WO2008061447A1

WO2008061447A1 - A medicine for treating eczema and process of ointment thereof

Info

Publication number: WO2008061447A1
Application number: PCT/CN2007/003272
Authority: WO
Inventors: Jinghua Chen
Original assignee: Shen Zhen Bei Ke Lian Pharmaceutical Sci-Tech Co., Ltd
Priority date: 2006-11-20
Filing date: 2007-11-20
Publication date: 2008-05-29
Also published as: CN101019952A; CN101019952B

Abstract

A medicine for treating eczema and process of ointment thereof. The medicine is prepared by using 150-600 parts by weight of radix sophora flavescens Ait., 100-300 parts by weight of cortex dictamnus dasycarpus Turcz., 150-600 parts by weight of cortex paeonia suffruticosa Andr., and 5-25 parts by weight of borneol as raw materials.

Description

Confirmation method for preparing eczema and preparation method thereof

The invention relates to a traditional Chinese medicine for treating eczema and a preparation method thereof.

Background technique

Eczema is a common inflammatory skin disease of the skin, which is named after the rash lesion has a tendency to exude moisture. The course of the disease is protracted and easy to relapse. The clinical symptoms of eczema vary widely. According to the different manifestations of skin lesions during the onset, they are classified into acute, subacute and chronic types. The damage of acute eczema is pleomorphic, initially erythema, consciously burning and itching. Following the presence of scattered or dense papules or small blisters on the erythema, after scratching or rubbing, it smashes to form a smashed, oozing surface. After a long time or after treatment, the acute inflammation is relieved, the skin lesions are dry, crusted, and scaly, and enter the subacute phase. Chronic eczema is caused by acute and subacute recurrent episodes, or chronic inflammation at the beginning. It is often characterized by a long-term unhealed condition in a certain part, which is characterized by thickening of the skin and deepening of the skin. Infiltration, pigmentation, etc. The main symptoms are intense itching.

The etiology and pathogenesis of eczema is quite complex and involves many factors, both internal and external. It is a delayed type of allergic reaction that occurs in the skin. This disease often occurs in individuals with allergic qualities. Anyone with this quality, allergic substances in and out of the body, such as protein in food, especially fish, shrimp, eggs and milk, as well as chemicals, plants, animal leather and feathers, parasites in the intestines, infections The effect of the stove is prone to allergic reactions than normal people. Some even physical stimuli such as sunlight, wind, and cold can induce eczema. In addition, the occurrence of eczema may sometimes have a certain relationship with neurological dysfunction, endocrine disorders, dyspepsia, intestinal diseases, metabolic abnormalities, etc. In summary, the onset of eczema is caused by the interaction of various factors. ' At present, the treatment of eczema, Western medicine is more than oral antihistamine treatment, such as diphenhydramine, phenacetin, chlorpheniramine, cyproheptadine, etc., can be used alone or in combination, but also with Sedatives, vitamin C, etc. Use together. The external dosage form depends on the clinical skin lesions, such as redness and swelling. Exudation should be selected as cold and wet compress, erythema and papules can be used as lotion, emulsion, mud, oil, etc.; blisters, smashed need to use Oil; It is an ointment for scaling and crusting; if the moss is changed, choose a mud, ointment, emulsion, filming agent, tincture and hard plaster.

There are oral and topical medicines for the treatment of eczema. Zhongcheng has medicines such as stomach sputum pills and dehumidification pills, and there are various lotions for external use.

With the research and development of the treasure house of Chinese medicine in the motherland, people's health awareness has improved, and the side effects of traditional Chinese medicine in the treatment of diseases have been accepted. The use of natural Chinese medicine for the treatment of human diseases has become the first choice.

Purpose of the invention

The object of the present invention is to provide a traditional Chinese medicine preparation for treating eczema, and enrich the treasure house of Chinese medicine.

Another object of the present invention is to provide a method for preparing a traditional Chinese medicine ointment for treating eczema for the convenience of a patient.

The traditional Chinese medicine formula for treating eczema of the present invention is that the medicine is an agent made of the following raw materials by weight ratio:

Kushen 150~600 white fresh skin 100~300 peony skin 150~600 ice sheet 5~25

A preferred embodiment of the medicament for treating genital warts of the present invention, an agent made from the following raw materials by weight:

Kushen 300 white fresh skin 200 peony skin 300 ice sheet 10

The main ingredients of Sophora flavescens are more than 10 kinds of alkaloids such as matrine and alkali, which are characterized by sexual cold and bitter taste. The main functions are heat-clearing diuretic and dampness. The main components of borneol are L-Dragon's brain and a small amount of eucalyptus oil, L-camphor and sesquiterpene alcohol. Its characteristics are slightly cold, taste hard, and aromatic sputum. The main effect is to reduce swelling and pain, and to clear eyesight.

The main ingredients of peony bark are peony phenol, peony peony, volatile oil, etc. Its characteristics are slightly cold, bitter and spicy, and its main effect is clearing heat and cooling blood, promoting blood circulation and removing blood stasis.

The main ingredients of white fresh skin are white fresh alkali, alkaloids, and jalapeno. Their characteristics are sexual cold and bitter taste. The main functions are detoxification, dehumidification, hurricane and insecticide.

The medicament of the invention has the effects of clearing heat and dampness, detoxifying and relieving itching, and is mainly used for damp-heat injection type, and the symptoms such as severe itching, thickening of the skin, pigmentation and the like.

The process steps of the preparation method of the traditional Chinese medicine ointment preparation for treating eczema of the present invention are as follows:

1) Take 300g of Sophora flavescens, 200g of raw material of white fresh skin, add 10 times of water each time, decoct 3 times, each time for 2 hours, take decoction separately, filter, combine the filtrate, and set it for use;

2) 300g raw material of peony bark, add 20 times of water, heat to 45 ^e C, immerse for 1 hour, distill, collect 10 times of distillate of medicinal material, filter, add 5% sodium chloride to the filtrate, collect the medicinal materials 3 times the amount of distillate, refrigerated, crystallization, combined crystallized, obtained paeonol, and set aside;

3) Add 6 times the amount of water to the dregs obtained in step 2), decoct for 1 hour, filter, and combine the filtrates, and use them separately;

4) Combine the steps 1) and 3) the filtrate, concentrate to a relative density of about 1.06-1.10 (60 ° C), add ethanol to make the alcohol content 60%, refrigerate for 24 hours, filter, and recover ethanol under reduced pressure (60 ~70 ° C, -0.08 Mpa), concentrated to a relative density of about 1.28-1.35 (60 ° C), that is, a drug thick cream;

5) taking 150 g of stearic acid, 20 g of lanolin, 250 ml of liquid paraffin, 50 g of glycerin, 8 g of triethanolamine, 20 g of sodium decyl sulfate, 370 ml of water to prepare a matrix, and obtaining paeonol with step 2), Step 4) A drug ointment and 10 g of borneol are uniformly mixed to obtain about 1000 g of a drug ointment for treating eczema. The invention has the advantages of simple use, small side effects, and clinically proven that the total effective rate is over 80%.

detailed description

The medicament for treating eczema of the present invention is a medicament prepared from the following raw materials by weight ratio: Sophora flavescens 150^600 white fresh skin 100~300 Mudanpi 150~600 borneol 5~25

The preferred embodiment of the present invention for treating eczema is prepared according to the following raw materials by weight ratio: bitter ginseng 300 white fresh skin 200 peony bark 300 ice piece 10

The pharmaceutical dosage form is any of the pharmaceutically acceptable dosage forms, and the object of the invention can be achieved.

The preparation method of the ointment for treating eczema according to the present invention is particularly important because the medicine is mainly treated, and the antibacterial and anti-inflammatory effect is particularly important. In the design of the process route, the antibacterial and anti-inflammatory medicinal ingredients are mainly preserved. According to the Chinese medicine literature of the motherland, the main active ingredients of Sophora flavescens are alkaloids such as matrine and oxymatrine, mainly in the peony bark. There are paeonol and paeoniflorin, etc. According to the above studies, it is known that the active ingredients of the main drugs in the drug are relatively clear, and the process steps are as follows:

a. The water extraction process of Sophora flavescens is preferably determined as follows:

Al, pre-test: Weigh 15 g of Sophora flavescens, 10 g of white fresh skin, smash into coarse particles (about 10 mesh), add 6 times of water, boil for 1 h, filter, let cool, absorb 98 ml. The absorption ratio is 2.08 times. ,

A.2. Orthogonal test: According to the results of pre-test, choose three factors: solvent dosage, boiling time and boiling time. The process is preferred at three levels of each factor. The factor level table is shown in Table-1.

Table-1 Level Table of Water Extraction Process Factors: Horizontal factor ABC

Water addition (times) boiling time (h) number of boiling times (times)

1 6 1 1

2 8 1.5 2

3 10 2 3 a.2.1 Orthogonal test method:

A.2.1.1 Determination of matrine content: Weigh 15g of Sophora flavescens coarse powder, 10g of white fresh skin, test according to the orthogonal table, filter, the filtrate is fixed to the corresponding volumetric flask, let cool, add water separately To the scale, shake well and serve as the test solution. The dried reference constant dry matrine reference substance 2.80mg, dissolved in methanol, transferred to a 5ml volumetric flask, as a reference solution. Precisely draw the lOul of each test solution under the orthogonal table, the lOul and 5ul of the reference solution, point on the same silica gel G thin plate, with benzene-acetone-ethyl acetate-concentrated ammonia (2: 3: 4) : 0.2) is a developing agent, unrolled, taken out, dried, and developed with dilute potassium iodide, covered with a glass plate of the same size on a thin layer, surrounded by a tape, and scanned with a CS-9301 thin layer scanner. , Wavelength: XS = 530nm, λ R = 650nm, measure the integral value of the absorbance of the test product and the absorbance integral value of the reference product, and calculate the content.

A.2.1.1 Determination of the creaming rate: According to the orthogonal test, the filtrate is set to 1000 ml volumetric flask, add water to the mark, shake well, take 50ml, place the constant weight of the evaporating dish, water bath Evaporate to dryness, transfer to an oven, bake at 80 ° C to dry paste, and weigh.

A.2.2 Orthogonal test results and analysis: The matrine content and the ointment rate are used for the statistics. The summary and analysis of the orthogonal test results are shown in Table -2 and Table -3 and Table -4.

Table -2 Analysis of orthogonal test results of Sophora flavescens water extraction process:

Test No. A B C D ~~ matrine amount (mg/g medicinal material) ~~ creaming rate (%)

1 1 1 1 1 1.809 13.51

2 1 2 2 2 5.928 24.31

3 1 3 3 3 6.719 28.34

4 2 1 2 3 5.230 22.22

5 2 2 3 1 6.943 27.94 6 2 1 3 2 3.540 18.56

7 3 1 3 2 5.763 26.28

8 3 2 1 3 3.671 17.15

9 3 3 2 1 6.801 26.18

I 14.456 12.802 9.02 15.553 Matrine

II 15.713 16.542 17.959 15.231

ΠΙ 16.235 17.06 19.425 15.62

R 1.779 4.258 10.405 0.389

I 66.16 62.01 49.22 67.63 Erasing rate

II 68.72 69.40 72.71 69.15

ΠΙ 69.61 73.08 82.56 67.71

R 3.45 . 11.07 33.34 1.52

The analysis of variance was performed on the results obtained. The results are as follows:

Analysis of variance of maternal orthogonal test results:

Table "4 Analysis of Variance of Orthogonal Test Results of Ointment Rate:

Variance source deviation square sum degree freedom degree variance F value

A 2.1387 2 1.0694 4.38

B 21.1888 2 10.5944 43.44

C 195.5954 2 97.7977 400.97

D 0.4878 2 0.2439 F0.05(2,2)=19.0 F0.01(2,2)=99.0

According to the results of the study, the extraction number C is the main influencing factor, and C3>C2>C1, so the C3 level is selected; the B factor is also the main factor, but combined with the results of the range analysis, B2 and B3 levels. There is not much difference, but there is a big difference with B1. Therefore, the B3 level can be selected. In the A factor, the A2 and A3 levels are not much different, but there is a big difference with A1. Therefore, the A3 level can be selected. The preferred process conditions are A3B3C3; B and C are significant factors in terms of the creaming rate, but 3 is the most ambiguous in the orthogonal table, namely A1B3C3, so the comprehensive consideration of A3B3C3 is considered as the best condition, that is, the medicine is added to 10 Double the amount of water, decoct 3 times, 2 hours each time.

A.2.3 Verification test: According to the conditions determined by the orthogonal test, the operation is performed in parallel twice, and the verification test is carried out with the matrine and the ointment rate as indicators. The comparison test is carried out according to the optimal process A3B3C3 in the process optimization. The following table. It indicates that the preferred process is better than the reference process, and the determined process is a better process. Table -5 Results of the verification process of the extraction process of Sophora flavescens water:

2) 300 g of raw material of peony bark, add 20 times of water, heat to 45 ° C, immerse for 1 hour, distill, collect 10 times of distillate of medicinal material, filter, add 5% sodium chloride to the filtrate, collect 3 times the amount of distillate of the medicinal material, refrigerated, crystallization, combined with crystallization, obtained paeonol, and set aside;

3) Add 6 times of water to the obtained dregs of step 2), decoct for 1 hour, filter, and combine the filtrates for use;

4) Combine the steps 1) and 3) the filtrate, concentrate to a relative density of about 1.06-1.10 (60 ° C), add ethanol to make the alcohol content 60%, refrigerate for 24 hours, filter, and recover ethanol under reduced pressure (60 ~70 ° C, -0.08 Mpa), concentrated to a relative density of about 1.28-1.35 (60" C), that is, a drug thick cream;

The selection process of a peony skin medicinal material is preferably determined as follows: The extraction experiment of paeonol in al medicinal materials is as follows - a.1.1 peony bark is mainly composed of paeonol, which is proposed as much as possible without excessive dissolution of polymer viscous material, which makes filtration difficult. When energy consumption is used, we use the double extraction method to optimize the extraction of the active ingredients as much as possible in the shortest possible time, and to maintain the characteristics of the traditional decoction.

Firstly, the peony skin material is coarsely pulverized to make it "fine but not powder", which can increase the surface area to facilitate the dissolution of the components, and does not cause the gelatinization to affect the dissolution and filtration of the components. In addition, in order to maintain the characteristics of the decoction as much as possible, and to take into account the water-soluble ingredients, three factors, including the water addition ratio, the pretreatment of the medicinal material and the salt addition amount, were designed for comparative tests.

A.1.2 Pre-test: We carried out a pre-test for extracting paeonol, weighed 20g of peony bark, placed it in a 500ml round bottom flask, extracted by steaming, collected different volumes of distillate, refrigerated and crystallized, filtered, and filtrate added. Distilled with 5% sodium chloride, collected 3 times distillate, recrystallized and crystallized, filtered, and the filtrate was extracted with diethyl ether three times, 50 ml each time, and the ether was evaporated. The crystals were combined, dried at 40 ° C for 1 hour, and weighed. As follows: Extraction of paeonol pre-test results:

From the results, it is appropriate to collect 10 times of distillate.

A.1.3 Orthogonal test: Based on the results of the preliminary test, we performed an orthogonal test of 3 factors and 3 levels to optimize the optimal process of double extraction.

A.1.3.1 Factor level table: According to the results of the pre-test, the factor level table of the double-rectification orthogonal test is designed, see Table -7.

Table -7 Paeonol extraction factor level table:

Horizontal ABC Add water to pre-treatment and add salt (%)

1 15 Do not soak 0

2 20 cold soak lh 5

3 25 Warming lh 10 a丄3.2 Test method: Weigh 100g of peony bark (roughly crushed through 10 mesh sieve), according to the test conditions under the orthogonal test column number in Table-8, the temperature control time is controlled at 45 °C. Left and right, extract by distillation, collect 10 times of distillate, recrystallize and crystallize, filter, filtrate and add 5% sodium chloride to distillate, collect 3 times of distillate, recrystallize and crystallize, filter, crystallize, 40 Ό dry, weigh Heavy, comparison. The paeonol yield (g) is used as an indicator to enter the statistics. The results of the orthogonal test are shown in Table -8.

Table -8 Orthogonal test and analysis of paeonol extraction: Test No. A B C D Paeonol Weight (g)

1 1 1 1 1 1. 064

2 1 2 2 2 1. 308

3 1 3 3 3 1. 331

4 2 1 2 3 1. 334

5 2 2 3 1 1. 312

6 2 3 1 2 1. 193

7 3 1 3 2 1. 225

8 3 2 1 3 1. 141

9 3 3 2 1 1. 337

I 3. 703 3. 623 3. 398 3. 713

II 3. 839 3. 761 3. 979 3. 726

ΙΠ 3. 703 3. 861 3. 868 3. 806

R 0. 136 0. 238 0. 581 0. 093 The results obtained were analyzed by ANOVA. The results are as follows: Table -9 Analysis of the results of orthogonal test of paeonol extraction:

°1 D 0. 001691 2 0. 000846

F0.05 (2,2)=19.0 F0.01 (2,2)=99.0

According to the above analysis, C is the main factor, should choose the best level C2, A, B are secondary factors, combined with economic and provincial time preference, should choose A 1 and B1, but considering the slow discharge of large production equipment, the distillation time should be extended At the same time, considering the dissolution of water-soluble components, A2 can be selected, because the temperature immersion can speed up the distillation time, so the extraction process of paeonol is preferably A2B3C2, that is, the medicinal material is added with 20 times of water, first immersed for 1 hour, and then distilled and extracted, and Secondary distillation plus 5 ^β /. Sodium chloride.

A.1.3.3 Verification test: We carried out the verification test of extracting paeonol. According to the proportion of prescription, accurately weigh 100g of peony bark, operate 2 times according to the experimental conditions, add 20 times of water, extract the paeonol by distillation. Phenol, and a comparative test of No. 9 experiment A3B3C2, which is intuitively analyzed in the orthogonal table of the process, was carried out. The results are shown in the table below, indicating that the preferred process is comparable to that obtained by A3B3C2, and the determined process is a better process.

Table-10 Table of results of paeonol extraction verification test:

a, 2 water boiling partial boiling times:

After the filtered water is filtered, the dregs still contain water-soluble components. Since it has been distilled for a long time, it can be boiled for a short time. Because the first decoction has been fully swelled, the second frying is added. The amount of liquid was determined to be 6 times. We used the yield of ethanol extract as an indicator to investigate the number of decoctions of the drug.

A.2.1 Test method: Weigh 100g of peony bark, and test according to the preferred conditions. After the extraction of paeonol, filter it, collect the drug solution as sample 1, add 6 times of water to the dregs, and fry 2 , every time for 1 hour, filter, collect the liquid, get sample 2, sample 3, 3 samples are separately concentrated to 100ml (60'C), add an equal volume of ethanol, so that the alcohol-soluble components are dissolved, refrigerated for 24 hours, Filtration, filtrate Concentrate to dryness, bake in an oven to constant weight (105 ^e C), weigh, and subtract the weight of the evaporating dish to obtain the amount of ethanol extract.

A.2.2 Test results and analysis are shown in Table -11

Table - 11 Results of decoction times of pecan phenolic herbs

From the above test data analysis, the weight of the ethanol extract obtained by the third decoction only accounted for 4% of the total decoction of Sanjian, and during the test, the appearance 1 was dark brown, and the sample 2 was light brown. It is only light red. From the perspective of saving time and saving energy, make sure that the water is boiled and boiled twice.

A.2.3 Verification test: We carried out the verification test of the number of decoction of the dregs after extracting paeonol. According to the proportion of prescription, we accurately weighed lKg of peony bark and operated according to the experimental conditions. The results are shown in the table below, indicating that the medicinal material is extracted. After the phenol, add 6 times the amount of water to cook for 1 hour.

Table -12 Table of results of verification test of the extraction times of peony skin material:

Number of trials Ϊ 2

The ratio of the first two fried alcohol extracts (%) 95.08 95.17

The proportion of the third decocted alcohol extract (%) 4.92 4.83 b, the decoction alcohol precipitation process is preferred: according to the extraction process preferred results, water decoction to achieve a paste of about 40%, after the alcohol precipitation, the paste rate can be greatly reduced The alcohol precipitation can remove polymer impurities such as pectin and starch to achieve further purification. Therefore, the aqueous extract can be concentrated and then refined by an alcohol precipitation process. In the experiment, the alcohol precipitation was compared to make the alcohol content up to 40%, 50%, 60%, and 70%.

Test method: According to the prescription ratio, weighed 75g of Sophora flavescens and 50g of white fresh skin, a total of 175g, coarsely crushed, According to the optimal conditions obtained by the process, the filtrate is combined; 50 g of peony bark is taken, extracted by distillation, and the filtrate is combined, and then combined with the above solution, and further concentrated to a relative density of 1.06 (60 ° C), about 175 ml. .

Divide the above liquid into five parts, one part to 100 ml, and the other four parts with ethanol to make the alcohol concentration 40%, 50%, 60%, 70%, refrigerate, stand overnight, filter, fully The filter residue was washed, ethanol was recovered, and the volume was adjusted to 100 ml, and the sample was directly sampled to determine matrine. In addition, 20 ml of the drug solution was accurately weighed to dryness, and the obtained paste rate of each sample was measured. The dry paste powder was transferred to a 100 ml round bottom flask, refluxed with 50 ml of absolute ethanol for 1 hour, filtered, and the filtrate was steamed to about 5 ml in a water bath, transferred to a 5 ml volumetric flask, and anhydrous ethanol was added to the mark to measure The content of paeoniflorin, the results are shown in Table-13:

Table -13 Comparison of different concentrations of alcohol precipitation and impurity removal:

Alcohol concentration Matrine (mg/g medicinal material) Dry paste rate (%) Paeoniflorin content (mg/g medicinal material)

Original liquid 6.558 38.75 9.308

40% ethanol 5.352 17.90 3.825

50% ethanol 5.504 14.70 5.730

60% ethanol 6.285 11.59 7.762

70% ethanol 5.994 10.99 7.458 It can be seen from the experiment that 60%, 70% alcohol precipitation removes more impurities, but the content of 60% alcohol matrine and paeoniflorin is more reserved and economical, so we finally choose The concentration of the alcohol precipitate was 60%.

c. Concentration process research:

(1) The water extract is concentrated to a relative density of 1.06-1.10 (60 ^e C), and ethanol precipitation is preferred. When the relative density of the liquid is less than 1.06, the concentration of the liquid is relatively thin, and the amount of alcohol is large; when the relative density of the liquid is higher than 1.10, the concentration of the liquid is large, and the liquid is not easily dispersed even when the alcohol is sedimented. The water extract is concentrated by three-effect decompression, and the efficiency is low.

(2) The water-decoction portion of the prescription is extracted and alcohol-precipitated according to the above preferred conditions, and the filtrate is subjected to reduced pressure recovery of ethanol (60-70'C, -0.08 Mpa), and the temperature is kept as low as possible to avoid destruction of the active ingredient.

β After recovering the ethanol, it is more suitable to continue to concentrate to a concentrated extract having a relative density of 1.28-1.35 (60 Ό), which is easy to mix with the matrix. Experiments have shown that the relative density of the extract is less than 1.28. After mixing with the matrix, the ointment is thinner and the stability is not satisfactory. The relative density of the extract is higher than 1.35, which is difficult to mix with the matrix and is not easy to mix evenly.

5) taking 150 g of stearic acid, 20 g of lanolin, 250 ml of liquid paraffin, 50 g of glycerin, 8 g of triethanolamine, 20 g of sodium lauryl sulfate, 370 ml of water to prepare a matrix, and step 2) to obtain paeonol. Step 4) After the drug thick cream and the borneol 10g are uniformly mixed, a pharmaceutical ointment for treating eczema can be obtained by about 1000 g.

Screening of the ointment base of the present invention: The base is prepared according to the following matrix formulation, and then mixed with the drug cream by a grinding method. It is preferred to use skin irritation and heat resistance and cold resistance tests as indicators.

The results are shown in Table -14:

(1) Lanolin 30g Vaseline 400g Paraben ethyl ester 0. 5g

(2) Stearic acid 160g glyceryl monostearate 60g Vaseline 60g

Lanolin 80g liquid paraffin 12g azone ketone 20 g

Glycerin 80g ethylparaben 2g triethanolamine 8g water 480 ml

(3) octadecyl alcohol 200g petroleum jelly 200g liquid paraffin 120ml

Glycerin 100 g ethylparaben 2g sodium lauryl sulfate 20g

Azone 20 g water 350 ml

(4) Stearic acid 150g Lanolin 20g Liquid paraffin 250ml Glycerin 50g

Triethanolamine 8g sodium lauryl sulfate 20g water 450ml Table -14 Matrix Preferred Results

Softness, skin irritation, heat resistance test, cold resistance experiment

(1) Hardness is viscous and resistant to 55. C resistant to -15. C (2) Softness is easy to apply and is not resistant to 45'C.

(3) Soft and hard, easy to apply, not tolerant to 45 °C, not resistant to -15 ^e C

(4) Soft and hard, easy to apply, resistant to 55. C resistance -15 ° C From the results analysis, the matrix (4) is more suitable. Namely, 150 g of stearic acid, 20 g of lanolin, 250 ml of liquid paraffin, 50 g of glycerin, 8 g of triethanolamine, 20 g of sodium decyl sulfate, and 450 ml of water. ,

Claims

Claim

A medicament for treating eczema, characterized in that: the medicament is an medicament made of the following raw materials by weight:

Bitter ginseng 150~600 white fresh skin 100~300 peony skin 150~600 ice piece 5~25

2. The medicament for treating eczema according to claim 1, wherein: the weight ratio of each raw material is:

Kushen 300 white fresh skin 200 peony skin 300 ice sheet 10

The method for preparing an ointment for treating eczema according to claim 1 or 2, wherein the process steps of the method are as follows:

2) 300g raw material of peony bark, add 20 times of water, heat to 45'C, immerse for 1 hour, distill, collect 10 times of distillate of medicinal material, filter, add 5% sodium chloride to the filtrate, collect 3 times the amount of distillate of the medicinal material, refrigerated, crystallization, combined crystallized, obtained paeonol, and used separately;

3) Add 6 times of water to the dregs obtained in step 2), decoct for 1 hour, filter, and combine the filtrates for use;

4) Combine the steps 1) and 3) the filtrate, concentrate to a relative density of about 1.06-1.10 (60 ° C), add ethanol to make the alcohol content 60%, refrigerate for 24 hours, filter, and recover ethanol under reduced pressure (60 ~70.C, -0.08Mpa), concentrated to a relative density of about 1.28-1.35 (60 ° C), that is, a drug thick paste

5) taking 150 g of stearic acid, 20 g of lanolin, 250 ml of liquid paraffin, 50 g of glycerin, 8 g of triethanolamine, 20 g of sodium lauryl sulfate, 370 ml of water to prepare a matrix, and step 2) to obtain paeonol. Step 4) The drug thick cream and the borneol 10g are uniformly mixed, and about 1000 g of the medical ointment for treating eczema can be obtained.