CN102988906B - Traditional Chinese medicine combination for treating cirrhosis - Google Patents
Traditional Chinese medicine combination for treating cirrhosis Download PDFInfo
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- CN102988906B CN102988906B CN201310005292.3A CN201310005292A CN102988906B CN 102988906 B CN102988906 B CN 102988906B CN 201310005292 A CN201310005292 A CN 201310005292A CN 102988906 B CN102988906 B CN 102988906B
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Abstract
The invention discloses a traditional Chinese medicine combination for treating cirrhosis and belongs to traditional Chinese medicine combinations. The traditional Chinese medicine combination comprises astragalus mongholicus, radix bupleuri, bighead atractylodes rhizome, radix paeoniae alba, curcuma aromatica, wine-treated rhubarb, endothelium corneum gigeriae galli, salviae miltiorrhizae, rhizoma sparganii, curcuma zedoary, chinese polyphaga and liquorice according to weight ratio. The traditional Chinese medicine combination for treating cirrhosis strengthens spleen, soothes liver, activates blood, softens hard mass, and can effectively treat cirrhosis.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of liver cirrhosis.
Background technology
Liver cirrhosis is hepatitis interstitialis chronica, and liver cirrhosis is clinical common chronic hepatopathy, and liver is carrying out property, diffusivity, fibrous lesions.Be embodied in hepatocyte diffusivity degeneration necrosis, then there is proliferation of fibrous tissue and the regeneration of hepatocyte nodositas, these three kinds of changes are staggered carrying out repeatedly, and result lobules of liver structure and blood circulation approach are reconstructed gradually, makes liver distortion, hardening and cause liver cirrhosis.The formation of liver cirrhosis is due to for a long time under harmful factor (as ethanol, hepatitis virus, Developmental and Metabolic Disorder) effect, hepatic necrosis, degeneration and inflammatory reaction, thus liver sternzellen stimulated, the fibrous material of a lot of formation of secretion, in the course of time, liver develops to liver cirrhosis from fibrosis.This disease is in early days because liver compensation more by force can non-evident sympton, stage is take liver function injury and portal hypertension as main manifestations, and have multisystem to get involved, often there is the complication death such as upper gastrointestinal hemorrhage, hepatic encephalopathy, secondary infection, hypersplenism, ascites, canceration late period.The method Main Basis patient's of western medical treatment liver cirrhosis severity extent and determining, does not have unified Therapeutic Method, and it is large to take Western medicine side effect, for patients with terminal, adopts liver transplantation more, and surgery cost is high, and risk is large.In traditional Chinese medical science books, there is no the name of disease of liver cirrhosis, only have the symptom sick similar with liver cirrhosis.Disease is seen: spiritlessness and weakness, the pain over the hypochondriac region, abdominal distension and anorexia, yellow urine etc.Treatment by Chinese herbs is mainly with blood circulation promoting and blood stasis dispelling, soothing the liver eliminate indigestion, and invigorating spleen for diuresis is main.By treatment by Chinese herbs, improve autoimmunity, impel downright bad hepatocyte and Fibrotic hepatic tissue to absorb rapidly, effective, side effect is little, double taking stopgap measures originally.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has effective for treatment liver cirrhosis, and side effect is little, the double feature originally of taking stopgap measures.
The present invention selects the Radix Astragali, Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Curcumae, Radix et Rhizoma Rhei (stir-fried with wine), Endothelium Corneum Gigeriae Galli, Radix Salviae Miltiorrhizae, Rhizoma Sparganii, Rhizoma Curcumae, Eupolyphaga Seu Steleophaga and Radix Glycyrrhizae to combine, make each efficacy of drugs produce synergism these drug regimens, make it to there is invigorating the spleen and relieving depression of liver-QI, the effect of movable blood soft hard, thus liver cirrhosis can effectively be treated.
The effect of Chinese medicine of the present invention:
Wherein: the Radix Astragali: be the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali.Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.Effect: invigorating QI to consolidate the body surface resistance, diuretic detumescent etc., have the effect protecting the liver.
Radix Bupleuri: be dry root or the herb of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Nature and flavor: bitter, pungent, be slightly cold.Return liver, lung, spleen channel.Function: dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.For stagnation of QI due to depression of the liver, costa sternales distension pain.
The Rhizoma Atractylodis Macrocephalae: be the rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: air making-up and spleen enlivening, dampness diuretic.< < Tang materia medica > >: diuresis.
The Radix Paeoniae Alba: be the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae (cultigen).Nature and flavor: bitter, sour, cool.Return liver, spleen channel.Effect: depressed liver-energy dispersing and QI regulating, easing the affected liver nourishes blood, slow middle pain relieving, suppressing the hyperactive liver yin fluid astringing.There is protecting the liver, fall the effect of enzyme, for the breast abdomen pain over the hypochondriac region.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " sealing rushes down, and receives adverse flow of liver-QI pain, takes good care of conscience spleen channel blood, relaxes through sending down the abnormal ascending QI, only irritability pain for purgation of spleen excess heat, only abdomen pain." < < herbal classic > > Radix Paeoniae, though do not distinguish red whitely, the two is respectively main to some extent.So seek and unravel silk it and cure mainly all diseases, one is that replenishing blood and nourishing liver spleen is Kidney-Yin, and receive, takes the photograph the at random of temper, and throwing off restraint of irritability is horizontal, the Radix Paeoniae Alba.
Radix Curcumae: be the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor: pungent, bitter, cold.Return liver, the heart, lung meridian.Effect: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.
Radix et Rhizoma Rhei (stir-fried with wine): be polygonum rheum palmatum, the dry root and rhizome of Rheum tanguticum or Rheum officinale.Nature and flavor: hardship, cold.Return stomach, spleen, large intestine, liver, pericardium channel.Effect: heat and toxic materials clearing away, removing pathogenic heat from blood and toxic substance from the body, promoting the function of the gallbladder to alleviate jaundice.
Endothelium Corneum Gigeriae Galli: be the dry gizzard inwall (muscular stomach) of Chordata Phasianidae animal man chicken (Gallus gallus domesticus Brisson).Nature and flavor: sweet, cold.Return spleen, stomach, small intestinal, urinary bladder channel.Effect: promoting digestion and invigorating the stomach, arresting seminal emission.Stagnant for removing food stagnancy, strengthening the spleen and stomach.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Nature and flavor: hardship, tepor.GUIXIN, Liver Channel.Effect: promoting blood circulation and stopping pain, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.For costa sternales hypochondriac pain, improve liver microcirculation, can suppress or alleviate hepatocellular degeneration, necrosis and inflammatory reaction, promote liver cell regeneration, and have anti-fibrosis effect.
Rhizoma Sparganii: be the tuber of Sparganiaceae plant rhizoma scirpi, spire rhizoma scirpi, little rhizoma scirpi.Nature and flavor: pungent, bitter, flat.Return liver, spleen channel.Effect: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For distending pain over the hypochondrium, food stagnation distending pain.< < Records of Tradition Chinese and Western Medicine in Combination > >: Rhizoma Sparganii abnormal smells from the patient is all light, micro-have a pungent meaning; Rhizoma Curcumae mildly bitter flavor, feeble QI perfume (or spice), also micro-have a pungent meaning, and all tepors of property, are the key medicine of Removing Blood Stasis.To control man's mass beside the umbilicus, woman's lump in the abdomen, menstruation is obstructed, the non-very speed of fiercely making contributions of property.The power of its circulation of qi promoting, can control again trusted subordinate's pain, the lower swollen pain of the side of body, the disease of all blood clotting stagnation of QIs.If with ginseng, art, all medicines of stilbene use, energy stimulating appetite, adjusts blood and blood greatly.
Rhizoma Curcumae: be monocotyledon Zingiberaceae Zingiberaceae Rhizoma Curcumae Curcuma phaeocaulis Val., or RADIX CURCUMAE (claiming again warm Rhizoma Curcumae) C. wenyujin Y. H. Chen et C. Ling, the dry rhizome of Guangxi zedoary (claiming again osmanthus Rhizoma Curcumae) C.kwangsiensis S. lee et C. F. Liang.Nature and flavor: pungent, bitter, temperature.Return liver, spleen channel.Effect: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.The alanine aminotransferase (ALT) that curcumenol extract and volatile oil cause carbon tetrachloride (CCI4) thioacetamide (TAA) raises obvious reducing effect.
Eupolyphaga Seu Steleophaga: be the female worm dry body of Corydiidae insecticide eupolyphoge sinensis Eupolyphagasinensis Walker or Ji eupolyphoge sinensis Steleophaga plancyi (Boleny).Nature and flavor: salty, cold; Slightly poisonous.Return Liver Channel.Effect: eliminating stasis to stop pain.
Radix Glycyrrhizae: be dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. G. inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G. glabra L..Nature and flavor: sweet, flat.Return spleen, stomach, lung meridian.Effect: QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.
Medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope: Radix Astragali 25-35 part, Radix Bupleuri 5-13 part, Rhizoma Atractylodis Macrocephalae 7-17 part, Radix Paeoniae Alba 7-17 part, Radix Curcumae 15-25 part, Radix et Rhizoma Rhei (stir-fried with wine) 2-4 part, Endothelium Corneum Gigeriae Galli 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Rhizoma Sparganii 5-15 part, Rhizoma Curcumae 5-15 part, Eupolyphaga Seu Steleophaga 4-8 part, Radix Glycyrrhizae 4-8 part.
Wherein be preferably: 30 parts of the Radixs Astragali, 9 parts of Radix Bupleuri, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts of the Radix Paeoniae Albas, 20 parts of Radix Curcumaes, 3 parts of Radix et Rhizoma Rhei (stir-fried with wine), 15 parts of Endothelium Corneum Gigeriae Galli, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of Rhizoma Sparganii, 10 parts of Rhizoma Curcumae, 6 parts of Eupolyphaga Seu Steleophagas, 6 parts, Radix Glycyrrhizae.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.For example these crude drug pulverize mix homogeneously can be made to powder takes after mixing it with water; Can use decocting, obtain after filtration filtrate, add antiseptic to make oral liquid; Also can directly take if desired decoction.
Medicine of the present invention has invigorating the spleen and relieving depression of liver-QI, and the effects such as movable blood soft hard are effective, and side effect is little, doublely takes stopgap measures this, according to clinical 200 routine patients are observed to statistics, uses 80%, two of one of the medicine of the present invention total effective rate course for the treatment of total effective rate course for the treatment of 94%.
The specific embodiment
Embodiment mono-, 25 parts of the Radixs Astragali, 5 parts of Radix Bupleuri, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 7 parts of the Radix Paeoniae Albas, 15 parts of Radix Curcumaes, 2 parts of Radix et Rhizoma Rhei (stir-fried with wine), 10 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Radix Salviae Miltiorrhizaes, 5 parts of Rhizoma Sparganii, 5 parts of Rhizoma Curcumae, 4 parts of Eupolyphaga Seu Steleophagas, 4 parts, Radix Glycyrrhizae.
Embodiment bis-, 30 parts of the Radixs Astragali, 9 parts of Radix Bupleuri, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts of the Radix Paeoniae Albas, 20 parts of Radix Curcumaes, 3 parts of Radix et Rhizoma Rhei (stir-fried with wine), 15 parts of Endothelium Corneum Gigeriae Galli, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of Rhizoma Sparganii, 10 parts of Rhizoma Curcumae, 6 parts of Eupolyphaga Seu Steleophagas, 6 parts, Radix Glycyrrhizae.
Embodiment tri-, 35 parts of the Radixs Astragali, 13 parts of Radix Bupleuri, 17 parts of the Rhizoma Atractylodis Macrocephalaes, 17 parts of the Radix Paeoniae Albas, 25 parts of Radix Curcumaes, 4 parts of Radix et Rhizoma Rhei (stir-fried with wine), 20 parts of Endothelium Corneum Gigeriae Galli, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts of Rhizoma Sparganii, 15 parts of Rhizoma Curcumae, 8 parts of Eupolyphaga Seu Steleophagas, 8 parts, Radix Glycyrrhizae.
The clinical statistics data that patient uses medicine of the present invention below:
One, physical data
Accept out-patient's totally 200 examples for medical treatment, wherein male's 158 examples, women's 42 examples, M-F 3.8:1,51 years old mean age.
Two, diagnostic criteria
Main indications: 1. scope or esophagus gulp down the inspection of barium x-ray and find esophageal varicosis.2. B ultrasonic prompting liver echo obviously strengthens, uneven, luminous point is thick; Or liver surface owes smooth, uneven or indentation, or portal vein diameter >=1.4cm; Or splenomegaly, splenic vein diameter >=1.0cm.3. ascites, companion's vena epigastrica anger is opened.4. CT shows liver outer rim nodositas protuberance, and fissure expands, caudal lobe/lobus dexter ratio > 0.05cm, the changes such as splenomegaly.5. peritoneoscope or needle biopsy of liver are examined as liver cirrhosis person.Above except 5. one can make a definite diagnosis, the less important indication of other any one bound fractions, can make a definite diagnosis.
Less important indication: 1. chemical examination: (A/G is inverted general abnormal liver function, protein electrophoresis A reduces, gamma globulin raises, serum bilirubin raises, prolonged prothrombin etc.), or Serum hyaluronic acid (HA), III procollagen type Ⅲ (P III P), ammoxidation single enzyme (MAO), ADA Adenosine deaminase (ADA), flaggy element (hN) increase.2. sign: hepatic facies (face clouding is simple and unadorned), multiple spider angiomas and color is dark, liver palm, jaundice, lower limbs edema, Liver on Judge Hardness is partially hard, splenomegaly, gynaecomastia, above chemical examination and sign arrive, and needn't know standby.
Three, Therapeutic Method
According to drug weight proportioning of the present invention, weighting raw materials (daily dose), decocting, filter and remove residue, services once sooner or later, within 30th, is a course for the treatment of.
Four, efficacy assessment standard
Cure: ascites, jaundice disappear completely, transference cure, the deliquescing that obviously bounces back of liver spleen, liver function recovery is normal, antisecosis can be engaged in general work, drug withdrawal later six months recidivist not above.
Effective: ascites, jaundice disappear, cardinal symptom disappears, and muscle power is obviously recovered, and liver spleen is stablized constant, the obvious improver of liver function; Or reached clinical cure standard and within half a year recidivist.
Effective: ascites, jaundice obviously disappear, symptom, liver function are not all improved person.
Invalid: after treatment first quarter moon symptom, sign, liver function all without improvement, or further deterioration or died.
Five, therapeutic outcome statistics
Wherein: total effective rate=cure rate+obvious effective rate+effective percentage
Model case and curative effect:
Case one, week certain, man, 44 years old, find the year before liver cirrhosis, at examination in hospital, liver function is undesired: glutamate pyruvate transaminase 136u/L, hepatic fibrosis index obviously increases, B ultrasonic shows: liver echo obviously strengthens, uneven, luminous point is thick, splenomegaly.Give after the course for the treatment of of Drug therapy of the present invention, liver power recovery is normal, and hepatic fibrosis index is normal, and B ultrasonic shows the deliquescing that obviously bounces back of liver spleen, can be engaged in general work, after drug withdrawal half a year without recurrence.
Case two, grandson, man, 55 years old, liver cirrhosis was found in 2010 annual tests, occurred at that time going after hurt like hell checking, examination in hospital is found lobules of liver structure disturbance, hepatocyte edema, and liver surface has a small amount of ascites, and see proliferation of fibrous tissue, pseudolobuli forms, and occurs that trick has edema.Give after the course for the treatment of of Drug therapy of the present invention, hepatocyte absorption of edema, inflammation is clearly better, and fibrous tissue reduces, and pseudolobuli disappears.After the course for the treatment of of continual cure, stable disease, muscle power is obviously recovered, and substantially reaches clinical cure.
Case three, Lee, female, 56 years old, there is hepatitis B medical history, before 3 years, be diagnosed as liver cirrhosis, liver function is abnormal for a long time, moderate jaundice, conscious lassitude and weak, has swollen or twinge during hepatic region, inappetence, abdominal distention, oliguria, defecates rare.B ultrasonic shows: liver peplos owes smooth, and in liver, echo is coarse, visible multiple lesser tubercle, portal vein 1.4cm, dirty thick 6.7cm, 5.7cm under rib, hilus lienis vein 0.8cm, the visible free fluid in abdominal cavity.Cirrhotic ascites, splenomegaly.Result of laboratory test: five indexes of hepatitis b (hepatitis B small three positive) DNA1.46 × glutamate pyruvate transaminase 105u/L, paddy turns the mould 171u/L of ammonia, turns the mould 204u/L of peptide, the mould 189u/L of alkali phosphoric acid, total bilirubin 83.4, bilirubin direct 43.6, albumin 29, Archon ratio 0.46.Give after two courses for the treatment of of medicine of the present invention, patient sign improves, and appetite obviously increases, hepatalgia, abdominal distention are alleviated gradually, edema of lower limbs disappears, and defecation is also normal, review result: B ultrasonic shows: liver peplos is smooth, in liver, echo owes equal, without obviously tuberosity sense, portal vein 1.1cm, the thick 5.3cm of spleen, 3.8cm under rib, hilus lienis vein 0.6cm.Result of laboratory test: five indexes of hepatitis b (small three positive) DNA feminine gender, liver function normal, blood albumin 35, Archon ratio 1.28.Stable disease, Hepatic function improvement, spleen obviously bounces back, and symptom is all improved substantially.
Claims (2)
1. treat the Chinese medicine composition of liver cirrhosis for one kind, it is characterized in that, this Chinese medicine composition is the ingredients by following weight portion: Radix Astragali 25-35 part, Radix Bupleuri 5-13 part, Rhizoma Atractylodis Macrocephalae 7-17 part, Radix Paeoniae Alba 7-17 part, Radix Curcumae 15-25 part, Radix et Rhizoma Rhei (stir-fried with wine) 2-4 part, Endothelium Corneum Gigeriae Galli 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Rhizoma Sparganii 5-15 part, Rhizoma Curcumae 5-15 part, Eupolyphaga Seu Steleophaga 4-8 part, Radix Glycyrrhizae 4-8 part.
2. the Chinese medicine composition for the treatment of liver cirrhosis according to claim 1, it is characterized in that, by the ingredients of following weight portion: 30 parts of the Radixs Astragali, 9 parts of Radix Bupleuri, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts of the Radix Paeoniae Albas, 20 parts of Radix Curcumaes, 3 parts of Radix et Rhizoma Rhei (stir-fried with wine), 15 parts of Endothelium Corneum Gigeriae Galli, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of Rhizoma Sparganii, 10 parts of Rhizoma Curcumae, 6 parts of Eupolyphaga Seu Steleophagas, 6 parts, Radix Glycyrrhizae.
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| CN105194554A (en) * | 2015-10-13 | 2015-12-30 | 肇庆医学高等专科学校 | Preparation method of traditional Chinese medicine composition for preventing and treating cirrhosis esophageal variceal bleeding |
| CN105194553B (en) * | 2015-10-13 | 2019-01-11 | 肇庆医学高等专科学校 | A kind of Chinese medicine composition for preventing and treating cirrhosis Esophageal varicosis rupture hemorrghage |
| CN113694166A (en) * | 2021-09-29 | 2021-11-26 | 曾亚奇 | Toxin-removing medicine for blood and liver to expel toxin and preparation method thereof |
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| CN101530594B (en) * | 2009-04-17 | 2012-08-15 | 谷井文 | Ultra-fine grain traditional Chinese medicine defibrination paste used for treating liver cirrhosis |
| CN101884761A (en) * | 2009-05-15 | 2010-11-17 | 张春 | Medicament for treating cirrhosis and portal hypertension |
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