CN103272109B

CN103272109B - Agent for curing brain cancer

Info

Publication number: CN103272109B
Application number: CN201310241277.9A
Authority: CN
Inventors: 黄禀檐
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-06-19
Filing date: 2013-06-19
Publication date: 2014-07-09
Anticipated expiration: 2033-06-19
Also published as: CN103272109A

Abstract

The invention relates to an agent for curing brain cancer. The agent contains the following materials in ratio by weight: 20-25 parts of rhizoma arisaematis, 50-70 parts of geum japonicum thumnb, 12-15 parts of paris polyphylla, 20-25 parts of forsythia suspense, 20-30 parts of selfheal, 20-25 parts of root of rehmannia, 20-25 parts of cudrania cochinchinensis kudo et masam, 15-21 parts of Chinese yam, 20-15 parts of dragon bone, 20-30 parts of walnut kernel and 15-20 parts of pinellia ternate. The agent for curing the brain cancer has the characteristics of low cost, easy preparation, small toxic and side effects and significant effect.

Description

A kind of medicament for the treatment of the brain cancer

Technical field

The present invention relates to tcm field, specifically, relate to a kind of medicament for the treatment of the brain cancer.

Background technology

Cerebroma claims again intracranial tumor, and sickness rate is about 4～5,/10 ten thousand left and right.Western medical treatment is mainly operative treatment and Radiotherapy chemotherapy etc., and patient treatment is painful large, and relapse rate is high, and difficulty is thoroughly eradicated.Primary disease belongs to the categories such as the traditional Chinese medical science " unendurable headache due to invasion of brain by pathogen ", " headache ", " bones of the body are dizzy ", " apoplexy ", " vomiting ", " wind syndrome of head ", and the traditional Chinese medical science is thought brain being the marrow sea, therefore cerebroma is brain pathological changes, and how because of vital QI being weakened and pathogen being violent, internal organs virtual loss, wind-phlegm ecchymosis hinders due to brain.Primary symptom is shown in dizziness, headache, feels sick, vomits, or with quadriplegia, epilepsy and mental symptom etc.

Summary of the invention

The object of this invention is to provide a kind of medicament for the treatment of the brain cancer.

In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of the brain cancer, the material that it comprises following weight proportioning: Rhizoma Arisaematis 20-50 part, Radix Gei japonici 50-70 part, Rhizoma Paridis 12-15 part, Fructus Forsythiae 20-25 part, Spica Prunellae 20-30 part, Radix Rehmanniae 20-25 part, Radix Cudraniae 20-25 part, Rhizoma Dioscoreae 15-21 part, Os Draconis 20-25 part, Semen Juglandis 20-30 part and Rhizoma Pinelliae 15-20 part.

Preferably, the kit of the treatment brain cancer of the present invention is containing the material of following weight proportioning: 20 parts of 30 parts of Rhizoma Arisaematiss, 60 parts of Radix Gei japonicis, 15 parts of Rhizoma Paridis, 20 parts of Fructus Forsythiaes, 25 parts of Spica Prunellaes, 20 parts, the Radix Rehmanniae, 25 parts of Radix Cudraniaes, 20 parts of Rhizoma Dioscoreaes, 20 parts of Os Draconis, 25 parts of Semen Juglandis and the Rhizoma Pinelliaes.

More preferably, the medicament of the treatment brain cancer of the present invention also comprises the material of following weight proportioning: 5 parts of 5 parts of Fructus Broussonetiaes, 6 parts of 3 parts of, Herba Thlaspiss of RADIX PEUCEDANI, 5 parts of Rhizoma Smilacis Chinensiss, 7 parts of Herba Cichoriis, Rhizoma Dioscoreae Septemlobae 46 parts of Fen, Herba Siegesbeckiaes, 3 parts of Herba Gendarussaes, 5 parts of Cortex Syingae Amurensiss, 3 parts of Herba pterocephali, 3 parts of Nodus Nelumbinis Rhizomatis, 7 parts of Medulla Stachyuri (Medulla Helwingiae)s, 4 parts of Flos Bombacis Malabaricis, 5 parts of Concha Arcaes, 3 parts of Caulis Mahoniaes, 6 parts of Folium Sauropis, 7 parts of Semen Lablab Albums, 3 parts of Retinervus Luffae Fructuss, 5 parts of Herba Polygoni cymosis, 3 parts of Semen Celosiae and Fructus Litseae.

More preferably, described medicament can be tablet, dispersible tablet, decoction or capsule.

Radix Cudraniae

[source] Moraceae three-bristle cudrania platymiscium cudrania cochinchinensis Cudrania cochin chinensis (Lour.) Kudo et Masam., is used as medicine with root.Can adopt the whole year, and clean section is dried.

[meridian distribution of property and flavor] micro-hardship, flat.

Character identification

Root is cylindrical, different in size, diameter and 1.5-2.5cm; Or be cut into circular sheet.Crust is yellow or orange red, has significant vertical wrinkle and minority mark of fibrous root.Cork is thin and easily come off.Quality is hard, not frangibility, and section skin zone is thin, lark, tool toughness fiber, woody part accounts for the overwhelming majority.Yellow, bavin, guide hole is obvious, and some central parts have little marrow.Feeble QI, lightly seasoned.

Radix Gei japonici

[English name] Root of Thinleaf Adina

[source] medical material Ji Yuan: be the root of dicotyledon medicine Maguireothamnus speciosus spire Ramulus et Folium Adinae Piluliferae.

Latin plant animal mineral name: Adina rubella (Sieb.EtZucc.) Hance gathers and stores: summer, autumn are excavated the root of old plant for many years, cleans, section using fresh herb or dry.

[former form] Fructus Adinae, machaka, high 1-1.5m. sprig is elongated, and bronzing, by pubescence; Old branch is without hair.Leaf alternate: the extremely short or nothing of petiole; Stipule 2, with leaf to life, triangle; Leaf papery; Blade ovum shape lanceolar or ovum shape ellipse, long 3-4cm, wide 1-2.5cm, tip is point gradually, the wide wedge shape of base portion, full edge, above bottle green, without hair, below light green, the slightly white pubescence of lateral vein.Head inflorescence is spherical, and top is raw or axil is raw, Sheng type diameter 1.5-2cm; Total long 2-3cm of bennet, by pubescence; Calyx is brief, and tip 5 splits; Corolla tubulose, long 5-10mm, aubergine or white, tip 5 splits, and black color dots is arranged at sliver top; Stamen 5, filigree is short; Ovary is the next, Room 2, and style is elongated, exceeds corolla more than 1 times.Capsule wedge shape, is about 3mm, is with aubergine when ripe, and collection generates spherical.Seed majority, tiny, oblong, there is wing at two ends.The florescence 6-7 month.The fruit phase 9-10 month.

[character] character identification root is carefully cylindrical, how bending, has branch, and long 30-80cm, is also cut into short section of long 5-6cm.Root head is slightly thick, down gradually thin, and diameter 2-3mm. surface Lycoperdon polymorphum Vitt or lark have thin vertical wrinkle and radicula trace, and person is rufous to strike off cork.Body is light, sanction firmly tough, not frangibility, section is soaked through smooth, skin zone easily respectful fall, woody part accounts for major part, lark is to brown color.Feeble QI, mildly bitter flavor is puckery.Take the thick person of root bar as good.

Microscopical identification root cross section: phellem layer is made up of ordered series of numbers cork cell, yellowish-brown.Cortex is advised born of the same parents' ordered series of numbers, and ovalize tangentially extends.Phloem has numerous bast fibre bundles, and my arranged radially is embarked on journey or is dispersed in, wall thickness, micro-lignify; Phloem ray is obvious, and top expansion is leaks half shape.Xylem broadness, conduit is single to be dispersed in, diameter 25-135 μ m; The wood fiber is dispersed in, wall thickness, lignify; The wide 1-2 cell of xylem ray.

[discriminating] physicochemical identification (1) is got this product powder 2g, and the 20ml that adds water heats 1h in the water-bath of 50-60 ℃, filters.Get filtrate 1ml, put strong oscillating in test tube and insert, produce more and lasting foam.(check Saponin (2) flight of steps leading to a palace hall this product powder 2g, add ethanol 20ml, reflux 20min, filters.Get filtrate 2ml, put in evaporating dish, volatilize, residue is beaten and is added acetic anhydride number and drip and make to dissolve, then adds 1 of concentrated sulphuric acid, and displaing amaranth, is finally dirty green.(checking steroid class)

[nature and flavor] bitter in the mouth; Pungent; Cool in nature

[return through] liver; Lung; Kidney channel

The medicament of the treatment brain cancer of the present invention has the advantages that cost is low, preparation is easy, toxic and side effects is little, curative effect is showing.

The specific embodiment

Embodiment 1:

Take 20 grams of 30 grams of Rhizoma Arisaematiss, 60 grams of Radix Gei japonicis, 15 grams of Rhizoma Paridis, 20 grams of Fructus Forsythiaes, 25 grams of Spica Prunellaes, 20 grams, the Radix Rehmanniae, 25 grams of Radix Cudraniaes, 20 grams of Rhizoma Dioscoreaes, 20 grams of Os Draconis, 25 grams of Semen Juglandis and the Rhizoma Pinelliaes, add 5000 milliliters, water, under the condition of reflux, heat 5 hours, filter, filtrate is concentrated into 800 milliliters, be cooled to room temperature, obtain decoction of the present invention.

Embodiment 2:

Take 30 grams of Rhizoma Arisaematiss, 60 grams of Radix Gei japonicis, 15 grams of Rhizoma Paridis, 20 grams of Fructus Forsythiaes, 25 grams of Spica Prunellaes, 20 grams, the Radix Rehmanniae, 25 grams of Radix Cudraniaes, 20 grams of Rhizoma Dioscoreaes, 20 grams of Os Draconis, 25 grams of Semen Juglandis, 20 grams of the Rhizoma Pinelliaes, 5 grams of Fructus Broussonetiaes, 3 grams of RADIX PEUCEDANI, 6 grams of Herba Thlaspiss, 5 grams of Rhizoma Smilacis Chinensiss, 7 grams of Herba Cichoriis, 4 grams of Rhizoma Dioscoreae Septemlobaes, 6 grams of Herba Siegesbeckiaes, 3 grams of Herba Gendarussaes, 5 grams of Cortex Syingae Amurensiss, 3 grams of Herba pterocephali, 3 grams of Nodus Nelumbinis Rhizomatis, 7 grams of Medulla Stachyuri (Medulla Helwingiae)s, 4 grams of Flos Bombacis Malabaricis, 5 grams of Concha Arcaes, 3 grams of Caulis Mahoniaes, 6 grams of Folium Sauropis, 7 grams of Semen Lablab Albums, 3 grams of Retinervus Luffae Fructuss, 5 grams of Herba Polygoni cymosis, 5 grams of 3 grams of Semen Celosiae and Fructus Litseae, add 8000 milliliters, water, under the condition of reflux, heat 5 hours, filter, filtrate is concentrated into 800 milliliters, be cooled to room temperature, obtain decoction of the present invention.

Experimental example

Clinical data

All cases is is in hospital and out-patient, all has head portion imaging diagnosis or pathological diagnosis.Wherein male's 20 examples, women's 26 examples; The oldest 75 years old, minimum 9 years old; Former brain tumor 28 examples, transitivity brain tumor 18 examples; The longest medical history of first visit 11 months, the shortest 3 months.Be divided into two groups, every group of 23 routine patients, two groups are compared there was no significant difference (P > 0.05) in sides such as sex, age, the course of disease, state of an illness scorings, have comparability.

First group of decoction prepared by the oral embodiment 1 of patient, every day twice, each oral 100 milliliters.Take continuously 6 months.

Second group of decoction prepared by the oral embodiment 2 of patient, every day twice, each oral 100 milliliters.Take continuously 6 months.

Criterion of therapeutical effect

Judge curative effect with reference to traditional Chinese medical science disease evaluation criteria in " national new Chinese medicine clinical research derivation principle " (2003.5).

Clinical cure: after treatment, integration reduces >=95% than the front integration for the treatment of;

Effective: after treating, integration is than treating front integration minimizing >=70% but < 95%;

Effective: after treating, integration is than treating front integration minimizing >=30% but < 70%;

Invalid: after treatment, integration reduces < 30% than the front integration for the treatment of.

Therapeutic outcome

During patient takes medicine, transference cure, alleviate after, and continue to observe stability person more than 1 month, according to traditional Chinese medical science disease, evaluation judges curative effect.In first group of patient, clinical cure 5 examples, effective 7 examples, effective 8 examples, invalid 3 examples; In first group of patient, clinical cure 6 examples, effective 8 examples, effective 8 examples, invalid 1 example.

Claims

1. treat the decoction of the brain cancer for one kind, it is characterized in that it makes by following method: take 20 grams of 30 grams of Rhizoma Arisaematiss, 60 grams of Radix Gei japonicis, 15 grams of Rhizoma Paridis, 20 grams of Fructus Forsythiaes, 25 grams of Spica Prunellaes, 20 grams, the Radix Rehmanniae, 25 grams of Radix Cudraniaes, 20 grams of Rhizoma Dioscoreaes, 20 grams of Os Draconis, 25 grams of Semen Juglandis and the Rhizoma Pinelliaes, add 5000 milliliters, water, under the condition of reflux, heat 5 hours, filter, filtrate is concentrated into 800 milliliters, be cooled to room temperature, obtain described decoction, twice of described decoction every day, each oral 100 milliliters, take continuously 6 months.