steps: according to the medicine proportion, raw materials (one dose) are weighed, pills are obtained according to a common preparation method, 2 pills are taken every day, the pills are taken in the morning and at night, 7 days are taken as a treatment course, the shortest treatment course is 2 treatment courses, and the longest treatment course is 6 treatment courses. And (3) judging the curative effect: and (3) healing: the purpura is completely removed, gastrointestinal tract symptoms are completely eliminated, and joint swelling and pain are eliminated; the method has the following advantages: most purpura disappear, gastrointestinal symptoms are basically controlled, and joint swelling and pain are improved; and (4) invalidation: after treatment, symptoms and signs are not changed compared with before treatment.

Case 1

Ding X, male, Anhui, 45 years old, 1 year purpura, abdominal pain, and hematochezia in severe cases, and the disease does not occur after the medicine is taken for three months (three months is a treatment course).

Case 2

Plum X, female, Jiangsu people, 30 years old, epilepsy for 2 years, appearing hematuria or microscopic hematuria, proteinuria and tubiform urine, after taking the medicine for six months, the symptoms disappear, and the physique is obviously improved.

Case 3

Yang XX, female, 25 years old, epilepsy for 3 years, bleeding spots appear on the arms, even large ecchymosis, after nine months of taking the medicine of the invention, the symptom disappears, the physique is obviously improved.

The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes and modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention.

Claims

1. A traditional Chinese medicine composition for treating purpura is characterized by comprising the following raw materials: 10 g of codonopsis pilosula, 15 g of astragalus membranaceus, 10 g of fried bighead atractylodes rhizome, 3 g of amber powder, 20 g of poria cocos, 10 g of angelica sinensis, 10 g of red peony root, 20 g of Chinese yam, 10 g of ligusticum wallichii, 10 g of lithospermum, 20 g of madder, 10 g of cornus officinalis, 10 g of cortex moutan, 20 g of salvia miltiorrhiza, 10 g of periostracum cicada, 10 g of radix curcumae, 15 g of radix rehmanniae, 15 g of pseudo-ginseng, 30g of lalang grass rhizome, 30g of cornu bubali, 15 g of cat claw, 15 g of schisandra chinensis, 20 g of agrimony, 20 g of field thistle, 10 g of raw hawthorn, 15 g of medicinal cyathula root, 6 g of prepared rhubarb, 30g of perfoliate knotweed, 10 g of pyrrosia leaf, 10 g of crinis carbonisatus.

2. A preparation method of a traditional Chinese medicine composition for treating purpura is characterized by comprising the following steps: weighing the raw material medicaments as claimed in claim 1 according to a prescription, leaching with clear water to remove impurities, drying, grinding the dried raw material medicaments into fine powder, uniformly mixing, adding a common carrier, and forming the preparation to obtain the pill.