BR112013006265A2 - espectros antibióticos gerais análogos a arilomicina - Google Patents
espectros antibióticos gerais análogos a arilomicinaInfo
- Publication number
- BR112013006265A2 BR112013006265A2 BR112013006265A BR112013006265A BR112013006265A2 BR 112013006265 A2 BR112013006265 A2 BR 112013006265A2 BR 112013006265 A BR112013006265 A BR 112013006265A BR 112013006265 A BR112013006265 A BR 112013006265A BR 112013006265 A2 BR112013006265 A2 BR 112013006265A2
- Authority
- BR
- Brazil
- Prior art keywords
- arylomycin
- analogs
- antibiotic
- bioactivity
- methods
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 4
- 238000001228 spectrum Methods 0.000 title abstract 4
- 230000001580 bacterial effect Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 229930014626 natural product Natural products 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- YFSXYWAZCKMYJN-UHFFFAOYSA-N arylomycin A2 Natural products C=1C=C(O)C2=CC=1CC(C(O)=O)NC(=O)C(C)NC(=O)C(N(C)C(=O)CNC(=O)C(C)NC(=O)C(CO)N(C)C(=O)CCCCCCCCC(C)C)C1=CC=C(O)C2=C1 YFSXYWAZCKMYJN-UHFFFAOYSA-N 0.000 abstract 1
- 108010047091 arylomycin A2 Proteins 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- YFSXYWAZCKMYJN-JBBOGOJTSA-N chembl1231055 Chemical compound C=1C=C(O)C2=CC=1C[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N(C)C(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](CO)N(C)C(=O)CCCCCCCCC(C)C)C1=CC=C(O)C2=C1 YFSXYWAZCKMYJN-JBBOGOJTSA-N 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 108010087967 type I signal peptidase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38298810P | 2010-09-15 | 2010-09-15 | |
| PCT/US2011/049967 WO2012036907A2 (en) | 2010-09-15 | 2011-08-31 | Broad spectrum antibiotic arylomycin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013006265A2 true BR112013006265A2 (pt) | 2016-06-07 |
Family
ID=45832167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013006265A BR112013006265A2 (pt) | 2010-09-15 | 2011-08-31 | espectros antibióticos gerais análogos a arilomicina |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9187524B2 (https=) |
| EP (1) | EP2616093A4 (https=) |
| JP (1) | JP2013539751A (https=) |
| KR (1) | KR20130105659A (https=) |
| CN (1) | CN103209700A (https=) |
| BR (1) | BR112013006265A2 (https=) |
| CA (1) | CA2811295A1 (https=) |
| MX (1) | MX2013003035A (https=) |
| RU (1) | RU2013112483A (https=) |
| WO (1) | WO2012036907A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013006265A2 (pt) | 2010-09-15 | 2016-06-07 | Scripps Research Inst | espectros antibióticos gerais análogos a arilomicina |
| US10501493B2 (en) | 2011-05-27 | 2019-12-10 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
| TWI642684B (zh) * | 2011-05-27 | 2018-12-01 | Ｒｑｘ製藥股份有限公司 | 廣效性抗生素 |
| CA2867448A1 (en) * | 2012-03-14 | 2013-09-19 | Floyd E. Romesberg | Broad spectrum antibiotic arylomycin analogs |
| KR20150088292A (ko) * | 2012-11-21 | 2015-07-31 | 알큐엑스 파마슈티컬스, 인크. | 광범위한 마크로사이클릭 항생제 |
| CN103103261A (zh) * | 2013-01-05 | 2013-05-15 | 张国新 | 检测幽门螺杆菌对克拉霉素耐药性试剂盒及制备方法 |
| WO2015179441A2 (en) * | 2014-05-20 | 2015-11-26 | Rqx Pharmaceuticals, Inc. | Macrocyclic broad spectrum antibiotics |
| AU2015339039B2 (en) * | 2014-10-31 | 2019-11-28 | Temple University -- Of The Commonwealth System Of Higher Education | Synergistic compositions for treating microbial infections |
| US11072635B2 (en) | 2015-11-20 | 2021-07-27 | Rqx Pharmaceuticals, Inc. | Macrocyclic broad spectrum antibiotics |
| WO2017214534A1 (en) | 2016-06-10 | 2017-12-14 | The Scripps Research Institute | Synthesis of the arylomycin macrocyclic core |
| AU2018222093B2 (en) * | 2017-02-15 | 2022-03-31 | Genentech, Inc. | Macrocyclic broad spectrum antibiotics |
| EP3388445A1 (en) * | 2017-04-10 | 2018-10-17 | F. Hoffmann-La Roche AG | Peptide macrocycles and use thereof in the treatment of bacterial infections |
| JP7078807B2 (ja) | 2019-05-28 | 2022-05-31 | エフ．ホフマン－ラ ロシュ アーゲー | 大環状広域スペクトル抗生物質 |
| CN116023430B (zh) * | 2022-12-20 | 2025-11-25 | 中国药科大学 | 2-(2-(2-苯甲酰氨基)乙酰胺)苯甲酸类衍生物及其制备方法和用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0862638A1 (en) * | 1995-11-03 | 1998-09-09 | E.I. Du Pont De Nemours And Company | Positive selection vector for bacillus sp. |
| US6951840B2 (en) * | 2001-08-31 | 2005-10-04 | Eli Lilly And Company | Lipoglycopeptide antibiotics |
| DE102005014245A1 (de) | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Antibakterielle Amid-Makrozyklen V |
| CN102939095A (zh) | 2010-03-09 | 2013-02-20 | 默沙东公司 | 增强β-内酰胺抗菌药物的活性的桥联脂糖肽类 |
| BR112013006265A2 (pt) | 2010-09-15 | 2016-06-07 | Scripps Research Inst | espectros antibióticos gerais análogos a arilomicina |
| TWI642684B (zh) * | 2011-05-27 | 2018-12-01 | Ｒｑｘ製藥股份有限公司 | 廣效性抗生素 |
| CA2867448A1 (en) | 2012-03-14 | 2013-09-19 | Floyd E. Romesberg | Broad spectrum antibiotic arylomycin analogs |
-
2011
- 2011-08-31 BR BR112013006265A patent/BR112013006265A2/pt not_active IP Right Cessation
- 2011-08-31 RU RU2013112483/04A patent/RU2013112483A/ru not_active Application Discontinuation
- 2011-08-31 WO PCT/US2011/049967 patent/WO2012036907A2/en not_active Ceased
- 2011-08-31 EP EP11825668.4A patent/EP2616093A4/en not_active Withdrawn
- 2011-08-31 US US13/821,195 patent/US9187524B2/en not_active Expired - Fee Related
- 2011-08-31 JP JP2013529181A patent/JP2013539751A/ja not_active Ceased
- 2011-08-31 CA CA2811295A patent/CA2811295A1/en not_active Abandoned
- 2011-08-31 MX MX2013003035A patent/MX2013003035A/es not_active Application Discontinuation
- 2011-08-31 KR KR1020137009510A patent/KR20130105659A/ko not_active Withdrawn
- 2011-08-31 CN CN2011800550186A patent/CN103209700A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130105659A (ko) | 2013-09-25 |
| CA2811295A1 (en) | 2012-03-22 |
| US9187524B2 (en) | 2015-11-17 |
| EP2616093A4 (en) | 2014-02-26 |
| WO2012036907A2 (en) | 2012-03-22 |
| CN103209700A (zh) | 2013-07-17 |
| JP2013539751A (ja) | 2013-10-28 |
| RU2013112483A (ru) | 2014-10-20 |
| EP2616093A2 (en) | 2013-07-24 |
| WO2012036907A3 (en) | 2012-08-09 |
| MX2013003035A (es) | 2013-12-16 |
| US20130281360A1 (en) | 2013-10-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112013006265A2 (pt) | espectros antibióticos gerais análogos a arilomicina | |
| MX2014011067A (es) | Analogos de antibiótico de arilomicina de amplio espectro. | |
| BR112016002496A2 (pt) | composto de fórmula i, composição farmacêutica, método para inibição de kdm1a, método para tratamento de uma doença mediada por globina, método para atingir um efeito em um paciente, e, método para inibir pelo menos uma função de kdm1a | |
| BR112015026307A2 (pt) | heterociclo bicíclicos como inibidores de fgfr | |
| UA111579C2 (uk) | ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ | |
| BR112014018027A8 (pt) | Composto, composição farmacêutica e usos dos mesmos e métodos para aumentar a inclusão de éxon 7 de ame2 em rnam que é transcrito a partir do gene ame2 e para aumentar a quantidade de proteína smn | |
| BR112012027034A2 (pt) | inibidores da arginase e suas aplicações terapêuticas | |
| BR112014030202A2 (pt) | microorganismos e métodos para a produção de 4-hidroxibutirato 1,4-butanodiol e compostos relacionados | |
| BR112013005235A2 (pt) | "métodos e sistemas para processamento de misturas de açúcar e composições resultantes". | |
| BR112012029975A2 (pt) | peptídeo como medicamento, em particular para o tratamento do câncer. | |
| BR112017013258A8 (pt) | Derivados de 5-[(piperazin-1-il)-3-oxo-propil]-imidazolidina-2,4-diona como inibidores de adamts para o tratamento de osteoartrite | |
| BR112016023559A2 (pt) | mutações de deleção | |
| PH12015501074A1 (en) | Triazolopyrazine | |
| PH12013500152A1 (en) | New aminopyrazoloquinazolines | |
| BR112015014372A2 (pt) | inibidores de autotaxina | |
| MY173447A (en) | Processing materials | |
| BR112015011697A2 (pt) | antibióticos macrocíclicos de amplo espectro | |
| MX2020010375A (es) | Nuevos derivados de ester fosforamidato 3'-desoxiadenosina de 2' y/o 5' aminoacido como compuestos anti-cancer. | |
| BR112017006683A2 (pt) | método de produção de biopolímeros, método de produção de composto de matriz de biopolímero e composto de matriz de biopolímero | |
| WO2012024405A3 (en) | Curcumin compositions and uses thereof | |
| BR112016016853A2 (pt) | Compostos contendo nitrogênio, seu uso e seu processo de preparação, composição farmacêutica e seu uso | |
| BR102012019673A8 (pt) | Reator tubular | |
| JO3611B1 (ar) | سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم | |
| BR112014026605A2 (pt) | produção melhorada de produtos de proteína solúvel a partir de grãos de leguminosas | |
| BR112018010255A2 (pt) | antibióticos macrocíclicos de amplo espectro |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |