CN103272060A - Pharmaceutical composition for treating diarrhea and preparation method thereof - Google Patents

Abstract

The invention relates to a pharmaceutical composition, and in particular relates to a pharmaceutical composition for treating diarrhea and a preparation method thereof. The pharmaceutical composition comprises the components in parts by weight: 120-150 parts of Humulus scandens, 15-20 parts of pomegranate rind, and 15-20 parts of morel. The components are decocted and purified to be prepared into thick paste or particles, and are used by soaking feet. The pharmaceutical composition has the characteristics of easily available materials, low price, exact curative effect, capability of overcoming refractory diarrhea and no toxic or side effect.

Description

A kind of pharmaceutical composition for the treatment of dysentery and preparation method thereof

Technical field

The present invention relates to a kind of pharmaceutical composition, particularly a kind of pharmaceutical composition for the treatment of dysentery and preparation method thereof.

Background technology

Dysentery is namely had loose bowels." Elaboration of Bureau Prescription ": " husband's dysentery card, its class is many especially, so the virtuous many one-tenth that wet of saying rush down, this appropriate view on politics is also." dysentery is different with dysentery, the card of no tenesmus, stool containing pus and blood." dysentery card converge with ginseng " volume two: " card of dysentery there is no tenesmus, only feels asthenia, if dysentery is quite different, or pus or blood, or red white holding concurrently down, though different that does it hurt arranged, right tenesmus all.Cardinal symptom has: it is thin to defecate, even water sample, and increased frequency does not generally have pus and blood and tenesmus.The slow person of the thin and gesture of stool matter is for letting out, defecate as water and gesture urgency person for rushing down.Be more common in acute chronic enteritis, gastrointestinal dysfunction, Anaphylaxis enteritis, ulcerative colitis, tuberculosis of intestine of western medicine etc.

At present, the medicine for the treatment of dysentery both at home and abroad is more, has Western medicine that Chinese medicine is also arranged, still, ubiquity contain various antibiotic big, expensive to the human injury, to shortcomings such as intractable dysentery poor effect.

Uprooting plants after their edible portions have been harvested, is a kind of perennial herbaceous plant that climbs up by holding on to, and has the effect of cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling, is born in the other or limes marginis thick grass of hillside rock more, and main product Anhui, Hebei, Shaanxi, Henan, Shandong are a kind of and the Chinese medicine raw material that is easy to get.

Pericarpium Granati has relieving diarrhea with astringents, hemostasis, and the function of anthelmintic is used for chronic diarrhea, and chronic dysentery is had blood in stool, proctoptosis, metrorrhagia, leucorrhea, abdominal pain due to worm stagnation.

Herba Solani Nigri is Solanaceae Solanum annual herb plant, and all there is distribution China various places, easily gathers.Herba Solani Nigri is cold in nature, and bitter in the mouth is little sweet, has mild toxicity, returns lung, stomach, urinary bladder channel, and the effect of heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, inducing diuresis to remove edema, eliminating phlegm and stopping cough is arranged.

The inventor filters out that some medicines have formed that material is easy to get, low price, determined curative effect, can overcome the intractable dysentery and the pharmaceutical composition of the treatment dysentery that has no side effect on the basis of clinical empirical summary and Professional knowledge for many years.

Summary of the invention

At the medicine of present treatment dysentery exist expensive, to the shortcoming of intractable dysentery unsatisfactory curative effect, the invention provides that a kind of material is easy to get, low price, determined curative effect, can overcome the intractable dysentery and the pharmaceutical composition of the treatment dysentery that has no side effect.

The object of the invention to solve the technical problems realizes by the following technical solutions.

The invention provides a kind of pharmaceutical composition for the treatment of dysentery and comprise that 120～150 weight portions uproot plants after their edible portions have been harvested 15～20 weight portion Pericarpium Granatis, 15～20 weight portion Herba Solani Nigris.

A kind of pharmaceutical composition for the treatment of dysentery provided by the invention comprises that further 150 weight portions uproot plants after their edible portions have been harvested 20 weight portion Pericarpium Granatis, 20 weight portion Herba Solani Nigris.

The present invention also provides a kind of preparation of drug combination method for the treatment of dysentery, may further comprise the steps:

(1) gets the uprooting plants after their edible portions have been harvested of recipe quantity, Pericarpium Granati and Herba Solani Nigri, add weight 8-10 decocting doubly and boiled 1.5-2 hour, filter to get filtrate;

(2) the filtering residue adding weight 8-10 decocting doubly of getting step (1) boiled 1.5-2 hour, filtered to get filtrate;

(3) filtrate with step (1) and step (2) merges, and the above temperature evaporation and concentration of 80 degree gets 1: 1.28 unguentum; Perhaps the above temperature evaporation and concentration of 80 degree gets concentrated solution, and described concentrated solution is carried out the solid that vacuum drying gets moisture＜9%, and crushing screening is granulated.

A kind of preparation of drug combination method for the treatment of dysentery provided by the invention further may further comprise the steps:

(1) get the uprooting plants after their edible portions have been harvested of recipe quantity, Pericarpium Granati and Herba Solani Nigri, the decocting that adds 10 times of weight boiled 2 hours, filtered to get filtrate;

(2) filtering residue of getting step (1) decocting that adds 10 times of weight boiled 2 hours, filtered to get filtrate;

(3) filtrate with step (1) and step (2) merges, and the above temperature evaporation and concentration of 80 degree gets 1: 1.28 unguentum; Perhaps the above temperature evaporation and concentration of 80 degree gets concentrated solution, and described concentrated solution is carried out the solid that vacuum drying gets moisture＜9%, pulverizes 80 mesh sieves, granulates.

The present invention has that material is easy to get, low price, determined curative effect, the characteristics that can overcome the intractable dysentery and have no side effect.

Usage and dosage: potion medicinal liquid or granule are poured in the basin, added the above hot water of an amount of 85 degree, begin to fumigate, treat that water temperature adapts to back bubble sufficient 40-60 minute, water temperature is heat as far as possible, cold add boiled water, every day three times, making sure to keep in mind can not be oral.

The relation of described weight portion and parts by volume is the relation of g/ml.

The specific embodiment

Embodiment 1:

(1) get that 150g uproots plants after their edible portions have been harvested, 20g Pericarpium Granati, 20g Herba Solani Nigri, the decocting that adds 1900ml boiled 2 hours, filtered to get filtrate;

(2) filtering residue of getting step (1) decocting that adds 10 times of weight boiled 2 hours, filtered to get filtrate;

(3) filtrate with step (1) and step (2) merges, and the above temperature evaporation and concentration of 80 degree gets 1: 1.28 unguentum.

Embodiment 2:

(1) get that 150g uproots plants after their edible portions have been harvested, 20g Pericarpium Granati, 20g Herba Solani Nigri, the moisture that adds 1900ml decocted 2 hours, filtered to get filtrate;

(2) filtering residue of getting step (1) decocting that adds 10 times of weight boiled 2 hours, filtered to get filtrate;

(3) filtrate with step (1) and step (2) merges, and the above temperature evaporation and concentration of 80 degree gets concentrated solution, and described concentrated solution is carried out the solid that vacuum drying gets moisture＜9%, pulverizes 80 mesh sieves, granulates.

Embodiment 3:

(1) get that 120g uproots plants after their edible portions have been harvested, 15g Pericarpium Granati, 15g Herba Solani Nigri, the decocting that adds 1500ml boiled 2 hours, filtered to get filtrate;

(2) filtering residue of getting step (1) decocting that adds 10 times of weight boiled 2 hours, filtered to get filtrate;

(3) filtrate with step (1) and step (2) merges, and the above temperature evaporation and concentration of 80 degree gets 1: 1.28 unguentum.

Embodiment 4:

(1) get that 120g uproots plants after their edible portions have been harvested, 15g Pericarpium Granati, 15g Herba Solani Nigri, the decocting that adds 1300ml boiled 2 hours, filtered to get filtrate;

(2) filtering residue of getting step (1) decocting that adds 10 times of weight boiled 2 hours, filtered to get filtrate;

(3) filtrate with step (1) and step (2) merges, and the above temperature evaporation and concentration of 80 degree gets concentrated solution, and described concentrated solution is carried out the solid that vacuum drying gets moisture＜9%, pulverizes 80 mesh sieves, granulates.

Embodiment 5:

(1) get that 130g uproots plants after their edible portions have been harvested, 17g Pericarpium Granati, 17g Herba Solani Nigri, the decocting that adds 1500ml boiled 1.5 hours, filtered to get filtrate;

(2) filtering residue of getting step (1) decocting that adds 10 times of weight boiled 1.5 hours, filtered to get filtrate;

(3) filtrate with step (1) and step (2) merges, and the above temperature evaporation and concentration of 80 degree gets 1: 1.28 unguentum.

Embodiment 6:

(1) get that 140g uproots plants after their edible portions have been harvested, 20g Pericarpium Granati, 15g Herba Solani Nigri, the decocting that adds 1700ml boiled 2 hours, filtered to get filtrate;

(2) filtering residue of getting step (1) decocting that adds 10 times of weight boiled 2 hours, filtered to get filtrate;

(3) filtrate with step (1) and step (2) merges, and the above temperature evaporation and concentration of 80 degree gets concentrated solution, and described concentrated solution is carried out the solid that vacuum drying gets moisture＜9%, pulverizes 80 mesh sieves, granulates.

Clinical therapeutic efficacy:

Criterion of therapeutical effect: a kind of curative effect for the treatment of the pharmaceutical composition of dysentery judges whether mainly be dependent on the dysentery symptom disappears.Medication 7 days was a course for the treatment of.Concrete curative effect is divided following three grades: cure---and the dysentery symptom all disappears; Taking a turn for the better---the dysentery symptom obviously alleviates; Invalid---after medication course for the treatment of, the dysentery symptom has no to disappear.

Effect: with Drug therapy dysentery patient 100 examples of the present invention, treat 1 course for the treatment of, wherein cure 90 examples, 10 examples that take a turn for the better, cure rate is 90%, effective percentage is 100%.

Model case:

Case 1: the man, 9 years old, had loose bowels 40 days, with foam just, and abdominal distention, dull pain, the routine administration transfusion is had an injection to take medicine and is not felt any better, back trial edition invention pharmaceutical composition bubble foot therapy, the retrogradation of defecating after 2 days, dull pain abdominal distention disappeared in the 4th day, consolidated again 2 days, not recurrence.

Case 2:, the woman, 63 years old, had loose bowels 27 days, have casing slime and blood in just, battle array is painful, seven days transference cures of hospitalization are left hospital, the situation before recovering again to be in hospital in the back of leaving hospital on the 4th day, after begin to recover normally not repeatedly in seven days with pharmaceutical composition bubble foot of the present invention.

Case 3, the woman, 27 years old, loose stool is with dense blood, and was weak all over, and always sleepy is felt, and routine was not felt any better with diarrhea in 20 days, began to use pharmaceutical composition of the present invention to steep antidiarrheal after sufficient three days, and above transference cure does not recur after seven days.

Claims (4)

1. a pharmaceutical composition for the treatment of dysentery is characterized in that, comprises that 120～150 weight portions uproot plants after their edible portions have been harvested 15～20 weight portion Pericarpium Granatis, 15～20 weight portion Herba Solani Nigris.

2. pharmaceutical composition as claimed in claim 1 is characterized in that, comprises that 150 weight portions uproot plants after their edible portions have been harvested 20 weight portion Pericarpium Granatis, 20 weight portion Herba Solani Nigris.

3. a preparation of drug combination method for the treatment of dysentery is characterized in that, may further comprise the steps:

(1) gets the uprooting plants after their edible portions have been harvested of recipe quantity, Pericarpium Granati and Herba Solani Nigri, add weight 8-10 decocting doubly and boiled 1.5-2 hour, filter to get filtrate;

(2) the filtering residue adding weight 8-10 decocting doubly of getting step (1) boiled 1.5-2 hour, filtered to get filtrate;

(3) filtrate with step (1) and step (2) merges, and the above temperature evaporation and concentration of 80 degree gets 1: 1.28 unguentum; Perhaps the above temperature evaporation and concentration of 80 degree gets concentrated solution, and described concentrated solution is carried out the solid that vacuum drying gets moisture＜9%, and crushing screening is granulated.

4. preparation of drug combination method as claimed in claim 3 is characterized in that, may further comprise the steps:

(1) get the uprooting plants after their edible portions have been harvested of recipe quantity, Pericarpium Granati and Herba Solani Nigri, the moisture that adds 10 times of weight decocted 2 hours, filtered to get filtrate;

(2) filtering residue of getting step (1) decocting that adds 10 times of weight boiled 2 hours, filtered to get filtrate;

(3) filtrate with step (1) and step (2) merges, and the above temperature evaporation and concentration of 80 degree gets 1: 1.28 unguentum; Perhaps the above temperature evaporation and concentration of 80 degree gets concentrated solution, and described concentrated solution is carried out the solid that vacuum drying gets moisture＜9%, pulverizes 80 mesh sieves, granulates.