CN103238616A - Insecticide composite containing metaflumizone and flubendiamide - Google Patents
Insecticide composite containing metaflumizone and flubendiamide Download PDFInfo
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- CN103238616A CN103238616A CN201210031922XA CN201210031922A CN103238616A CN 103238616 A CN103238616 A CN 103238616A CN 201210031922X A CN201210031922X A CN 201210031922XA CN 201210031922 A CN201210031922 A CN 201210031922A CN 103238616 A CN103238616 A CN 103238616A
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Abstract
The invention discloses an insecticide composite containing metaflumizone and flubendiamide. The composite is mainly characterized by comprising metaflumizone and flubendiamide as active ingredients, and the balance of auxiliaries, wherein the weight ratio of two active ingredients, namely the metaflumizone and flubendiamide is (1:80)-(80:1). The composite can be prepared into wettable powder, a water dispersible granule, a suspending agent, a suspoemulsion, an emulsion in water and a microemulsion. The composite can prevent and treat various injurious insects, has obvious synergism effects, expands the insecticidal spectrum, and has relatively high activity on rice leaf folder, Chilo suppressalis, tryporyza incertulas, cabbage caterpillar, asparagus caterpillar, prodenia litura, cotton bollworm, pink bollworm, fall webworm, codling moth and the like of rice, vegetables, cotton and fruit trees; and in the insecticide composite, pesticide dosage is reduced, the residual quantity of the pesticide is reduced, and the environmental pollution is lightened; the insecticide composite is safe to people and livestock and has good environment compatibility, and the injurious insect has small possibility of generating resistance to drugs.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of Pesticidal combination that contains metaflumizone and fipronil bisamide.
Background technology
Metaflumizone (metaflumizone) chemical name: (E+Z)-2-[2-(4-cyano group benzene)-1-(3-trifluoromethylbenzene) ethylidene]-N-(4-trifluomethoxybenzene) hydrazine carbonyl oxamides, molecular formula: C
24H
16F
6N
4O
2, metaflumizone is by on the acceptor that is attached to sodium-ion channel, and it is current to hinder sodium ion, does not have cross resistance with the compound of chrysanthemum ester class or other kinds.This medicine mainly is to get food by insect to enter in its body and stomach toxicity to take place kill off the insect pests, and action of contace poison is less, no systemic action.This medicine has the better prevention effect for target pest, the larva in each length of time, this medicine enters polypide behind the insect's food-taking, by the sodium-ion channel on the mechanism of action blocking-up insect neuron axon film of uniqueness, make sodium ion can not pass through axolemma, and then suppress nerve impulse and make excessive the loosening of polypide, paralysis is behind the several hrs, insect namely stops to get food, and is dead in 1～3d.
Fipronil bisamide (flubendiamide), chemical name: 3-iodo-N '-(2-mesyl-1,1-dimethyl ethyl group-N-{4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl) ethyl]-the 0-tolyl } phthalamide, molecular formula: C
23H
22F
7IN
2O
4S belongs to novel phthalic amide insecticides, activates calcium release channel in blue Buddhist nun's alkali recipient cell, the property out of control release that causes storing calcium ion.It is the compound that acts on the blue Buddhist nun's alkali of insect cell acceptor at present few in number.Lepidoptera pest there is the spectrum preventive effect, does not have cross resistance with existing insecticide and produce, be suitable for very much the control that existing insecticide produces the insect of resistance.Larva there is very outstanding preventive effect, limited to the adult preventive effect, there is not ovicidal action.Slightly conduct by xylem the back in the infiltration plant body.Resistance of rainwater washing against.
In the real process of agricultural production, the problem that pest control is easy to generate most is the generation of pest resistance to insecticide.The different cultivars composition carries out composite, is the very common method of control resistant insect.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals all is additive effect, and the seldom composite of synergistic effect really arranged, especially synergistic effect very obviously, co-toxicity coefficient very high composite just still less.Through inventor research, find can produce good synergistic effect after metaflumizone and fipronil bisamide is composite, and still unexposed about the composite relevant report of metaflumizone and fipronil bisamide.
Summary of the invention
Degradation problem under the resistance generation that the long-term use of metaflumizone list agent may bring, the drug effect, the Pesticidal combination that the present invention proposes contains metaflumizone, two kinds of active components of fipronil bisamide, and an amount of surfactant and carrier.
A kind of Pesticidal combination that contains metaflumizone and fipronil bisamide comprises effective active component metaflumizone, fipronil bisamide, auxiliary agent surplus, it is characterized in that: metaflumizone and fipronil bisamide weight ratio are 1: 80～80: 1.
Described Pesticidal combination is characterized in that: the weight ratio of metaflumizone and fipronil bisamide is 1: 40～60: 1.
Described Pesticidal combination is characterized in that: the weight ratio of metaflumizone and fipronil bisamide is 1: 20～40: 1.
Described Pesticidal combination is characterized in that: the weight ratio of metaflumizone and fipronil bisamide is 1: 5～25: 1.
Described Pesticidal combination is characterized in that: the weight percentage of active component is 0.5%～90% of gross weight in the composition.
Described Pesticidal combination is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion.
Described Pesticidal combination is used for the application of insect on control paddy rice, vegetables, cotton, the fruit tree.
The weight ratio of metaflumizone and two kinds of active components of fipronil bisamide is 1: 80～80: 1.Usually the weight percentage of active component is 0.5%～90% of gross weight in the composition, and preferable is 5%～85%.According to different preparation types, the active component content scope is different.Usually, liquid preparation contains 1%～70% active substance by weight, preferably is 5%～50%; Solid pharmaceutical preparation contains 5%～85% active substance by weight, preferably is 10%～80%.
At least contain a kind of surfactant in the Pesticidal combination of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of Pesticidal combination of the present invention is known in those skilled in the art: can be selected from dispersant, wetting agent, binding agent or the defoamer one or more.According to different dosage form, can also contain disintegrant known in those skilled in the art, antifreeze etc. in the preparation.
Composition of the present invention can be by the user before use through dilution or directly use.Its preparation can be by common processing method preparation known in those skilled in the art, be about to active substance and after liquid flux or solid carrier mix, add in surfactant such as dispersant, stabilizing agent, wetting agent, binding agent, the defoamer etc. one or more again.
When making wetting powder, composition comprises following constituent content: metaflumizone 1%～80%, fipronil bisamide 1%～80%, dispersant 2%～10%, wetting agent 2%～10%, filler 8%～94%.
With active component metaflumizone, fipronil bisamide, dispersant, wetting agent, filler mix, and mix in mixed cylinder, mix after airslide disintegrating mill is pulverized again, and namely can be made into wetting powder product of the present invention.
When making water dispersible granules, composition comprises following constituent content: metaflumizone 1%～80%, fipronil bisamide 1%～80%, dispersant 3%～12%, wetting agent 1%～8%, disintegrant 1%～10%, binding agent 1%～8%, filler 10%～92%.
With active component metaflumizone, fipronil bisamide, dispersant, wetting agent, disintegrant, filler etc. are pulverized the particle diameter that obtains needs through air-flow together, add other auxiliary agents such as binding agent again, obtain the materials of granulating.It is interior through after granulation and the drying to expect that product are quantitatively sent the fluidized bed granulation dryer to, makes water dispersible granules product of the present invention.
Comprise following constituent content when composition is made suspending agent: metaflumizone 1%～60%, fipronil bisamide 1%～60%, dispersant 2%～10%, wetting agent 2%～10%, defoamer 0.1%～1%, thickener 0.1%～2%, antifreeze 0.1%～8%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add active component metaflumizone, fipronil bisamide, ball milling is 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make suspending agent product of the present invention.
Comprise following constituent content when composition is made suspension emulsion: metaflumizone 1%～60%, fipronil bisamide 1%～60%, emulsifier 2%～12%, dispersant 2%～10%, defoamer 0.1%～2%, thickener 0.1%～2%, antifreeze 0.1%～8%, stabilizing agent 0.05%～3%, water add to 100%.
Dispersant, defoamer, thickener, antifreeze, stabilizing agent in the above-mentioned formulation material are mixed through high speed shear, add the active component fipronil bisamide, ball milling is 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make fipronil bisamide suspension agent, then with active component metaflumizone, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make suspension emulsion product of the present invention.
Comprise following constituent content when composition is made aqueous emulsion: metaflumizone 1%～60%, fipronil bisamide 1%～60%, solvent 0%～30%, emulsifier 1%～15%, antifreeze 0%～10%, thickener 0.1%～2%, defoamer 0.01%～2%, deionized water are supplied surplus.
Above-mentioned formulation material is mixed, active ingredient, solvent, emulsifier, co-emulsifier are added together, make and be dissolved into even oil phase; Water, antifreeze, thickener, defoamer are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, make aqueous emulsion product of the present invention.
Comprise following constituent content when composition is made microemulsion: metaflumizone 1%～60%, fipronil bisamide 1%～60%, solvent 0%～30%, emulsifier 3%～20%, antifreeze 0%～10%, thickener 0.1%～2%, defoamer 0.01%～2%, stabilizing agent 0%～4%, deionized water is supplied surplus.
Active component metaflumizone, the former medicine of fipronil bisamide are dissolved in the homogenizer that solvent and cosolvent are housed; Mix strongly after joining emulsifier, stabilizing agent and antifreeze, water in the homogenizer that above-mentioned solution is housed and homogenize, obtain the as clear as crystal microemulsion product of the present invention of outward appearance at last.
Described dispersant is selected from alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, the naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, polyoxyethylene carboxylate, during the ester polyoxyethylene is phonetic one or more.
Described wetting agent is selected from: lauryl sodium sulfate, neopelex, Nekal BX, washing powder, farming breast 2000
#Series, wetting and penetrating agent F, wetting agent T, spaonin powder, tea are withered, in the silkworm excrement, sldium lauryl sulfate one or more.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, glucose, the aluminium chloride.
Described emulsifier is selected from: agricultural newborn 500# (alkyl benzene calcium sulfonate), OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600# phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, farming newborn 400# (benzyl dimethyl phenol polyoxy ethyl ether), farming newborn 600# (phenyl phenol polyoxy ethyl ether), Nongru-700 # (alkylphenol-formaldehyde resin polyoxy ethyl ether), farming newborn 36# (phenethyl fluosite polyoxy ethyl ether), farming newborn 1600# (phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), By series (castor oil polyoxyethylene ether), farming newborn 33# (alkylaryl polyoxyethylene polyoxypropylene ether), farming newborn 34# (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), in the AEO series (fatty alcohol-polyoxyethylene ether) one or more.
Described co-emulsifier is one or more in butanols, isobutanol, dodecanol-1, tetradecanol-1, the octadecanol-1;
Described solvent is selected from one or more in toluene, dimethylbenzene, methyl alcohol, ethanol, acetone, ether, cyclohexanone, vegetable oil, dimethyl formamide, acetonitrile, polyethylene glycol, pyrrolidones, the solvent N-chain alkyl pyrrolidones;
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described defoamer is selected from: silicone, C
8～10Aliphatic alcohols, C
10～20In saturated fat acids (as capric acid) and acid amides, silicone oil, the silicone compound one or more.
Described preservative is selected from one or more in formaldehyde, sodium salicylate, Sodium Benzoate, the dichlorophen;
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
The invention has the advantages that:
(1) metaflumizone and fipronil bisamide composite after, have notable synergistic and lasting effect;
(2) enlarged insecticidal spectrum, the rice leaf roller on paddy rice, vegetables, cotton, the fruit tree, striped rice borer, paddy stem borer, cabbage caterpillar, beet armyworm, prodenia litura, cotton bollworm, pink bollworm, fall webworm, codling moth etc. have all been had greater activity;
(3) reduce the dosage of agricultural chemicals, reduced the residual quantity of agricultural chemicals on crop, alleviated environmental pollution;
(4) to the person poultry safety, Environmental compatibility is good, and insect is difficult for developing immunity to drugs.
Embodiment
Below in conjunction with the further instruction of the present invention of embodiment, the percentage among the embodiment is weight percentage, but the present invention is not limited thereto.
Application Example one
Example 1 80% metaflumizone fipronil bisamide wetting powder
Metaflumizone 75%, fipronil bisamide 5%, ester polyoxyethylene are phonetic 7%, soapberry powder 4%, precipitated calcium carbonate add to 100%, and mixture carries out air-flow to be pulverized, and makes 80% metaflumizone fipronil bisamide wetting powder.
Example 2 60% metaflumizone fipronil bisamide wetting powders
Metaflumizone 50%, fipronil bisamide 10%, polyoxyethylene carboxylate 6%, silkworm excrement 5%, white carbon add to 100%, and mixture carries out air-flow to be pulverized, and makes 60% metaflumizone fipronil bisamide wetting powder.
Example 3 45% metaflumizone fipronil bisamide wetting powders
Metaflumizone 30%, fipronil bisamide 15%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 7%, spaonin powder 4%, bentonite add to 100%, and mixture carries out air-flow to be pulverized, and makes 45% metaflumizone fipronil bisamide wetting powder.
Example 4 10% metaflumizone fipronil bisamide wetting powders
Metaflumizone 5%, fipronil bisamide 5%, alkylaryl APEO 7%, tea are withered 4%, attapulgite adds to 100%, and mixture carries out air-flow to be pulverized, and makes 10% metaflumizone fipronil bisamide wetting powder.
Example 5 80% metaflumizone fipronil bisamide water dispersible granules
Metaflumizone 79%, fipronil bisamide 1%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 7%, sldium lauryl sulfate 3%, sodium carbonate 3%, diatomite add to 100%, the mixed 80% metaflumizone fipronil bisamide water dispersible granules that gets.
Example 6 48% metaflumizone fipronil bisamide water dispersible granules
Metaflumizone 40%, fipronil bisamide 8%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, neopelex 3%, aluminium chloride 3%, bentonite add to 100%, the mixed 48% metaflumizone fipronil bisamide water dispersible granules that gets.
Example 7 40% metaflumizone fipronil bisamide water dispersible granules
Metaflumizone 20%, fipronil bisamide 20%, polycarboxylate 6%, sldium lauryl sulfate 3%, sodium bicarbonate 2%, starch add to 100%, the mixed 40% metaflumizone fipronil bisamide water dispersible granules that gets.
Example 8 15% metaflumizone fipronil bisamide water dispersible granules
Metaflumizone 5%, fipronil bisamide 10%, lignosulfonates 6%, silkworm excrement 3%, sodium bicarbonate 2%, kaolin add to 100%, the mixed 15% metaflumizone fipronil bisamide water dispersible granules that gets.
Example 9 50% metaflumizone fipronil bisamide suspension agents
Metaflumizone 1%, fipronil bisamide 49%, alkylphenol-polyethenoxy are phonetic 6%, tea is withered 4%, silicone 2%, CMC 1.4%, polyethylene glycol 0.7%, deionized water add to 100%, mixed 50% metaflumizone fipronil bisamide suspension agent.
Example 10 30% metaflumizone fipronil bisamide suspension agents
Metaflumizone 25%, fipronil bisamide 5%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, spaonin powder 4%, C
10～20Saturated fat acids 0.6%, Magnesiumaluminumsilicate 1.8%, deionized water add to 100%, the mixed 30% metaflumizone fipronil bisamide suspension agent that gets.
Example 11 20% metaflumizone fipronil bisamide suspension agents
Metaflumizone 12%, fipronil bisamide 8%, alkylphenol-polyethenoxy are phonetic 6%, sldium lauryl sulfate 5%, silicone oil 1.2%, polyvinylpyrrolidone 2%, deionized water add to 100%, mixed 20% metaflumizone fipronil bisamide suspension agent.
Example 12 12% metaflumizone fipronil bisamide suspension agents
Metaflumizone 2%, fipronil bisamide 10%, the phonetic formaldehyde condensation products sulphate 6% of alkylphenol-polyethenoxy, spaonin powder 3%, silicone oil 0.5%, melon glue 1.9%, deionized water add to 100%, the mixed 12% metaflumizone fipronil bisamide suspension agent that gets.
Example 13 50% metaflumizone fipronil bisamide suspension emulsions
Metaflumizone 25%, fipronil bisamide 25%, polycarboxylate 6%, wetting and penetrating agent F 4%, styrene polyoxyethylene ether ammonium sulfate salt 4%, ethylene glycol monomethyl ether 6%, silicone compound 0.4%, sodium phosphate trimer 2%, polyethylene glycol 1.6%, deionized water add to 100%, the mixed 50% metaflumizone fipronil bisamide suspension emulsion that gets.
Example 14 36% metaflumizone fipronil bisamide suspension emulsions
Metaflumizone 30%, fipronil bisamide 6%, aryl phenol polyoxyethylene succinate sulfonate 7%, Nekal BX 3%, fatty alcohol-polyoxyethylene ether 3%, silicone 0.6%, gelatin 1.6%, glycerine 2%, deionized water add to 100%, the mixed 36% metaflumizone fipronil bisamide suspension emulsion that gets.
Example 15 25% metaflumizone fipronil bisamide suspension emulsions
Metaflumizone 15%, fipronil bisamide 10%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 7%, Nekal BX 4%, polyoxyethylene nonylphenol ether phosphate 5%, silicone oil 0.5%, xanthans 1.5%, diethylene glycol (DEG) 1.2%, deionized water add to 100%, the mixed 25% metaflumizone fipronil bisamide suspension emulsion that gets.
Example 16 9% metaflumizone fipronil bisamide suspension emulsions
Metaflumizone 6%, fipronil bisamide 3%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 7%, spaonin powder 4%, castor oil polyoxyethylene ether 5%, silicone oil 0.3%, methylcellulose 2%, ethylene glycol 1.6%, deionized water add to 100%, the mixed 9% metaflumizone fipronil bisamide suspension emulsion that gets.
Example 17 50% metaflumizone fipronil bisamide microemulsions
Metaflumizone 40%, fipronil bisamide 10%, sorbitan monostearate 7%, 3-methyl cyclohexanol ketenes 4%, ethylene glycol 3%, polyvinylpyrrolidone 1%, C
8～10Aliphatic alcohols 0.4%, organic acid 2%, deionized water supplies 100%, the mixed 50% metaflumizone fipronil bisamide microemulsion that gets.
Example 18 42% metaflumizone fipronil bisamide microemulsions
Metaflumizone 35%, fipronil bisamide 7%, toluene 7%, triethylene glycol 5%, phenolic resins 1.6%, alkylphenol-formaldehyde resin polyoxy ethyl ether 7%, silicone 1.4%, monoethanolamine 2.5%, deionized water supplies 100%, makes 42% metaflumizone fipronil bisamide microemulsion.
Example 19 20% metaflumizone fipronil bisamide microemulsions
Metaflumizone 15%, fipronil bisamide 5%, N-pyrrolidones 7%, styrene polyoxyethylene ether ammonium sulfate salt 6%, PAA 1.5%, polyethylene glycol 4%, silicone oil 1.6%, tributyl phosphate 3%, deionized water supplies 100%, the mixed 20% metaflumizone fipronil bisamide microemulsion that gets.
Example 20 7% metaflumizone fipronil bisamide microemulsions
Metaflumizone 6%, fipronil bisamide 1%, ethyl acetate 7%, ethylene oxide-propylene oxide block copolymer 8%, melon glue 1%, triethylene glycol 3%, silicone compound 2%, diethanol amine 2%, deionized water supplies 100%, the mixed 7% metaflumizone fipronil bisamide microemulsion that gets.
Example 21 52% metaflumizone fipronil bisamide aqueous emulsions
Metaflumizone 48%, fipronil bisamide 4%, ethylene glycol monomethyl ether 8%, cyclohexanone 4%, alkyl benzene calcium sulfonate 7%, polyethylene glycol 2%, silicone oil 0.8%, deionized water adds to 100%, the mixed 52% metaflumizone fipronil bisamide aqueous emulsion that gets.
Example 22 30% metaflumizone fipronil bisamide aqueous emulsions
Metaflumizone 27.5%, fipronil bisamide 2.5%, acetone 5%, butyl ether 5%, benzyl dimethyl phenol polyoxy ethyl ether 8%, polyethylene glycol 2.6%, silicone oil 0.8%, deionized water adds to 100%, through the mixed 30% metaflumizone fipronil bisamide aqueous emulsion that gets.
Example 23 18% metaflumizone fipronil bisamide aqueous emulsions
Metaflumizone 15%, fipronil bisamide 3%, butanols 4%, ethyl acetate 7%, benzyl dimethyl phenol polyoxy ethyl ether 7%, PAA 2.8%, silicone 0.4%, deionized water adds to 100%, through the mixed 18% metaflumizone fipronil bisamide aqueous emulsion that gets.
Example 24 10% metaflumizone fipronil bisamide aqueous emulsions
Metaflumizone 9%, fipronil bisamide 1%, propyl alcohol 5%, ethyl acetate 5%, phenethyl fluosite polyoxy ethyl ether 8%, glycerine 2.4%, C
8～10Aliphatic alcohols 1%, deionized water adds to 100%, through the mixed 10% metaflumizone fipronil bisamide aqueous emulsion that gets.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.Earlier by Toxicity Determination, the co-toxicity coefficient (CTC) after clear and definite two kinds of medicaments are composite by a certain percentage, CTC＜80 are antagonism, and 80≤CTC≤120 are summation action, and CTC＞120 are synergistic effect, on this basis, carry out field trial again.
Test method: respectively the mother liquor of each mixed agent is diluted to five series concentration during test, places beaker standby respectively.Adopt and to soak the method that connects worm behind the leaf earlier, the blade of the same size that does not contact any medicament soaked in the soup that configures behind the 5s take out, dry naturally, put into insect box, connect then for the examination larva, under 25 ℃ of conditions, raise, every processing repeats for 3 times, every to repeat used examination borer population be 50, establishes blank simultaneously, checks dead borer population in 72h, calculate lethality and corrected mortality, try to achieve virulence regression equation and calculate LC
50Value.If the contrast lethality then is considered as invalid test greater than 10%.Computing formula is as follows:
The insect corrected mortality is converted into probit value (y), and concentration for the treatment of (μ g/ml) converts logarithm value (x) to, draws virulence regression equation with method of least squares, and calculates the value of every kind of medicament thus.Calculate co-toxicity coefficient CTC according to the abundant equation of Sun Yun.Computing formula following (be standard medicament with the metaflumizone, its toxicity index is 100):
TI * the P of theoretical toxicity index (TTI)=metaflumizone of M
MetaflumizoneTI * the P of+fipronil bisamide
Fipronil bisamide
In the formula: M is the mixture of different proportionings;
P
Fipronil bisamideBe fipronil bisamide shared ratio in composition;
P
MetaflumizoneBe metaflumizone shared ratio in composition.
Application Example two:
For trying insect: cotton bollworm.
Test medicine provides by Shaanxi agricultural chemicals Co., Ltd of U.S. nation.
Experimental scheme: effective lethal concentration scope of determining metaflumizone, the former medicine of fipronil bisamide and the two different proportioning mixture through preliminary experiment.
Toxicity test result one
The different proportionings with fipronil bisamide of table 1 metaflumizone are to the toxicity test of cotton bollworm
As shown in Table 1, the proportioning of the composite control of metaflumizone and fipronil bisamide striped rice borer was at 80: 1 to 1: 80 o'clock, co-toxicity coefficient is all greater than 120, illustrating that both were mixed in the scope at 80: 1 to 1: 80 all shows synergistic effect, especially when metaflumizone and fipronil bisamide get proportioning at 20: 1 to 1: 15, synergistic effect is more obviously outstanding, co-toxicity coefficient maximum when metaflumizone and fipronil bisamide weight ratio are 5: 1 wherein, and synergistic effect is the most obvious.Test is simultaneously found, when metaflumizone and fipronil bisamide proportioning are obvious to insect synergistic effects such as rice leaf roller, striped rice borer, paddy stem borer, cabbage caterpillar, beet armyworm, prodenia litura, cotton bollworm, pink bollworm, fall webworm, codling moths during at 19: 1,18: 1,17: 1,16: 1,14: 1,13: 1,12: 1,11: 1,10: 1,9: 1,7: 1,6: 1,4: 1,3: 1,2: 1,1: 2,1: 3,1: 4,1: 6,1: 7,1: 9,1: 10,1: 11,1: 12,1: 13,1: 14, co-toxicity coefficient is all greater than 120.
Application Example three metaflumizones and fipronil bisamide and the composite control wild cabbage diamond-back moth test of pesticide effectiveness thereof
This experimental establishment is in Liquan County, Xianyang, Shanxi province city, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 22% metaflumizone suspending agent (commercial), 10% fipronil bisamide suspension agent (autogamy).
Investigation wild cabbage diamond-back moth insect pest index in the dispenser of insect pest initial stage of origination, was investigated the insect pest indexes in 1 day, 3 days, 7 days after the dispenser and is calculated preventive effect before the medicine.Experimental result is as follows:
Table 2 metaflumizone, fipronil bisamide and the composite control wild cabbage diamond-back moth test of pesticide effectiveness thereof
As can be seen from Table 2, can effectively prevent and treat the wild cabbage diamond-back moth after metaflumizone and fipronil bisamide are composite, control efficiency all is better than the preventive effect of single agent, and the preventive effect time is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example four metaflumizones and fipronil bisamide and the composite control snout moth's larva of rice test of pesticide effectiveness thereof
This experimental establishment is in the Haiyan County, Jiaxing City, Zhejiang Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 22% metaflumizone suspending agent (commercial), 10% fipronil bisamide suspension agent (autogamy).
Investigation snout moth's larva of rice insect pest index before the medicine in the dispenser of insect pest initial stage of origination, was investigated the insect pest indexes in 1 day, 3 days, 7 days after the dispenser and is calculated preventive effect.Experimental result is as follows:
Table 3 metaflumizone, fipronil bisamide and the composite control snout moth's larva of rice thereof are imitated test
As can be seen from Table 3, can effectively prevent and treat the snout moth's larva of rice after metaflumizone and fipronil bisamide are composite, control efficiency all is better than the preventive effect of single agent, and the preventive effect time is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example five metaflumizones and fipronil bisamide and composite control cotton cotton bollworm thereof are imitated test
This experimental establishment is at Shaanxi Province's Weinan City Linwei District, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 22% metaflumizone suspending agent (commercial), 10% fipronil bisamide suspension agent (autogamy).
Investigation cotton cotton bollworm insect pest index in the dispenser of insect pest initial stage of origination, was investigated the insect pest indexes in 1 day, 3 days, 7 days after the dispenser and is calculated preventive effect before the medicine.Experimental result is as follows:
Table 4 metaflumizone, fipronil bisamide and the composite control cotton cotton bollworm test of pesticide effectiveness thereof
As can be seen from Table 4, can effectively prevent and treat the cotton cotton bollworm after metaflumizone and fipronil bisamide are composite, control efficiency all is better than the preventive effect of single agent, and the preventive effect time is long.In the test scope of medication, the target crop is had no adverse effects.
Claims (8)
1. a Pesticidal combination that contains metaflumizone and fipronil bisamide comprises effective active component metaflumizone, fipronil bisamide, auxiliary agent surplus, it is characterized in that: metaflumizone and fipronil bisamide weight ratio are 1: 80～80: 1.
2. Pesticidal combination according to claim 1, it is characterized in that: the weight ratio of metaflumizone and fipronil bisamide is 1: 40～60: 1.
3. Pesticidal combination according to claim 2, it is characterized in that: the weight ratio of metaflumizone and fipronil bisamide is 1: 20～40: 1.
4. Pesticidal combination according to claim 3, it is characterized in that: the weight ratio of metaflumizone and fipronil bisamide is 1: 5～25: 1.
5. Pesticidal combination according to claim 1, it is characterized in that: the weight percentage of active component is 0.5%～90% of gross weight in the composition.
6. Pesticidal combination according to claim 1, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion.
7. Pesticidal combination according to claim 1 is used for the application of insect on control paddy rice, vegetables, cotton, the fruit tree.
8. application according to claim 7 is characterized in that described insect comprises: rice leaf roller, striped rice borer, paddy stem borer, cabbage caterpillar, beet armyworm, prodenia litura, cotton bollworm, pink bollworm, fall webworm, codling moth.
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Application publication date: 20130814 |