CN103239426B - Preparation method of far-infrared gel composition and preparation method of gel paste - Google Patents
Preparation method of far-infrared gel composition and preparation method of gel paste Download PDFInfo
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- CN103239426B CN103239426B CN201210022600.9A CN201210022600A CN103239426B CN 103239426 B CN103239426 B CN 103239426B CN 201210022600 A CN201210022600 A CN 201210022600A CN 103239426 B CN103239426 B CN 103239426B
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Abstract
The invention relates to the technical field of medical plasters, and discloses a preparation method of a medicinal gel composition (paste) and a preparation method of a gel paste. The gel composition contains 3-7wt% of a far-infrared material, 20-35wt% of a plant extract product, 1-4wt% of an acrylic resin, 0.1-0.4wt% of a cross-linking agent, 20-35wt% f a humectant, 1.5-3.0wt% of a transdermal enhancer, 1-3wt% of a filler, 5-7wt% of an adhesive, and the balance water, wherein the far-infrared material is tourmaline or Chinese medical stone, and the acrylic resin is an acrylic acid-sodium acrylate copolymer or sodium polyacrylate. The gel composition has a magnetic therapy function, has a good cross-linking performance because of the above unique formula, makes a paste leakage phenomenon not appear during application, and is convenient to use.
Description
Technical field
The present invention relates to a kind of technical field of Medical plaster, specifically disclose the preparation of a kind of pharmaceutical gel compositions (mastic) and gel ointment.
Background technology
Gel ointment (former name cataplasma Gataplasma) 20 century 70s are derived from Japan, introduce China the beginning of the eighties, and the nineties, China started large-scale production Chinese medicine gel ointment.Mono-of 2010 editions < < Chinese Pharmacopoeia > > definition to gel ointment is: mean extract, decoction pieces or and after chemicals and suitable hydrophilic matrix mix, coat the emplastrum of making on back lining materials.
Gel ointment is to take the external use plaster that high molecular weight water soluble polymer is matrix scaffold material, have drug loading large, can repeatedly paste the advantages such as use, comfortable, nonirritant and anaphylaxis, air permeable humidity retaining, good penetrability.Because Chinese medicine is all used as medicine with compound recipe, extracts active ingredients purification ratio is more difficult, mostly be to extract to be refined into certain density extractum and to make again corresponding preparation and will reach should effective in cure general dosage larger, and that the advantage of gel ointment is drug loading is large, can repeatedly take off subsides again, while sticking again, still can keep good stickiness, therefore gel ointment is very extensive in the application prospect in pharmaceutical formulation field.
Far-infrared radiation material (hereinafter to be referred as: far-infrared material) as tourmaline, Maifanitum etc. and Related product thereof are developed at home and go on the market, underwear as warm in the middle section of middle arteries and veins science and technology, quilt, list, pillow etc.Confirm according to the study: far infrared penetrates body, pass through resonance absorption, play micro-massage effect, have non-thermal effect, this effect can be expanded local blood capillary, promote that cell expansion becomes porous state, promote drug absorption, and accelerate microcirculation, promote cell metabolism, play the therapeutical effect of blood circulation promoting and blood stasis dispelling, really embody the treatment rule of theory of Chinese medical science " general rule is not bitterly ".And tourmaline, Maifanitum etc. as treatment acute and chronicly sprain, one of the functional component of the gel ointment of soft tissue injury type also has no report.
Due to being cross-linked of some composition influence gel combination in Chinese medicine, this impact is one of this area difficult problem urgently to be resolved hurrily always.This patent efficiently solves the impact on cross-linking properties of some composition of Chinese medicine in gel ointment, the materials such as far-infrared material tourmaline powder, medical stone powder in gel combination, have been introduced simultaneously, in original treatment, acute and chronicly sprain, on the basis of soft tissue injury, have certain physical therapy efficacy concurrently simultaneously.
Summary of the invention
The present invention aims to provide a kind of gel combination that contains far-infrared material of special formulation, makes take its gel ointment that is mastic (cataplasma) to have reason (magnetic) and treats effect; This gel combination has again good cross-linking properties simultaneously, makes take its gel ointment that is mastic when sticking, to there will not be mastic to ooze cloth phenomenon.
The second object of the present invention is to provide the preparation method of above-mentioned gel combination.
The 3rd object of the present invention is to provide a kind of gel ointment that contains above-mentioned gel combination.
In a first aspect of the present invention, a kind of far infrared gel compositions is provided, in the gross weight of described gel combination, it contains following component:
Far-infrared material 3～7wt%, plant extract 20～35wt%, acrylic resin 1～4wt%, cross-linking agent 0.1～0.4wt%, wetting agent 20～35wt%, transdermal enhancer 1.5～3.0wt%, filler 1～3wt%, binding agent 5～7wt%, surplus are water;
Wherein said far-infrared material is selected from tourmaline or Maifanitum; Described acrylic resin is selected from copolymer or the sodium polyacrylate of acrylic acid and sodium acrylate.
In another preference, described plant extract is mixed by the extract of Hibisci Mutabilis, Fructus Capsici and three kinds of Chinese medicines of Semen Phaseoli.
In another preference, described cross-linking agent is selected from one or more in dihydroxyaluminum aminoacetate, sweet aminoacid or cumyl peroxide.
In another preference, described wetting agent is selected from one or more in glycerol, propylene glycol, sorbitol or Polyethylene Glycol.
In another preference, described transdermal enhancer is selected from one or more in azone, propylene glycol or eucalyptus oil.
In another preference, described filler is selected from one or more in Kaolin, kieselguhr or Pulvis Talci.
In another preference, described binding agent is selected from one or more in carboxymethyl cellulose, sodium carboxymethyl cellulose, polyvinyl alcohol or polyvinylpyrrolidone.
In a second aspect of the present invention, provide a kind of preparation method of above-mentioned far infrared gel compositions of the present invention.
In a third aspect of the present invention, a kind of gel ointment is provided, described gel ointment contains above-mentioned far infrared gel compositions of the present invention.
The details of various aspects of the present invention will be able to detailed description in chapters and sections subsequently.By below and the description of claim, feature of the present invention, object and advantage will be more obvious.
The specific embodiment
Inventor, through extensive and deep research, has been surprised to find that a kind of gel combination that contains the compositions such as far-infrared material, plant extract, wetting agent, cross-linking agent, acrylic resin, filler, binding agent.When the content of these compositions is in a suitable scope, resulting gel combination can discharge far infrared, makes take its gel ointment that is mastic to have reason (magnetic) and treats effect; This gel combination has again good cross-linking properties simultaneously, makes take its gel ointment that is mastic when sticking, to there will not be mastic Seepage, easy to use.
Far-infrared material
The far-infrared material that the present invention uses comprises tourmaline, Maifanitum, charcoal etc.They,, by absorbing human heat, discharge the materials such as far infrared, anion, sub-ion, mineral element.The far infrared discharging acts on human body, produce resonance absorption and penetrate cortical tissue, directly act on blood vessel and nerve, the generation of triggering human body causes organizes excited energy, produce non-thermal effect, cause telangiectasis, microcirculatory blood flow increases, promote systemic blood circulation and metabolism, thereby play the effect for the treatment of chronic disease.In addition, the self-heating effect of far-infrared material itself also has for the gel ointment of pattern of fever the effect that improves hotness.The far-infrared material that the present invention preferably uses is tourmaline, Maifanitum etc.Its amount ranges is 3～7wt%, and preferable range is 3.2～6.8wt%
Plant (Chinese medicine) extract
The plant extract that the present invention uses can be by the conventional method of this area as the directly extraction acquisition from several kinds of Chinese medicinal materials plant such as water extraction, organic solvent extraction, supercritical extraction; Also various plants extract can be mixed and uses.Preferably use the mixed extract (as used in embodiment) that comprises Hibisci Mutabilis, Fructus Capsici, Semen Phaseoli three Plant Extracts, above several medicines share has good effect to detumescence, promoting the circulation of blood, pain relieving etc.Its amount ranges is 20～35wt%, and preferable range is 22～33wt%.
Acrylic resin
The acrylic resin pharmaceutic adjuvant that the present invention uses, comprise a class by acrylic acid (or methacrylic acid and their ester as: methyl ester, ethyl ester etc.) with body (a kind of monomer) polymerization, or the macromolecular compound forming with two kinds of monomers (binary) copolymerization by a certain percentage with methacrylic acid (or its ester as: methyl ester, ethyl ester, dimethylamino ethyl ester etc.).The present invention preferably uses " polyacrylic acid that part is neutralized " (i.e. " copolymer of acrylic acid and sodium acrylate ", as Viscomate NP600, NP700, NP800), and amount ranges is 1～4wt%, and preferable range is 1.2～3.8wt%.
Cross-linking agent
The conventional gel ointment cross-linking agent in this area mostly is high-valency metal salt, is mainly aluminum salt, as crystal aluminum chloride, aluminum sulfate, aluminum glycinate, Alumen or clad aluminum salt etc.The cross-linking agent that the present invention preferably uses is dihydroxyaluminum aminoacetate, sweet aminoacid, cumyl peroxide etc.Amount ranges is 0.1～0.4wt%, and preferable range is 0.12～0.38wt%.
Wetting agent
The water content of gel ointment is large, and solution moisturizing, water conservation problem are the important steps in gel ointment preparation.Wetting agent can with gel ointment in water-solublely close, complexation, association, prevent evaporation of water and loss, keep water content, make the balance and stability of paste substrate exempt from destruction.Therefore, select suitable wetting agent very important.The wetting agent that the present invention preferably uses comprises glycerol, propylene glycol, sorbitol, Polyethylene Glycol etc.Amount ranges is 20～35wt%, and preferable range is 20～33wt%.
Transdermal enhancer
Percutaneous absorption enhancer refers to all materials that can increase Drug Percutaneous Absorption speed or increase drug transdermal amount.The conventional Percutaneous absorption enhancer in this area comprises dimethyl sulfoxide, azone (Azone), Oleum menthae, Borneolum Syntheticum, eucalyptus oil, propylene glycol etc.The transdermal enhancer that the present invention preferably uses is azone, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods.Its amount ranges is 1.5～3.0wt%, and preferable range is 1.7～2.8wt%.
Filler
Filler is used in external plaster gel ointment to be had for gel ointment inborn nature and molding effect, and can improve stickiness and plasticity, gel ointment is reached and be affixed on the due adhesive force of skin, has again necessary cohesiveness and reaches due specification requirement.The filler series that the present invention uses is selected from Kaolin, kieselguhr, Pulvis Talci, graphite, white carbon black, alumina powder, glass dust, flake asbestos, mica powder, silica flour, carbon fiber, dust cork, corundum etc.The filler that the present invention preferably uses comprises Kaolin, kieselguhr, Pulvis Talci.Its amount ranges is 1～3wt%, and preferable range is 1.2～2.8wt%.
Binding agent
Binding agent is the main matter that gel ointment mastic produces stickiness, mostly is macromolecular compound and forms, and by its source, can be divided into water-soluble polymer substance and semi-synthetic and synthetic hydrophilic polymer material.The conventional water-soluble polymer substance in this area has gelatin, tragacanth, arabic gum, agar, Rhizoma Bletillae gel, Resina persicae, starch, alginate etc.Wherein gelatin foaming characteristic is very strong, and film property is good, in non-crosslinked type gel ointment, Chang Zuowei gel skeleton composition, but compare with agar, its coagulation force a little less than.The effect of tragacanth, Resina persicae is mainly the denseness that improves the front substrate of molding, can improve the adhesion of gel ointment to skin simultaneously.Semi-synthetic and synthetic hydrophilic polymer adhesive agent is conventional methylcellulose, carboxymethyl cellulose and sodium salt thereof (CMC-Na), sodium polyacrylate, polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), carbomer, xanthan gum etc.The binding agent that the present invention preferably uses comprises CMC-Na, PVP K-90 etc.Its amount ranges is 5～7wt%, and preferable range is 5.2～6.8wt%.
Except mentioned component, gel combination of the present invention can also contain one or more other additives, as antiseptic, pH adjusting agent etc.Conventional antiseptic includes but not limited to: benzoic acid (benzoic acid), Liquid Germall pus, oneself two diluted acids, the acetic acid that anhydrates, p-hydroxybenzoic acid, aethyl parabenum, propyl parabene, Butyl Chemosept, p-hydroxybenzoic acid isopropyl ester, p-hydroxybenzoic acid isobutyl ester, Borax, methyl salicylate etc.The antiseptic that the present invention preferably uses is methyl salicylate, Liquid Germall pus.Its amount ranges is 0.1～1.5wt%, and preferable range is 0.2～1.0wt%.The pH value of pH adjusting agent scalable gel combination, comprises tartaric acid or citric acid etc.The present invention preferably uses tartaric acid.Its amount ranges is 0.1～0.5wt%, and preferable range is 0.12～0.48wt%.
Gel combination of the present invention can prepare by the conventional method of this area, wetting agent, cross-linking agent, binding agent, filler, Percutaneous absorption enhancer, far-infrared material of first getting formula ratio etc. prepared oil phase, get again plant extract and the water of formula ratio and prepare water, then water is added and in oil phase, stir and get final product.Prepared gel combination of the present invention is a kind of thick colloid that has certain cohesiveness, it is evenly applied on backing non-woven fabrics, after covering anti-mucosa, place, allow it further complete crosslinked, after crossing cutting, packing, obtain the sizing gel ointment using clinically.
Far infrared transmissivity>=88% of the contained far-infrared material of gel combination of the present invention (detection of national authority mechanism), 1060/cm of anion burst size
3.Owing to having added far-infrared material, make gel combination of the present invention there is the function of magnetic therapy.After far infrared, anion, sub-ion and the mineral element etc. that the far-infrared material such as tourmaline, Maifanitum discharges are absorbed by the body, can promote blood circulation and the metabolism of human body, thereby produce the effect of beauty treatment, body shaping and treatment chronic disease.Meanwhile, gel combination of the present invention, because its unique formula has good cross-linking properties, there will not be mastic Seepage when sticking, easy to use.
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment are only not used in and limit the scope of the invention for the present invention is described.The experimental technique of unreceipted actual conditions in the following example, conventionally according to normal condition or the condition of advising according to manufacturer.Unless otherwise indicated, otherwise all percent, ratio, ratio or umber by weight.
Unit in percentage by weight in the present invention is well-known to those skilled in the art, for example, refer to the weight of contained effective ingredient in the preparation of 100 unit of weights, and symbol is " wt% ".
Unless otherwise defined, the same meaning that all specialties of using in literary composition and scientific words and one skilled in the art are familiar.In addition, any method similar or impartial to described content and material all can be applicable in the inventive method.The use that better implementation method described in literary composition and material only present a demonstration.
The above-mentioned feature that the present invention mentions, or the feature that embodiment mentions can combination in any.All features that patent specification discloses can with any composition forms use, each feature disclosing in description, can anyly provide the alternative characteristics of identical, impartial or similar object to replace.Therefore apart from special instruction, the feature disclosing is only the general example of equalization or similar features.
Embodiment 1 gel combination consists of by weight mixing following composition:
Preparation method is as follows:
1, prepare oil phase: the glycerol that accurately takes formula ratio, dihydroxyaluminum aminoacetate, CMC-Na, PVP K-90, NP600, Kaolin, methyl salicylate, azone, eucalyptus oil, propylene glycol, tourmaline powder etc., above material be put in open container dispersed with stirring evenly after, place stand-by;
2, prepare water: accurately take the tartaric acid of formula ratio, then add purified water, constantly stir it is dissolved, then add plant extract, continue to stir until water becomes uniform solution;
3, prepare gel ointment substrate: water is added to rapidly in oil phase, stir immediately, first rapid stirring after 2 minutes in low rate mixing 6 minutes, now be formed with the thick colloid of certain cohesiveness, colloid is evenly applied on backing non-woven fabrics, after covering anti-mucosa, place, allow it further complete crosslinked.Through cutting packing, make gel ointment.
The gel ointment mastic making is carried out to plastic property test, and result shows: cream face, without trickling phenomenon, meets the requirements.
Embodiment 2 gel combinations consist of by weight mixing following composition
Preparation method according to embodiment 1 is prepared gel ointment.Gel ointment mastic to the present embodiment formula carries out plastic property test, and result shows: cream face, without trickling phenomenon, meets the requirements.
Embodiment 3 gel combinations consist of by weight mixing following composition
Preparation method according to embodiment 1 is prepared gel ointment.Gel ointment mastic to the present embodiment formula carries out plastic property test, and result shows: cream face, without trickling phenomenon, meets the requirements.
Embodiment 4 gel combinations consist of by weight mixing following composition
Preparation method according to embodiment 1 is prepared gel ointment.Gel ointment mastic to the present embodiment formula carries out plastic property test, and result shows: cream face, without trickling phenomenon, meets the requirements.
Embodiment 5 gel combinations consist of by weight mixing following composition
Preparation method according to embodiment 1 is prepared gel ointment.Gel ointment mastic to the present embodiment formula carries out plastic property test, and result shows: cream face, without trickling phenomenon, meets the requirements.
Embodiment 6 gel combinations consist of by weight mixing following composition
Preparation method according to embodiment 1 is prepared gel ointment.Gel ointment mastic to the present embodiment formula carries out plastic property test, and result shows: cream face, without trickling phenomenon, meets the requirements.
Many aspects involved in the present invention have been done as above and have been set forth.Yet, it should be understood that before not departing from spirit of the present invention and put, those skilled in the art can be equal to and change and modify it, and described change and modification fall into the coverage of the claim of present patent application equally.
Claims (7)
1. a far infrared gel compositions, is characterized in that, in the gross weight of described gel combination, it contains following component:
Far-infrared material 3～7wt%, plant extract 20～35wt%, acrylic resin 1～4wt%, cross-linking agent 0.1～0.4wt%, wetting agent 20～35wt%, transdermal enhancer 1.5～3.0wt%, filler 1～3wt%, binding agent 5～7wt%, surplus are water
Wherein said far-infrared material is selected from tourmaline or Maifanitum, and described plant extract is mixed by the extract of Hibisci Mutabilis, Fructus Capsici and three kinds of Chinese medicines of Semen Phaseoli and described acrylic resin is selected from copolymer or the sodium polyacrylate of acrylic acid and sodium acrylate.
2. the far infrared gel compositions of claim 1, is characterized in that, described cross-linking agent is selected from one or more in dihydroxyaluminum aminoacetate, sweet aminoacid or cumyl peroxide.
3. the far infrared gel compositions of claim 1, is characterized in that, described wetting agent is selected from one or more in glycerol, propylene glycol, sorbitol or Polyethylene Glycol.
4. the far infrared gel compositions of claim 1, is characterized in that, described transdermal enhancer is selected from one or more in azone, propylene glycol or eucalyptus oil.
5. the far infrared gel compositions of claim 1, is characterized in that, described filler is selected from one or more in Kaolin, kieselguhr or Pulvis Talci.
The far infrared gel compositions of claim 1, it is characterized in that, described binding agent is selected from one or more in carboxymethyl cellulose, sodium carboxymethyl cellulose, polyvinyl alcohol or polyvinylpyrrolidone.
7. a gel ointment, is characterized in that, described gel ointment contains just like the far infrared gel compositions described in the arbitrary claim of claim 1～6.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103451973B (en) * | 2013-09-03 | 2015-08-05 | 上海波顺服饰有限公司 | The Health shoulder pad of far infrared fabric, its preparation method and preparation thereof |
| CN103932408B (en) * | 2014-04-18 | 2016-08-24 | 乔志宏 | A kind of external used medicine vest treating the syndrome of dyspnea and process for preparing medicine |
| CN105362253A (en) * | 2014-08-29 | 2016-03-02 | 安徽华艾生物科技有限公司 | Novel far-infrared gel paste |
| CN104958244A (en) * | 2015-06-22 | 2015-10-07 | 上海梅派化妆品有限公司 | Multipurpose product capable of improving in-vivo and in-vitro metabolism of body skin, whitening skin and resisting ageing |
| CN114470145A (en) * | 2022-01-25 | 2022-05-13 | 河北化工医药职业技术学院 | Warm moxibustion type gel plaster for relieving pain of bone diseases and preparation method thereof |
| CN115160869A (en) * | 2022-07-04 | 2022-10-11 | 北京慧盈科技有限公司 | Energized biological coating liquid material, preparation method thereof and energized biological coating |
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| CN1714838A (en) * | 2005-06-17 | 2006-01-04 | 吴湘君 | Medical gel and its preparing method and device |
| CN101301339A (en) * | 2008-06-20 | 2008-11-12 | 牛天卓 | Babu far infrared medicinal plaster for treating arthralgia and myalgia, and wind-cold syndrome and numbness |
| CN101780169A (en) * | 2010-03-10 | 2010-07-21 | 广州白云山制药股份有限公司白云山何济公制药厂 | Traumatic injury analgesic cataplasm preparation and preparation method thereof |
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| CN1714838A (en) * | 2005-06-17 | 2006-01-04 | 吴湘君 | Medical gel and its preparing method and device |
| CN101301339A (en) * | 2008-06-20 | 2008-11-12 | 牛天卓 | Babu far infrared medicinal plaster for treating arthralgia and myalgia, and wind-cold syndrome and numbness |
| CN101780169A (en) * | 2010-03-10 | 2010-07-21 | 广州白云山制药股份有限公司白云山何济公制药厂 | Traumatic injury analgesic cataplasm preparation and preparation method thereof |
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Denomination of invention: Far infrared gel composition and preparation of gel paste Effective date of registration: 20230517 Granted publication date: 20141112 Pledgee: Shanghai Siling Enterprise Development Partnership (L.P.) Pledgor: Fang Shanghai Pharmaceutical Technology Co.,Ltd. Registration number: Y2023310000193 |
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