CN103211889A

CN103211889A - Externally applied medicine used for treating wound difficult to heal

Info

Publication number: CN103211889A
Application number: CN2013101805272A
Authority: CN
Inventors: 胡俊明
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-05-16
Filing date: 2013-05-16
Publication date: 2013-07-24

Abstract

The invention provides an externally applied medicine used for treating a wound difficult to heal, relates to externally applied medicine powder or ointment used for treating the wound difficult to heal and is especially applicable to healing of chronic ulcer, bedsore, scald and a deep wound. According to the externally applied medicine, rheum officinale, giant knot weed, sanguisorba officinalis and calomel are taken as main raw materials to prepare the powder or ointment. The externally applied medicine used for treating the wound difficult to heal has good effects of eliminating inflammation, promoting tissue regeneration, protecting granulation and epithelial tissue and promoting wound healing and is easy to prepare and use, raw materials are available, price is low, and a good medical treatment effect and good social benefit can be achieved.

Description

A kind of treatment is difficult to the external used medicine of healing of wound

Technical field:

The invention discloses the external used medicine of the wound that a kind of treatment is difficult to heal, relating to a kind of is the powder and the ointment of feedstock production with Chinese medicine.

Background technology:

Solve at present the ulcer disunion of a specified duration that causes because of wound or internal diseases and mainly adopt operation stitching, skin-grafting, Therapeutic Method such as anti-inflammation.Said method mainly is that various single medicine that causes of pathogenic flora is difficult to onset because of the complicated medicine of factors such as the wound environment that is difficult to heal, circulation is difficult to arrive disease institute, and the course of disease delay time is long, skin grafting medical expense height.

Summary of the invention:

In view of above-mentioned the deficiencies in the prior art, the purpose of this invention is to provide and a kind ofly be difficult to healing, and medicine evident in efficacy at the wound that causes because of Different types of etiopathogenises such as antibacterial, fungus, virus, parasite, tumor, endocrine.

The object of the present invention is achieved like this, and it is made up of following materials of weight proportions: Radix Et Rhizoma Rhei 20-32%; Rhizoma Polygoni Cuspidati 20-32%; Radix Sanguisorbae 20---32%; Calomelas 3-10% is made powder.Perhaps in 100 gram vaseline, add Radix Et Rhizoma Rhei 5-12 grams; Rhizoma Polygoni Cuspidati 5-12 grams; Radix Sanguisorbae 5-12 grams; Calomelas 0.5-1 gram.Boric acid 3 grams～8 grams, Mel 6 grams～15 are restrained into ointment.The pharmacological action of its each medicine is:

Radix Et Rhizoma Rhei:

1, antibacterial action:

Chrysophanic acid in the rhubarb anthraquinone, emodin, aloe-emodin have inhibitory action in various degree to staphylococcus, streptococcus, diphtheria corynebacterium, bacillus subtilis various bacteria.Aqueous solution has inhibitory action to multiple funguses such as trichophyton, trichophyton interdigitales.Antibacterial action mechanism: the enzyme system that influences folic acid; Suppress bacterial nucleic acid and protein synthesis; Suppress the bacterium living beings oxidase system; Inducement interferon.

2, anastalsis:

Characteristics: effect is definite, instant effect.

The hemostasis effective ingredient is α-catechin, gallic acid.Anastalsis mechanism: promote hematoblastic adhesion and aggregation capability; Platelet increasing number and fibrinogen content; Reduce the antithrombin activity; Make injured partial vasoconstriction

3, antitumor action:

Its mechanism be anticancer breathing, oxidative dehydrogenation and DNA biosynthesis and directly destroy tumor cell.

Rhizoma Polygoni Cuspidati: staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, micrococcus catarrhalis, escherichia coli, Bacillus proteus, shigella flexneri, bacillus pyocyaneus are all had the good restraining effect.The Rhizoma Polygoni Cuspidati decoct has convergence, protects from infection and antiinflammation scald wound.And to bacillus subtilis, Resina garciniae eight repeatedly bacterium etc. stronger bactericidal action is arranged

Radix Sanguisorbae:

1. astriction:

A large amount of tannins that Radix Sanguisorbae is contained have stronger convergence and vasoconstrictive and hemostatic effect, can reduce the permeability of blood vessel, reduce inflammatory exudation.External Radix Sanguisorbae preparata powder has remarkable astriction to II degree, III degree scald face, can make to ooze out minimizing, infection rate reduction. and suppress the hypertrophy of granuloma induced by implantation of cotton pellets, promote wound healing.Also can adopt Radix Sanguisorbae ethanol liquid (Radix Sanguisorbae is cleaned and to dry, and grinds coarser powder and extracts clear liquid with 70～75% ethanol percolation, boils to liquid level thin film to occur, cools off standby) to be coated with burn wound, every day 2～3 times, not wrap up.The coating number of times forms dry crusts and be full of cracks degree of being do not occur with wound surface.To the wound surface that has polluted the debridement treatment of should going ahead of the rest.By to one, second degree burn patient's observation; prove this method to superficial burns, special centering small size, to pollute lighter burn effect better, generally can form 1 layer of brown protecting film on the wound surface through 12～24 hours; this oozes out preventing germ contamination, minimizing wound surface, and good influence is all arranged.

2. antibacterial action: the decocting liquid of Radix Sanguisorbae 100% all has in various degree inhibitory action to Bacillus typhi, meningococcus, shigella flexneri, bacterium sonnei, beta hemolytic streptococcus, staphylococcus aureus, Diplococcus pneumoniae, diphtheria corynebacterium, escherichia coli, bacillus subtilis, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera and Bacillus tuberculosis.Some fungus also there is in various degree inhibitory action.There is report to think that the antibacterial action of Radix Sanguisorbae is with wherein contained tannic acid is relevant.Medicinal liquid through autoclaving then bacteriostasis obviously weaken.Also has the obvious sterilization effect simultaneously.

3. antiinflammatory action:

The swelling of Radix Sanguisorbae PARA FORMALDEHYDE PRILLS(91,95) pedal swelling mouse knoting oil auricular concha has the obvious suppression effect; Hyperfunction to the skin microvascular permeability that prostaglandin E causes, Radix Sanguisorbae has very strong inhibitory action; Still the bullate hypertrophy of rat granuloma can be suppressed, and wound healing can be promoted.

4. anastalsis:

Radix Sangusorbae, water extract, charred Radix Sanguisorbae, Rhizoma sanguisorbae preparation all have the effect of system blood. and the Radix Sanguisorbae water extract can make the bleeding time obviously shorten. and the charred Radix Sanguisorbae decoct obviously shortens for the oral clotting time that can make of rabbit; Injection can make the bleeding time shorten to mouse peritoneal; Frog hind leg perfusion experiment visible vessels is shunk. and there is report to point out, the Radix Sanguisorbae heating is concocted its content of tannin is reduced, anastalsis weakens. because the anastalsis of Radix Sanguisorbae is main relevant with tannin, therefore reporter's suggestion be used for the treatment of hemorrhage when being main disease giving birth to product for well, and advise with the content of tannin being the quality standard of Radix Sanguisorbae.

5, promoting muscle growth functions:

Bright Radix Sanguisorbae injection has the effect of antitumor and leukocyte increasing. and the Radix Sanguisorbae water extract gives the postoperative rat of gastric fistula oral, can significantly increase it to proteinic digestion power.

Calomelas: the master contains the chlorination mercurous dispel significantly cold necrotic tissue and promoting muscle growing, bactericidal action.Modern pharmacology proves that its water logging agent all has in various degree inhibitory action to dermatophytess such as trichophyton, epidermophyton rubrum, star-shaped nocardias.

The present invention shows to have following characteristics through clinical use result;

1, disunion wound of a specified duration had good convergence, antiinflammatory, protection granulation, epithelial tissue, the effect of promotion wound healing.

2, easy to use, instant effect can be granulation promoting healing in 3-10 days according to wound size and gradient of infection.

3, scope of application speech is wide, and clinically mechanical wound, burn due to hot liquid or fire, decubital ulcer, diabetes are caused ulcer, and fistula all has curative effect preferably, and toxic and side effects is little.

4, medical expense is low, and is economical and practical.

Enumerating the present invention treats the part that wound is difficult to heal and falls ill:

1, Hu, man, 48 years old, worker, people from Pingjiang River, Hunan.In August, 2010 is injured at stone factory's work left index finger finger tip, makes debridement treatment in local commune hospital, and surplus anti-inflammation treats 20 do not heal in the sky.Wound still has a large amount of juices when examining, with 13 gram of this SHENGJISAN, recovery from illness in 7 days.

2, Hu, man, 50 years old, peasant, people from Pingjiang River, Hunan.Cause left hand upper arm many places wound in July, 2012 by motorcycle, make debridement treatment in local commune hospital, surplus anti-inflammation treats ten do not heal in the sky.Wound still has a large amount of juices when examining, and wound area is totally 12 ㎝, with 13 gram of this SHENGJISAN, recovery from illness in 4 days.

3, Hu, man, 60 years old, peasant, people from Pingjiang River, Hunan.In JIUYUE, 2012 left leg wound to local clinic prescription on individual diagnosis externally-applied ointment, day does not heal surplus the antibiosis anti-inflammatory drug 20 for oral administration.Wound area 4cm when examining has juice to ooze out, with 13 gram of this SHENGJISAN, recovery from illness in 4 days.

4, Hu, man, 30 years old, doctor, people from Pingjiang River, Hunan.Weight caused the left leg closed type and weighed wounded in July, 2012, an orthopedic hospital do manual reduction and anti-inflammation treat ten surplus day, blood-activating and stasis-removing for oral administration.Wound suppuration after February, wound still has a large amount of juices when examining, and crevasse area 10cm is with 26 grams of this SHENGJISAN, recovery from illness in 6 days.

5 Hus, man, 43 years old, peasant, people from Pingjiang River, Hunan.In November, 2012 is injured because of the planer improper use causes right hand forefinger finger tip, makes debridement treatment in local commune hospital, and the anti-inflammation treatment was not healed in 12 days.Wound still has a large amount of juices when examining, with 13 gram of this SHENGJISAN, recovery from illness in 4 days.

6, the hair certain, man, 55 years old, peasant, people from Pingjiang River, Hunan.Root is fractured after causing left foot in July, 2011 by motorcycle, and the muscle degree of depth is dampened, the debridement that operates in orthopedic hospital treatment, and it is surplus that draw point location and anti-inflammation are treated January, blood-activating and stasis-removing for oral administration.Antibiotic, anti-inflammatory treatment is made repeatedly in local hospital in the back of leaving hospital, and external Hong Kong SHENGFU GAO did not still heal in 16 months at ordinary times.Wound still has a large amount of juices when examining, and crevasse area 10cm with 6 18 grams of this SHENGJISAN, takes an evident turn for the better after January, and secretions reduces, and wound surface dwindles.

Specific embodiment:

One, powder:

1, Calx is fried earlier, selected size, uniform 50% Radix Et Rhizoma Rhei of thickness to add to stir to the Calx cooling of sieving that takes on a red color to loose fluent.

2, get remaining 50% Radix Et Rhizoma Rhei and Radix et Rhizoma Rhei (processed), Radix Sanguisorbae, pulverized 120 mesh sieves jointly.

3, get above-mentioned mixed-powder 50 grams and Calomelas mix homogeneously, with equivalent big medicine of incremental method addition and mix homogeneously.With 3 the gram be unit pack into the packing in.

4, using method is 1 day 2-3 time, applies the wound surface that looses with medicine at every turn.

Two, ointment: in 100 gram vaseline, add Radix Et Rhizoma Rhei 5-12 grams; Rhizoma Polygoni Cuspidati 5-12 grams; Radix Sanguisorbae 5-12 grams; Calomelas 0.5-1 gram; Boric acid 3 grams～8 grams; Mel 6 grams～15 restrain.

Claims

1. a treatment is difficult to the external used medicine of healing of wound, it is characterized in that being made up of the raw material of following weight ratio: Radix Et Rhizoma Rhei 20-32%; Rhizoma Polygoni Cuspidati 20-32%; Radix Sanguisorbae 20---32%; Calomelas 3-10%.