CN1279951C - Pure Chinese traditional medicine capsule for treating hyperthyroidism and simple goiter - Google Patents

Abstract

The present invention relates to a pure traditional Chinese drug capsule for treating hyperthyroidism and simple goiter. The present invention provides a pure traditional Chinese drug preparation for a patient suffering from hyperthyroidism and simple goiter. The preparation is prepared by 16 kinds of traditional Chinese drug materials, such as radix paeoniae alba, radix astragali seu hedysari, pangolin, etc. In the preparation technology, firstly, animal drug decoction pieces are mixed and pulverized into a fine powder drug, and then other vegetable drug decoction pieces are decocted three times to concentrate filter liquor into thick paste. Fine powder drugs are added in the thick paste and are evenly stirred to make soft drugs, and finally, the soft drugs are sieved, granulated, dried, shaped and capsulized. The traditional Chinese drug preparation has the advantages of novel formula, complementary drug effect, simple and convenient preparation technology, low production cost and convenient administration and has an obvious therapeutic effect on hyperthyroidism and a simple thyroid disease.

Description

Treatment hyperthyroidism and the big pure Chinese medicine capsule of simple goiter

Affiliated technical field

The present invention treats hyperthyroidism and the big pure Chinese medicine capsule of simple goiter belongs to the medicine for the treatment of endocrinopathy, relates in particular to medicament and preparation technology thereof with pure treatment by Chinese herbs thyroid disease.

Background technology

Hyperthyroidism (back claims hyperthyroidism) and simple goiter are greatly common thyroid diseases, it is self property disease, thyroid is high function, the patient relates to each age level crowd, the field relates to many medical specialties, different expressions, changeful is thrown off restraint in clinical manifestation thousand, is a kind of disease that has a strong impact on patients ' life quality.

The medicine of tradition Chinese traditional treatment hyperthyroidism and the big disease of simple goiter is a lot, but prescription respectively with heat clearing away, invigorate blood circulation, eliminate the phlegm, regulate the flow of vital energy, calm the nerves, suppressing the hyperactive liver to relieve the wind syndrome.Tonify deficiency is a main disease to be treated, again based on decoction, but therapeutic efficiency inclined to one side, easily form and attend to one thing and lose sight of another, curative effect instability, and decoction is to boil with the side, operation can not standard, convert the water yield, the difficult grasp of firepower, and patient's dose is big, and mouthfeel is poor, takes for a long time very easily to cause and detest medicine, especially child and teenager take more not convenient, market lack to the big disease of hyperthyroidism and simple goiter simultaneously effectively, strong, the therapeutic effect of prescription medicine synergism significantly, the pure Chinese medicinal preparation of convenient oral.

Summary of the invention

The objective of the invention is: develop a kind of hyperthyroidism and big compound Chinese medicinal preparation of simple goiter for the treatment of, not only to possess heat clearing away simultaneously, invigorate blood circulation, eliminate the phlegm, regulate the flow of vital energy, calm the nerves, suppressing the hyperactive liver to relieve the wind syndrome and tonify deficiency curative effect, and preparation technology's standard, suitable batch production production, convenient oral, evident in efficacy, and can shorten the treatment phase, reduce the patient treatment cost.

Technical scheme of the present invention is: crude drug is made up of the Radix Paeoniae Alba 8.00%, the Radix Astragali 10.50%, Semen Ziziphi Spinosae 6.00%, Radix Angelicae Sinensis 7.50%, Rhizoma Chuanxiong 6.00%, Spica Prunellae 7.50%, Rhizoma Coptidis 3.60%, Radix Rehmanniae 9.00%, Radix Scrophulariae 4.55%, the Rhizoma Atractylodis Macrocephalae 5.50%, Rhizoma Arisaematis 3.00%, the Rhizoma Pinelliae 3.00%, Concha Ostreae 9.00%, Carapax Trionycis 9.00%, Carapax Et Plastrum Testudinis 7.40%, Squama Manis 0.45% in the big pure Chinese medicine capsule prescription of treatment hyperthyroidism and simple goiter.

The modern Chinese medicine galenic pharmacy confirms, plant amedica all can decoct decoction and takes in this prescription, animal drugs all can be ground into powder and is used as medicine, therefore this pharmaceutical formulation is in preparation technology, after plant amedica decoction three times, filtrate is merged the back concentrating under reduced pressure become thick paste, all animals medicine mixed powder is broken into fine powder, and thick paste and fine powder puddled make soft material, get patent medicine through sieve series grain, drying, granulate, No. 0 capsule of packing at last.

Hyperthyroidism and simple goiter belong to autoimmune endocrine greatly together, its pathogenesis has deficiency of vital energy stagnation of liver-QI, expectorant knot blood stagnation, the characteristics of fire-transformation impairment of YIN, how real the primary disease initial stage is, prolonged illness is then empty, pathological change is earlier with the stagnation of QI, has that the stagnation of QI, liver-fire, expectorant coagulate, the deficiency of YIN, and that pathological change relates to liver, the heart, spleen, kidney etc. is dirty.Above-mentioned pathological change also can form because of being subjected to strong direct stimulation or soldier to feel exopathogen suddenly.Modern medicine study confirms that hyperthyroidism is to be high function by the thyroid that multiple reason causes, by the one group common endocrinopathy of thyroid hormone secretion due to too much, often be mixed with the big symptom of diffuse goiter in its clinical manifestation, be diffusivity on the pathology, nodositas or Combination goiter; pathological changes is directly relevant with immunoglobulin (TSI) with thyroxin (TSH); when TSH combines with thyroid cell; tsh receptor is activated; thus thyroid function is upset; cause hyperthyroidism and thyromegaly; the characteristics of its clinical manifestation have thyromegaly; exophthalmos; bulimia; lose weight; tachycardia; emotion is emotional angry; To Be Protected from Heat perspires, and hands is trembled, rapid pulse.Its disease and nerve centre, hypothalamic function, suppressor T cell (TS), interleukin, lymphocyte, protein synthesis etc. are directly related.

Traditional Chinese medical theory can confirm to treat Rhizoma Coptidis energy heat clearing and damp drying, eliminating fire and detoxication in hyperthyroidism and the big pure Chinese medicine capsule prescription of simple goiter; The Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Carapax Et Plastrum Testudinis energy nourishing YIN for suppressing the hyperactive YANG, heat-clearing and toxic substances removing; Rhizoma Chuanxiong energy activating QI to alleviate the depression, promoting blood circulation and stopping pain, collateral dredging blood stasis dispelling; Squama Manis can be invigorated blood circulation, collateral dredging, detumescence; The Rhizoma Pinelliae can disappear painful abdominal mass, eliminating stagnation, reduce phlegm; The Rhizoma Arisaematis pain relieving of reducing phlegm; Rhizoma Atractylodis Macrocephalae energy and middle QI invigorating, invigorating the spleen and regulating the stomach; Semen Ziziphi Spinosae can nourish heart, calms the nerves, arresting sweating; Concha Ostreae can suppressing the hyperactive liver and subsiding YANG, hard masses softening and resolving, convergence are astringent or styptic treatment for spontaneous sweating; Radix Astragali energy tonifying Qi and lifting yang, benefit are defended consolidating superficial resistance; Radix Angelicae Sinensis can be enriched blood, invigorated blood circulation, pain relieving, intestine moistening; The Radix Paeoniae Alba can nourish blood yin fluid astringing, easing the affected liver to relieve pain, suppressing liver-YANG; Carapax Trionycis energy nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving.All medicines divide tool clearing away heat-fire, heat clearing and damp drying, clearing away heat and cooling blood, heat-clearing and toxic substances removing, invigorate blood circulation, eliminate the phlegm, regulate the flow of vital energy, calm the nerves, suppressing the hyperactive liver to relieve the wind syndrome, QI invigorating, enrich blood, the merit of nourishing YIN, compatibility is reasonable, Synergistic treatment hyperthyroidism and simple goiter are evident in efficacy greatly.

Modern Chinese medicine research also confirms, the contained berberine of Rhizoma Coptidis can significantly reduce its myocardial ischemia to failure heart in treatment hyperthyroidism and the big pure Chinese medicine capsule prescription of simple goiter, myocardium fibrillation there is antagonism, can resist the enteral hypersecretion, and to suppress with the alanine be the gluconeogenesis and the platelet aggregation of substrate; The contained total saponins of Spica Prunellae has the function that reduces diastolic pressure and systolic pressure simultaneously; Radix Rehmanniae can promote protein synthesis, speeds leukocyte and produces, and recovers thyroid function; Radix Scrophulariae has good antipyretic effect and antibacterial action, energy alleviating vascular spasm; The contained ligustrazine of Rhizoma Chuanxiong has blood pressure lowering and significantly increases the effect of coronary flow, has and suppresses the infringement of oxygen-derived free radicals to cerebral tissue, alleviates the damage of neuron and blood capillary inner cell, improves effects such as neurosigns; The effect that Squama Manis has direct dilating effect and prolongs clotting time and blood viscosity lowering blood vessel wall; The Rhizoma Pinelliae has antitussive and phlegm-dispelling functions, and can promote cell division and blood lymphocyte to transform; The Rhizoma Arisaematis decoct has tangible calmness, analgesia and phlegm-dispelling functions; The Rhizoma Atractylodis Macrocephalae can promote protein synthesis, can prolong lymphocyte life span, can strengthen the removing ability of human body to free radical, and has and avoid the destruction of harmful substance to the histiocyte 26S Proteasome Structure and Function; Jujuboside has sedative-hypnotic effect, and myocardial damage is had protective effect, can improve lymphocyte transformation value and obviously enhancing antibody hemolysin generation; The fine and close blood capillary of calcium salt energy in the Concha Ostreae, the permeability of reduction blood vessel absorbs and regulates electrolyte balance, suppresses nervimuscular excitement; Astragalus decoction can improve patient's immunity, can promote serum and hepatic protein to upgrade; The Radix Angelicae Sinensis infusion can significantly promote hemoglobin and erythrocytic generation, has the platelet aggregation of reduction and anti thrombotic action, and nervus centralis is had inhibitory action; The Radix Paeoniae Alba has blood vessel dilating and increases the effect of organ pipe blood flow, and enkephalin receptor, adrenoceptor, angiotensin receptor are all had inhibitory action; The oral content of hemoglobin that improves of the contained Colla carapax Trionycis of Carapax Trionycis.Above-mentioned Chinese medicine is by improving patient body immunity, adjust the endocrine disturbance, reduce myocardial ischemia, promote protein and hemoglobin, erythrocytic generation, the alleviating vascular spasm, blood vessel dilating brings high blood pressure down, and suppresses the infringement of oxygen-derived free radicals to cerebral tissue, changes tachycardia, suppress the neuromuscular excitement, improve function of nervous system, stabilizing the emotions, hands are trembled phenomenon and are disappeared, promote lymphocyte transformation, slow down thyroid hormone secretion, the thyroid function and the elimination simple goiter that reduce hyperthyroidism disease effectively are big, accelerate patient's speedy recovery to health.

The beneficial effect that the present invention treats hyperthyroidism and the big pure Chinese medicine capsule of simple goiter is: prescription medicine compatibility is reasonable, strong to the main disease to be treated synergistic therapeutic effect, preparation technology's standard, processing method is simple, production cost is low, taking convenience, observe suffering from the big patient's long-term efficacy of hyperthyroidism and simple goiter by prescription drugs, take medicine every day 3 times, each 3-5 grain, 20 days is a course of treatment, take medicine continuously two courses of treatment, observe adult patient's 120 examples altogether, disappear with the thyroid anthorisma, it is normal that the focus blood vessel dilating recovers, weight increase, trick is not trembled, be emotionally stable to complete more standard, contract flat with thyroid follicle epithelium column, hyperplasia stops, the diffusivity lymphocytic infiltration disappears, hands is trembled rapid pulse and is slowed down and be the improvement standard, 85 examples entirely wherein heal, account for 70.83%, 26 examples that take a turn for the better account for 21.67%, invalid 9 examples, account for 7.50%, curative effect is obvious, has remedied long defective of similar curative effect of medication difference and treatment phase.

Specific embodiments

1, during the big pure Chinese medicine capsule processing of treatment hyperthyroidism and simple goiter in per 1000 gram raw materials each prescription medicine weight be respectively: the Radix Paeoniae Alba 80 grams, the Radix Astragali 105 grams, Semen Ziziphi Spinosae 60 grams, Radix Angelicae Sinensis 75 grams, Rhizoma Chuanxiong 60 grams, Spica Prunellae 75 grams, Rhizoma Coptidis 36 grams, Radix Rehmanniae 90 grams, Radix Scrophulariae 45.5 grams, the Rhizoma Atractylodis Macrocephalae 55 grams, Rhizoma Arisaematis 30 grams, the Rhizoma Pinelliae 30 grams, Concha Ostreae 90 grams, Carapax Trionycis 90 grams, Carapax Et Plastrum Testudinis 74 grams, Squama Manis 4.5 grams.

2, treatment hyperthyroidism and the big pure Chinese medicine capsule preparation technology of simple goiter:

Earlier take by weighing Concha Ostreae by formula ratio, Carapax Trionycis, Carapax Et Plastrum Testudinis, Squama Manis four flavor animal drugs are drunk raw sheet and are mixed and pulverized 80 mesh sieves and become standby behind the fine powder, take by weighing the Radix Paeoniae Alba by formula ratio again, the Radix Astragali, Semen Ziziphi Spinosae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Spica Prunellae, Rhizoma Coptidis, Radix Rehmanniae, Radix Scrophulariae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Arisaematis, the Rhizoma Pinelliae 12 kind of plant medicines are drunk raw and are added water 10-8 doubly after sheet mixes at every turn, decoct three times, decocted 2 hours for the first time, back twice 1.5 hours respectively, collecting decoction filters, it is the thick paste of 1.2-1.25 (80 ℃) that filtrate decompression is concentrated relative density, adding standby medicated powder at last mixes thoroughly and makes soft material, crossing 16 mesh sieves granulates, granulate behind 60 ℃ of-80 ℃ of temperature dryings, No. 0 capsule of packing into gets patent medicine.

Prescription also can be processed into tablet, granule or pill in view of the above.

3, treatment hyperthyroidism and big pure Chinese medicine capsule instructions of taking of simple goiter and consumption:

Oral: as to be grown up each 3-5 grain three times on the one.

Claims (2)

1, a kind of treatment hyperthyroidism and the big pure Chinese medicine capsule of simple goiter is characterized in that crude drug is made up of the Radix Paeoniae Alba 8.00%, the Radix Astragali 10.50%, Semen Ziziphi Spinosae 6.00%, Radix Angelicae Sinensis 7.50%, Rhizoma Chuanxiong 6.00%, Spica Prunellae 7.50%, Rhizoma Coptidis 3.60%, Radix Rehmanniae 9.00%, Radix Scrophulariae 4.55%, the Rhizoma Atractylodis Macrocephalae 5.50%, Rhizoma Arisaematis 3.00%, the Rhizoma Pinelliae 3.00%, Concha Ostreae 9.00%, Carapax Trionycis 9.00%, Carapax Et Plastrum Testudinis 7.40%, Squama Manis 0.45% in the prescription.

2, treat the preparation technology of hyperthyroidism and the big pure Chinese medicine capsule of simple goiter according to claim 1, it is characterized in that: take by weighing Concha Ostreae by formula ratio earlier, Carapax Trionycis, Carapax Et Plastrum Testudinis, Squama Manis four flavor animal drugs are drunk raw sheet and are mixed and pulverized 80 mesh sieves and become standby behind the fine powder, take by weighing the Radix Paeoniae Alba by formula ratio again, the Radix Astragali, Semen Ziziphi Spinosae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Spica Prunellae, Rhizoma Coptidis, Radix Rehmanniae, Radix Scrophulariae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Arisaematis, the Rhizoma Pinelliae 12 kind of plant medicines are drunk raw and are added water 10-8 doubly after sheet mixes at every turn, decoct three times,-inferior decoction 2 hours, back twice 1.5 hours respectively, collecting decoction filters, relative density was the thick paste of 1.2-1.25 when filtrate decompression was concentrated into 80 ℃, adding standby medicated powder at last mixes thoroughly and makes soft material, crossing 16 mesh sieves granulates, granulate behind 60 ℃ of-80 ℃ of temperature dryings, No. 0 capsule of packing into gets patent medicine.