CN103229780B - Cyantraniliprole-imidacloprid pesticide composition - Google Patents
Cyantraniliprole-imidacloprid pesticide composition Download PDFInfo
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- CN103229780B CN103229780B CN201310141138.9A CN201310141138A CN103229780B CN 103229780 B CN103229780 B CN 103229780B CN 201310141138 A CN201310141138 A CN 201310141138A CN 103229780 B CN103229780 B CN 103229780B
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- imidacloprid
- bemisia tabaci
- bromine cyanogen
- insect amide
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Abstract
The invention discloses a pesticide prepared from effective ingredients of cyantraniliprole and imidacloprid according to an effective mass ratio of (9:1)-(1:1.5) and application thereof, especially application thereof in controlling tobacco whiteflies. The mixing of the cyantraniliprole and the imidacloprid according to the mass ratio shows remarkable synergistic or additive action, improves the control effect on pests (especially tobacco whiteflies), reduces the consumption of field pesticides and postpones the pesticide resistance of pests.
Description
Technical field
The present invention relates to a kind of insecticide, belong to the pesticide field of crop pest control.
Background technology
Bemisia tabaci Bemisia tabaci belongs to Homoptera (Semiptera), Aleyrodidae, the multiple horticultural crops such as cucumber, tomato, eggplant, cowpea, dish soybean, cabbage mustard and cauliflower of mainly causing harm, it not only stings and inhales the host plant of causing harm, but also propagate multiple virus disease, due to the tomato yellow leaf curl virus disease (TYLCD) that causes some areas tomato canopy total crop failure highlighting in production is in the last few years propagated by Bemisia tabaci.The control of China's Bemisia tabaci is in chemical control mode as main at present.Bemisia tabaci adults has certain ability of circling in the air, and is to be difficult to one of insect of control most on producing, and along with the continuous use of single insecticide, Bemisia tabaci has produced pesticide resistance in various degree to increasing insecticide.Especially there is variation sharply in China's Bemisia tabaci biotype in recent years, most areas was Q type Bemisia tabaci by former Type B Bemisia tabaci succession of causing harm, and host's adaptability of Q type Bemisia tabaci is more extensive, the ability of propagation geminivirus infection is higher, stronger to the patience of insecticide, therefore, Q type Bemisia tabaci replacement Type B Bemisia tabaci makes China face more challenges to the control of this worm.
A lot of research is verified; for most of insecticides; Q type Bemisia tabaci has stronger drug resistance and pesticide resistance than Type B Bemisia tabaci; indoor Q type resistance Bemisia tabaci still keeps higher resistance level (Nauen et al. Pest Manag. Sci. after 2 years in raising; 2002,58:868-875; Horowitz et al., Arch. Insect Biochem. Physiol., 2005,58:216-225).Domestic a lot of area all monitors the drug-fast generation of Q type Bemisia tabaci, and resistant multiple is higher than Type B Bemisia tabaci, especially obvious for nicotinic insecticide.Imidacloprid is first generation nicotinic insecticide, has the features such as wide spectrum, efficient, low toxicity, low-residual, and have tag, the multiple activity such as stomach toxicity and interior suction, be mainly used in preventing and treating the sucking pest in field, as aleyrodid, aphid, plant hopper etc.Its insecticidal mechanism is mainly that selectivity suppresses insect nerve system nicotinic acetylcholine esterase acceptor, thereby the normal conduction of blocking-up insect central nervous system causes insect to occur paralysis and then dead.China develops Imidacloprid in phase early 1990s, and since 1996, the production of Imidacloprid presents fast rise trend always, is widely used.Owing to using for a long time and frequently, insect rises obviously to its pesticide resistance.Especially the substituting of Bemisia tabaci biotype (Q type substitutes Type B) in recent years, Preliminary Study shows that substituting of this biotype may have Close relation with the long-term of the nicotinic insecticide such as Imidacloprid and use widely.The phenomenon that Imidacloprid significantly declines for the control efficiency of Q type Bemisia tabaci is also found in field, and some areas have even proposed to suspend the warning of Imidacloprid Contol ofCotton Bemisia tabaci, has beaten alarm bell service life to the field of this class pest of Imidacloprid Contol ofCotton and Imidacloprid.
Bromine cyanogen insect amide is a kind of Novel ortho aminobenzamide insecticides, belongs to second generation ryanodine receptor insecticide, and its mechanism of action is the ryanodine receptor by activating target pest, discharges the calcium in striated muscle and smooth muscle cell, causes insect paralysis dead.High medicament insecticidal spectrum is extensive, and evidence is not only effective to lepidoptera pest, and the sucking pests such as Bemisia tabaci, aphid, thrips are also had to good control efficiency.This medicament has extremely strong Bidirectional Conduction and interior absorption energy, also there is certain contact toxicity, evidence bromine cyanogen insect amide and anabasine and Nylar etc. are without cross resistance (Li et al. Pest Manag. Sci., 2012,68:83-81), therefore there is the Bemisia tabaci field populations that nicotinic insecticide is developed immunity to drugs and will there is higher cytotoxicity and good gram anti-effect.
In order to overcome the higher pesticide resistance of Bemisia tabaci to Imidacloprid and other nicotinic insecticides, especially the pesticide resistance of Q type Bemisia tabaci, simultaneously in order to extend the service life of cheap Imidacloprid, improve the control efficiency of Bemisia tabaci, reduce the usage amount of field insecticide, be necessary to find or research and develop new insecticide.
Summary of the invention
For the deficiencies in the prior art and demand, the present invention has filtered out these two mechanism of action of bromine cyanogen insect amide and Imidacloprid different insecticides and has had for Bemisia tabaci the ratio range of high co-toxicity.
Technical problem to be solved by this invention is: a kind of low toxicity, low-residual are provided, are suitable for the efficient chemical control insecticide of vegetable fields Bemisia tabaci.
Technical scheme provided by the invention is: a kind of insecticide, its active ingredient is to be made up of according to the mass ratio 9:1-1:1.5 of active ingredient bromine cyanogen insect amide and Imidacloprid.
Preferably, the mass ratio of described bromine cyanogen insect amide and Imidacloprid active ingredient is 9:1-7:3.
More preferably, the mass ratio of described bromine cyanogen insect amide and Imidacloprid active ingredient is 9:1 or 4:1.
Insecticide of the present invention can be mixed with upper wettability pulvis, suspending agent, granule, water dispersible granules, missible oil and the microemulsion formulation etc. that allow of agricultural.
It is sucking pest that described insecticide is applied to control crop pest, in particular for preventing and treating Bemisia tabaci.
The present invention has following beneficial effect: the present invention filters out the composition pesticide with synergistic effect that contains bromine cyanogen insect amide and Imidacloprid, when bromine cyanogen insect amide and Imidacloprid carry out proportioning according to effective mass than 9:1-1:1.5, in the time of control vegetable fields Bemisia tabaci, show obvious synergy or summation action, the synergistic effect during wherein with 9:1-7:3 ratio is more obvious.Insecticides low toxicity of the present invention, low-residual, be suitable for the efficient chemical control of vegetable fields Bemisia tabaci, simultaneously have the double effect of controlling for other sucking pest such as aphid, thrips, this composition can reduce field insecticide consumption, slow down the development of sucking pest resistance to insecticide and extend service life etc. of nicotinic insecticide.
Embodiment
Detailed description below by embodiment is further illustrated the present invention, but is not limitation of the present invention, only does example explanation.
for examination worm source and medicament
The Bemisia tabaci that the Bemisia tabaci Shi Ben seminar adopting in test gathered on the eggplant of Haidian District Beijing field " assorted No. 16 of circle " in 2012, indoor is Q type through Biotype Determination.Before proportioning screening test, exceeded for 3 generations in indoor feeding, do not contact any insecticide.
Be that 10% bromine cyanogen insect amide dispersibles oil-suspending agent (du pont company's product) for examination insecticide; 10% imidacloprid wettable powder (Hebei Weiyuan Biochemical Co., Ltd.'s product).
Host's blade that the test of indoor Bemisia tabaci adults toxicity test is used by cultivate without worm wild cabbage (
brassica oleraceaL. var.
capitata) obtain on seedling, kind is " rich No. 1 of capital ".
data processing and computational methods
Test data adopts the each concentration of Probit software analysis to process the dead ratio of different time points Bemisia tabaci, draws slope, the LC of each medicament and different proportionings
50and 95% confidence limit etc.The lethality of blank can not exceed 10%, otherwise writes off, and repeats this test.The computational methods of bromine cyanogen insect amide proportioning co-toxicity coefficients different from Imidacloprid (CTC) are carried out according to the abundant method of Sun Yun, actual and the theoretical toxicity index (ATI, TTI) of the single dose toxicity index (TI) of each proportioning, mixture (being made as M) respectively, last co-toxicity coefficient (CTC) of being tried to achieve each proportioning by ATI/TTI.Judge according to common poison dilution CTC whether the two exists synergistic effect.In the time of CTC < 80, it is antagonism, 80～120 is summation action, when > 120, be synergistic effect, and conventionally only have the mix ratio as CTC > 200, in actual production, be just regarded as thering is remarkable synergistic effect.
The data acquisition DPS v3.01 professional version that efficiency test investigation obtains is calculated bromine cyanogen insect amide and Imidacloprid single dose and the relative control effect of different proportioning to Bemisia tabaci adults thereof, and between processing, the significance of difference adopts LSD method to analyze.Computational methods are shown in two formula below.
Insect population decline rate (%)=[insect population radix before (insect population number after the front insect population radix-medicine of medicine)/medicine] × 100
Control efficiency (%)=[(the insect population decline rate of the insect population decline rate-blank of processing)/(the insect population decline rate of 100-blank)] × 100
embodiment mono-: Bemisia tabaci adults Toxicity Determination
On the basis of preliminary experiment, the scope that bromine cyanogen insect amide and Imidacloprid are set to respectively to 9:1～1:9 according to the mass ratio of active ingredient is measured its co-toxicity to Bemisia tabaci adults.Take respectively appropriate bromine cyanogen insect amide and Imidacloprid calculating on the basis of two kinds of insecticide consumptions, then add suitable quantity of water and be dissolved to desired concn, for agar leaf dipping method determination test below.
The toxicity test of Bemisia tabaci adults is carried out in glass dactylethrae.Specific operation process is as follows: spread 1.8%～2% agar 2mL in glass dactylethrae bottom, after agar solidifies, wipe main wall steam with blotting paper.Gather the blade of wild cabbage not dispenser, smooth without worm seedling, get with card punch the leaf disk that diameter is 22mm, avoid thick vein place as far as possible.Test arranges 5～7 concentration, and establishes clear water blank, and every processing arranges 4 repetitions.Prepare after liquid, each roundleaf sheet soaks 10 seconds in the liquid of variable concentrations, and it is smooth in the pipe end that room temperature is dried rear face down.The dactylethrae mouth of pipe down, is patted and is stopped the blade having for examination Bemisia tabaci Bemisia tabaci adults is freely flown into, and 20～35 of every pipes, fill in 2/3 pipe range with tampon, keep and blade pitch from being not less than 15mm.Then dactylethrae is inverted and is put in illumination box, 25 ± 1 DEG C of set temperatures, the photoperiod is 14h: 8h(L: D), after 48h, check the death toll of Bemisia tabaci in each pipe and the number of surviving.
Bromine cyanogen insect amide and Imidacloprid and the two are mixed the toxicity test concrete outcome of Bemisia tabaci in table 1 according to different proportionings.
table 1 bromine cyanogen insect amide and the Imidacloprid co-toxicity to Bemisia tabaci
Table 1 has shown in bromine cyanogen insect amide and Imidacloprid single dose and different proportioning situation thereof, to the indoor virulence of Bemisia tabaci adults.The LC of bromine cyanogen insect amide to Bemisia tabaci
50for 54.41mg/L, the LC of Imidacloprid to Bemisia tabaci
50for 238.57mg/L.Known by the abundant method result of calculation of Sun Yun, along with the increasing gradually of minimizing, Imidacloprid adding proportion gradually of bromine cyanogen insect amide ratio in compound, compound reduces gradually to the cytotoxicity of Bemisia tabaci adults, be that LC50 value raises gradually, but its co-toxicity coefficient changes to some extent, while mixing with 9:1-7:3 ratio with bromine cyanogen insect amide and Imidacloprid, CTC value is greater than 120, illustrate that aforementioned proportion scope is synergistic effect, while wherein mixing with 9:1 ratio with bromine cyanogen insect amide and Imidacloprid, synergistic effect is the most remarkable, and co-toxicity coefficient CTC is 492.58.And 1.5:1-1:1.5 presents summation action, indoor mixing has no bad reaction, and therefore field efficiency test is carried out in next step simulation.
embodiment bis-: the efficiency test of each medicament and different proportionings thereof
Field efficiency test indoor pot without worm cotton seedling " middle cotton 49 " on carry out, when test, cotton is 4-6 sheet true leaf.The mass ratio that bromine cyanogen insect amide (No. 1), Imidacloprid (No. 2), bromine cyanogen insect amide and Imidacloprid active ingredient are set is respectively respectively No. 9:1(3), No. 4:1(4), No. 7:3(5), No. 1.5:1(6), No. 1:1(7), No. 1:1.5(8), No. 3:7(9), No. 1:4(10) and No. 1:9(11) etc. 11 different chemicals treatment, add a clear water contrast, totally 12 different disposal.Every strain cotton seedling is as 1 repetition, and each processing arranges 4 strain cotton seedlings, repeats respectively as 4 times.Measure respectively 10% appropriate bromine cyanogen insect amide and dispersible oil-suspending agent and 10% Imidacloprid preparation wetting powder, then after the two thoroughly being mixed according to the mass ratio of the active ingredient of 9:1,4:1,7:3,1.5:1,1:1,1:1.5,3:7,1:4 and 1:9, get respectively 1-11 Treatment Solution, dilute 2000 times of liquid, spray for subsequent use.The liquid medicine of different disposal is all now with the current.
Put into respectively in getting Bemisia tabaci adults at dusk the small-sized gauze tent that is placed with cotton seedling, treat Bemisia tabaci adults radix in the every strain of its stable " Invest, Then Investigate " the next morning.Then carry out the positive and negative blade face of complete stool even spraying with manual sprayer, (No. 12) are processed in clear water spraying in contrast.Afterwards respectively at after medicine 1 day, 3 days and within 7 days, investigate the Bemisia tabaci adults quantity of each processing.
The insect population radix of variant processing is investigated in spraying before efficiency test, after dispenser 1 day, 3 days and within 7 days, investigate respectively the quantity of each processing Bemisia tabaci adults, relative control effect and the significance of difference analysis in table 2 of different chemicals treatment to Bemisia tabaci in different control times.
the control efficiency comparison to Bemisia tabaci adults of table 2 bromine cyanogen insect amide and Imidacloprid and different proportioning thereof
Note: in table, data are the mean value repeating for 4 times.It is not remarkable that what lowercase was identical be illustrated in p=0.05 level difference, and what capitalization was identical shows at p=0.01 level difference not remarkable.
As can be seen from Table 2, along with the prolongation of spraying time, the relative control effect of each chemicals treatment all rises to some extent, but not obvious.After medicine 1 day, bromine cyanogen insect amide and Imidacloprid all show certain quick-acting, its relative control effect is respectively 81.47% and 50.07%, wherein Imidacloprid single dose preventive effect is significantly lower than the relative control effect of all the other each processing, bromine cyanogen insect amide is a little less than the relative control effect under 1:1.5 proportioning, and difference is not remarkable.Bromine cyanogen insect amide and Imidacloprid show obvious synergistic effect during according to the mass ratio of 9:1,4:1 and 7:3 active ingredient, and relative control effect is apparently higher than the control efficiency of the additive combination ratio within the scope of 1.5:1-1:1.5; Along with the further minimizing (when itself and Imidacloprid ratio are 3:7,1:4 and 1:9) of bromine cyanogen insect amide effective mass ratio, the relative control effect of its combination declines, significantly lower than the preventive effect of all the other ratios, but still higher than the control efficiency of Imidacloprid single dose.After medicine, 3 days trend during with 7 days is consistent.
Therefore, field modeling result of the test further shows, when bromine cyanogen insect amide and Imidacloprid carry out proportioning according to the quality 9:1-1:1.5 of active ingredient, the control efficiency when relative control effect of 1 day, 3 days and 7 days is all processed separately higher than two kinds of single doses after medicine, the synergistic effect during wherein with 9:1-7:3 ratio is more obvious.
Claims (2)
1. comprise the insecticide of bromine cyanogen insect amide and Imidacloprid active ingredient in the application preventing and treating in Q type aleyrodid, it is characterized in that: described bromine cyanogen insect amide and the mass ratio of Imidacloprid active ingredient are 9:1-4:1.
2. application as claimed in claim 1, is characterized in that: described bromine cyanogen insect amide and the mass ratio of Imidacloprid active ingredient are 9:1 or 4:1.
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| CN105284876A (en) * | 2015-12-02 | 2016-02-03 | 河北省农林科学院植物保护研究所 | Insecticide composition for preventing and treating cylas formicarius |
| CN106070295A (en) * | 2016-06-21 | 2016-11-09 | 南京华洲药业有限公司 | A kind of brominated cyanogen insect amide and the Synergistic insecticidal compositions of imidacloprid and application thereof |
| CN109100443A (en) * | 2018-09-30 | 2018-12-28 | 浙江省检验检疫科学技术研究院 | The method of various new nicotinoids drug and its metabolite residue amount in royal jelly is measured simultaneously |
| CN110495469A (en) * | 2019-10-09 | 2019-11-26 | 江苏钟山化工有限公司 | A kind of composition pesticide and its application |
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| CN102726380A (en) * | 2012-07-24 | 2012-10-17 | 联保作物科技有限公司 | Cyantraniliprole aqueous dispersion granule and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102283205A (en) * | 2004-07-26 | 2011-12-21 | 杜邦公司 | Mixtures of anthranilamide invertebrate pest control agents |
| EP2269455A1 (en) * | 2009-06-24 | 2011-01-05 | Bayer CropScience AG | Combinations of biological control agents and insecticides |
| CN102626071A (en) * | 2012-03-29 | 2012-08-08 | 广西田园生化股份有限公司 | Ultra-low volume liquid containing cyantraniliprole and neonicotinoid insecticides |
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