CN103191160A - Preparation method of chimonanthus salicifolius formula granule - Google Patents
Preparation method of chimonanthus salicifolius formula granule Download PDFInfo
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- CN103191160A CN103191160A CN2013101293895A CN201310129389A CN103191160A CN 103191160 A CN103191160 A CN 103191160A CN 2013101293895 A CN2013101293895 A CN 2013101293895A CN 201310129389 A CN201310129389 A CN 201310129389A CN 103191160 A CN103191160 A CN 103191160A
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Abstract
The invention discloses a preparation method of a chimonanthus salicifolius formula granule. The preparation method comprises the following steps: step 1, crushing chimonanthus salicifolius stem leaves into coarse powder, adding water the chimonanthus salicifolius coarse powder for refluxing, refluxing and extracting for twice to three times, and collecting volatile oil and combining extracting solutions; step 2, covering the volatile oil with beta-cyclodextrin and drying the covered volatile oil to obtain white powder inclusion compound, and concentrating and drying the extracting solutions to obtain extract; step 3, uniformly mixing the extract with the inclusion compound, adding auxiliary materials for mixing, and adding alcohol to the mixture in which the auxiliary materials are added to obtain a soft material, passing the soft material through sieves of No.12 to No.14 to obtain granule; and finally, drying the granule and separating the granule through the sieve I and the sieve V to obtain the chimonanthus salicifolius formula granule. The preparation method of the chimonanthus salicifolius formula granule is simple in steps; the content of the active ingredients including volatile oil, flavone and the like in the product is high; inactive ingredients including plant fibers and the like are effectively removed, so that the stability is increased, and therefore, the chimonanthus salicifolius formula granule is easy to store and convenient to take.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, relate to a kind of preparation method of Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule.
Background technology
Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. is She's medication, have induce sweat, effect such as heat-clearing and toxic substances removing, regulating qi-flowing for strengthening spleen, food stagnation removing antidiarrheal, can be used for wind heat exterior syndrome, insufficiency of the spleen dyspepsia, have loose bowels, the treatment of gastric abscess, noisy, acid regurgitation, diarrhoea, enteritis etc.Mainly containing volatile oil, total flavones, total polyphenols in the Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc., is its main effective ingredient.The present clinical practice of Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. is wider, is used for the treatment of cold-damp disturbing the spleen, incoordination between the liver and stomach, digestive functional disturbance and the gastrointestinal upset, the abdominal part distending pain that cause, digestive tract disease such as have loose bowels, and has obtained better curative effect.
Chinese medicinal granule is under Chinese medical theory instructs, and the prepared slices of Chinese crude drugs of concocting processing with standard are raw material, takes to extract, the Technology of cryoconcentration, wink-dry and the granule made.It both can be for clinical flexible prescription, and allotment is taken after mixing it with water, and can be used as the raw material of industry of Chinese medicine preparation again, also provides new approach for the tcm clinical practice medication.
At present, what the preparation of Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. was adopted is traditional Chinese herbs decoction, and its deficiency that exists in application is, decocts and take equal inconvenience, and dose is big, and it is wayward to decoct quality, is not easy to preserve and carry.
Summary of the invention
The purpose of this invention is to provide a kind of preparation method of Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule, solved the Chinese herbs decoction that exists in the prior art, decoct and take equal inconvenience, dose is big, and it is wayward to decoct quality, is not easy the problem of preserving and carrying.
The technical solution adopted in the present invention is that a kind of preparation method of Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule may further comprise the steps:
Step 1, Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. stem and leaf is ground into coarse powder, gives in the Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. to add 8-12 times of water gaging, 98 ℃-100 ℃ backflow 0.5-2 hour, reflux, extract, 2-3 time is collected volatile oil and merge extractive liquid, simultaneously;
Step 2, volatile oil being carried out enclose with beta-schardinger dextrin-, make the clathrate of white powder after the drying, is extractum with extracting solution at 50 ℃ of-80 ℃ of concentrate dryings in addition;
Step 3, elder generation are evenly mixed extractum with clathrate, doubly adding adjuvant by the 1-3 of mixture quality again mixes, make soft material in adding the ethanol that ratio that mixture behind the adjuvant and ethanol mass ratio be 2:1-8:1 adds 55%-95% then, soft material becomes granule through No. 12-No. 14 sieve series, drying, sieve two screenings with No. 1 and No. 5 respectively at last and get, namely get Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule.
The invention has the beneficial effects as follows, traditional Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. decoction liquor is made granule, remove the Plant fiber effectively and wait the non-activity composition, increase stability, easily store taking convenience; This method step is simple, and the general flavone content of the grain products that obtains is not less than 3.5mg/kg, general flavone content composition height in the product.
The specific embodiment
The present invention is described in detail below in conjunction with the specific embodiment.
The preparation method of Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule of the present invention may further comprise the steps:
Step 1, Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. stem and leaf is ground into coarse powder, gives in the Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. to add 8-12 times of water gaging, 98 ℃-100 ℃ backflow 0.5-2 hour, reflux, extract, 2-3 time is collected volatile oil and merge extractive liquid, simultaneously;
Step 2, volatile oil being carried out enclose with beta-schardinger dextrin-, make the clathrate of white powder after the drying, is extractum with extracting solution at 50 ℃ of-80 ℃ of concentrate dryings in addition;
Beta-schardinger dextrin-wherein is 3-10 times of volatile oil quality, and the enclose temperature is 40 ℃-60 ℃, and the enclose time is 0.5-1.5 hour.
Step 3, elder generation are evenly mixed extractum with clathrate, doubly adding adjuvant by the 1-3 of mixture quality again mixes, (adjuvant is selected one of soluble starch, cane sugar powder, dextrin or lactose for use), make soft material in adding the ethanol that ratio that mixture behind the adjuvant and ethanol mass ratio be 2:1-8:1 adds 55%-95% concentration then, soft material becomes granule through No. 12-No. 14 sieve series, drying is sieved two screenings with No. 1 and No. 5 respectively at last and is got, and namely gets Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule.
In the step 1, can also be divided into twice decoction, amount of water 5-9 doubly decocted 1.0-1.5 hour for the first time, and amount of water 4-7 doubly decocted 0.5-1.0 hour for the second time; Merging filtrate filters.Wherein, preferably decocting condition is, amount of water is 8 times for the first time, decocts 1.0 hours, and amount of water is 6 times for the second time, decocts 0.5 hour.
Embodiment 1
Give in the Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. and add 8 times of water gagings, 99 ℃ of little boiling were refluxed 0.5 hour, reflux, extract, 2 times, extract is obtained extractum at 60 ℃ of following concentrating under reduced pressure, collect volatile oil simultaneously, beta-cyclodextrin inclusion compound volatile oil with 3 times of amounts, the enclose temperature is 40 ℃, and the enclose time is 1.5 hours, makes white powder, be extractum with extracting solution at 80 ℃ of concentrate dryings in addition, evenly mix with extractum then, add in the mixture as adjuvant with the soluble starch of 3 times of amounts, add the ethanol of 65% concentration again, the mixture and the ethanol mass ratio that add behind the adjuvant are 2:1, make soft material, soft material becomes granule through No. 12 sieve series, at 60 ℃ of following constant pressure and dries, sieve two screenings with No. one and No. five and get, namely get Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule.
Embodiment 2
Give in the Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. and add 10 times of water gagings, 99 ℃ of little boiling were refluxed 1.0 hours, reflux, extract, 2 times, extract is obtained extractum at 60 ℃ of following concentrating under reduced pressure, collect volatile oil simultaneously, beta-cyclodextrin inclusion compound volatile oil with 6 times of amounts, the enclose temperature is 50 ℃, and the enclose time is 1 hour, makes white powder, be extractum with extracting solution at 60 ℃ of concentrate dryings in addition, evenly mix with extractum then, add in the mixture as adjuvant with the dextrin of 2 times of amounts, add the ethanol of 95% concentration again, the mixture and the ethanol mass ratio that add behind the adjuvant are 4:1, make soft material, soft material becomes granule through No. 14 sieve series, at 60 ℃ of following constant pressure and dries, sieve two screenings with No. one and No. five and get, namely get Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule.
Embodiment 3
Give in the Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. and add 12 times of water gagings, 99 ℃ of little boiling were refluxed 1.5 hours, reflux, extract, 3 times, extract is obtained extractum at 60 ℃ of following concentrating under reduced pressure, collect volatile oil simultaneously, beta-cyclodextrin inclusion compound volatile oil with 8 times of amounts, the enclose temperature is 60 ℃, and the enclose time is 0.5 hour, makes white powder, be extractum with extracting solution at 50 ℃ of concentrate dryings in addition, evenly mix with extractum then, add in the mixture as adjuvant with the cane sugar powder of 1 times of amount, add the ethanol of 85% concentration again, the mixture and the ethanol mass ratio that add behind the adjuvant are 8:1, make soft material, soft material becomes granule through No. 13 sieve series, at 60 ℃ of following constant pressure and dries, sieve two screenings with No. one and No. five and get, namely get Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule.
The inventive method step is simple, volatile oil in the product, and flavone isoreactivity component content height is removed the Plant fiber effectively and is waited the non-activity composition, increases stability, easily stores taking convenience.
Claims (3)
1. the preparation method of a Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule, its characteristics are, may further comprise the steps:
Step 1, Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. stem and leaf is ground into coarse powder, gives in the Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. to add 8-12 times of water gaging, 98 ℃-100 ℃ backflow 0.5-2 hour, reflux, extract, 2-3 time is collected volatile oil and merge extractive liquid, simultaneously;
Step 2, volatile oil being carried out enclose with beta-schardinger dextrin-, make the clathrate of white powder after the drying, is extractum with extracting solution at 50 ℃ of-80 ℃ of concentrate dryings in addition;
Step 3, elder generation are evenly mixed extractum with clathrate, doubly adding adjuvant by the 1-3 of mixture quality again mixes, make soft material in adding the ethanol that ratio that mixture behind the adjuvant and ethanol mass ratio be 2:1-8:1 adds 55%-95% then, soft material becomes granule through No. 12-No. 14 sieve series, drying, sieve two screenings with No. 1 and No. 5 respectively at last and get, namely get Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule.
2. the preparation method of Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule according to claim 1, its characteristics are: in the described step 2, beta-schardinger dextrin-be the volatile oil quality 3-10 doubly, the enclose temperature is 40 ℃-60 ℃, the enclose time is 0.5-1.5 hour.
3. the preparation method of Folium Salicis Babylonicae wax prunus mume (sieb.) sieb.et zucc. granule according to claim 1, its characteristics are: described adjuvant is selected one of soluble starch, cane sugar powder, dextrin or lactose for use.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107410810A (en) * | 2017-04-07 | 2017-12-01 | 福建农林大学 | A kind of Liu Yazi solid beverage and preparation method thereof |
Citations (4)
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|---|---|---|---|---|
| CN1931200A (en) * | 2005-09-12 | 2007-03-21 | 刘忠达 | Application of shiliangcha extract in preparing medicine |
| CN101836752A (en) * | 2010-03-29 | 2010-09-22 | 同济大学丽水中药研究院 | Chimonanthus beverage and preparation method thereof |
| CN102218026A (en) * | 2011-06-14 | 2011-10-19 | 浙江农林大学 | Use of willow leaf wintersweet extract in preparation of mosquito repelling agent |
| CN102805756A (en) * | 2011-05-30 | 2012-12-05 | 刘忠达 | Application of extract of Chimonanthus Salicifolius. S.Y.H. in preparation of gastric cancer treating medicine |
-
2013
- 2013-04-15 CN CN2013101293895A patent/CN103191160A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931200A (en) * | 2005-09-12 | 2007-03-21 | 刘忠达 | Application of shiliangcha extract in preparing medicine |
| CN101836752A (en) * | 2010-03-29 | 2010-09-22 | 同济大学丽水中药研究院 | Chimonanthus beverage and preparation method thereof |
| CN102805756A (en) * | 2011-05-30 | 2012-12-05 | 刘忠达 | Application of extract of Chimonanthus Salicifolius. S.Y.H. in preparation of gastric cancer treating medicine |
| CN102218026A (en) * | 2011-06-14 | 2011-10-19 | 浙江农林大学 | Use of willow leaf wintersweet extract in preparation of mosquito repelling agent |
Non-Patent Citations (2)
| Title |
|---|
| 刘忠达等: "柳叶蜡梅提取物对人胃癌SGC-7901细胞的作用机制研究", 《中华中医药杂志》, no. 10, 31 December 2011 (2011-12-31), pages 2420 - 2422 * |
| 温慧萍 等: ""畲药柳叶蜡梅止泻作用的初步探讨"", 《江西中医药》, vol. 43, no. 349, 31 January 2012 (2012-01-31) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107410810A (en) * | 2017-04-07 | 2017-12-01 | 福建农林大学 | A kind of Liu Yazi solid beverage and preparation method thereof |
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Application publication date: 20130710 |
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