Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has effective for the treatment liver cirrhosis, and side effect is little, the double characteristics originally of taking stopgap measures.
The present invention selects Radix Bupleuri, the Radix Paeoniae Alba, Radix Curcumae, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae, Herba Leonuri, Fructus Polygoni Orientalis, Radix Angelicae Sinensis, Herba Verbenae, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Herba Taraxaci, Periostracum Cicadae, Pericarpium Arecae, Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Semen Arecae Prepareta, Caulis Perillae, Radix Adenophorae (Radix Glehniae), Radix Scrophulariae to make up, make each efficacy of drugs produce synergism these drug regimens, make it to have dispersing the stagnated live-QI to relieve the stagnation of QI, regulating qi-flowing for strengthening spleen, the effect of promoting blood circulation and stopping pain, thus liver cirrhosis can effectively be treated.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Bupleuri: be dry root or the herb of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Nature and flavor: bitter, hot, be slightly cold.Return liver, lung, spleen channel.Effect: dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Be used for stagnation of QI due to depression of the liver, costa sternales distension pain.
The Radix Paeoniae Alba: be the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae (cultigen).Nature and flavor: bitter, sour, cold.Return liver, spleen channel.Effect: depressed liver-energy dispersing and QI regulating, easing the affected liver nourishes blood, slow middle pain relieving, suppressing the hyperactive liver yin fluid astringing.Have protecting the liver, fall the effect of enzyme, be used for the breast abdomen pain over the hypochondriac region." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " purgation of spleen excess heat, it is painful to end abdomen, and sealing rushes down, and it is painful to receive adverse flow of liver-QI, takes good care of conscience spleen channel blood, relaxes through sending down the abnormal ascending QI, ends irritability pain." " herbal classic " Radix Paeoniae, though do not distinguish red white, the two each main to some extent.So seek and unravel silk it and cure mainly all diseases, one is that the replenishing blood and nourishing liver spleen is Kidney-Yin, takes the photograph the at random of temper and receive, and throwing off restraint of irritability is horizontal, then the Radix Paeoniae Alba.
Radix Curcumae: be the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor: hot, bitter, cold.Return liver, the heart, lung meridian.Effect: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Nature and flavor: hardship, tepor.GUIXIN, Liver Channel.Effect: promoting blood circulation and stopping pain, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.Be used for the costa sternales hypochondriac pain, improve the liver microcirculation, can suppress or alleviate hepatocellular degeneration, necrosis and inflammatory reaction, promote liver cell regeneration, and anti-fibrosis effect is arranged.
Pericarpium Citri Reticulatae: be the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor: temperature, hot, bitter.Go into spleen, stomach, lung meridian.Effect: regulating qi-flowing for strengthening spleen, in the accent, dampness is reduced phlegm.
Herba Leonuri: be the fresh or dry aerial parts of labiate Herba Leonuri Leonurus japonicus Houtt..Nature and flavor: hot, bitter, be slightly cold.Go into the heart, liver, urinary bladder channel.Effect: invigorate blood circulation, blood stasis dispelling, regulating menstruation, water disappears.
Fructus Polygoni Orientalis: be the dry mature fruit of polygonaceae plant smartweed PolygonumorientaleLinn..Nature and flavor: salty, be slightly cold.Go into liver, stomach, spleen channel.Effect: eliminating mass and relieving fullness eliminating stagnation, clearing away heat to alleviate pain.Join Pericarpium Arecae, Pericarpium Arecae Wen Tongxin looses, energy promoting the circulation of QI to alleviate the stagnation in middle-JIAO, promoting diuresis by dispersing lung-QI; Herba Polygoni Orientalis edema of the legs during pregnancy fragrance is salty, can rush down down by softening the hard mass treatment abdominal distention edema.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, hot, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood, invigorate blood circulation, menstruction regulating and pain relieving is moisturized laxation.
Herba Verbenae: be the dry aerial parts of Verenaceae plant Herba Verbenae Verbena officinalis L..Nature and flavor: hardship, cold.Return liver, spleen channel.Effect: promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, detoxifcation, inducing diuresis to remove edema.
Radix Astragali: be the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali.Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.Effect: invigorating QI to consolidate the body surface resistance, diuretic detumescent etc. have the effect that protects the liver.
Rhizoma Atractylodis Macrocephalae: be the rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: air making-up and spleen enlivening, dampness diuretic.
Herba Taraxaci: for feverfew Herba Taraxaci Toraxacum mongolicum Hand. Mazz., alkali ground Herba Taraxaci Toraxacum borealisinense Kitam. or belong to the dry herbs of several plants together.Nature and flavor: sweet, little hardship, cold.Go into bright, the Taiyin channels of sun.Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Periostracum Cicadae: exuviae shell when sprouting wings for the nymph of cicada Cryptotympana atrata Fabr. Cryptotympana pustulata Fabricius.Nature and flavor: sweet, cold.Return lung, Liver Channel.Effect: the wind heat extraction that looses, sore-throat relieving, rash, nebula removing, spasmolytic.
Pericarpium Arecae: be the dry peel of babassu Semen Arecae Areca catechu L..Nature and flavor: suffering, tepor.Return spleen, stomach, large intestine, small intestine meridian.Effect: therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.
Fructus Crataegi (parched to brown): be the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge. var. major N. E. Br. or Fructus Crataegi Crataegus pinnatifida Bge..Nature and flavor: acid, sweet, tepor.Return spleen, stomach, Liver Channel.Effect: promoting digestion and invigorating the stomach, blood circulation promoting and blood stasis dispelling, convergence dysentery relieving.
Fructus Hordei Germinatus (parched to brown): for the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L. gets through the drying of germinateing.Nature and flavor: sweet, flat.Return spleen, stomach warp, Liver Channel.Effect: promote qi circulation digestion promoting, dyspepsia and intestinal stasis relieving.
Massa Medicata Fermentata (parched to brown): mix the processed goods that forms by fermentation for whole wheat flour and other drug (Herba Artemisiae Annuae, Herba Xanthii, buds such as Herba polygoni hydropiperis, Semen Armeniacae Amarum, Semen Phaseoli).Nature and flavor: sweet, hot, temperature.Return spleen, stomach warp.Effect: promoting digestion and removing stagnation, invigorating the spleen and regulating the stomach.
Semen Arecae Prepareta: be the dry mature seed of babassu Semen Arecae Areca catechu L..The process of preparing Chinese medicine processed goods of Semen Arecae.Nature and flavor: bitter, hot, temperature.Return stomach, large intestine channel.Effect: dyspepsia and intestinal stasis relieving.
Caulis Perillae: be the dry stem of labiate Folium Perillae Perilla frutescens (L.) Britt..Nature and flavor: suffering, temperature.Return lung, spleen channel.Effect: regulating the flow of QI to ease the stomach, pain relieving, antiabortive.
Radix Adenophorae (Radix Glehniae): for campanulaceae Lady bell plant four leaf Radix Adenophorae (Radix Glehniae) Adenophora tetraphylla (Thunb.) Fisch.A. berticillata (Pall.) Fisch., Folium Pruni Radix Adenophorae (Radix Glehniae) A. axilliflora Borb A. stricta Miq. or its congener, be used as medicine with root.Nature and flavor: sweet, cold.Attach to the lung and stomach meridians.Effect: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid, QI invigorating is reduced phlegm.
Radix Scrophulariae: be the dry root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl..Nature and flavor: sweet, bitter, salty, be slightly cold.Return lung, stomach, kidney channel.Effect: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.
Medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have curative effect preferably in the following weight parts scope: Radix Bupleuri 10-20 part, Radix Paeoniae Alba 10-20 part, Radix Curcumae 10-20 part, Radix Salviae Miltiorrhizae 25-35 part, Pericarpium Citri Reticulatae 7-17 part, Herba Leonuri 25-35 part, Fructus Polygoni Orientalis 25-35 part, Radix Angelicae Sinensis 7-17 part, Herba Verbenae 10-20 part, Radix Astragali 10-20 part, Rhizoma Atractylodis Macrocephalae 25-35 part, Herba Taraxaci 10-20 part, Periostracum Cicadae 2-6 part, Pericarpium Arecae 7-17 part, Fructus Crataegi (parched to brown) 10-20 part, Fructus Hordei Germinatus (parched to brown) 10-20 part, Massa Medicata Fermentata (parched to brown) 10-20 part, Semen Arecae Prepareta 10-20 part, Caulis Perillae 7-17 part, Radix Adenophorae (Radix Glehniae) 7-17 part, Radix Scrophulariae 5-15 part.
Wherein be preferably: 15 parts of Radix Bupleuri, 15 parts of the Radix Paeoniae Albas, 15 parts of Radix Curcumaes, 30 parts of Radix Salviae Miltiorrhizaes, 12 parts of Pericarpium Citri Reticulataes, 30 parts of Herba Leonuris, 30 parts of Fructus Polygoni Orientaliss, 12 parts of Radix Angelicae Sinensis, 15 parts of Herba Verbenae, 15 parts of Radix Astragali, 30 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Herba Taraxacis, 4 parts of Periostracum Cicadaes, 12 parts of Pericarpium Arecae, 15 parts of Fructus Crataegi (parched to brown)s, 15 parts of Fructus Hordei Germinatus (parched to brown)s, 15 parts of Massa Medicata Fermentata (parched to brown), 15 parts of Semen Arecae Preparetas, 12 parts of Caulis Perillaes, 12 parts of Radix Adenophorae (Radix Glehniae), 10 parts of Radix Scrophulariaes.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.For example these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Can use decocting, get filtrate after filtration, add antiseptic and make oral liquid; Also can directly take decoction in case of necessity.
Medicine of the present invention has dispersing the stagnated live-QI to relieve the stagnation of QI, regulating qi-flowing for strengthening spleen, and effects such as promoting blood circulation and stopping pain, effective, side effect is little, and double taking stopgap measures originally according to clinical 200 routine patients are observed statistics, used medicine total effective rate course for the treatment of total effective rate 80%, two course for the treatment of 96% of the present invention.
The specific embodiment
Embodiment one, 10 parts of Radix Bupleuri, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Curcumaes, 25 parts of Radix Salviae Miltiorrhizaes, 7 parts of Pericarpium Citri Reticulataes, 25 parts of Herba Leonuris, 25 parts of Fructus Polygoni Orientaliss, 7 parts of Radix Angelicae Sinensis, 10 parts of Herba Verbenae, 10 parts of Radix Astragali, 25 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Herba Taraxacis, 2 parts of Periostracum Cicadaes, 7 parts of Pericarpium Arecae, 10 parts of Fructus Crataegi (parched to brown)s, 10 parts of Fructus Hordei Germinatus (parched to brown)s, 10 parts of Massa Medicata Fermentata (parched to brown), 10 parts of Semen Arecae Preparetas, 7 parts of Caulis Perillaes, 7 parts of Radix Adenophorae (Radix Glehniae), 5 parts of Radix Scrophulariaes.
Embodiment two, 15 parts of Radix Bupleuri, 15 parts of the Radix Paeoniae Albas, 15 parts of Radix Curcumaes, 30 parts of Radix Salviae Miltiorrhizaes, 12 parts of Pericarpium Citri Reticulataes, 30 parts of Herba Leonuris, 30 parts of Fructus Polygoni Orientaliss, 12 parts of Radix Angelicae Sinensis, 15 parts of Herba Verbenae, 15 parts of Radix Astragali, 30 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Herba Taraxacis, 4 parts of Periostracum Cicadaes, 12 parts of Pericarpium Arecae, 15 parts of Fructus Crataegi (parched to brown)s, 15 parts of Fructus Hordei Germinatus (parched to brown)s, 15 parts of Massa Medicata Fermentata (parched to brown), 15 parts of Semen Arecae Preparetas, 12 parts of Caulis Perillaes, 12 parts of Radix Adenophorae (Radix Glehniae), 10 parts of Radix Scrophulariaes.
Embodiment three, 20 parts of Radix Bupleuri, 20 parts of the Radix Paeoniae Albas, 20 parts of Radix Curcumaes, 35 parts of Radix Salviae Miltiorrhizaes, 17 parts of Pericarpium Citri Reticulataes, 35 parts of Herba Leonuris, 35 parts of Fructus Polygoni Orientaliss, 17 parts of Radix Angelicae Sinensis, 20 parts of Herba Verbenae, 20 parts of Radix Astragali, 35 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of Herba Taraxacis, 6 parts of Periostracum Cicadaes, 17 parts of Pericarpium Arecae, 20 parts of Fructus Crataegi (parched to brown)s, 20 parts of Fructus Hordei Germinatus (parched to brown)s, 20 parts of Massa Medicata Fermentata (parched to brown), 20 parts of Semen Arecae Preparetas, 17 parts of Caulis Perillaes, 17 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Radix Scrophulariaes.
Be the clinical statistics data that the patient uses medicine of the present invention below:
One, physical data
Accept out-patient's totally 200 examples for medical treatment, male's 108 examples wherein, women's 92 examples, M-F 1.2:1,53 years old mean age.
Two, diagnostic criteria
Main indications: 1. scope or esophagus gulp down barium X ray examination and find esophageal varicosis.2. B ultrasonic prompting liver echo obviously strengthen, uneven, luminous point is thick; Or the liver surface owes smooth, uneven or indentation, or portal vein diameter 〉=1.4cm; Or spleen increases splenic vein diameter 〉=1.0cm.3. ascites is accompanied angry of vena epigastrica.4. CT shows liver outer rim nodositas protuberance, and fissure enlarges, caudal lobe/lobus dexter ratio>0.05cm, changes such as splenomegaly.5. peritoneoscope or needle biopsy of liver are examined and are the liver cirrhosis person.More than except 5. one can make a definite diagnosis, the less important indication of other each bound fractions can be made a definite diagnosis.
Less important indication: 1. chemical examination: (A/G is inverted general abnormal liver function, protein electrophoresis A reduces, gamma globulin raises, serum bilirubin raises, prolonged prothrombin etc.), or Serum hyaluronic acid (HA), III procollagen type peptide (P III P), ammoxidation single enzyme (MAO), ADA Adenosine deaminase (ADA), flaggy element (hN) increase.2. sign: hepatic facies (the face clouding is simple and unadorned), a plurality of spider angiomas and color is dark, liver palm, jaundice, lower limbs edema, the liver quality is hard partially, splenomegaly, gynaecomastia, more than chemical examination and sign arrive, and needn't know fully.
Three, Therapeutic Method
According to drug weight proportioning of the present invention, weighting raw materials (daily dose), decocting, filter and remove residue services once sooner or later, and 30 is a course for the treatment of.
Four, efficacy assessment standard
Cure: ascites, jaundice complete obiteration, transference cure, the liver spleen deliquescing that obviously bounces back, liver function recovery is normal, and antisecosis can be engaged in general work, recidivist not more than drug withdrawal later six months.
Produce effects: ascites, jaundice disappear, and cardinal symptom disappears, and muscle power is obviously recovered, and the liver spleen is stablized constant, the obvious improver of liver function; Or reached the clinical cure standard and in half a year the recidivist.
Effectively: ascites, jaundice obviously disappear, and symptom, liver function all have the improver.
Invalid: symptom, sign, liver function all do not have improvement behind the treatment first quarter moon, or further worsen or dead person.
Five, therapeutic outcome statistics
Wherein: total effective rate=cure rate+obvious effective rate+effective percentage
Model case and curative effect:
Case one, week certain, the man 44 years old, suffers from liver cirrhosis due to hbv, ascites more than 6 years, again and again, and repeatedly is in hospital.Current ascites increase has had some months, and abdominal distention is serious, and result of laboratory test shows that ALB drops to 24, and total bilirubin is that 90, AST is apparently higher than ALT.Give the patient and take Drug therapy of the present invention after two courses for the treatment of, ascites disappears, and abdominal distention disappears.
Case two, poplar, the man, 25 years old, looked into before 4 years and suffer from hepatitis B, conscious weak, fatiguability, yellowish urine etc., B ultrasonic: liver echo strengthens slightly, splenomegaly, gallbladder no abnormality seen.Dim complexion when examine the beginning of this year, hepatosplenomegaly, purplish tongue, stringy and hesitant pulse, B ultrasonic: show that hepatocyte has slight necrosis, slight liver fiber becomes, and is diagnosed as liver cirrhosis.The patient takes Drug therapy of the present invention after two courses for the treatment of, and symptom disappears substantially, and complexion takes a turn for the better, and liver function recovery is normal.
Case three, Lee, the woman, 56 years old, suffer from liver cirrhosis, conscious lassitude and weak, loss of appetite, dyspepsia is felt sick, vomiting, upper right abdomen dull pain, and suffer from diarrhoea often.B ultrasonic prompting: liver cirrhosis and a small amount of ascites.The patient takes Drug therapy of the present invention after two courses for the treatment of, and through the ultrasound diagnosis result: liver echo no abnormality seen, liver function is obviously improved, and recovers normal.