CN103209700A - 广谱抗生素Arylomycin类似物 - Google Patents

广谱抗生素Arylomycin类似物 Download PDF

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Publication number
CN103209700A
CN103209700A CN2011800550186A CN201180055018A CN103209700A CN 103209700 A CN103209700 A CN 103209700A CN 2011800550186 A CN2011800550186 A CN 2011800550186A CN 201180055018 A CN201180055018 A CN 201180055018A CN 103209700 A CN103209700 A CN 103209700A
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CN
China
Prior art keywords
alkyl
staphylococcus
amino
arylomycin
signal peptidase
Prior art date
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Pending
Application number
CN2011800550186A
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English (en)
Chinese (zh)
Inventor
弗洛伊德·E·罗梅斯伯格
彼得·A·史密斯
塔克·C·罗伯茨
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Scripps Research Institute
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Scripps Research Institute
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Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of CN103209700A publication Critical patent/CN103209700A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN2011800550186A 2010-09-15 2011-08-31 广谱抗生素Arylomycin类似物 Pending CN103209700A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38298810P 2010-09-15 2010-09-15
US61/382,988 2010-09-15
PCT/US2011/049967 WO2012036907A2 (en) 2010-09-15 2011-08-31 Broad spectrum antibiotic arylomycin analogs

Publications (1)

Publication Number Publication Date
CN103209700A true CN103209700A (zh) 2013-07-17

Family

ID=45832167

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800550186A Pending CN103209700A (zh) 2010-09-15 2011-08-31 广谱抗生素Arylomycin类似物

Country Status (10)

Country Link
US (1) US9187524B2 (https=)
EP (1) EP2616093A4 (https=)
JP (1) JP2013539751A (https=)
KR (1) KR20130105659A (https=)
CN (1) CN103209700A (https=)
BR (1) BR112013006265A2 (https=)
CA (1) CA2811295A1 (https=)
MX (1) MX2013003035A (https=)
RU (1) RU2013112483A (https=)
WO (1) WO2012036907A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106661084A (zh) * 2014-05-20 2017-05-10 阿奇克斯制药公司 大环广谱抗生素
CN110520413A (zh) * 2017-02-15 2019-11-29 阿奇克斯制药公司 大环广谱抗生素
CN116023430A (zh) * 2022-12-20 2023-04-28 中国药科大学 2-(2-(2-苯甲酰氨基)乙酰胺)苯甲酸类衍生物及其制备方法和用途

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013006265A2 (pt) 2010-09-15 2016-06-07 Scripps Research Inst espectros antibióticos gerais análogos a arilomicina
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
TWI642684B (zh) * 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
CA2867448A1 (en) * 2012-03-14 2013-09-19 Floyd E. Romesberg Broad spectrum antibiotic arylomycin analogs
KR20150088292A (ko) * 2012-11-21 2015-07-31 알큐엑스 파마슈티컬스, 인크. 광범위한 마크로사이클릭 항생제
CN103103261A (zh) * 2013-01-05 2013-05-15 张国新 检测幽门螺杆菌对克拉霉素耐药性试剂盒及制备方法
AU2015339039B2 (en) * 2014-10-31 2019-11-28 Temple University -- Of The Commonwealth System Of Higher Education Synergistic compositions for treating microbial infections
US11072635B2 (en) 2015-11-20 2021-07-27 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
WO2017214534A1 (en) 2016-06-10 2017-12-14 The Scripps Research Institute Synthesis of the arylomycin macrocyclic core
EP3388445A1 (en) * 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Peptide macrocycles and use thereof in the treatment of bacterial infections
JP7078807B2 (ja) 2019-05-28 2022-05-31 エフ．ホフマン－ラ ロシュ アーゲー 大環状広域スペクトル抗生物質

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048694A (en) * 1995-11-03 2000-04-11 E. I. Du Pont De Nemours And Company Bacterial positive selection vector

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6951840B2 (en) * 2001-08-31 2005-10-04 Eli Lilly And Company Lipoglycopeptide antibiotics
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
CN102939095A (zh) 2010-03-09 2013-02-20 默沙东公司 增强β-内酰胺抗菌药物的活性的桥联脂糖肽类
BR112013006265A2 (pt) 2010-09-15 2016-06-07 Scripps Research Inst espectros antibióticos gerais análogos a arilomicina
TWI642684B (zh) * 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
CA2867448A1 (en) 2012-03-14 2013-09-19 Floyd E. Romesberg Broad spectrum antibiotic arylomycin analogs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048694A (en) * 1995-11-03 2000-04-11 E. I. Du Pont De Nemours And Company Bacterial positive selection vector

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JUDITH SCHIMANA 等: "Arylomycins A and B, new biaryl-bridged lipopeptide antibiotics produced by Streptomyces sp. Tü 6075. I. Taxonomy, fermentation, isolation and biological activities.", 《THE JOURNAL OF ANTIBIOTICS》, vol. 55, no. 6, 30 June 2002 (2002-06-30), pages 565 - 570 *
MARK S. BUTLER 等: "Natural products—The future scaffolds for novel antibiotics？", 《BIOCHEMICAL PHARMACOLOGY》, vol. 71, 31 December 2006 (2006-12-31), pages 919 - 929 *
PALANIAPPAN KULANTHAIVEL等: "Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》, vol. 279, no. 35, 1 June 2004 (2004-06-01), pages 36250 - 36258 *
PETER A. SMITH 等: "Broad-Spectrum Antibiotic Activity of the Arylomycin Natural Products Is Masked by Natural Target Mutations", 《CHEM BIOL.》, vol. 17, no. 11, 24 November 2010 (2010-11-24), pages 1223 - 1231, XP027511224, DOI: doi:10.1016/j.chembiol.2010.09.009 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106661084A (zh) * 2014-05-20 2017-05-10 阿奇克斯制药公司 大环广谱抗生素
CN106661084B (zh) * 2014-05-20 2021-08-31 阿奇克斯制药公司 大环广谱抗生素
CN110520413A (zh) * 2017-02-15 2019-11-29 阿奇克斯制药公司 大环广谱抗生素
CN110520413B (zh) * 2017-02-15 2023-02-17 阿奇克斯制药公司 大环广谱抗生素
CN116023430A (zh) * 2022-12-20 2023-04-28 中国药科大学 2-(2-(2-苯甲酰氨基)乙酰胺)苯甲酸类衍生物及其制备方法和用途

Also Published As

Publication number Publication date
KR20130105659A (ko) 2013-09-25
CA2811295A1 (en) 2012-03-22
US9187524B2 (en) 2015-11-17
EP2616093A4 (en) 2014-02-26
WO2012036907A2 (en) 2012-03-22
BR112013006265A2 (pt) 2016-06-07
JP2013539751A (ja) 2013-10-28
RU2013112483A (ru) 2014-10-20
EP2616093A2 (en) 2013-07-24
WO2012036907A3 (en) 2012-08-09
MX2013003035A (es) 2013-12-16
US20130281360A1 (en) 2013-10-24

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Application publication date: 20130717