CN103271992A - Pharmaceutical composition for improving immunity - Google Patents
Pharmaceutical composition for improving immunity Download PDFInfo
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- CN103271992A CN103271992A CN201310185062XA CN201310185062A CN103271992A CN 103271992 A CN103271992 A CN 103271992A CN 201310185062X A CN201310185062X A CN 201310185062XA CN 201310185062 A CN201310185062 A CN 201310185062A CN 103271992 A CN103271992 A CN 103271992A
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- pharmaceutical composition
- spleen
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- stomach
- river deer
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Abstract
The invention discloses a pharmaceutical composition for improving immunity. The pharmaceutical composition with the functions of promoting a digestive function and an immunologic function, tonifying spleen and nourishing stomach is prepared from deer ridge, cordyceps mycelia, ginseng, astragalus membranaceus and root of red-rooted salvia as main effective ingredients. The composition is integrated with the effects of effective ingredients of a plurality of traditional Chinese medicines, plays a complementary action, and has good effect on improvement of the function of a digestive system, improvement of the immunity, spleen-tonifying and stomach-nourishing.
Description
Technical field
The invention belongs to compound Chinese medicinal preparation and field of health care products, be with Chinese medicine be feedstock production be used for improving digestive system function, improve immunity, the pharmaceutical composition of spleen is supported in stomach invigorating.
Background technology
Immunity is the defense mechanism of human body self, is human body identification and any foreign body (virus, antibacterial etc.) of eliminating external intrusion; Handle the ability of self cell and identification and processing vivo mutations cell and the virus infected cell of old and feeble, damage, dead, degeneration.The health of hypoimmunity very easily causes infection such as antibacterial, virus, fungus, so the most direct performance of hypoimmunity is exactly liable to illness.Because of often ill, increased the weight of the consumption of body, so generally have a delicate constitution, performances such as malnutrition, lethargy, fatigue and weak, appetite depression, sleep disorder.
Experimental analysis in recent years shows; the protein content of river deer treasured reaches 39%, contains 17 seed amino acids such as taurine and threonine simultaneously, and wherein 7 kinds is the human body essential amino acid; and content is higher than general milk product, and wherein the content with glutamic acid, proline, valine and lysine is high especially.The result of inorganic elements analysis shows that the calcareous content of river deer treasured is higher, and per 100 gram dry powder contain 959.5mg, and the content of copper, manganese is the several times of other food, and content and the milk product of zinc, magnesium are suitable.
The inventor is through research with keen determination, especially to the river deer treasured in the effect that improves digestive function, enhancing human body immunity power and the research of mechanism, can replenish the effect of various trace element and then raising immunity well based on the river deer treasured, comprehensive other severally has the Chinese medicine that improves immunity again, for the patient of hypoimmunity provides new therapeutic scheme.
Summary of the invention
The invention provides a kind ofly be used to improving digestive system function, improve immunity, the pharmaceutical composition of spleen is supported in stomach invigorating, helps appetite stimulator, the empty body of tonification, and eliminating blood stasis to promote regeneration of blood improves digestive system function, enhancing human body immunity power.
This pharmaceutical composition is under the guidance of theory of Chinese medical science, optimizes and selects that Chinese medicine formula obtains, and each component comprehensively plays a role, and has good curing and preventive effect for hypoimmunity, gastrointestinal dysfunction.
Pharmaceutical composition of the present invention is made by following raw materials in weight portion: the precious 20-30 part of river deer, Cordyceps mycelium 18-25 part, Radix Ginseng 8-12 part, Radix Astragali 15-25 part, Radix Salviae Miltiorrhizae 20-30 part.With said components drying, pulverizing, grind the back altogether and crossed 200 mesh sieves, add conventional adjuvant and make granule or make tablet or optionally be prepared into clinical other dosage form commonly used with conventional method.
The river deer treasured: warm in nature, sweet in the mouth is flat, the effect that invigorating the spleen and regulating the stomach, dyspepsia and intestinal stasis relieving are arranged, braces up energy and delay senility.
Cordyceps mycelium: property is flat, sweet in the mouth, tonifying deficiency, beneficial vital essence, relieving cough and resolving phlegm.
Radix Ginseng: property is flat, sweet in the mouth, little hardship, tepor.Strongly invigorating primordial QI, multiple arteries and veins takes off invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves admittedly.
The Radix Astragali: slightly warm in nature, sweet in the mouth has benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.
Radix Salviae Miltiorrhizae: cold nature, bitter in the mouth, energy stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, promoting blood flow to regulate menstruation, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.
Above-mentioned five kinds of combinations of substances together, coordination of cold and heat has tonification deficient, the merit of eliminating blood stasis to promote regeneration of blood.
The consumption of raw material components of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components all has better curative effect in the following portions by weight scope.
The invention provides pharmaceutical composition, made by the raw material of following weight portion:
Be preferably:
Can add various conventional adjuvant required when preparing different dosage form in the pharmaceutical composition of the present invention, as disintegrating agent, lubricant, binding agent etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as granule, pill, powder, tablet, capsule, oral liquid etc.
Effective ingredient river deer treasured among the present invention can adopt method well known in the art to obtain, for example raise and train the above newborn river deer of breeding three generations and sucking river deer milk back stomach, especially form Off-white solid or semi-solid block in abomasum (glandular stomach) meeting, underwent operative is drying to obtain after taking out.
Particularly: 1. select the above newborn river deer of breeding three generations of raising and train of 12 ages in days to raise with river deer breast bottlefeeding.After three hours, lump can be touched in this breast river deer glandular stomach position;
2. newborn river deer is anaesthetized sterilization, bring aseptic operating room into, be fixed in operating-table, carry out the live body operation, cut glandular stomach open, taking-up Off-white solid or semi-solid block, 200 mesh sieves are crossed in dry, pulverizing, and namely obtaining can be for the river deer treasured of the present invention's use.
Certainly, the present invention also can adopt the precious raw material medicine of commercially available river deer, and the river deer treasured of the concrete employing of following examples institute is the commercially available prod.
The specific embodiment
Embodiment 1:
Take by weighing precious 25 parts of river deer, 20 parts of Cordyceps myceliums, 10 parts of Radix Ginsengs, 20 parts of the Radixs Astragali, 25 parts of Radix Salviae Miltiorrhizaes, with said components drying, pulverizing, mixing is ground the back altogether and is crossed 200 mesh sieves, gets compositions.
Described drying is lyophilizing, oven dry or natural air drying.Described pulverizing is sheared or comminution by gas stream for grinding, ball milling.Describedly be mixed into manual mixing or mix by various types of mixers, incorporation time is 0.5 to 5 hour.
The test example:
Below further sets forth the beneficial effect of pharmaceutical composition of the present invention by testing example, these are tested the routine impact effect for mouse immune organ thymus, spleen weight and determination of immunoglobulin, endurance of the present composition that comprised and test.
Test example 1: the present composition is to the influence of mouse immune organ thymus, spleen weight
Method: (14～18g) 40, single sex is divided into 4 groups at random, blank group and treatment group to get inbred mouse.The treatment group gives the normal saline suspension of the compositions of embodiment 1, is divided into basic, normal, high 3 dosage groups, dosage in the river deer treasured be followed successively by 25,50,100mgkg
-1The blank group gives isopyknic normal saline.Give volume and be 0.2ml (10g)
-1, irritate stomach 1 time/day, successive administration 7 days, next day after the last administration, eye socket sacrificed by exsanguination mice is weighed, and gets spleen, thymus, liver and claims weight in wet base, is thymus or spleen index with weight (mg) and the likening to of body weight (g) of thymus or spleen.
Result of the test:
Compositions is to the influence of mouse spleen index and thymus index
Conclusion (of pressure testing): the high, medium and low dosage group of compositions all can improve spleen index and the thymus index of mice.By the spleen index data as seen, low dose group and blank group relatively have significant difference (P＜0.05), and middle and high dosage group and blank group relatively have utmost point significant difference (P＜0.01)
Test example 2 present compositions are to the influence of the mouse immuning ball protein of immunocompromised
Method: (14～18g) 30, single sex is divided into 3 groups at random, blank group, model group and medicine group to get inbred mouse.The blank group: any processing is not done in normal raising in the experiment process; Model group: intraperitoneal injection 100mg/kg cyclophosphamide causes the hypoimmunity model, and 1 time/d, for three days on end; The medicine group: intraperitoneal injection 100mg/kg cyclophosphamide causes the hypoimmunity model, 1 time/d, for three days on end, and gave the normal saline suspension 1 time of the compositions of embodiment 1 in first day in modeling, in 50mgkg-1/ gastric infusion of river deer treasured, one Zhou Houzai gives the normal saline suspension 1 time of the compositions of embodiment 1, in 50mgkg-1/ gastric infusion of river deer treasured.The last administration is cervical vertebra dislocation method execution mice after 4 days, the aseptic spleen of getting.Place the plate that fills an amount of aseptic Hank ' s liquid, gently spleen is ground with tweezers, make the individual cells suspension, filter through 200 eye mesh screens, with cell suspension in the complete culture solution of 1mL, adjust cell concentration 1 * 109L-1, carefully the splenocyte suspension of the abundant mixing of 100 μ L is added to the bottom of sample introduction pipe with micropipettor, add 20 μ L monoclonal antibodies, low-speed oscillation mixing 3S, the room temperature lucifuge is hatched 30min, behind the countlerPREP broken red blood cell, detects T cell subsets content with flow cytometer.Mainly comprise: helper T cell (CD4+), cytotoxic T lymphocyte (CD8+), CD4+/CD8+.
Result of the test:
The T cell subsets influence
Compare with normal blank group: △ P＜0.05; With than model group: * P＜0.05.
Conclusion (of pressure testing): compare with the blank group, model group mouse spleen CD4+ cell subsets percentage ratio descends, and CD8+ cell subsets percentage ratio rises, and has significant difference, P＜0.05, and CD4+/CD8+ ratio obviously reduces, and has utmost point significant difference, P＜0.01.And the medicine group can obviously be offset the effect that cyclophosphamide destroys immunity, has significant difference, P＜0.05.
Test example 3: measure the present composition to the anti-fatigue test of mice endurance influence
Test method: (20～22g) 40, single sex is divided into 4 groups at random, blank group and medicine group to get inbred mouse.The medicine group gives the normal saline suspension of the compositions of embodiment 1, is divided into basic, normal, high 3 dosage groups, dosage in the river deer treasured be followed successively by 25,50,100mgkg-1; The blank group gives isopyknic normal saline.Give volume and be 0.2ml (10g)-1, irritate stomach 1 time/day, successive administration 15 days, 30min after the last administration puts into tank with mice and carries out swimming test, depth of water 25cm, 25 ℃ of water temperatures, every Mus afterbody bears a heavy burden and is body weight 10%.Put into tank and pick up counting, 10s does not float end to the mice submerged, records every Mus swimming time.
Result of the test:
Compositions is to the influence of mice swimming endurance
Annotate: compare * P＜0.05, * * P＜0.01 with the blank group.
Conclusion (of pressure testing): compare with the blank group, the middle and high dosage group energy of present composition significant prolongation mice swimming time has utmost point significance meaning (P＜0.01), shows that the present composition has antifatigue effect, and is the dosage effect dependence.
In sum, the present composition has remarkable result to spleen index and the thymus index that improves mice, can obviously offset the effect that cyclophosphamide destroys immunity, has good anti-fatigue effect, and is the dosage effect dependence.Can draw the present composition accordingly and have the effect that strengthens mouse immune power, for the research that improves human immunity power provides foundation.
Claims (3)
1. one kind is improved digestive system function, improves immunity, and the pharmaceutical composition of spleen is supported in stomach invigorating, is made by following raw materials in weight portion:
2. compositions as claimed in claim 1, made by following raw materials in weight portion:
3. compositions as claimed in claim 1 or 2, it is prepared to granule, pill, powder, tablet, capsule or oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310185062.XA CN103271992B (en) | 2013-05-20 | 2013-05-20 | Pharmaceutical composition for improving immunity |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310185062.XA CN103271992B (en) | 2013-05-20 | 2013-05-20 | Pharmaceutical composition for improving immunity |
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| CN103271992A true CN103271992A (en) | 2013-09-04 |
| CN103271992B CN103271992B (en) | 2014-10-08 |
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| CN201310185062.XA Expired - Fee Related CN103271992B (en) | 2013-05-20 | 2013-05-20 | Pharmaceutical composition for improving immunity |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125606A (en) * | 2015-07-17 | 2015-12-09 | 浙江大学 | Chewable tablet for improving immunity and preparation method of chewable tablet |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998647A (en) * | 2006-12-31 | 2007-07-18 | 张永华 | Traditional Chinese medicine composition for strengthening the body resistance and tonifying the liver, preparations and use thereof |
| CN102961611A (en) * | 2012-12-07 | 2013-03-13 | 杨军峰 | Health-care medicinal liquor and preparation method thereof |
-
2013
- 2013-05-20 CN CN201310185062.XA patent/CN103271992B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998647A (en) * | 2006-12-31 | 2007-07-18 | 张永华 | Traditional Chinese medicine composition for strengthening the body resistance and tonifying the liver, preparations and use thereof |
| CN102961611A (en) * | 2012-12-07 | 2013-03-13 | 杨军峰 | Health-care medicinal liquor and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125606A (en) * | 2015-07-17 | 2015-12-09 | 浙江大学 | Chewable tablet for improving immunity and preparation method of chewable tablet |
| CN105125606B (en) * | 2015-07-17 | 2018-10-19 | 浙江大学 | Improve the chewable tablets and preparation method thereof of immunity |
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| Publication number | Publication date |
|---|---|
| CN103271992B (en) | 2014-10-08 |
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