CN105194554A - Preparation method of traditional Chinese medicine composition for preventing and treating cirrhosis esophageal variceal bleeding - Google Patents
Preparation method of traditional Chinese medicine composition for preventing and treating cirrhosis esophageal variceal bleeding Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine products and particularly relates to a preparation method of traditional Chinese medicine composition for preventing and treating cirrhosis esophageal variceal bleeding. With the adoption of the method, according to characteristics of traditional Chinese medicinal materials, in combination of the pathology of cirrhosis, a scientific formula is formed, further, the composition is prepared with a proper method, has the functions of benefiting qi, promoting blood circulation, removing stasis and eliminating concretions, has significant curative effects on symptoms such as hepatalgia, jaundice, ascites, spider angioma, liver palms, tongue margin ecchymoses, splenomegaly and the like which are shown by cirrhosis esophageal varices, and has the effective rate higher than 95%, and a patient suffering from the cirrhosis esophageal variceal bleeding cannot bleed again after keeping taking the traditional Chinese medicine composition for treatment. Portal venous pressure and esophageal variceal pressure can be significantly reduced, esophageal varices can be improved, and bleeding can be prevented; hepatic fibrosis can be improved, hepatic vessel and portal collateral vessel resistance can be reduced, meanwhile, the immunity of the human body is enhanced, the body resistance is strengthened, and the primary affection is treated.
Description
Technical field
The invention belongs to Chinese medicine product field, be specifically related to a kind of preparation method of preventing and treating the Chinese medicine composition of liver cirrhosis Esophageal varicosis rupture hemorrghage.
Background technology
Liver cirrhosis Esophageal varicosis rupture hemorrghage is one of complication that cirrhosis patients in decompensation is common, the most serious, and mortality rate is up to 40% ~ 70%.Therefore, stop the deterioration of liver cirrhosis, prevent Esophageal varicosis rupture hemorrghage to have very important meaning to the life extending patient.At present, the method for conventional prevention Cirrhotic Patients with Esophageal Varices Rupture haemorrhag is more clinically, mainly contains operation, sclerotherapy, cirso-cover bundle, medicine reduction portal vein pressure etc.But most of Cirrhotic Patients should not be performed the operation or can not tolerate surgery; Sclerotherapy and cirso-cover are pricked more untoward reaction; Mostly chemoprophylaxis is to carry out from hemodynamic angle, comprise non-selective beta-blocker, nitrose vasodilation and calcium channel blocker etc., these medicines can slow down the generation of Esophageal varicosis rupture hemorrghage to a certain extent, and to causing the liver cirrhosis of portal hypertension itself to there is no obvious effect, can not stop in the progress of hepatic fibrosis and liver caused by liver cirrhosis and the increase of door body vascular resistance.
For the problems referred to above, inventor is under the theoretical direction of traditional Chinese medical science treating both the principal and secondary aspects of a disease, the hepatalgia, jaundice, ascites, spider pearl nevus etc. that show for liver cirrhosis esophageal varix belong to the symptom of TCM Blood Stasis & Blood category, adopt a kind of benefiting QI for activating blood circulation, the Chinese medicine composition of Hua Yu Xiao Disorder treats, significantly can not only reduce portal pressure, prevention esophageal varices hemorrhage, can also anti-hepatic fibrosis, enhancing body resistance, reaches the object for the treatment of protopathy.
Summary of the invention
In order to overcome the shortcoming of prior art with not enough, provide a kind of Chinese medicine composition preventing liver cirrhosis Esophageal varicosis rupture hemorrghage.
A preparation method for Chinese medicine composition, comprises the following steps:
1) Chinese crude drug of following mass fraction is weighed: Carapax Trionycis 30-40 part, Rhizoma Curcumae 25-35 part, Rhizoma Sparganii 25-35 part, Radix Panacis Quinquefolii 30-40 part, Radix Astragali 15-25 part, Radix Paeoniae Alba 30-40 part, Rhizoma Atractylodis Macrocephalae 15-30 part, Poria 15-30 part, Radix Et Rhizoma Rhei 5-15 part, Moschus 1-2 part, Radix Glycyrrhizae 10-20 part;
2) carry out brewed to portion of material: wherein, Carapax Trionycis, Rhizoma Curcumae, Rhizoma Sparganii, the equal processed with vinegar of the Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae parched with bran, all the other medicines are used as medicine with conventional decoction pieces;
3) except Moschus, be ground into fine powder by after all the other 10 taste Chinese crude drugs mixing, then Moschus be ground into fine powder and other medicated powder is mixed together evenly, sieve;
4) prepare anhydrous Mel and first use big fire infusion, endure and after boiling, to change that little fire is slow to be endured into, keep temperature 119 ~ 122 DEG C, Mel is tempered into old honey.
5) Mel of tempering slowly is poured in medicated powder, constantly stir simultaneously, while medicated powder is mixed well on the limit of falling Mel, stop adding honey to when substantially can't see dry medicated powder, then by medicated powder be one;
6) medicine of becoming reconciled group is evenly cut the little medicine group of the 3g that attaches most importance to, round becomes big honeyed pills;
7) the big honeyed pills Cera Flava got ready wraps, and deposits for subsequent use with disinfector dress.
Further, the mass fraction of described Chinese crude drug is: Carapax Trionycis 30 parts, Rhizoma Curcumae 30 parts, Rhizoma Sparganii 30 parts, Radix Panacis Quinquefolii 30 parts, the Radix Astragali 20 parts, the Radix Paeoniae Alba 30 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, 20 parts, Poria, Radix Et Rhizoma Rhei 10 parts, 1 part, Moschus, 15 parts, Radix Glycyrrhizae.
Further, step 3) described in sieve into cross 120 mesh sieves.
Further, step 4) in the quality of anhydrous Mel be step 3) in 1 ~ 1.2 times of medicated powder gross mass of preparation.
Further, step 4) in, refine old sweet relative density and be about 1.40.
Further, step 6) in and ball time can with a little Oleum sesami smear the centre of the palm with make pill light.
Content of the present invention also comprises the Chinese medicine composition prepared by said method.
Further, content of the present invention also comprises the application of above-mentioned Chinese medicine composition in prevention liver cirrhosis Esophageal varicosis rupture hemorrghage.
In the present invention, effect in described Chinese medicine composition of each raw material and effect:
Carapax Trionycis: nourishing YIN for suppressing the hyperactive YANG, bring down a fever except steam, hard masses softening and resolving.After Carapax Trionycis processed with vinegar in the present invention, strengthen the effect of convergence, removing toxic substances, eliminating stasis to stop pain, the effect that medicine enters liver removing food stagnancy, hard masses softening and resolving can also be strengthened.The connective tissue proliferation of liver, spleen can be suppressed, improve plasma protein levels, there is the effects such as antitumor.
Rhizoma Curcumae: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.After Rhizoma Curcumae processed with vinegar in the present invention, strengthen effect of promoting the circulation of QI to relieve pain, Po Disorder removing food stagnancy, and easily enter Liver Channel.There is direct destruction to multiple cancerous cell, by immune system, specific immunity strengthened and make body obtain obvious immunoprotective effec, arteriole restoration of blood flow can be promoted, stop arteriole to shrink completely, obviously promote that local microcirculation is recovered.
Rhizoma Sparganii: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Enter blood system, Liver Channel after Rhizoma Sparganii processed with vinegar in the present invention, strengthen the effect of removing blood stasis softening the hard mass, Xiao Disorder pain relieving.There are antitumor, anticoagulant and anti-thrombosis function, there is analgesia, improve the effect of body immunity.
Radix Panacis Quinquefolii: boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Can improve immunity of organisms, anticancer grows, and has the effect reducing blood coagulability, suppress platelet aggregation.
The Radix Astragali: benefiting qi and nourishing blood, inducing diuresis to remove edema, the stagnant blood stasis dispelling of row, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation.The immunity of human body being improved, slow down aging, antitumor, the effect having the liver protecting, prevent hepatic glycogen from reducing, also having certain effect to preventing hepatic fibrosis.
The Radix Paeoniae Alba: nourish blood yin fluid astringing, easing the affected liver to relieve pain.In the present invention, Radix Paeoniae Alba vinegar relatively holds back liver pain relieving, nourishing blood to suppress the hyperactive liver after frying.Can albuminous synthesis be promoted, there is protecting the liver, fall the effect of enzyme, can ease pain, antiinflammatory, immunity moderation.
The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, dampness diuretic.In the present invention, the Rhizoma Atractylodis Macrocephalae can relax dry property after parched with bran, in entering, strengthens spleen invigorating, detumescence effect by means of bran.Hepatic glycogen can be alleviated reduce and hepatocellular degeneration necrosis, promote that hepatocyte increases, the ALT of rising is declined, there is obvious and lasting diuresis, gastrointestinal motility function, enhancing human body immunity function, antioxidation, anti-stress, anticoagulation, antitumor etc. can also be adjusted.
Poria: promoting diuresis to eliminate damp pathogen, invigorating the spleen and benefiting QI.Gpt activity can be made obviously to reduce, prevent hepatic necrosis, there is good diuresis and antitumor action, can body immunity be improved.
Radix Et Rhizoma Rhei: heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating.In the present invention, Radix Et Rhizoma Rhei selects Radix Et Rhizoma Rhei, can remove microcirculation disturbance, improve vascular fragility, promotes blood coagulation, treatment acute hemorrhage of upper gastrointestinal tract Be very effective, has good treatment and preventive effect to gastric hemorrhage and hemorrhagic focus; There is significant choleretic effect, enzyme, tension and relaxation sphincter can be fallen by sharp pancreas, viral hepatitis, acute pancreatitis, cholecystitis etc. can be treated; Energy enhancing human body immunity, has the effects such as antitumor, antiinflammatory, analgesia.
Moschus: promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.Logical all keys, open meridians ， Xiao mass in the abdomen.There is good antiinflammatory, antitumor action, be usually used in digestive tract tumor.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Carapax Trionycis enters liver removing food stagnancy, hard masses softening and resolving, Moschus sensible active, invigorate blood circulation Xiao Disorder, is monarch drug; Rhizoma Curcumae and Rhizoma Sparganii blood-activating and qi-promoting, Xiao Disorder pain relieving are ministerial drug; Radix Panacis Quinquefolii and Radix Astragali benefiting vital QI and blood, hold up beneficial healthy energy, Radix Paeoniae Alba easing the affected liver to relieve pain, the Rhizoma Atractylodis Macrocephalae and Poria invigorating the spleen and benefiting QI, diuretic damp eliminating are adjuvant drug altogether; Radix Et Rhizoma Rhei blood circulation promoting and blood stasis dispelling, cleanse damp and hot, Radix Glycyrrhizae relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, altogether for making medicine.All medicines share, and gather effect of benefiting QI for activating blood circulation, Hua Yu Xiao Disorder altogether.Be made as honeyed pill, both the merit of desirable planning slowly and carefully, again taking convenience, easily accepted by patient.Clinical efficacy is remarkable, has no side effect.
The invention has the beneficial effects as follows, the effect possessing benefiting QI for activating blood circulation, Hua Yu Xiao Disorder of the Chinese medicine composition provided, the symptom such as hepatalgia, jaundice, ascites, spider pearl nevus, liver palm, tongue limit ecchymosis, splenomegaly showed for liver cirrhosis esophageal varix has significant curative effect, effective percentage reaches more than 95%, and liver cirrhosis Esophageal varix bleeding patient can not Recurrent Bleeding again after adhering to taking traditional Chinese medicine composition for treating of the present invention.Significantly can not only reduce portal venous pressure and esophageal veins pressure, improve esophageal varicosis, prevent hemorrhage; Can also hepatic fibrosis be improved, reduce blood vessel and door side branch vessel resistance in liver, simultaneously enhancing body resistance and righting, reach the object for the treatment of protopathy, thus realize treating both the principal and secondary aspects of a disease.In addition, also possess and make simply, with low cost, safe without toxic side effect, is easy to carry, the features such as taking convenience.
In order to understand better and implement, the following detailed description of the present invention.
Specific embodiment
[embodiment 1] prescription
Carapax Trionycis 30g, Rhizoma Curcumae 30g, Rhizoma Sparganii 30g, Radix Panacis Quinquefolii 30g, Radix Astragali 20g, Radix Paeoniae Alba 30g, Rhizoma Atractylodis Macrocephalae 20g, Poria 20g, Radix Et Rhizoma Rhei 10g, Moschus 1g, Radix Glycyrrhizae 15g.
[embodiment 2] preparation method and usage, consumption
Step one, weighing: form by the active component of quality by following raw material: Carapax Trionycis 30g, Rhizoma Curcumae 30g, Rhizoma Sparganii 30g, Radix Panacis Quinquefolii 30g, Radix Astragali 20g, Radix Paeoniae Alba 30g, Rhizoma Atractylodis Macrocephalae 20g, Poria 20g, Radix Et Rhizoma Rhei 10g, Moschus 1g, Radix Glycyrrhizae 15g.
Step 2, pure: by load weighted classification of TCD removal of contamination, to clean, dry or dry.
Step 3, the process of preparing Chinese medicine: Carapax Trionycis, Rhizoma Curcumae, Rhizoma Sparganii, the equal processed with vinegar of the Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae parched with bran, all the other medicines are used as medicine with conventional decoction pieces.
Carapax Trionycis stir-baking with vinegar: clean sand is made popular with high heat (to drop into the scraps of paper about 1min in pot in brown color for preference temperature), add clean Carapax Trionycis, constantly stir, fry to loose, surface is faint yellow, after taking out, sieve removes sand, drops into while hot in the edible rice vinegar got ready and carries out quench in vinegar, drying for standby; During quench in vinegar, every 100g Carapax Trionycis, uses vinegar 20g.
Rhizoma Curcumae stir-baking with vinegar: get clean Rhizoma Curcumae and put in pot, adds a certain amount of rice vinegar and proper amount of clear water submergence, boils altogether to the saturating heart and vinegar liquid and is sucked, cut to inspect and take out without during the white heart, be cut into sheet after slightly cool with slow fire, after dry in cutin sample, micro-ly have vinegar fragrance.Every 100g Rhizoma Curcumae, uses vinegar 15g.
Rhizoma Sparganii, Radix Paeoniae Alba stir-baking with vinegar: clean Rhizoma Sparganii, clean Radix Paeoniae Alba edible rice vinegar vinegar are mixed thoroughly, moistening 1h, slow fire is fried dark to complexion changed.The ratio of Rhizoma Sparganii, the Radix Paeoniae Alba and rice vinegar is 100:15.
Rhizoma Atractylodis Macrocephalae parched with bran method: Testa Tritici is removed impurity, is spilled in wheat bran after being melted by refined honey with a little boiled water, slightly vexed after mixing thoroughly, first uses low baking temperature fried dry, frying with high heat to smoldering again, adding Rhizoma Atractylodis Macrocephalae sheet, the Rhizoma Atractylodis Macrocephalae is fried to yellowish-brown, accidental focal spot, effusion burnt odor gas, takes out sieve and removes processed with honey wheat bran.
Step 4, pulverizing: except Moschus, be ground into fine powder by after all the other 10 taste Chinese crude drugs mixing, then Moschus be ground into fine powder and other medicated powder is mixed together evenly, mistake 120 mesh sieves.
Step 5, refined honey: with medicated powder and honey quality in 1: 1 ~ 1.2 ratio get anhydrous Mel ready, then with high heat first, endure and after boiling, to change that slow fire is slow to be endured into, Mel is tempered into old honey.Prepare anhydrous Mel first with sparking infusion, endure and after boiling, to change that little fire is slow to be endured into, Mel is tempered into old honey.Refining temperature reaches 119 ~ 122 DEG C, during refining there is " buphthalmos bubble " (larger rufous bubble) in surface, " can drip into pearl " (instillation cold water spherical in shape and do not fall apart), it is strong that finger twists with the fingers stickiness, and two refer to separately adularescent long filament (being commonly called as " breaking white silk ").Relative density is about 1.40, in rufous, glossy.
Step 6, adjust medicine: slowly poured in medicated powder by the Mel of tempering, constantly stir simultaneously, while medicated powder is mixed well on the limit of falling Mel, stop adding honey to when substantially can't see dry medicated powder, then with the both hands of sterilizing by medicated powder be one.
Step 7 and ball: the little medicine group medicine of becoming reconciled group evenly being cut the 3g that attaches most importance to, round becomes big honeyed pills.The centre of the palm can be smeared to make pill light with a little Oleum sesami with during ball.
Step 8, packaging: the big honeyed pills Cera Flava got ready wraps, deposit for subsequent use with disinfector dress.
The usage of Chinese medicine composition of the present invention and consumption.
Each 2 balls, warm water delivery service, every day 2 times 3 months was 1 course for the treatment of.Coagulation disorders person, gynecologic menstrual are cautious use of, contraindication in pregnancy.
[embodiment 3] Clinic Case
(1) Lee, man, 36 years old, Xin Yi village, Zhu Maan town.After suffering from hepatitis B, repeatedly there are hepatalgia, abdominal distention 7 years, increase the weight of companion's oliguria, draw black stool 10 days, go to a doctor October 12 nineteen ninety-five.Disease of being admitted to hospital sees darkish complexion, and body constitution is partially thin, and women's head-ornaments neck and chest has more spider angioma, abdominal tympanites, and stomach wall has varicosis, and shifting dullness is positive, and splenomegaly matter is hard, and there is percussion pain hepatic region, two lower limbs edema.Abnormal liver function.Ultrasound diagnosis finds inner diameter of portal vein 16mm, Dsv 12mm.Fibergastroscopy prompting is shown in 3 anfractuosity shape varicosis apart from front tooth 25cm place, and width is about 7mm, and cirso-surface, nearly cardia place has redness to levy, and gastric mucosa piebaldism is congested, is diagnosed as that esophageal vein V is write music, superficial gastritis (companion is rotten to the corn).Give patient and take the embodiment of the present invention 1 Chinese medicine composition, each 2 balls, every day 2 times is oral.After 1 week, hepatalgia, abdominal distention alleviate, and two lower limbs edema disappears.After 1 month, spirit is clearly better, and jaundice disappears, and ascites disappears, and spider angioma, liver palm are clearly better, and ultrasound diagnosis prompting spleen has and reduces, and inner diameter of portal vein reduces to 11mm.Continue to take medicine 3 months, symptom all disappears, liver function is normal, ultrasound diagnosis prompting inner diameter of portal vein 9mm, Dsv 9mm, it is the varicose of anfractuosity shape that gastroscopy prompting esophagus stage casing 27cm starts visible esophageal vein, and width is about 4mm, and redness levies disappearance, be kept to ball every day 2 so take medicine, adhere to taking half a year.To check on April 2nd, 1997, patients symptomatic all disappears, and liver function is normal, and ultrasound diagnosis prompting liver morphology is normal, inner diameter of portal vein 9mm, Dsv are about 10mm, and after this interval is taken medicine, and survives till now always, and can adhere to light physical labor.
(2) Wang, suffer from hepatitis B, after develop into liver cirrhosis, because hematemesis, melena are admitted to hospital, gastroscopy prompting esophageal varix V degree, esophagus have blood crusts, namely give patient's oral embodiment of the present invention 1 traditional Chinese medicine composition for treating after hemostasis, after adhering to taking half a year, hepatocirrhosis symptoms disappears substantially, liver function is normal, and portal vein, Dsv reduce, after this not hemorrhage again.
(3) beam, outer court is diagnosed as liver cirrhosis, esophageal varix, and fundamental symptoms arrives the court out of admiration for a famous person after controlling and seeks medical advice, and give this Chinese medicine embodiment 1 compositions and treat 1 year, hepatocirrhosis symptoms significantly alleviates, not hemorrhage again.
(4) week certain, outer court is diagnosed as liver cirrhosis, esophageal varix Rupture haemorrhag, superficial gastritis, gives the embodiment of the present invention 1 traditional Chinese medicine composition for treating, adhere to taking 9 months, liver cirrhosis related symptoms disappears substantially, and splenomegaly alleviates, and auxiliary examination finds that degree of hepatic fibrosis alleviates, liver function is normal, portal vein, Dsv reduce, and after this intermittently take this Chinese medicine composition, and esophagus is not hemorrhage again, muscle power still can, can normally work.
[embodiment 4] clinical statistics
From in July, 1994 in December ,-2013, collect liver cirrhosis Esophageal varicosis rupture hemorrghage patient 450 example in Zhaoqing institute of traditional Chinese medicine, Zhaoqing Affiliated Hospital of Medical college, include case in and meet the hepatitis interstitialis chronica clinical diagnosis and Chinese medical discrimination and efficacy assessment standard that in November, the 1993 Luoyang meeting of combination of Chinese and Western medicine disease for digest Professional Committee formulates.Patient is divided into 2 groups at random by medical order.The routine patient of A group 300 takes Chinese medicine composition of the present invention, and each 2 balls, take 2 day; The routine patient of B group 150 takes Radix Et Rhizoma Rhei et Eupolyphaga Seu Steleophaga Pilulae, each 6g, every day 2 times.2 groups of patients all accept the general Primary Care measure of hepatitis interstitialis chronica, are 1 course for the treatment of with 3 months, treat 2 courses for the treatment of altogether, and follow up a case by regular visits to 1 time.Observe symptom, sign and tongue pulse condition change before and after 2 groups of patient treatments; Endoscopy patient Esophago-gastric varices and gastric mucosa situation; Ultrasound diagnosis patient portal vein, Dsv and splenomegaly situation.
According to " liver cirrhosis clinical diagnosis-differential diagnosis in tcm and efficacy assessment standard ", A group patient effective percentage is 93.37%, B group patient effective percentage is that 86.67%, two groups of curative effects have remarkable type difference.
Esophageal veins width before A group patient treatment is (6.12 ± 1.38) mm, portal vein width is (14.48 ± 2.82) mm, splenic vein width is (10.65 ± 3.32) mm, and the esophageal veins width after treatment is (4.58 ± 1.02) mm, portal vein width is (12.38 ± 2.36) mm, splenic vein width is (8.96 ± 2.26) mm.Esophageal veins width before B group patient treatment is (6.04 ± 1.25) mm, portal vein width is (14.36 ± 2.86) mm, splenic vein width is (10.89 ± 3.12) mm, and the esophageal veins width after treatment is (5.88 ± 0.86) mm, portal vein width is (13.98 ± 1.28) mm, splenic vein width is (9.98 ± 2.88) mm.Statistics shows, the esophageal veins of varicose after two groups of patient treatments, portal vein, splenic vein width significantly narrow with before treatment, and the esophageal veins of A group patient varicose, portal vein, splenic vein narrowing degree are significantly better than B group.According to the standard that esophageal varicosis width is higher more than the hemorrhage probability of 6mm, the esophageal varicosis of A, B two groups of patients all narrows after treatment, meet significantly effective standard, but the esophageal varicosis degree of A group patient is improved more remarkable.
The present invention is not limited to above-mentioned embodiment, if do not depart from the spirit and scope of the present invention to various change of the present invention or distortion, if these are changed and distortion belongs within claim of the present invention and equivalent technologies scope, then the present invention is also intended to comprise these changes and distortion.
Claims (8)
1. prevent and treat a preparation method for the Chinese medicine composition of liver cirrhosis Esophageal varicosis rupture hemorrghage, comprise the following steps:
1) Chinese crude drug of following mass fraction is weighed: Carapax Trionycis 30-40 part, Rhizoma Curcumae 25-35 part, Rhizoma Sparganii 25-35 part, Radix Panacis Quinquefolii 30-40 part, Radix Astragali 15-25 part, Radix Paeoniae Alba 30-40 part, Rhizoma Atractylodis Macrocephalae 15-30 part, Poria 15-30 part, Radix Et Rhizoma Rhei 5-15 part, Moschus 1-2 part, Radix Glycyrrhizae 10-20 part;
2) carry out brewed to portion of material: wherein, Carapax Trionycis, Rhizoma Curcumae, Rhizoma Sparganii, the equal processed with vinegar of the Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae parched with bran, all the other medicines are used as medicine with conventional decoction pieces;
3) except Moschus, be ground into fine powder by after all the other 10 taste Chinese crude drugs mixing, then Moschus be ground into fine powder and other medicated powder is mixed together evenly, sieve;
4) prepare anhydrous Mel and first use big fire infusion, endure and after boiling, to change that little fire is slow to be endured into, keep temperature 119 ~ 122 DEG C, Mel is tempered into old honey.
5) Mel of tempering slowly is poured in medicated powder, constantly stir simultaneously, while medicated powder is mixed well on the limit of falling Mel, stop adding honey to when substantially can't see dry medicated powder, then by medicated powder be one;
6) medicine of becoming reconciled group is evenly cut the little medicine group of the 3g that attaches most importance to, round becomes big honeyed pills;
7) the big honeyed pills Cera Flava got ready wraps, and deposits for subsequent use with disinfector dress.
2. method according to claim 1, it is characterized in that, step 1) described in the mass fraction of Chinese crude drug be: Carapax Trionycis 30 parts, Rhizoma Curcumae 30 parts, Rhizoma Sparganii 30 parts, Radix Panacis Quinquefolii 30 parts, the Radix Astragali 20 parts, the Radix Paeoniae Alba 30 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, 20 parts, Poria, Radix Et Rhizoma Rhei 10 parts, 1 part, Moschus, 15 parts, Radix Glycyrrhizae.
3. method according to claim 1 and 2, is characterized in that, step 3) described in sieve into cross 120 mesh sieves.
4. method according to claim 1 and 2, is characterized in that, step 4) in the quality of anhydrous Mel be step 3) in 1 ~ 1.2 times of medicated powder gross mass of preparation.
5. method according to claim 1 and 2, is characterized in that, step 4) in, refine old sweet relative density and be about 1.40.
6. method according to claim 1 and 2, is characterized in that, step 6) in and ball time can with a little Oleum sesami smear the centre of the palm with make pill light.
7. the Chinese medicine composition prepared according to arbitrary described method in claim 1-6.
8. the application of Chinese medicine composition according to claim 7 in control liver cirrhosis Esophageal varicosis rupture hemorrghage.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107224554A (en) * | 2016-12-31 | 2017-10-03 | 麻凯 | Ruangansuopi pill |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101530594A (en) * | 2009-04-17 | 2009-09-16 | 谷井文 | Ultra-fine grain traditional Chinese medicine defibrination paste used for treating liver cirrhosis |
| CN102988906A (en) * | 2013-01-08 | 2013-03-27 | 于收 | Traditional Chinese medicine combination for treating cirrhosis |
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| 《中西医结合肝病杂志》 * |
| 《北京中医药大学学报》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107224554A (en) * | 2016-12-31 | 2017-10-03 | 麻凯 | Ruangansuopi pill |
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Application publication date: 20151230 |
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