CN104474074A - Traditional Chinese medicine external plaster used for treating itchy skin eruption and stuck to navel and preparation method of plaster - Google Patents

Traditional Chinese medicine external plaster used for treating itchy skin eruption and stuck to navel and preparation method of plaster Download PDF

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CN104474074A
CN104474074A CN201410656224.8A CN201410656224A CN104474074A CN 104474074 A CN104474074 A CN 104474074A CN 201410656224 A CN201410656224 A CN 201410656224A CN 104474074 A CN104474074 A CN 104474074A
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parts
chinese medicine
itchy skin
skin eruption
traditional chinese
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龚富先
龚俊豪
黄永
王昌记
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/648—Myriapods, e.g. centipedes or millipedes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/754—Evodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Insects & Arthropods (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a traditional Chinese medicine external plaster used for treating itchy skin eruption and stuck to navel. The Traditional Chinese medicine external plaster adopts the following components: astragalus membranaceus, white paeony root, perfoliote knotweed herb, snake cicada, nidus vespae, centipedes, stiff silkworms, densefruit pittany root-bark, medicinal evodia fruit, Chinese gall and flos caryophyllata. The traditional Chinese medicine external plaster disclosed by the invention is prepared into an emulsible paste to be externally stuck on the navel by adopting a modern scientific and technical preparation process, has the advantages of strong permeability and quick action, cannot cause pains and side effects, can be accepted by children, adults and old people, is convenient to operate, and is worthy of clinical promotion and application.

Description

A kind of Chinese medicine patch umbilicus externally applied ointment for the treatment of itchy skin eruption and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of itchy skin eruption, be specifically related to a kind of Chinese medicine patch umbilicus externally applied ointment for the treatment of itchy skin eruption and preparation method thereof.
Background technology
Itchy skin eruption is a kind of commonly encountered diseases, frequently-occurring disease, patient common 1 ~ 10 years old child and middle-aged and elderly people, classical symptom is from the beginning of being welt sample pimple and herpes, welt disappears subsequently, form foxtail millet grain to the harder pimple of the large matter of Semen phaseoli radiati, acute pruritus, because scabies grabs visible scratch, blood crusts, pigmentation or depigmentation and lichenization repeatedly, is apt to occur in trunk and extremity stretch side and back.
Motherland's medical science is thought that human body is reported and is not tolerated skin, fur interspaces of skin and muscles being loose, retention of damp-heat in the interior, caused by diseases caused by exogenous pathogenic factor ailment said due to cold or exposure insect poison; Modern medicine thinks relevant with allergy, insect bite, focus, antibacterial or fungal infection, gastrointestinal dysfunction, and endocrine divides tune and Nervous and Mental Factors etc. relevant.
Current treatment prurigo pharmacopoeia is various, antiallergic, calmness, immune class.Cry and scream when within 1 ~ 3 year old, child takes medicine and mismatch, the child that goes to school drowsiness impact of taking medicine is attended class, and growing up takes medicine affects work.
Summary of the invention
For this reason, the object of this invention is to provide a kind of Chinese medicine patch umbilicus externally applied ointment for the treatment of itchy skin eruption and preparation method thereof.
The object of the invention is to find by the following technical programs, the Chinese medicine patch umbilicus externally applied ointment of this treatment itchy skin eruption is prepared from by the raw material of following weight portion: the Radix Astragali 80 ~ 160 parts, the Radix Paeoniae Alba 60 ~ 120 parts, Herba Polygoni cymosi 100 ~ 200 parts, Serpentis Cicadae 50 ~ 100 parts, Nidus Vespae 80 ~ 160 parts, Scolopendra 20 ~ 40 parts, stiff silkworm 50 ~ 100 parts, Cortex Dictamni 50 ~ 100 parts, Fructus Evodiae 50 ~ 100 parts, Galla Chinensis 20 ~ 40 parts, Flos Caryophylli 20 ~ 40 parts.
For obtaining above-mentioned plaster, its preparation method:
(1), get the Herba Polygoni cymosi of described weight portion, Nidus Vespae, stiff silkworm, the Radix Astragali, Serpentis Cicadae, Cortex Dictamni add ten times of soak by water, concentratedly removes medicinal residues, filter, obtain medicine juice for subsequent use; Emulsifiable paste matrix preparation technology makes emulsifiable paste routinely;
(2), get the Galla Chinensis of described weight portion, Scolopendra, Flos Caryophylli, this three tastes Chinese medicine porphyrize face is added in the emulsifiable paste made and mixes evenly, the Chinese medicine patch umbilicus externally applied ointment of itchy skin eruption must be treated.
This externally applied ointment uses Therapeutic Method: the Chinese medicine patch umbilicus externally applied ointment 1 ~ 5g made is applied external Sterilized application on patient's umbilicus and fix 6 ~ 12 hours and take off, once a day, and seven days courses for the treatment of.
In the present invention: Radix Astragali QI invigorating, consolidating superficial resistance, enhancing human body immunity function.
The Radix Paeoniae Alba: nourish blood, ease pain, calm.
Serpentis Cicadae: nature and flavor, Gan Xianping, heat-clearing and toxic substances removing, dispelling wind for relieving itching.
Nidus Vespae: Gan Ping, slightly poisonous, removing toxic substances of dispeling the wind, spasmolytic is antipruritic.
Scolopendra: warm in nature, acrid in the mouth is poisonous.There is the function of endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.
Bombyx Batryticatus: acrid in the mouth, salty, property is put down, and has expelling wind to relieve convulsion, dissipating phlegm and resolving masses, effect of heat-clearing and toxic substances removing dampness.
Cortex Dictamni: nature and flavor are bitter, cold, heat clearing and damp drying, dispelling wind for relieving itching.
Fructus Evodiae: nature and flavor are pungent, hot greatly, killing parasites for relieving itching, convergence, dampness.
Flos Caryophylli: pungent, warm, Wen Han activates yang, sterilizing skin moistening.
Galla Chinensis: nature and flavor acid, cold, removing dampness, holds back rash.
Therapy of the present invention utilizes umbilicus sensitivity high, and penetration is strong.Meet the principle of motherland's medical science dialectical treatmert, make the feature of drug effect disperse whole body, medicine is spread on umbilical part, drug osmotic is absorbed, harmonizing yingfen and weifen, strengthening the body resistance, make that high and level tone sun is close, dampness toxin expelling, reach the object of dispelling wind for relieving itching.
Detailed description of the invention
The object of the invention is to find by the following technical programs, the Chinese medicine patch umbilicus externally applied ointment of this treatment itchy skin eruption is prepared from by the raw material of following weight portion: the Radix Astragali 80 ~ 160 parts, the Radix Paeoniae Alba 60 ~ 120 parts, Herba Polygoni cymosi 100 ~ 200 parts, Serpentis Cicadae 50 ~ 100 parts, Nidus Vespae 80 ~ 160 parts, Scolopendra 20 ~ 40 parts, stiff silkworm 50 ~ 100 parts, Cortex Dictamni 50 ~ 100 parts, Fructus Evodiae 50 ~ 100 parts, Galla Chinensis 20 ~ 40 parts, Flos Caryophylli 20 ~ 40 parts.
For obtaining above-mentioned plaster, its preparation method:
(1), get the Herba Polygoni cymosi of described weight portion, Nidus Vespae, stiff silkworm, the Radix Astragali, Serpentis Cicadae, Cortex Dictamni add ten times of soak by water, concentratedly removes medicinal residues, filter, obtain medicine juice for subsequent use; Emulsifiable paste matrix preparation technology makes emulsifiable paste routinely;
(2), get the Galla Chinensis of described weight portion, Scolopendra, Flos Caryophylli, this three tastes Chinese medicine porphyrize face is added in the emulsifiable paste made and mixes evenly, the Chinese medicine patch umbilicus externally applied ointment of itchy skin eruption must be treated.
Embodiment: get Herba Polygoni cymosi 200g, Nidus Vespae 160g, Radix Astragali 160g, Radix Paeoniae Alba 80g, stiff silkworm 100g, Serpentis Cicadae 100g, Cortex Dictamni 100g add ten times of decocting persons and concentratedly remove medicinal residues, filter and stay medicine juice about 1220 milliliters for subsequent use;
Cream preparation method:
Oil phase: stearic acid 80g, simethicone 40g, white vaseline 180g, azone 40ml, monoglyceride stearic acid 40g heat homoiothermic 80 degree.
Aqueous phase: above-mentioned concentrated medicine juice 1220 milliliters, polysorbate60 milliliter, glycerol 100 milliliters, 2 grams, oxybenzene second fat heating homoiothermic 80 degree.
Emulsifying oil phase slowly pours aqueous phase into, is stirred to cool one-tenth emulsifiable paste shape to a direction.
Stir in the emulsifiable paste becoming fine flour to add Galla Chinensis 30g, Scolopendra 30, Flos Caryophylli 20g tri-taste Chinese medicine powder to make, the Chinese medicine patch umbilicus externally applied ointment of itchy skin eruption must be treated.
Usage: each consumption 1 ~ 5 gram, apply umbilicus, external use sterile is applied ointment or plaster fixing.Once a day, seven days courses for the treatment of.
Clinical data
1, physical data, all patients derive from out-patient treatment in 2012 ~ 2014 years, totally 280 examples, treatment group 140 example, child 84 example, 2 ~ 10 years old mean age, adult 56 example, 30 ~ 70 years old mean age.Treatment is one week.
2, Therapeutic Method: the breast made instruction medicine Liu 1 ~ 5g is applied external Sterilized application on patient's umbilicus and fix 6 ~ 12 hours and take off, once a day, seven days courses for the treatment of.
3, therapeutic outcome: two groups for the treatment of comparitive study are in table 1.
Table 1 liang group treatment comparitive study
Note: treatment group total effective rate 95.204%, matched group total effective rate is 71.43%, two groups has significant difference clinical comparison, and treatment group is better than matched group.
Model case: Lee, man, 5 years old, in JIUYUE, 2012 was with regard to rash, suffer from prurigo from the beginning of being welt sample pimple sample herpes, extremity, trunk, back pruritus at night are cry and screamed and are not fallen asleep, and adopt and paste umbilicus cream about 2 grams, external use sterile is applied ointment or plaster fixing, infant was normally fallen asleep that night, once a day, within seven days, pimple disappears, and does not have new prurigo to occur.

Claims (2)

1. treat a Chinese medicine patch umbilicus externally applied ointment for itchy skin eruption, it is characterized in that what the Chinese medicine patch umbilicus externally applied ointment of this treatment itchy skin eruption was prepared from by the raw material of following weight portion: the Radix Astragali 80 ~ 160 parts, the Radix Paeoniae Alba 60 ~ 120 parts, Herba Polygoni cymosi 100 ~ 200 parts, Serpentis Cicadae 50 ~ 100 parts, Nidus Vespae 80 ~ 160 parts, Scolopendra 20 ~ 40 parts, stiff silkworm 50 ~ 100 parts, Cortex Dictamni 50 ~ 100 parts, Fructus Evodiae 50 ~ 100 parts, Galla Chinensis 20 ~ 40 parts, Flos Caryophylli 20 ~ 40 parts.
2. treat the preparation method of the Chinese medicine patch umbilicus externally applied ointment of itchy skin eruption as claimed in claim 1 for one kind, it is characterized in that this preparation method is: (one), the Herba Polygoni cymosi getting described weight portion, Nidus Vespae, stiff silkworm, the Radix Astragali, Serpentis Cicadae, Cortex Dictamni add ten times of soak by water, concentrate and remove medicinal residues, filter, obtain medicine juice for subsequent use; Emulsifiable paste matrix preparation technology makes emulsifiable paste routinely;
(2), get the Galla Chinensis of described weight portion, Scolopendra, Flos Caryophylli, this three tastes Chinese medicine porphyrize face is added in the emulsifiable paste made and mixes evenly, the Chinese medicine patch umbilicus externally applied ointment of itchy skin eruption must be treated.
CN201410656224.8A 2014-11-18 2014-11-18 Traditional Chinese medicine external plaster used for treating itchy skin eruption and stuck to navel and preparation method of plaster Pending CN104474074A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114788847A (en) * 2022-06-08 2022-07-26 山西省中医药研究院（山西省中医院） Traditional Chinese medicine composition containing folium isatidis and application of traditional Chinese medicine composition in treatment of targeted drug-related rash

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CN103100002A (en) * 2013-02-05 2013-05-15 徐辉 Medicament for treating acute herpes zoster caused by retention of damp-heat in the interior
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114788847A (en) * 2022-06-08 2022-07-26 山西省中医药研究院（山西省中医院） Traditional Chinese medicine composition containing folium isatidis and application of traditional Chinese medicine composition in treatment of targeted drug-related rash

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RJ01 Rejection of invention patent application after publication

Application publication date: 20150401

RJ01 Rejection of invention patent application after publication