CN103190983A - Aqueous humor drainage implant - Google Patents
Aqueous humor drainage implant Download PDFInfo
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- CN103190983A CN103190983A CN2012100016833A CN201210001683A CN103190983A CN 103190983 A CN103190983 A CN 103190983A CN 2012100016833 A CN2012100016833 A CN 2012100016833A CN 201210001683 A CN201210001683 A CN 201210001683A CN 103190983 A CN103190983 A CN 103190983A
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Abstract
The invention relates to an aqueous humor drainage implant. The aqueous humor drainage implant comprises a T-shaped drainage tube and a drainage disk, which are connected, wherein a liquid inlet transverse tube of the T-shaped drainage tube has the same curvature radius as that of a limbus corneae; a drain groove is formed at the contact surface between the liquid inlet transverse tube and an aqueous humor; an aqueous humor outflow controller is formed by a drainage long tube of the T-shaped drainage wrapped along protuberant ridges of the drainage disk or by utilizing a double-leaf flap valve, so as to avoid or reduce the occurrence of shallow anterior chamber and ocular hypotension in early period of post operation; a liquid outlet end of the drainage tube is matched with an anti-fall off clamp on the drainage disk; the liquid inlet transverse tube and the drainage long tube are integrally formed, or abutted through a leak-proof clamp so as to reduce the cost of a secondary surgery and facilitate the replacement of the drainage tube when an operation fails due to blockage of the drainage tube; a 5-Fu lipidosome biological filtering membrane is attached to the inner wall of the drain groove so as to effectively control the formation of blood coagulation as well as the scarring of a surgical area; suture holes are formed at the front end of the drainage disk; and aqueous humor traffic holes are formed in the center of the drainage disk and the protuberant ridges are arranged at the periphery of the drainage disk. The novel aqueous humor drainage implant is applicable to the treatment of glaucoma, the volume of a filtering area is enlarged, and the drainage tube can be replaced, thereby reducing the difficulty of the secondary surgery.
Description
Technical field
The present invention relates to a kind of medical artificial implantation, specifically a kind of aqueous humor drainage implant that can set up effective filtration passage behind the glaucoma operation that is applicable to is particularly useful for intractable glaucoma.
Background technology
Glaucoma be a kind ofly fall ill rapidly, hazardness causes the common difficult oculopathy of losing one's sight greatly, at any time, glaucoma accounts for second of blinding oculopathy in China, feature is exactly the horizontal exceeding eyeball tolerant degree of institute that intraocular pressure is interrupted or persistence raises and bring infringement for eyeball each several part tissue and visual function, cause optic atrophy, constriction of visual field, visual deterioration, final blind.Glaucoma filtration surgery is the important operation for the treatment of glaucoma medicine can not control intraocular pressure the time at present, and the purpose of filtration surgery is to make one to make aqueous humor flow out the outer fistula road of eye and reduce intraocular pressure.The success rate of filtering surgery commonly used can reach 70% at present---and 90%, yet it is lower to intractable glaucoma filtration success rate of operation, greatly about 11%---between 52%, the main cause of filtering surgery failure is the synthetic of art district fibroblasts proliferation and extracellular matrix, cause tissue fibering and cicatrization, effective filtration passage be can not set up, drain and the diffusion of aqueous humor hindered.
(Aqueous drainage devices's at present a lot of aqueous humor drainage devices ADDs) arises at the historic moment.The structure of existing aqueous humor drainage implant is made of two parts usually: the one, implant the drainage tube in the anterior chamber, and be responsible for aqueous humor drainage to coupled explant place; The 2nd, explant for being positioned at aequator oculi or conjunctiva-Tenon ' s capsule thereafter, has the drain dish of definite shape and surface area.Its mechanism is to settle the aqueous humor drainage implant under room before eyes and the conjunctiva-fascia, to obtain nonvolatil aqueous humor drainage passage.To form a potential aqueous humor impoundment dedicated around the explant, its be positioned at the rear portion, equator sclera external drainage dish around form a loose cellular connective tissue blister cavities that surface area is identical with it, claim the rear portion to filter bubble, aqueous humor is through the passive diffusion of this cyst membrane or infiltrate through the intercellular substance of eye socket tissue, absorbed by blood capillary and lymphatic vessel, intraocular pressure is stable decline therefore.
Modern aqueous humor drainage implant can be divided into non-limiting aqueous humor drainage implant and restricted aqueous humor drainage implant according to whether having the pressure sensibility valve cell that the restriction aqueous humor flows.The former is as Molteno, Schocket, Baerveldt and the homemade HAD implant etc. of import; The latter mainly contains Krupin, White pump part flow arrangement, Ahmed glaucoma drain valve and Optimed glaucoma pressure regulator etc.
The advantage of aqueous humor drainage device is to filter the success rate height, but kind surplus its postoperative complication can reach 20, relatively common complication has that shallow of anterior chamber, ocular hypotension, of short duration or persistent diplopia, choroid cavity of resorption hydrops, drainage tube internal orifice stop up, drainage tube is shunk back or erosion and drain dish fibers encapsulation etc. clinically.Though restricted aqueous humor drainage implant can reduce and keep intraocular pressure more reposefully with respect to non-limiting aqueous humor drainage implant, but still there is some structural defective in present restricted aqueous humor drainage implant, not all restricted aqueous humor drainage implant can both play restriction to ah outflow, and shallow of anterior chamber, ocular hypotension incidence rate are still higher.
Summary of the invention
Technical assignment of the present invention is at above the deficiencies in the prior art, mainly be effectively control shallow of anterior chamber, ocular hypotension, drainage tube is shunk back and the generation of complication such as drain dish fibers encapsulation, absorb, use for reference the advanced design theory of clinical aqueous humor drainage implanting device commonly used both at home and abroad, a kind of novel aqueous humor drainage implant (NADI) is provided, this aqueous humor drainage implant is difficult for taking place shallow of anterior chamber after can not only making implantation, be difficult for taking place corneosclera otch seepage, and can change drainage tube, the fibrosis of control drain dish.Intraocular pressure is reduced, and lasting stability, and then the sufferings of solution intractable glaucoma patient, the prevention patient is blind.
The technical scheme that the present invention adopts for its technical problem of solution is:
A kind of aqueous humor drainage implant, connected to form by class T shape drainage tube and drain dish, wherein class T shape drainage tube comprises feed liquor transverse tube and drain long tube two parts, it is characterized in that, there is the anticreep card connection liquid outlet of class T shape drainage tube and drain dish junction, and described drainage tube is removable; The drain long tube has the leakproof card near the outer wall of feed liquor transverse tube, and the feed liquor transverse tube of leakproof Ka Chu and drain long tube can one-body molded also sliceable formations; Feed liquor transverse tube and the aqueous humor contact surface of class T shape drainage tube have drainage trough, and the inwall of drainage trough has biological filter membrane, have the liposome of control fibrosis and scarring on the film; The leading edge of drain dish is provided with the suture hole, drain dish intermediate distribution comparatively dense houselet water access hole, the big aqueous humor access hole that evenly distributes on every side, the central authorities of drain dish and the bossed ridge of periphery design; The drain long tube is fixed by ridge along the coiling of drain dish, forms aqueous humor and flows out controller; Or the drain long tube utilizes the outflow of bilobate clack valve control aqueous humor, and wherein the bilobate clack valve is arranged on the liquid outlet of class T shape drainage tube.
The drain long tube preferably is connected the outer arc central authorities of feed liquor transverse tube.
Described feed liquor transverse tube has identical radian with limbus of corneae, and radius of curvature is preferably 5.85mm.
Described liposome is preferably the 5-Fu liposome.
Described drain dish is preferably fan-shaped, and the bottom surface bending of described drain dish is spherical in shape, conforms to the scleral surface curvature of human eye.
Described class T shape drainage tube and drain dish are preferably made by medical grade silicon rubber or other biomaterial for medical purpose.
Described ridge can support Tenon ' s capsule, enlarges the filtration zone volume, and peripheral ridge is to be interrupted to be arranged, be convenient to aqueous humor by the ridge gap to around diffusion.
The surface area of described drain dish is preferably 195.38mm
2, high 1.2mm.
The height of described ridge is preferably 0.8mm.
Described class T shape drainage tube is silica gel tube, and its specification is 0.6mm with external diameter preferably, and internal diameter is 0.3mm.
Described bilobate clack valve conforms to the preferred 0.3mm of lobe leaf diameter, thickness 0.2mm with described class T shape drainage tube specification.
Compared with prior art, the present invention has following outstanding beneficial effect:
Adopt the design of class T shape pipe, can keep drainage tube effective drainage position effectively, solve problems such as drainage tube is shifted, shrinks back, deviates to expose; The drainage tube transverse tube is close to the angle, room, and parallel with iris, can reduce that pipeline touches eye inner tissue and causes corresponding complication in the ocular movement process; The drainage trough inwall can effectively be controlled formation and the art district scarring of blood coagulation with the biological filter membrane of 5-Fu liposome class; The drainage tube outer wall has the leakproof card, in the art, postoperative can prevent corneosclera otch seepage, herein can one-body molded also sliceable formation, and reduce because of drainage tube and stop up second operation difficulty and the cost that causes; Drainage tube utilizes pipe friction and turning resistance or flows out controller, the generation of control shallow of anterior chamber and ocular hypotension by the leaf one-tenth aqueous humor of bivalve along the coiling of drain dish.The drain face of trying to get to the heart of a matter is consistent with the sclera sphere curvature radius, and explant and eyeball are closely attached, alleviate to eyeball and around the stimulation of socket of the eye tissue.Drain dish central authorities' houselet easy hypertrophy of water access hole fibrous tissue among a small circle, can limit the rear portion and filter bubble height and capacity, the ridge of central authorities and periphery can support Tenon ' s capsule, enlarges the filtration zone volume, the periphery ridge is be interrupted to be arranged, be convenient to aqueous humor by the ridge gap to around diffusion.Drainage tube and drain dish are separately made, and utilize the fixing and anticreep card connection of ridge, are convenient to the drainage tube obstruction and cause filtration failure back to change drainage tube.
Description of drawings
Fig. 1～7th, the structural representation of aqueous humor drainage implant, wherein:
Fig. 1 is that axonometric chart is placed in the front of I type aqueous humor drainage implant;
Fig. 2 is that axonometric chart is placed at the back side of I type aqueous humor drainage implant;
Fig. 3 is that axonometric chart is placed in the front of II type aqueous humor drainage implant;
Fig. 4 is that axonometric chart is placed at the back side of II type aqueous humor drainage implant;
Fig. 5 is the structural representation that the bilobed flap aqueous humor flows out controller;
Fig. 6,7 is respectively the sketch map that I type, II type aqueous humor drainage implant are implanted eyeball position.
Be described in further detail below in conjunction with operation principle and the construction features of accompanying drawing to novel aqueous humor drainage implant.
The specific embodiment
Shown in Fig. 1～7, novel aqueous humor drainage implant is linked to each other with drain dish 2 by the class T shape drainage tube 1 of implanting camera oculi anterior and constitutes.Class T shape drainage tube comprises feed liquor transverse tube 3 and drain long tube 4 two parts.Adopt the design of class T shape pipe, can keep drainage tube effective drainage position, solve problems such as drainage tube is shifted, shrinks back, deviates to expose.Feed liquor transverse tube and the limbus of corneae of drainage tube have identical radius of curvature, are close to the angle, room, and parallel with iris, can reduce that pipeline touches eye inner tissue and causes corresponding complication in the ocular movement process, and drain transverse tube and aqueous humor contact surface have drainage trough 5.The drainage trough inwall can effectively be controlled formation and the art district scarring of blood coagulation with the biological filter membrane of 5-Fu liposome class, reduces the postoperative drainage pipe and is caused the filtration failure by obstructions such as the blood in the anterior chamber, inflammation chip, fibrous membrane, iris, vitreous body.Drain long tube 4 has leakproof card 6 near the outer wall of feed liquor transverse tubes 3, in the art, postoperative can prevent corneosclera otch seepage.The drain face of trying to get to the heart of a matter is consistent with the sclera sphere curvature radius, and explant and eyeball are closely attached, alleviate to eyeball and around the stimulation of socket of the eye tissue.Drain dish leading edge has two suture holes 7, is convenient to implant is fixed on the shallow-layer sclera of ambitus.Drain dish central authorities' houselet water access hole 10 easy hypertrophy fibrous tissue among a small circle can limit the rear portion and filter bubble height and capacity, and fixation implant reduces the ophthalmic uncomfortable sense.The ridge 9 of the central authorities of drain dish (2) and periphery can support Tenon ' s capsule, enlarges the filtration zone volume, and peripheral ridge is to be interrupted to be arranged, be convenient to aqueous humor by the ridge gap to around diffusion.Drainage tube and drain dish are separately made, and utilize the fixing and anticreep card connection of ridge.Drainage tube and drain dish are the flexible material of certain tension force and make.
In Fig. 1,2,3,4 illustrated embodiments, the feed liquor transverse tube of leakproof Ka Chu and drain long tube can one-body molded also sliceable formations.One-body molded difficulty of processing is relatively low; Be spliced to form and reduce because drainage tube stops up the second operation difficulty that causes, reduce the operation cost simultaneously.In addition, inject the generation that medicine can be controlled post-operative complication in splicing place.
As shown in Figure 1, 2 among the embodiment, I type aqueous humor drainage implant drain long tube 4 coils along the drain dish, the hydromechanical principle of design considerations, utilize the linear loss of flow duct wall friction in the pipe and the local resistance at turning, make the leakproof card arrival end of drain long tube 4 form energy difference or pressure difference with the port of export that is connected with the drain dish, make drain long tube 4 self form aqueous humor and flow out control system.Liquid in pipe flows when liquid feeding end pressure reaches certain value; Otherwise no liquid flows when being lower than this value.According to the unlatching pressure that begins to have liquid flow in different materials resistance coefficient and the pipe, change length or the coiling mode of pipe.This aqueous humor flows out the generation that control system can effectively be controlled shallow of anterior chamber and ocular hypotension.
In Fig. 3,4,5 illustrated embodiments, the liquid outlet of II type aqueous humor drainage implant drainage tube 1 is provided with valve 11, and this valve is the bilobed flap structure, and current atrial pressure reaches by force to be opened when pressing, and bilobed flap is opened, the liquid drain; Current atrial pressure does not reach by force to be opened when pressing, the bilobed flap closure, and no liquid flows out.This valve can effectively be controlled the generation of shallow of anterior chamber and ocular hypotension.
Shown in Fig. 6,7, aqueous humor is drained near the drain dish 2 through the drain of class T shape drainage tube 1, constantly spreads by aqueous humor access hole 10, is absorbed by surrounding tissue gradually afterwards.
Below be the instantiation that the inventor provides, need to prove, the invention is not restricted to these embodiment.
Embodiment 1: as shown in Figure 1, novel aqueous humor drainage implant drainage tube becomes the silica gel tube of class T shape, and its specification can be selected external diameter 0.6mm, internal diameter 0.3mm for use.Wherein the transverse tube of class T shape drainage tube has and the about 5.85mm of the similar radius of curvature of corneoscleral junction.Transverse tube partly with on the aqueous humor contact surface has drainage trough in the described drainage tube room.Fan-shaped drain dish is a curved surface, is suitable for the sclera outer surface, and its specification can be for having the about 12mm of similar radius of curvature with sclera, and drain dish cart area is 195.38mm
2, high 1.2mm.The drain long tube coils along between ridge, forms aqueous humor and flows out control system, the high 0.8mm of ridge.
Embodiment 2: as shown in Figure 3, drainage tube and drain dish specification can be selected the specification among the embodiment 1 for use.The bilobate clack valve conforms to the drainage tube specification, lobe leaf diameter 0.3mm, thickness 0.2mm.
Claims (11)
1. aqueous humor drainage implant, connected to form by class T shape drainage tube (1) and drain dish (2), wherein class T shape drainage tube (1) comprises feed liquor transverse tube (3) and drain long tube (4) two parts, it is characterized in that, the liquid outlet of class T shape drainage tube (1) has anticreep card (8) to be connected with drain dish (2) junction, and described drainage tube (1) is removable; Drain long tube (4) has leakproof card (6) near the outer wall of feed liquor transverse tube (3), and the feed liquor transverse tube of leakproof Ka Chu and drain long tube can one-body molded also sliceable formations; The feed liquor transverse tube (3) of class T shape drainage tube (1) has drainage trough (5) with the aqueous humor contact surface, and the inwall of drainage trough (5) has biological filter membrane, has the liposome of control fibrosis and scarring on the film; The leading edge of drain dish is provided with suture hole (7), the houselet water access hole (10) of drain dish intermediate distribution comparatively dense, the big aqueous humor access hole (10) that evenly distributes on every side, the central authorities of drain dish (2) and periphery design bossed ridge (9); Drain long tube (4) is along drain dish (2) coiling, and is fixing by ridge (9), forms aqueous humor and flows out controller; Or drain long tube (4) utilizes the outflow of bilobate clack valve (11) control aqueous humor, and wherein bilobate clack valve (11) is arranged on the liquid outlet of class T shape drainage tube (1).
2. aqueous humor drainage implant as claimed in claim 1 is characterized in that, described drain long tube (4) is connected the outer arc central authorities of feed liquor transverse tube (3).
3. aqueous humor drainage implant as claimed in claim 2 is characterized in that, described feed liquor transverse tube (3) has identical radian with limbus of corneae, and radius of curvature is 5.85mm.
4. aqueous humor drainage implant as claimed in claim 2 is characterized in that, described liposome is the 5-Fu liposome.
5. aqueous humor drainage implant as claimed in claim 1 is characterized in that, described drain dish (2) is fan-shaped, and the bottom surface bending of described drain dish (2) is spherical in shape, conforms to the scleral surface curvature of human eye.
6. aqueous humor drainage implant as claimed in claim 1 is characterized in that, described class T shape drainage tube (1) and drain dish (2) are made by medical grade silicon rubber or other biomaterial for medical purpose.
7. aqueous humor drainage implant as claimed in claim 1 is characterized in that, described ridge (9) can support Tenon ' s capsule, enlarges the filtration zone volume, and peripheral ridge is to be interrupted to be arranged, be convenient to aqueous humor by the ridge gap to around diffusion.
8. aqueous humor drainage implant as claimed in claim 1 is characterized in that, the surface area of described drain dish (2) is 195.38mm
2, high 1.2mm.
9. aqueous humor drainage implant as claimed in claim 1 is characterized in that, the height of described ridge (9) is 0.8mm.
10. aqueous humor drainage implant as claimed in claim 1 is characterized in that, described class T shape drainage tube (1) is silica gel tube, and it is 0.6mm that its specification is selected external diameter for use, and internal diameter is 0.3mm.
11. aqueous humor drainage implant as claimed in claim 1 is characterized in that, described bilobate clack valve (11) conforms to described class T shape drainage tube (1) specification, lobe leaf diameter 0.3mm, thickness 0.2mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100016833A CN103190983A (en) | 2012-01-05 | 2012-01-05 | Aqueous humor drainage implant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100016833A CN103190983A (en) | 2012-01-05 | 2012-01-05 | Aqueous humor drainage implant |
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| CN103190983A true CN103190983A (en) | 2013-07-10 |
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| CN2012100016833A Pending CN103190983A (en) | 2012-01-05 | 2012-01-05 | Aqueous humor drainage implant |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016004223A1 (en) * | 2014-07-01 | 2016-01-07 | Cao Ariel | Methods and devices for implantation of intraocular pressure sensors |
| CN108524094A (en) * | 2017-03-03 | 2018-09-14 | 罗维亚克有限责任公司 | Glaucoma valve devices |
| CN109223302A (en) * | 2018-11-21 | 2019-01-18 | 中国人民解放军总医院 | A kind of aqueous humor drainage device and manufacturing method |
| CN110037854A (en) * | 2019-03-29 | 2019-07-23 | 温州医科大学附属眼视光医院 | A kind of aqueous humor drainage device for glaucoma and Aqueous Humor of Glaucomas drainage method |
| CN111449834A (en) * | 2020-04-15 | 2020-07-28 | 贵州省人民医院 | Lacrimal passage drainage device for lacrimal duct embolism and drainage method thereof |
| US10973425B2 (en) | 2014-07-01 | 2021-04-13 | Injectsense, Inc. | Hermetically sealed implant sensors with vertical stacking architecture |
| CN112689488A (en) * | 2018-09-06 | 2021-04-20 | 洛桑联邦理工学院 | Device for treating excess intraocular fluid with an elastic membrane |
| CN113576749A (en) * | 2021-07-30 | 2021-11-02 | 温州医科大学 | Glaucoma drainage device |
| CN113712731A (en) * | 2016-06-03 | 2021-11-30 | 新世界医学有限公司 | Intraocular drainage device |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10973425B2 (en) | 2014-07-01 | 2021-04-13 | Injectsense, Inc. | Hermetically sealed implant sensors with vertical stacking architecture |
| US10213107B2 (en) | 2014-07-01 | 2019-02-26 | Injectsense, Inc. | Methods and devices for implantation of intraocular pressure sensors |
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| CN112689488A (en) * | 2018-09-06 | 2021-04-20 | 洛桑联邦理工学院 | Device for treating excess intraocular fluid with an elastic membrane |
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| CN110037854A (en) * | 2019-03-29 | 2019-07-23 | 温州医科大学附属眼视光医院 | A kind of aqueous humor drainage device for glaucoma and Aqueous Humor of Glaucomas drainage method |
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| CN111449834B (en) * | 2020-04-15 | 2022-03-01 | 贵州省人民医院 | Lacrimal passage drainage device for lacrimal duct embolism and drainage method thereof |
| CN111449834A (en) * | 2020-04-15 | 2020-07-28 | 贵州省人民医院 | Lacrimal passage drainage device for lacrimal duct embolism and drainage method thereof |
| CN113576749A (en) * | 2021-07-30 | 2021-11-02 | 温州医科大学 | Glaucoma drainage device |
| CN113576749B (en) * | 2021-07-30 | 2024-03-15 | 温州医科大学 | Glaucoma drainage device |
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Application publication date: 20130710 |