CN103239495A - Applications of winged euonymus total flavones in antiallergic agent or cosmetic, and preparation method - Google Patents
Applications of winged euonymus total flavones in antiallergic agent or cosmetic, and preparation method Download PDFInfo
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Abstract
The invention relates to applications of winged euonymus total flavones in an antiallergic agent or a cosmetic, and a preparation method. A technology scheme comprises: using ultrasonic extraction, condensing an extract, passing a macroporous adsorption resin column, washing out by using distilled water and ethanol as an eluant, and condensing, drying and purifying the eluate, to obtain winged euonymus total flavones. For preparing an antiallergic agent or a cosmetic, 1-10% winged euonymus total flavones is used as a main material, and 0.01-6% of methoxy homogalacturonans is used as a auxiliary material; prepared medicaments comprise: a tablet, a capsule, a paste agent and a inunction; and prepared cosmetics comprise: a cream, an emulsion, a lotion, a mask, and a massage paste. Shown in an experiment result to a mouse, the winged euonymus total flavones have obvious antipruritic effect, body fluid and cellular immunity enhancing effect and in vitro anti-allergic effect. The preparation has a 100% effective rate on treatment of urticaria. Compared with a same kind of product, the preparation has characteristics of substantial effect and good security.
Description
Technical field
The invention belongs to Chinese medicine and use and preparation field, be specifically related to have application and the method for making thereof of winged euonymus total flavones in preparation antiallergic medicament, cosmetics of antianaphylaxis function.
Background technology
Anaphylactic disease is a kind of immune disease, mainly shows as urticaria, allergic rhinitis, asthma etc.Anaphylactic disease also is one of a kind of common epidemic disease.The effective method for the treatment of allergy is to seek anaphylactogen, but in numerous incitants, accurately finds virulence factor very difficult.The Claritin that gone on the market at present is large in the variety, and these medicines are only limited to the alleviation of symptom, is difficult to fundamentally change allergic constitution; And mostly be chemicals, significant side effects is arranged.Therefore, the winged euonymus total flavones preparation that development safety has no side effect is patient's urgent needs.
Winged euonymus (Euonymus japonica Thunb) has another name called Ramulus Euonymi, and the beginning is stated from Shennong's Herbal, and is cold in nature, bitter in the mouth, suffering are returned liver, spleen channel, and the traditional Chinese medical science thinks that its bitter cold can consolidating YIN heat clearing away, can go into blood again, be the drug for invigorating blood circulation and eliminating stasis of using always, has that removing blood stasis stimulates the menstrual flow, the merit of removing toxic substances and promoting subsidence of swelling parasite killing.In recent years, the clinical and experimentation report to Ramulus Euonymi has pharmacologically actives such as antiinflammatory, blood sugar lowering, treatment angina pectoris and pulmonary heart disease; Also there is report dulcitol extract that the effect that suppresses mastocyte is arranged.But do not see and use this method to extract the winged euonymus total flavones, do not see that the preparation that contains winged euonymus total flavones single effective ingredient is used for the treatment of the report of anaphylactic diseases such as urticaria.The author cleans treatment urticaria instant effect according to employing winged euonymus water extract among the people, and effect is remarkable, the characteristics of non-evident effect; Be main Chinese medicinal materials with the winged euonymus, make tablet, capsule, unguentum, it is remarkable to be used for the treatment of anaphylactic disease effects such as urticaria.This preparation compares with similar chemical antiallergic agent, not only curative effect certainly, have drowsiness but also overcome chemicals with the back more, side effect such as xerostomia, dizziness, patient is glad acceptance not, and can not use during operation high-altitude, high speed operator, when life-time service, easily produce chemical sproof deficiency again, be difficult for recurrence behind the disease cured; Research and development have good prospect to the winged euonymus total flavones as Claritin, all have very important meaning at aspects such as sports medical science, sanipratics and the protections of winged euonymus agriculture and forestry plant.
Summary of the invention
Be to solve the winged euonymus total flavones and use and preparation method, the purpose of this invention is to provide the application and the preparation method that contain the winged euonymus total flavones in the medicament that is used for the treatment of anaphylactic disease or the cosmetics.
For containing application and the preparation method of winged euonymus total flavones in the medicament of realizing the treatment anaphylactic disease and the cosmetics.Described method is as follows:
1. winged euonymus total flavone extracting method
Take by weighing stem (containing wing) the decoction pieces 1000g of winged euonymus, pulverize totally 9 parts.Adopt supersound extraction, the extracting solution sucking filtration to there not being the alcohol flavor, adds the distilled water of 3 times of medical material amounts with the rotary evaporator evaporation and concentration, at low temperature (4～6 ℃), leaves standstill about 20h, the extracting solution sucking filtration after leaving standstill 2 times, and concentrate, drying gets the winged euonymus total flavones; D101 macroporous adsorbent resin post is crossed in dried winged euonymus total flavones dissolving or above-mentioned concentrated solution, colourless or almost colourless until effluent with the distilled water flushing pillar earlier, discard water lotion to remove water-solubility impurity; Reuse 80% ethanol is the eluant eluting,,, meets indicator until eluent and does not have characteristic reaction when effluent makes indicator just during variable color as indicator with liquor ferri trichloridi.The eluent that receives is concentrated, evaporate to dryness get winged euonymus total flavones crude product.The residue water extraction is made medicament, is used for the treatment of diabetes.Ultrasound wave is a kind of elastic mechanical vibration wave, it can produce judder, high-speed, strong cavitation effect and stirring action, can destroy the cell membrane of vegetable drug, solvent is penetrated in the crude drug cell, thereby accelerate release and the stripping of the effective ingredient in the medical material.Compare with traditional solvent extraction method, this method has shortened extraction time to this product, the extraction ratio height, and extraction rate is fast, easily realizes having a good application prospect industrialization.
2. winged euonymus determination of total flavonoids method
The making of standard curve: measure winged euonymus content of total flavone in the extract (calculating with rutin) with UV2550 type ultraviolet-uisible spectrophotometer.In 507.0nm place working sample solution absorbency, calculation sample winged euonymus general flavone content.
3. the winged euonymus total flavones is to mouse immune organ weight's influence
Get 50 of mices, be divided into 5 groups at random, be respectively the high, medium and low dosage group of winged euonymus total flavones (0.32,0.16,0.8g/kg), positive group is lentinan film (100mg/kg) and blank group, 10 of every group of mices.Each group is all with gastric infusion, and blank group is given the equal volume purified water.With administration first day, every mouse peritoneal was injected 5% chicken red blood cell (CRBC) suspension 0.2ml and is carried out immunity, successive administration 7 days, once a day.40min after the last administration.Extract eyeball and get blood, centrifugal, get thymus, spleen is weighed.Get serum with 100 times of normal saline dilutions, get dilute serum 1ml and mix with 0.5ml 5% (CRBC) and 0.5%ml 10% fresh guinea pig serum (1: 10), in 37 ℃ of calorstats, be incubated 30min, put cessation reaction in 0 ℃ of refrigerator.Centrifugal, get supernatant, measure absorbance (A) value at ultraviolet spectrophotometer 507nm place.The results are shown in Table 1
The result shows, compares with the blank group, and lentinan film, winged euonymus total flavones height, middle dosage group can improve hemolytic antibody and generate, and can increase mouse thymus exponential sum index and spleen index, and prompting winged euonymus total flavones has certain body fluid and cellular immunization potentiation.
Table 1 pair mouse immune organ weight influence (X ± s, n=10)
4. the winged euonymus total flavones is to Oleum Tiglii induced mice auricle edema inhibitory action
Get 50 of mices, be divided into 5 groups at random, be made as respectively and be respectively the high, medium and low dosage group of winged euonymus total flavones (0.32,0.16,0.8g/kg) group, positive group is aspirin (200mg/kg) and blank group, 10 of every group of mices.Each group is all with gastric infusion, and blank group is given the equal volume purified water, and successive administration 7 days behind the last administration 0.5h, is got 0.05ml 2% Oleum Tiglii solution with microsyringe and is applied to the mouse right ear exterior feature, treats to put to death mice behind the 4h.Use the card punch of bore 8mm immediately, draw materials along mice left and right sides auricle same area punching, on electronic balance, weigh respectively, as the swelling level index, obtain percent inhibition (%) with the difference of two auricle weight (mg).The results are shown in Table 2.
The result shows, compares with the blank group, and the high, medium and low dosage group of winged euonymus total flavones and aspirin group all can obviously suppress the mice auricle swelling degree due to the Oleum Tiglii, and suppression ratio is at 37.5%-52.1%.Show that the winged euonymus total flavones has tangible antiinflammatory action.
Table 2 pair Oleum Tiglii cause mice auricle swelling influence (X ± s, n=10)
5. antiallergic test
48 of mices are got in the influence that dextran is caused the mouse skin pruritus, and male and female half and half are divided into 4 groups at random, 12 every group, give the matched group drinking water in addition.The winged euonymus total flavones is respectively established one group (0.32g/kg, 0.16g/kg), chlorphenamine group 5mg/kg.Gastric infusion, continuous 5d, 30min after the last administration, vein injection before each mouse tail, continuous 5d, 30min after the last administration, each mouse tail vein injection dextran 0.95mg/kg.Scratching one's head with the mice fore paw, trunk is scratched by portion, rear solid end, mouth is stung each position of whole body as mice pruritus number of times and pruritus persistent period in the pruritus indication record 30min.The results are shown in Table 3
Table 3 winged euonymus total flavones causes the influence of mouse skin pruritus to dextran
Annotate: compare * * P＜0.01 with matched group
The result shows that the winged euonymus total flavones causes the mouse skin pruritus to dextran obvious antipruritic effect.
6. the external antiallergic test of winged euonymus total flavones
As can be seen from Table 4, when winged euonymus total flavones concentration was 0.1g/mL, its suppression ratio to hyaluronidase was 58%, sample solution is along with the increase of concentration, its antiallergic activity also increases thereupon, and when solution concentration reached 0.5g/mL, its hyaluronic acid enzyme inhibition rate had reached 95%.As seen, winged euonymus total flavones solution has very strong inhibitory action to hyaluronidase activity.
Table 4 winged euonymus total flavones is to the inhibitory action of hyaluronidase
7. winged euonymus total flavones acute toxicity test:
Get 40 of mices, male and female half and half are divided into two groups, are made as blank group and winged euonymus total flavones group respectively.Winged euonymus total flavones group, 20 every group, winged euonymus total flavones concentration (0.65g/ml) is all given every group of mouse stomach administration with maximum volume (0.4ml/10g body weight), and the blank group gives with the volume purified water.Continuous use is 3 times in the 24h.Observed 14 days toxicities such as the external sight of record mice, appetite, behavioral activity, death continuously.The results are shown in Table 5
The acute toxicity test of table 5 winged euonymus total flavones (X ± SD, n=20)
Compare with the blank group: P＞0.05 result shows, mice body weight normal growth is without any side effects.Measure winged euonymus total flavones maximum dosage-feeding 16.1g/kg body weight, prompting winged euonymus total flavones toxicity is minimum.
The specific embodiment
Example one
Take by weighing stem (containing wing) the page or leaf 1000g of winged euonymus, pulverize.Adopt supersound extraction, the extracting solution sucking filtration to there not being the alcohol flavor, adds the distilled water of 3～4 times of medical material amounts with the rotary evaporator evaporation and concentration, puts into refrigerator (4～6 ℃), leaves standstill about 10～20h.Extracting solution sucking filtration after leaving standstill 2 times, and concentrate, get winged euonymus total flavones behind the vacuum drying, pulverize, add adjuvant: methoxyl group galacturonic acid polysaccharide 5%, Borneolum Syntheticum 1%, polyvidone 0.1%, sodium bicarbonate 50%, magnesium stearate 10%, with purified water or ethanol, the moistening granule of making, drying, tabletting is made the effervescent tablet finished product.
Usage and dosage: get 5 of above-mentioned effervescent tablets, add 50 ℃ of hot water 1000ml, after dissolving, clean immediately or the shower affected part.As the general urticaria, get 30 of above-mentioned effervescent tablets, add 50 ℃ of hot water 30000ml, treat effervescent tablet dissolving after, took a shower 30 minutes, use once, transference cure, severe patient can the while oral tablet every day three times, each 3.
Routine urticaria patient surplus the clinical observation 21 uses once, and effective percentage reaches 100%.
Example two
Take by weighing stem (containing wing) the decoction pieces 1000g of winged euonymus, pulverize.Adopt supersound extraction, the extracting solution sucking filtration to there not being the alcohol flavor, adds the distilled water of 3～4 times of medical material amounts with the rotary evaporator evaporation and concentration, puts into refrigerator (4～6 ℃), leaves standstill about 10～20h.Extracting solution sucking filtration after leaving standstill 3 times, and concentrate, concentrated solution is crossed the D101 macroporous adsorptive resins.Colourless or almost colourless until effluent with the distilled water flushing pillar earlier, discard water lotion to remove water-solubility impurity.Reuse 50%～80% ethanol is the eluant eluting, as indicator, when effluent makes indicator just during variable color, receives eluent with FeC13 solution, meets indicator until eluent and does not have characteristic reaction.The eluent that receives is concentrated, evaporate to dryness get the total flavones crude product.Get winged euonymus total flavones behind the vacuum drying, pulverize, add adjuvant: methoxyl group galacturonic acid polysaccharide 1%, polyvidone 0.2%, sodium bicarbonate 15%, magnesium stearate are an amount of, and with purified water or the moistening granule of making of ethanol, drying, tabletting is made oral finished product.
Usage and dosage: every day three times, each 3～5,7～30 days is a course for the treatment of.Clinical observation urticaria patient 15 examples, effective percentage reaches 95%.
Example three
Take by weighing winged euonymus decoction pieces 1000g, pulverize.Adopt supersound extraction, the extracting solution sucking filtration to there not being the alcohol flavor, adds the distilled water of 3～4 times of medical material amounts with the rotary evaporator evaporation and concentration, puts into refrigerator (4～6 ℃), leaves standstill about 10～20h.Extracting solution sucking filtration after leaving standstill 2～3 times, and concentrate, concentrated solution is crossed the D101 macroporous adsorptive resins.Colourless or almost colourless until effluent with the distilled water flushing pillar earlier, discard water lotion to remove water-solubility impurity.Reuse 70% ethanol is the eluant eluting, as indicator, when effluent makes indicator just during variable color, receives eluent with FeC13 solution, meets indicator until eluent and does not have characteristic reaction.The eluent that receives is concentrated, evaporate to dryness get the total flavones crude product.Get winged euonymus total flavones behind the vacuum drying, pulverize, add adjuvant: methoxyl group galacturonic acid polysaccharide 3%, polyvidone 0.2%, sodium bicarbonate 10%, hydroxyethyl-cellulose 0.5%.With the moistening granule of making of purified water, drying,, encapsulated, make capsule finished product.
Usage and dosage: every day three times, each 3～5,7～30 days is a course for the treatment of.Clinical observation urticaria patient 10 examples, effective percentage reaches 90%.
Example four
Take by weighing stem (the containing wing) 1000g of winged euonymus, pulverize.Adopt supersound extraction, the extracting solution sucking filtration to there not being the alcohol flavor, adds the distilled water of 3～4 times of medical material amounts with the rotary evaporator evaporation and concentration, puts into refrigerator (4～6 ℃), leaves standstill about 15～20h.Extracting solution sucking filtration after leaving standstill 2～3 times, and concentrate, concentrated solution is crossed the D101 macroporous adsorptive resins.Colourless or almost colourless until effluent with the distilled water flushing pillar earlier, discard water lotion to remove water-solubility impurity.Reuse 50%～80% ethanol is the eluant eluting, as indicator, when effluent makes indicator just during variable color, receives eluent with FeC13 solution, meets indicator until eluent and does not have characteristic reaction.The eluent that receives is concentrated, evaporate to dryness get the total flavones crude product.Get winged euonymus total flavones behind the vacuum drying, pulverize, add adjuvant: methoxyl group galacturonic acid polysaccharide 0.5%, Borneolum Syntheticum 0.1%, polyvidone 1%, sodium bicarbonate 5%, spermol 3%, stearamide propyl dimethylamine 1%, mixing is stirred in polydimethylsiloxane 2% dissolving, it is an amount of to add essence, makes massage cream.
Example five
Get winged euonymus total flavones behind the vacuum drying, pulverize, add adjuvant according to the following step:
Methoxyl group galacturonic acid polysaccharide, polyvidone be dispersed in handle in the sub-water, be warming up to 80 ℃ simultaneously, other components in the adding side then, (1) stirs; Above-mentioned spermol, stearamide propyl dimethylamine, polydimethylsiloxane, Cera Flava, paraffin, methyl parahydroxybenzoate are heated 80 ℃ of dissolvings respectively, and (2) stir; Mix (1) that continuation is good with above-mentioned dissolving and (2), stirs, and adds the winged euonymus total flavones, stirs, and adjust pH 6～7 stirs, and adds essence, to condensation, makes the antiallergic cream.
Example six
Get winged euonymus total flavones behind the vacuum drying, dissolving, standby.Operate according to the following step: get stearic acid, octadecanol, white lanoline, white vaseline and be oil phase in the water-bath fusing back of heating, insulation is between 75 ℃～80 ℃, other gets methyl parahydroxybenzoate and adds an amount of dissolve with ethanol, add sodium laurate again, tween 80 is dissolved as water, insulation is between 75 ℃～80 ℃, under constantly stirring, slowly water is added emulsifying in the oil phase, and then winged euonymus total flavones, the EDTA-Na2 that will dissolve in advance slowly add, and adds water to capacity, adds essence when being stirred to 40 ℃, get final product to condensation, make cream.
Model case one
The Wang, the man, 49 years old, in May, 2005, first visit: acute urticaria.The patient cuts firewood because going up a hill, and after going home, the many places welt appears in skin suddenly, enlarges gradually, is fused into great film shape erythra mutually, and boundary is clear, and high slightly of erythra is cerise, pore expansion, recessed, pachyderma, conscious violent pruritus.Welt continues slightly better after 4 hours, recurrence in 2 hours at interval, and after a collection of the disappearing, another batch rises again.With headache, general weakness, feel sick, uncomfortable in chest, dyspnea.Be diagnosed as acute urticaria.Give 30 of above-mentioned effervescent tablets, add 50 ℃ of hot water 30000ml, treat the effervescent tablet dissolving after, took a shower 30 minutes, use one time transference cure, do not follow up a case by regular visits in 7th and to recur.
Model case two
Zhang, the woman, 59 years old, in December, 2006, first visit, chronic urticaria.Patient's welt shows effect repeatedly, and the course of disease 1 year is surplus, and local erythra quantity is not limit, and friction, draws thorn or impacts skin, all can cause the welt outbreak, and welt appears in variable interval, companion's pruritus.Be diagnosed as chronic urticaria.Give above-mentioned oral tablet every day three times, each 4,14 is a course for the treatment of.Follow up a case by regular visits to after 2 months, not recurrence.
Typical case three
Week certain, the man, 60 years old, he mentioned the Herba Urticae Cannabinae exanthema of oneself and still has a lingering fear, " urticaria has almost been wanted my life.Week, certain health one was to fine, retirement adheres to beating Tai Ji afterwards every morning, go up several friends' fishing of climbing the mountain when weather is good approximately, but before half a year, he got urticaria, a large amount of " welt " appears in whole body, face and lip enlargement, it is hard to bear very to itch, and lasts for several years, tangle repeatedly, even General Symptomies such as chest pain, myocardial ischemia, arthralgia occurred.Song has walked many hospitals, can be by hormone control mostly, as long as do not take medicine and will recur in one day.Be diagnosed as chronic urticaria, take a shower for above-mentioned effervescent tablet, each 30, the next day once, add 50 ℃ of hot water 30000ml, treat the effervescent tablet dissolving after, bathed 30 minutes.Oral above-mentioned oral, every day three times, each 4, only through treatment in two months, week, the disease of certain just obtained healing.
Typical case four
Song, the woman, 40 years old, the government functionary mentioned the Herba Urticae Cannabinae exanthema of oneself and still has a lingering fear.Song suffers from hypothyroidism disease.The year before, he got urticaria, and a large amount of " welt " appears in whole body, face's enlargement, and red rash appears in exposure portion, and it is hard to bear very to itch, and lasts for several years, and tangles repeatedly, even General Symptoms such as uncomfortable in chest, arthralgia occurred.Song has walked many hospitals, and Chinese medicine, Western medicine have been eaten much, and still outbreak repeatedly as long as do not take medicine and will recur in one day.Be diagnosed as chronic urticaria and take a shower for above-mentioned effervescent tablet, each 30, the next day once, add 50 ℃ of hot water 30000ml, treat the effervescent tablet dissolving after, bathed 30 minutes.Oral above-mentioned oral, every day three times, each 4, only through the treatment in January, Song's disease has just obtained healing.Follow up a case by regular visits to not recurrence after half a year.
Typical case five
Grandson, man, 13 years old, suffer from Herba Urticae Cannabinae exanthema reach 3 years surplus, went to ground such as Beijing to seek medical advice and medicine the therapeutic process complexity, in the oral chlorphenamine, high enlightening capsule 1 year, certain effect is arranged in 3 months, attack times reduces, pruritus alleviates, and continues oral chlorphenamine, high enlightening capsule, during to five month, symptom such as welt, pruritus is outbreak repeatedly still, and a large amount of " welt ", face and lip enlargement appear in whole body, it is hard to bear very to itch, and lasts for several years, even General Symptomies such as uncomfortable in chest, dyspnea occurred.Grandson is ill to be by chlorphenamine control mostly, as long as do not take medicine and will recur in one day.
Be diagnosed as chronic urticaria, give above-mentioned effervescent tablet bathing, each 30, the next day once, add 50 ℃ of hot water 30000ml, treat the effervescent tablet dissolving after, bathed 30 minutes.Oral above-mentioned oral, every day three times, each 3, only through treatment in 1 month, grandson's chronic urticaria disease just obtained healing.
Model case six
Zhang, the man, 46 years old, the peasant, go to a doctor in May, 2005, and readme the back of the hand and back part are found many goose pimples, and redness is itched, and once treatment was smeared in the external-applied ointment affected part, DeGrain, outbreak repeatedly, obstinate.Be diagnosed as chronic urticaria, adopt the effervescent tablet bathing, each 30, the next day once, add 50 ℃ of hot water 30000ml, treat above-mentioned effervescent tablet dissolving after, bathed 30 minutes.Oral above-mentioned oral, every day three times, each 3, only through treatment in 1 month, transference cure.Followed up a case by regular visits in three months, and do not see recurrence.Zhang's chronic urticaria disease has obtained healing.
Claims (10)
1. one kind is used for antiallergic winged euonymus total flavones or winged euonymus total flavones, it is characterized in that described winged euonymus total flavones or winged euonymus total flavones are in application and the preparation of antiallergic, antiinflammatory, blood sugar lowering, treatment angina pectoris medicament or cosmetics.
2. according to the described winged euonymus total flavones of claim 1 or winged euonymus total flavones preparation method, it is characterized in that adopting supersound extraction, add the distilled water of 2～5 times of medical material amounts, low temperature (2～8 ℃) leaves standstill about 10～20h.Extracting solution sucking filtration after leaving standstill 2～3 times, and concentrate, drying gets the winged euonymus total flavones.Get winged euonymus total flavones or above-mentioned concentrated solution, by the D101 macroporous adsorptive resins.Colourless or almost colourless until effluent with the distilled water flushing pillar earlier, discard water lotion to remove water-solubility impurity.Reuse 60%～80% ethanol is the eluant eluting, in the elution process,, meets indicator until eluent and does not have characteristic reaction as indicator with liquor ferri trichloridi.The eluent that receives is concentrated, evaporate to dryness get the winged euonymus total flavones.
3. use in antiallergic, antiinflammatory, blood sugar lowering, treatment angina pectoris according to the described winged euonymus total flavones of claim 1 or winged euonymus total flavones and prepare, it is characterized in that in the medicament that main component contains the winged euonymus total flavones or the winged euonymus total flavones is 0.1%～10%, adjuvant: methoxyl group galacturonic acid polysaccharide 0.01%～6%, Borneolum Syntheticum 1%～3%, polyvidone 1%～3%, sodium bicarbonate 1%～50%, ethanol 20%～90%, magnesium stearate 0.5%～10%.Stearyl alcohol 0.1%～3%, spermol 0.1%～5%, stearamide propyl dimethylamine 0.1%～5%, polydimethylsiloxane 0.1%～5%, methyl parahydroxybenzoate 0.1%～0.4%, deionized water 30%～80%, sodium alkyl sulfate 0.1%～1.0%, white oil 5%～10%, 16,18 carbon fatty alcohols 8.0%～15.0%, monostearate glycerine ester 1%～4%.The medicament of making comprises: tablet, capsule, unguentum.Wherein tablet comprises effervescent tablet, slow releasing tablet, enteric coatel tablets, Film coated tablets, and capsule comprises hard capsule, soft capsule, enteric coated capsule, and unguentum comprises ointment, emulsifiable paste, lotion, inuncts; Make cosmetics: comprise cream, emulsion, astringent, facial film, massage cream.
4. use and preparation in antiallergic according to claim 1 or 3 described winged euonymus total flavones, it is characterized in that containing in the medicament main component, by mass percentage: the winged euonymus total flavones is 5%～10%, adjuvant: methoxyl group galacturonic acid polysaccharide 0.01%～0.2%, Borneolum Syntheticum 1%～3%, polyvidone 0.1%～3%, sodium bicarbonate 30%～50%, magnesium stearate 0.5%～5%, mix homogeneously, granulate, tabletting is made effervescent tablet.
5. use and preparation in antiallergic according to claim 1 or 3 described winged euonymus total flavones, it is characterized in that in the medicament, by mass percentage: containing the winged euonymus total flavones is 3%～6%, adjuvant: methoxyl group galacturonic acid polysaccharide 3%-6%, polyvidone 1%～3%, sodium bicarbonate 1%～5%, magnesium stearate 5%～10%, add an amount of ethanol, mixing is made granule, tabletting is made oral.
6. application and the preparation in antiallergic according to claim 1 or 3 described winged euonymus total flavones, it is characterized in that in the medicament, by mass percentage: containing the winged euonymus total flavones is 3%～6%, adjuvant: methoxyl group galacturonic acid polysaccharide 3%-6%, polyvidone 1%～3%, sodium bicarbonate 10%～30%, mixing, make granule, encapsulated, make capsule.
According to claim 1 or 3 described winged euonymus total flavones at antianaphylactic application and preparation, it is characterized in that in the medicament, by mass percentage: contain winged euonymus total flavones 2%～5%, methoxyl group galacturonic acid polysaccharide 0.1%～0.5%, stearyl alcohol 0.1%～3%, Borneolum Syntheticum 2%～3%, stearamide propyl dimethylamine 1%～4%, lanoline 10%～30%, vaseline 10%～40%, methyl parahydroxybenzoate 0.1% add an amount of ethanol or water dissolution, stir, mixing is made ointment.
According to claim 1 or 3 described winged euonymus total flavones at antianaphylactic application and preparation, it is characterized in that in the cosmetics, by mass percentage: contain winged euonymus total flavones 0.1%～0.5%, methoxyl group galacturonic acid polysaccharide 0.01%～0.2%, stearyl alcohol 0.1%～3%, Borneolum Syntheticum 0.1%～0.3%, spermol 0.1%～5%, stearamide propyl dimethylamine 1%～4%, polydimethylsiloxane 0.1%～4%, methyl parahydroxybenzoate 0.1%～2%, add an amount of water or ethanol, dissolving, mixing is made cold cream.
9. use and preparation in antiallergic according to claim 1 or 3 described winged euonymus total flavones, it is characterized in that in the cosmetics, by mass percentage: contain winged euonymus total flavones 0.01%～0.5%, methoxyl group galacturonic acid polysaccharide 0.01%～0.2%, Borneolum Syntheticum 0.1%～1%, stearyl alcohol 0.1%～3%, Cera Flava 5%～20%, paraffin 1%～4%, polydimethylsiloxane 0.1%～4%, methyl parahydroxybenzoate 0.1～1%%, add an amount of water or ethanol, dissolving adds essence, stirs, mixing is made emulsifiable paste.
10. use and preparation in antiallergic according to claim 1 or 3 described winged euonymus total flavones, it is characterized in that in the cosmetics, by mass percentage: contain winged euonymus total flavones 0.01%～0.5%, methoxyl group galacturonic acid polysaccharide 0.01%～0.2%, stearic acid 10%～30%, octadecanol 1%～5%, white lanoline 5%～20%, white vaseline 5%～10%, methyl parahydroxybenzoate 0.1～1%, sodium laurate 0.01%～0.2%, tween 80 0.01%～0.8%, EDTA-Na20.01%～0.5%, essence are an amount of.Operate according to the following step: get winged euonymus total flavones behind the vacuum drying, dissolving, standby; Other gets stearic acid, octadecanol, lanoline, white vaseline are oil phase after fusing is heated in water-bath in vain, insulation is between 75 ℃～80 ℃, other gets methyl parahydroxybenzoate and adds an amount of dissolve with ethanol, add sodium laurate again, tween 80 is dissolved as water, insulation is between 75 ℃～80 ℃, under constantly stirring, slowly water is added emulsifying in the oil phase, and then winged euonymus total flavones, the EDTA-Na2 that will dissolve in advance slowly add, and adds water to capacity, adds essence when being stirred to 40 ℃, get final product to condensation, make cream.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560332A (en) * | 2015-12-24 | 2016-05-11 | 西安医学院 | Ramulus euonymi extract product preparation and preparation and application of itching-relieving preparation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985917A (en) * | 2006-12-12 | 2007-06-27 | 王宝民 | Medicine composition for reducing blood sugar, reducing blood fat and controlling diabetes complication |
-
2012
- 2012-02-08 CN CN2012100270228A patent/CN103239495A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985917A (en) * | 2006-12-12 | 2007-06-27 | 王宝民 | Medicine composition for reducing blood sugar, reducing blood fat and controlling diabetes complication |
Non-Patent Citations (4)
| Title |
|---|
| 孙学斌等: "卫矛不同有效部位总黄酮含量及抗氧化性的研究", 《植物研究》 * |
| 林锋等: "卫矛总黄酮的超声提取工艺研究", <<哈尔滨医科大学学报>> * |
| 田永明等: "中药鬼箭羽的现代研究进展", 《吉林中医药》 * |
| 黄德斌等: "鬼箭羽三种提取物对氧自由基作用的影响", <<湖北民族学院学报>> * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560332A (en) * | 2015-12-24 | 2016-05-11 | 西安医学院 | Ramulus euonymi extract product preparation and preparation and application of itching-relieving preparation |
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Application publication date: 20130814 |