CN103230485B

CN103230485B - Medicine for treating Parkinson's disease and preparation method thereof

Info

Publication number: CN103230485B
Application number: CN201310140321.7A
Authority: CN
Inventors: 彭连志
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-04-23
Filing date: 2013-04-23
Publication date: 2014-12-10
Anticipated expiration: 2033-04-23
Also published as: CN103230485A

Abstract

The invention discloses a medicine for treating Parkinson's disease and a preparation method thereof. The medicine is mainly prepared by cornu bubali, antelope's horn, semen cassiae, uncaria and the like by a certain weight ratio. The medicine disclosed by the invention has the effects of clearing away heat and toxic materials, relieving dizziness and arresting convulsion and collecting oneself and calming down, and is good in curative effect, quick in effect and high in cure rate for treating Parkinson's disease.

Description

A kind of medicine for the treatment of parkinsonism and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of parkinsonism and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Parkinsonism is to betide adult's black substance above middle age and nigrostriatum path degenerative disease.Claiming again Parkinsonism, is the modal central nervous system degenerative disease of middle-aged and elderly people.Trembling is that finger and extremity tremble, jolting, and paralysis refers to that part or all limbs of limbs can not autonomic movement.The earliest this disease of system description be Zhan internist of Britain female this, parkinson, also do not know at that time which kind of disease is this disease should be included into, claim this disease for " Parkinsonism " [3], comprise the dyskinesia, tremble and muscular rigidity.Generally at 50～65 years old, start morbidity, sickness rate increases gradually with age growth, within 60 years old, sickness rate is about 1 ‰, within 70 years old, sickness rate reaches 3 ‰～5 ‰, and parkinsonism is having a strong impact on patient's daily life, at present, western medicine parkinsonism poor effect, and have more side effect, therefore, there is very large demand to the Chinese medicine of effective treatment parkinsonism in people.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment parkinsonism, thereby has completed the present invention.

Object of the present invention is just to provide a kind of composition of medicine that can effectively treat parkinsonism.

Another object of the present invention has just been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Cornu Bubali, Cornu Saigae Tataricae, Oleum menthae, Semen Cassiae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Rhizoma Arisaematis, Radix Et Rhizoma Rhei medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of parkinsonism.Wherein select Cornu Bubali to be because its nature and flavor hardship is salty, tremble with fear, have the function of heat clearing away, removing heat from blood, removing toxic substances, control calentura headache, high fever coma, macule, tells nosebleed, infantile convulsion, sore throat pharyngeal swelling.Select Cornu Saigae Tataricae to be because its nature and flavor are salty, cold, enter liver, heart channel, there is suppressing the hyperactive liver to relieve the wind syndrome, heat clearing away is relieving convulsion, and the function of removing toxic substances is controlled calentura coma convulsion and is fainted, and delirium is gone mad, and the dizzy ， Jing Epilepsy of having a headache is twitched, conjunctivitis.Select Oleum menthae to be because its nature and flavor are pungent, cool, nontoxic, have dispelling wind, the function of heat clearing away, controls affection due to external wind and heat, headache conjunctival congestion, pharyngalgia, toothache, skin pruritus due to wind pathogen.Select Semen Cassiae to be because its property bitter but sweet flavor is cool, enter liver, kidney channel, have liver heat removing, improving eyesight, diuretic, the function of relieving constipation, controls wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, liver cirrhosis abdomen, habitual constipation.Selecting Radix Saposhnikoviae is that temperature, enters bladder, lung, spleen channel, delivers because of its property acrid-sweet flavor, dispels the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, and anemofrigid-damp arthralgia, joint is ached, and extremity contraction is anxious, tetanus.Select Ramulus Uncariae Cum Uncis to be because its nature and flavor are bitter, cool, enter liver, heart channel, have heat clearing away suppressing the hyperactive liver, the function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., controls little Jing Epilepsy Chi Zong, and adult's blood pressure is higher, dizzy, dizzy, married woman's eclampsia.Rhizoma arisaematis is selected to be because its nature and flavor toil, temperature, poisonous, enter lung, liver, the spleen channel, have eliminating dampness and eliminating phlegm, dispelling wind and relieving convulsion, the function of dispersing swelling and dissipating binds, control apoplexy phlegm to stop up, facial paralysis, hemiplegia ， Dian Epilepsy, infantile convulsion, lockjaw, anemophlegmatic vertigo, larynx numbness, scrofula, carbuncle is swollen, falls and flutters injured, snake bite and insect sting.Select Radix Et Rhizoma Rhei to be because its nature and flavor are bitter, cold, enter stomach, large intestine, liver footpath, have the poison of purging heat, removing mass is stagnant, the function of clots absorbing blood, controls excess-heat constipation, and delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

25-35 grams of 160-250 grams of Oleum menthae of 160-250 grams of Cornu Saigae Tataricae of Cornu Bubali

250-350 grams of 45-55 grams of Ramulus Uncariae Cum Uncis of 45-55 grams of Radix Saposhnikoviaes of Semen Cassiae

45-55 grams of 25-35 grams of Radix Et Rhizoma Rhei of Rhizoma Arisaematis

Preferable amount is

30 grams of 200 grams of Oleum menthae of 200 grams of Cornu Saigae Tataricae of Cornu Bubali

300 grams of 50 grams of Ramulus Uncariae Cum Uncis of 50 grams of Radix Saposhnikoviaes of Semen Cassiae

50 grams of 30 grams of Radix Et Rhizoma Rhei of Rhizoma Arisaematis

The preparation method of medicine of the present invention is as follows

One, the preparation of decocting liquid

(1) get the raw materials ready

1, Cornu Bubali: rive, with hot-water soak, pull out, pound sheet, dries;

2, Cornu Saigae Tataricae: except boning plug, file broken;

3, Oleum menthae: get crude drug;

4, Semen Cassiae: get clean Semen Cassiae, put in pot and fry extremely micro-fragrance that has, take out, cool;

5, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

6, Ramulus Uncariae Cum Uncis: choose old stalk, impurity, clean, dry;

7, Rhizoma Arisaematis: choose decontamination, clean ash bits, dry;

8, Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries.

(2) preparation

By the Cornu Bubali of described weight, Cornu Saigae Tataricae, Semen Cassiae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Rhizoma Arisaematis, Radix Et Rhizoma Rhei medicine, add for the first time 6 times of amounts of water, soak after 100 minutes, intense fire decocts boiling 20 minutes, use again slow fire boiling after 20 minutes, again add 3 times of amounts of water, first boil with high heat, then use slow fire boiling 20 minutes, get filtrate, the Oleum menthae that adds described weight, stirs, and is divided into 3 doses and takes.

Two, the preparation of granule

1, the Cornu Bubali of described weight, Cornu Saigae Tataricae, Semen Cassiae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Rhizoma Arisaematis, Radix Et Rhizoma Rhei powder are broken into fine powder, then add the Oleum menthae of described weight, be pressed into granule.

2, each serving 10 grams, every day 3 times.

Medicine of the present invention has heat clearing away, removing toxic substances, dispelling wind, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., replenishing blood for nourishing heart, the calm function of composing oneself, and is used for the treatment of parkinsonism, short treating period, instant effect, non-relapse after healing, has no side effect.

The specific embodiment

By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 30ml/kg, and normal amount is 15ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] Drug therapy parkinsonism of the present invention

1, physical data

Accept out-patient's totally 120 examples for medical treatment.

2, diagnostic criteria

Parkinsonism diagnostic criteria

(1) clinical manifestation: most of parkinsonian, 60 years old sequela, occasionally has more than 20 year old and sends out patient.Much more hidden onset is, is slow development, increases the weight of gradually.Main manifestations is: (being often onset symptoms), myotonia, bradykinesia, posture abnormal gait, mouth, pharynx, palate myokinesis obstacle tremble.

(2) auxiliary examination: adopt high performance liquid chromatography (4-hydroxy-3-methoxy-.alpha.-toluic acid .) content in cerebrospinal fluid and urine can be detected and reduce.Cranium brain CT can have the broadening of brain ditch, the ventricles of the brain to expand.

(3) get rid of the parkinson that encephalitis, cerebrovascular, poisoning, wound etc. cause, and differentiate mutually with hysteria, tonicity, senile tremor.

3, Therapeutic Method

Select above-mentioned water preparation or granule, to patient, take, each serving with 1 dose, every day, early, middle and late respectively clothes 1 time, 30 days was a course for the treatment of, took continuously 3 courses for the treatment of.

4, efficacy assessment standard

Effective: transference cure, it is normal that body constitution is recovered, and observes half a year without recidivist;

Take a turn for the better: symptom is clearly better, and body constitution is progressively recovered;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy parkinsonism patient of the present invention 120 examples, effective 110 examples of result, obvious effective rate is 91.67%, 8 examples that take a turn for the better, and improvement rate is 6.67%, invalid 2 examples, total effective rate is 98.34%.

Claims

1. a medicine for the treatment of parkinsonism, is characterized in that: it is to be made by the crude drug in following weight range:

45-55 grams of 25-35 grams of Radix Et Rhizoma Rhei of Rhizoma Arisaematis.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

50 grams of 30 grams of Radix Et Rhizoma Rhei of Rhizoma Arisaematis.

3. according to the preparation method of medicine described in claim 1 or 2, it comprises the following steps:

(1) preparation of decocting liquid

(1) get the raw materials ready

1. Cornu Bubali: rive, with hot-water soak, pull out, pound sheet, dries;

2. Cornu Saigae Tataricae: except boning plug, file broken;

3. Oleum menthae: get crude drug;

4. Semen Cassiae: get clean Semen Cassiae, putting to fry in pot to micro-has fragrance, takes out, and cools;

5. Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

6. Ramulus Uncariae Cum Uncis: choose old stalk, impurity, clean, dry;

7. Rhizoma Arisaematis: choose decontamination, clean ash bits, dry;

8. Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;

(2) preparation

By the Cornu Bubali of described weight, Cornu Saigae Tataricae, Semen Cassiae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Rhizoma Arisaematis, Radix Et Rhizoma Rhei medicine, add for the first time 6 times of amounts of water, soak after 100 minutes, intense fire decocts boiling 20 minutes, use again slow fire boiling after 20 minutes, again add 3 times of amounts of water, first boil with high heat, then use slow fire boiling 20 minutes, get filtrate, the Oleum menthae that adds described weight, stirs, and is divided into 3 doses and takes;

(2) preparation of granule

(1) Cornu Bubali of described weight, Cornu Saigae Tataricae, Semen Cassiae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Rhizoma Arisaematis, Radix Et Rhizoma Rhei powder are broken into fine powder, then add the Oleum menthae of described weight, be pressed into granule;

(2) each serving 10 grams, every day 3 times.