CN109223302A - A kind of aqueous humor drainage device and manufacturing method - Google Patents
A kind of aqueous humor drainage device and manufacturing method Download PDFInfo
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- CN109223302A CN109223302A CN201811391213.6A CN201811391213A CN109223302A CN 109223302 A CN109223302 A CN 109223302A CN 201811391213 A CN201811391213 A CN 201811391213A CN 109223302 A CN109223302 A CN 109223302A
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- drainage tube
- aqueous humor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00885—Methods or devices for eye surgery using laser for treating a particular disease
- A61F2009/00891—Glaucoma
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Abstract
The embodiment provides a kind of aqueous humor drainage device and manufacturing methods, it is related to medical instruments field, the aqueous humor drainage device includes aqueous humor disc of confusion, intraocular drainage tube and drainage tube, aqueous humor disc of confusion is arranged under the conjunctiva of the eyeball upper half, on sclera in region, intraocular drainage tube and drainage tube are connect with aqueous humor disc of confusion, the input unit of intraocular drainage tube is used for and intraocular anterior chamber region or back room regional connectivity, the intraocular output section of drainage tube is connected to the input unit of drainage tube, and the output section of drainage tube with eyeball lower surface conjunctiva area for being connected to.The aqueous humor drainage device can improve the case where fiber package, meanwhile, the aqueous humor drainage device is in the case where there is fiber package, still effectively aqueous humor can be drained, the service life of entire aqueous humor drainage device extends, this is reasonable in design, practical.
Description
Technical field
The present invention relates to medical instruments fields, and in particular to a kind of aqueous humor drainage device and manufacturing method.
Background technique
Currently, this disease of glaucoma is that aqueous humor discharge is obstructed the main reason for generation, intraocular pressure is caused to increase.Therefore it controls
Intraocular pressure processed becomes the main means of glaucoma treatment, and the prior art guides the device of aqueous humor by aqueous humor by being implanted into eyeball
Drainage, thus reduces intraocular pressure.But the stimulation due to foreign matter to peribulbar tissue, aqueous humor is guided in the prior art
Device is easy to appear the case where fiber package, influences the normal drainage operation of the device of the guidance aqueous humor, and it is intraocular that reduction is not achieved
The effect of pressure, the device for the guidance aqueous humor that can only more renew, so that the service life of the device of the guidance aqueous humor is shorter.
Inventor has found that the prior art at least has the disadvantage in that under study for action
The case where being easy to appear fiber package of the device of existing guidance aqueous humor, causes to guide the device of aqueous humor can not be just
Chang Zuoye, and then cause entirely to guide the service using life of aqueous humor shorter.
Summary of the invention
The purpose of the present invention is to provide a kind of aqueous humor drainage devices, improve the deficiencies in the prior art, aqueous humor drainage dress
It sets in the case where there is fiber package, still effectively aqueous humor can be drained, to extend entire aqueous humor drainage dress
The service life set, this is reasonable in design, practical.
It is another object of the present invention to provide a kind of aqueous humor drainage device manufacturing methods, are used to manufacture above-mentioned mention
The aqueous humor drainage device arrived.
The embodiment of the present invention is achieved in that
The embodiment provides a kind of aqueous humor drainage devices comprising aqueous humor disc of confusion, intraocular drainage tube and outer
Drainage tube；
The aqueous humor disc of confusion is for being arranged under the conjunctiva of the eyeball upper half, on sclera in region；
The intraocular drainage tube and the drainage tube are connect with the aqueous humor disc of confusion, the intraocular drainage tube it is defeated
Enter portion to be used for and intraocular anterior chamber region or back room regional connectivity, output section and the drainage tube of the intraocular drainage tube
Input unit connection, the output section of the drainage tube is for Tonnon ' the s cystoblast regional connectivity with eyeball lower half.
Specifically, the aqueous humor drainage device can improve the case where fiber package, meanwhile, which is occurring
In the case that fiber wraps up, still effectively aqueous humor can be drained, to extend the use of entire aqueous humor drainage device
In the service life, this is reasonable in design, practical.
Optionally, the aqueous humor drainage device further includes liquid storage device；
The liquid storage device is connect with the aqueous humor disc of confusion；
The liquid storage apparatus has the accommodating chamber for accommodating aqueous humor, the output section of the intraocular drainage tube and the external drainage
The input unit of pipe is connected to the accommodating chamber；
Be provided with multiple first permeability holes on the liquid storage device, first permeability hole for make the accommodating chamber with it is described
Under the conjunctiva of the eyeball upper half, regional connectivity on sclera.
Optionally, the aqueous humor drainage device further includes secondary drainage tube；
The secondary drainage tube is connect with the aqueous humor disc of confusion；
The input unit of the secondary drainage tube is connected to the accommodating chamber, and the output section of the secondary drainage tube is used for and institute
It states under the conjunctiva of the eyeball upper half, regional connectivity on sclera.
Optionally, region includes the conjunctiva layer of the eyeball upper half and described under the conjunctiva of the eyeball upper half, on sclera
Tonnon ' the s cystoblast of the eyeball upper half, the liquid storage device have faying face, and the faying face is used for and the eyeball upper half
Conjunctiva layer be overlapped；
The junction of the output section of the liquid storage device and the intraocular drainage tube is the first connecting pin, the liquid storage device and institute
The junction for stating the input unit of drainage tube is second connection end, the company of the liquid storage device and the input unit of the secondary drainage tube
Meeting place is third connecting pin, and first connecting pin, the second connection end and the third connecting pin are respectively positioned on the combination
Between face and Tonnon ' the s cystoblast of the eyeball upper half, and the distance of first connecting pin to the faying face is greater than institute
Second connection end is stated to the distance of the faying face, the distance of the second connection end to the faying face is greater than third company
Connect the distance that the faying face is arrived at end；
The liquid storage device is additionally provided with multiple second permeability holes, and second permeability hole can be used for making the accommodating chamber and eye
Outer surface of ball regional connectivity.
Optionally, Tonnon ' the s cystoblast of the eyeball upper half, the aqueous humor disperse is arranged in the aqueous humor disc of confusion
At least one auxiliary installation through-hole is provided on disk.
Optionally, the aqueous humor disc of confusion is provided with first pipe, second pipe and third pipeline, the first pipe,
The second pipe and the third pipeline extend to the edge of the aqueous humor disc of confusion, institute from the liquid storage device position
First pipe is stated for making the intraocular drainage tube be arranged in the first pipe and be connected to the liquid storage device, described second
For making the drainage tube be arranged in the second pipe and be connected to the liquid storage device, the third pipeline is used for pipeline
It is arranged in the secondary drainage tube in the third pipeline and is connected to the liquid storage device.
Optionally, the internal diameter of the internal diameter of the intraocular drainage tube, the internal diameter of the drainage tube and the secondary drainage tube
It is equal.
Optionally, the aqueous humor drainage device further includes check valve；
The check valve is arranged between the input unit of the drainage tube and the output section of the drainage tube, and described
Check valve is for making output section one-way flow of the aqueous humor from the input unit of the drainage tube to the drainage tube.
Optionally, the aqueous humor drainage device further includes pressure valve；
The pressure valve is arranged between the input unit of the intraocular drainage tube and the output section of the intraocular drainage tube, and
The pressure valve is used to make the room in the intraocular drainage tube after aqueous humor pressure in the intraocular drainage tube is more than preset value
Water flows to the output section of the intraocular drainage tube from the input unit of the intraocular drainage tube.
The embodiments of the present invention also provide a kind of aqueous humor drainage device manufacturing methods, are used to manufacture room mentioned above
Water drainage device, the aqueous humor drainage device manufacturing method include:
The aqueous humor disc of confusion being made of biological collagen material is provided；
The intraocular drainage tube being made of biological collagen material is provided；
The drainage tube being made of biological collagen material is provided；
It connect the intraocular drainage tube and the drainage tube with the aqueous humor disc of confusion, makes the intraocular drainage tube
Output section be connected to the input unit of the drainage tube；
The method of the intraocular drainage tube being made of biological collagen material that provides includes:
The internal diameter of the intraocular drainage tube is according to formula F=1.323-2.180d1-0.012·P0It is calculated, wherein
F is volume flow of the aqueous humor in the intraocular drainage tube, d1For the internal diameter of the intraocular drainage tube, P0For intraocular pressure；
Or, according to formula v=0.609-1.448d2-0.026·P0It is calculated, wherein v is aqueous humor described intraocular
Average flow velocity in drainage tube, d2For the internal diameter of the intraocular drainage tube, P0For intraocular pressure.
Compared with prior art, the beneficial effect of the embodiment of the present invention includes, for example:
The present invention provides a kind of aqueous humor drainage device, which can improve the case where fiber wraps up, together
When, which still can effectively drain aqueous humor in the case where there is fiber package, extend whole
The service life of a aqueous humor drainage device, this is reasonable in design, practical.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not construed as pair
The restriction of range for those of ordinary skill in the art without creative efforts, can also be according to this
A little attached drawings obtain other relevant attached drawings.
Fig. 1 is structural schematic diagram of the aqueous humor drainage device provided in an embodiment of the present invention under the first visual angle；
Fig. 2 is structural schematic diagram of the aqueous humor drainage device provided in an embodiment of the present invention under the second visual angle；
Fig. 3 is the structural schematic diagram of eyeball provided in an embodiment of the present invention；
Fig. 4 is structural schematic diagram of the liquid storage device provided in an embodiment of the present invention under the first visual angle；
Fig. 5 is structural schematic diagram of the liquid storage device provided in an embodiment of the present invention under the second visual angle；
Fig. 6 is structural schematic diagram of the liquid storage device provided in an embodiment of the present invention under third visual angle；
Fig. 7 is the structural schematic diagram of aqueous humor disc of confusion provided in an embodiment of the present invention.
Icon: 100- aqueous humor drainage device；11- aqueous humor disc of confusion；111- first pipe；112- second pipe；113-
Three pipelines；114- assists installation through-hole；The intraocular drainage tube of 12-；121- tapered opening；13- drainage tube；14- liquid storage device；141-
First permeability hole；The second permeability hole of 142-；The secondary drainage tube of 15-；The first connecting pin 16-；17- second connection end；18- third connects
Connect end；19- pressure valve；20- check valve；Under the conjunctiva of the 300- eyeball upper half, region on sclera；The knot of the 31- eyeball upper half
Film layer；Tonnon ' the s cystoblast of the 32- eyeball upper half；Tonnon ' the s cystoblast region of 400- eyeball lower half；Outside 500- eyeball
Surface region.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is
A part of the embodiment of the present invention, instead of all the embodiments.The present invention being usually described and illustrated herein in the accompanying drawings is implemented
The component of example can be arranged and be designed with a variety of different configurations.
Therefore, the detailed description of the embodiment of the present invention provided in the accompanying drawings is not intended to limit below claimed
The scope of the present invention, but be merely representative of selected embodiment of the invention.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without creative efforts belongs to the model that the present invention protects
It encloses.
It should also be noted that similar label and letter indicate similar terms in following attached drawing, therefore, once a certain Xiang Yi
It is defined in a attached drawing, does not then need that it is further defined and explained in subsequent attached drawing.
In the description of the present invention, it should be noted that the orientation or position of the instructions such as term " on ", "lower", "inner", "outside"
Set relationship be based on the orientation or positional relationship shown in the drawings or the invention product using when the orientation or position usually put
Relationship is set, is merely for convenience of description of the present invention and simplification of the description, rather than the device or element of indication or suggestion meaning are necessary
It with specific orientation, is constructed and operated in a specific orientation, therefore is not considered as limiting the invention.
In addition, term " first ", " second ", " third " etc. are only used for distinguishing description, it is not understood to indicate or imply
Relative importance.
In the description of the present invention, it is also necessary to which explanation is unless specifically defined or limited otherwise, term " setting ",
" connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can be
Mechanical connection, is also possible to be electrically connected；It can be directly connected, two can also be can be indirectly connected through an intermediary
Connection inside element.For the ordinary skill in the art, above-mentioned term can be understood in the present invention with concrete condition
In concrete meaning.
It treats in the operation of glaucoma, usually using the device of implantation guidance aqueous humor, reduces intraocular pressure, but be implanted into aqueous humor and draw
Flowing device usually can generate foreign matter stimulate the reaction to the tissue around human eyeball, and the case where fiber package occurs, thus shadow
The normal operation of aqueous humor drainage device is rung, intraocular pressure still can not effectively decline, and a period of time often very short after operation,
Just will appear the case where fiber package is wrapped up in, influence the effect of operation, inventor faced with this situation when, attempt to reduce guidance aqueous humor
The contact area of device and eyes, thus reduce stress reaction, but the normal knot of the device due to must assure that guidance aqueous humor
Structure can not solve above-mentioned technical problem, inventor so the contact area of the device of guidance aqueous humor and eyes is still very big
The connecting tube using only conveying aqueous humor was attempted, the contact area with eyeball is reduced with this, but individual connecting tube is steady
It is qualitative to be unable to get guarantee, it is easy to loosen disengaging, the effect for reducing intraocular pressure is still bad, and the therapeutic effect of glaucoma is still
It is unable to get guarantee.Inventor upon to many attempts, has invented aqueous humor drainage device as described below, which exists
In the case where there is fiber package, still effectively aqueous humor can be drained, the service life of entire aqueous humor drainage device is prolonged
Long, the specific structure of the aqueous humor drainage device describes in detail in the following embodiments.
Embodiment 1
Fig. 1-Fig. 3 is please referred to, present embodiments provides a kind of aqueous humor drainage device 100 comprising aqueous humor disc of confusion 11, eye
Inner drainage tube 12 and drainage tube 13；
Aqueous humor disc of confusion 11 is for being arranged under the conjunctiva of the eyeball upper half, on sclera in region 300；
Intraocular drainage tube 12 and drainage tube 13 are connect with aqueous humor disc of confusion 11, and the input unit of intraocular drainage tube 12 is used for
It is connected to the output section of intraocular anterior chamber region or back room regional connectivity, intraocular drainage tube 12 with the input unit of drainage tube 13,
The output section of drainage tube 13 with Tonnon ' the s cystoblast region 400 of eyeball lower half for being connected to.
It should be noted that in the present embodiment, aqueous humor disc of confusion 11 is arranged under the conjunctiva of the eyeball upper half, on sclera
In region 300, and the output section of drainage tube 13 is connected to Tonnon ' the s cystoblast region 400 of eyeball lower half, aqueous humor disperse
Disk 11 under the conjunctiva of the eyeball upper half, region 300 contacts on sclera area it is big, cause the stress reaction of peribulbar tissue
Strongly, the case where being easy to appear fiber package, but Tonnon ' the s cystoblast region 400 of drainage tube 13 and eyeball lower half
The case where contact area is small, causes the foreign matter stimulate the reaction of peribulbar tissue small, is less prone to fiber package, can continue just
Normal conveying aqueous humor, so even if after the case where fiber package is wrapped up in occurs in aqueous humor disc of confusion 11, the aqueous humor drainage device 100
The conveying operation of aqueous humor can be still normally completed, specifically, the aqueous humor drainage device 100 is by aqueous humor from intraocular anterior chamber region
Or back room region is transported to Tonnon ' the s cystoblast region 400 of eyeball lower half, and then enters blood, the aqueous humor for completing standard follows
Ring process.
Please refer to Fig. 1-Fig. 3, under the conjunctiva of the upper half, scleral surface region 300 include the eyeball upper half conjunctiva layer 31
With Tonnon ' the s cystoblast 32 of the eyeball upper half, aqueous humor disc of confusion 11 is used to paste with Tonnon ' the s cystoblast 32 of the eyeball upper half
It closes, at least one auxiliary installation through-hole 114 is provided on aqueous humor disc of confusion 11.Specifically, in the present embodiment, auxiliary installation is logical
The quantity in hole 114 is three, when aqueous humor disc of confusion 11 is bonded with Tonnon ' the s cystoblast 32 of the eyeball upper half, aqueous humor disc of confusion
Air between 11 and Tonnon ' the s cystoblast 32 of the eyeball upper half can be excluded by auxiliary mounting hole, and utilize needlework suture side
Formula fixes aqueous humor disc of confusion 11, so that aqueous humor disc of confusion 11 is fixed on eyeball upper half area.
Specifically, the aqueous humor drainage device 100 occur fiber package in the case where, still can effectively to aqueous humor into
Row drainage, to extend the service life of entire aqueous humor drainage device 100, this is reasonable in design, practical.
Fig. 1-Fig. 4 is please referred to, in the present embodiment, aqueous humor drainage device 100 further includes liquid storage device 14；
Liquid storage device 14 is connect with aqueous humor disc of confusion 11；
Liquid storage device 14 has an accommodating chamber for accommodating aqueous humor, the output section of intraocular drainage tube 12 and drainage tube 13 it is defeated
Enter portion to be connected to accommodating chamber；
Multiple first permeability holes 141 are provided on liquid storage device 14, the first permeability hole 141 is for making accommodating chamber and eyeball upper half
Region 300 is connected under the conjunctiva in portion, on sclera.
In the present embodiment, liquid storage device 14 and aqueous humor disc of confusion 11 are integrally formed, specifically, the conjunctiva of the eyeball upper half
Under, on sclera the conjunctiva layer 31 in region 300 including the eyeball upper half and the eyeball upper half Tonnon ' s cystoblast 32, liquid storage device 14
With faying face, faying face with the conjunctiva layer 31 of the eyeball upper half for being overlapped, it is to be understood that referring to figure 3., liquid storage device
14 a part is located under the conjunctiva of the eyeball upper half, on sclera in region 300, and another part of liquid storage device 14 is towards far from eyeball
It is protruded relative to the conjunctiva layer 31 of the eyeball upper half in the direction of Tonnon ' the s cystoblast 32 of the upper half.
Referring to figure 4. and Fig. 2 and Fig. 3 is combined, the first permeability hole 141 is located at liquid storage device 14 close to the eyeball upper half
One end of Tonnon ' s cystoblast 32, after aqueous humor enters liquid storage device 14, aqueous humor can be directly entered eye by the first permeability hole 141
Tonnon ' the s cystoblast 32 of the ball upper half, subsequently into blood circulation, in addition, aqueous humor is in the process for passing through the first permeability hole 141
In can be effectively improved the formation of bubble in aqueous humor, bubble refers to bleb in the prior art here.
- Fig. 6 referring to figure 3., it should be noted that liquid storage device 14 is additionally provided with multiple second permeability holes 142, the second infiltration
Hole 142 is for being connected to accommodating chamber with eyeball exterior surface area 500.Specifically, the setting of the second permeability hole 142 is remote in liquid storage device 14
One end of Tonnon ' s cystoblast 32 from the eyeball upper half, the room when the room hypervolia in liquid storage device 14, in liquid storage device 14
Water can enter eyeball exterior surface area 500 by the second permeability hole 142, substitute tear, it is generally existing to alleviate glaucoma patient
Dry eye symptoms.
What needs to be explained here is that in practical applications, even if the Tonnon ' s when drainage tube 13 in eyeball lower half
The case where producing package when cystoblast region 400, doctor can also on the basis of aqueous humor drainage device 100, to patient into
Drainage tube 13 is directly pierced by eyeball lower surface conjunctiva area by row second operation, so that drainage tube 13 and eyeball outer surface
Region 500 is connected to.It is understood that can effectively change outer after drainage tube 13 is connected to eyeball exterior surface area 500
The case where fiber package that drainage tube 13 occurs, meanwhile, aqueous humor is introduced into eyeball exterior surface area 500, aqueous humor can substitute
Tear, can effectively mitigate the dry eye condition of glaucoma patient, and then further extend the use of the aqueous humor drainage device 100
Service life.
Fig. 1 is please referred to, in the present embodiment, aqueous humor drainage device 100 further includes secondary drainage tube 15；
Secondary drainage tube 15 is connect with aqueous humor disc of confusion 11；
The input unit of secondary drainage tube 15 is connected to accommodating chamber, and the output section of secondary drainage tube 15 is used for and the eyeball upper half
Conjunctiva under, on sclera region 300 be connected to.
In this embodiment, region 300 connects under the output section of secondary drainage tube 15 and the conjunctiva of the eyeball upper half, on sclera
Logical, the aqueous humor in liquid storage device 14 can be entered by secondary drainage tube 15 under the conjunctiva of the eyeball upper half, region 300 on sclera,
Specifically, water flow enters Tonnon ' the s cystoblast 32 of the eyeball upper half, subsequently into blood, the standard cycle mistake of aqueous humor is completed
Journey.
- Fig. 6 referring to figure 4., in the present embodiment, the junction of the output section of liquid storage device 14 and intraocular drainage tube 12 are the
One connecting pin 16, the junction of the input unit of liquid storage device 14 and drainage tube 13 are second connection end 17, liquid storage device 14 with it is secondary
The junction of the input unit of drainage tube 15 is third connecting pin 18, the first connecting pin 16, second connection end 17 and third connecting pin
18 are respectively positioned between faying face and Tonnon ' the s cystoblast 32 of the eyeball upper half, and the distance of the first connecting pin 16 to faying face is big
The distance of faying face is arrived in second connection end 17, the distance of second connection end 17 to faying face is greater than third connecting pin 18 to combination
The distance in face.
It should be noted that-Fig. 6, the conjunctiva layer 31 in the eyeball upper half arrive the eyeball upper half referring to figure 3.
On the direction of Tonnon ' s cystoblast 32, the first connecting pin 16, second connection end 17 and third connecting pin 18 be respectively positioned on faying face with
Between Tonnon ' the s cystoblast 32 of the eyeball upper half, the first connecting pin 16 close to the eyeball upper half Tonnon ' s cystoblast 32,
Three connecting pins 18 are located on one end of the conjunctiva layer 31 of the eyeball upper half, and second connection end 17 is located at 16 He of the first connecting pin
Between second connection end 17.
It is understood that aqueous humor passes through the first connecting pin 16 (output section of i.e. intraocular drainage tube 12) on liquid storage device 14
Into in the accommodating chamber of liquid storage device 14, first pass through the first permeability hole 141 aqueous humor is delivered under the conjunctiva of the eyeball upper half, sclera
Upper region 300, meanwhile, aqueous humor can be effectively improved the formation of bubble in aqueous humor by the first permeability hole 141；When in liquid storage device 14
Aqueous humor amount when gradually increasing, aqueous humor can by the second connection end 17 (i.e. the input unit of drainage tube 13) on liquid storage device 14 into
Enter drainage tube 13, then aqueous humor enters Tonnon ' the s cystoblast region 400 of eyeball lower half by drainage tube 13, in turn
Into blood, the cyclic process of aqueous humor is completed；When the aqueous humor amount in liquid storage device 14 further increases, in order to flow aqueous humor quickly
Logical, aqueous humor can enter secondary drainage tube by the third connecting pin 18 (input unit of secondary drainage tube 15) on liquid storage device 14 at this time
15, then aqueous humor entered under the conjunctiva of the eyeball upper half by secondary drainage tube 15, region 300 on sclera, and then enter blood
Liquid completes the cyclic process of aqueous humor；When the aqueous humor amount in liquid storage device 14 further walks increase, aqueous humor can be by liquid storage device 14
Second permeability hole 142, and then eyeball exterior surface area 500 is entered, it is general that substitution tear can effectively alleviate glaucoma patient
All over existing dry eye symptoms.
Fig. 7 is please referred to, in the present embodiment, aqueous humor disc of confusion 11 is provided with first pipe 111, second pipe 112 and
Three pipelines 113, first pipe 111, second pipe 112 and third pipeline 113 extend to aqueous humor from 14 position of liquid storage device
The edge of disc of confusion 11, first pipe 111 is for making intraocular drainage tube 12 be arranged in first pipe 111 and connect with liquid storage device 14
Logical, second pipe 112 is for making drainage tube 13 be arranged in second pipe 112 and be connected to liquid storage device 14, third pipeline 113
For being arranged in secondary drainage tube 15 in third pipeline 113 and being connected to liquid storage device 14.
In order to guarantee intraocular drainage tube 12, drainage tube 13 and secondary drainage tube 15 in the stabilization of the process of conveying aqueous humor
Property, in the present embodiment, specifically, intraocular drainage tube 12 is arranged in first pipe 111, drainage tube 13 is fastened on the second pipe
In road 112, secondary drainage tube 15 is fastened in third pipeline 113.
It please refers to Fig. 7 and combines Fig. 1, it is notable that in the present embodiment, liquid storage device 14 and aqueous humor disc of confusion 11 are big
Cause oval in shape, the long axis of liquid storage device 14 and the long overlapping of axles of aqueous humor disc of confusion 11, the short axle and aqueous humor disperse of liquid storage device 14
The short axle of disk 11 is overlapped, the long axis of the extending direction of first pipe 111 and the extending direction of second pipe 112 with liquid storage device 14
It is overlapped, the extending direction of second pipe 112 is overlapped with the short axle of liquid storage device 14.It should be noted that in other embodiments, room
The shape of water disc of confusion 11 can also be oval, obovate, wedge shape etc..
It please refers to Fig. 1 and combines Fig. 7, in the present embodiment, aqueous humor drainage device 100 further includes check valve 20；
Check valve 20 is arranged between the input unit of drainage tube 13 and the output section of drainage tube 13, and check valve 20 is used
In making output section one-way flow of the aqueous humor from the input unit of drainage tube 13 to drainage tube 13.
In the present embodiment, check valve 20 be arranged on aqueous humor disc of confusion 11, and the check valve 20 can only allow aqueous humor from
Output section one-way flow of the input unit of drainage tube 13 to drainage tube 13, prevents the refluence of aqueous humor, it should be noted that this
Check valve 20 in embodiment is similar with the principle of hydraulically-controlled one-way valve in the prior art, and which is not described herein again.In other implementations
In example, which can also be set between the input unit of secondary drainage tube 15 and the output section of secondary drainage tube 15, prevented
The only refluence of aqueous humor.
It please refers to Fig. 1 and combines Fig. 7, in the present embodiment, aqueous humor drainage device 100 further includes pressure valve 19；
Pressure valve 19 is arranged within the eye between the input unit of drainage tube 12 and the output section of intraocular drainage tube 12, and pressure valve
19 after the aqueous humor pressure in intraocular drainage tube 12 is more than preset value for making the aqueous humor in intraocular drainage tube 12 from intraocular drainage
The input unit of pipe 12 flows to the output section of intraocular drainage tube 12.
It should be noted that glaucoma patient perform the operation after a period of time in, the aqueous humor pressure in eyeball in aqueous humor region
Power is small, at this time if the drainage that the aqueous humor drainage device 100 helps aqueous humor to be assisted, will cause the intraocular aqueous humor pressure mistake of patient
Low, to Ocular hypotension Syndrome Symptoms occur, in the present embodiment, pressure valve 19 is arranged on aqueous humor disc of confusion 11, pressure valve
19 are provided with preset value, the aqueous humor pressure in intraocular drainage tube 12 be greater than preset value, aqueous humor could by pressure valve 19 into
In the accommodating chamber for entering liquid storage device 14, conversely, the pressure when aqueous humor is too small, when not reaching the preset value of pressure valve 19, this moment simultaneously
The drainage procedure outside carrying out aqueous humor is not needed, while it is postoperative as caused by intraocular aqueous humor hypotony to also improve patient
The problem of Ocular hypotension syndrome.It should be noted that pressure valve 19 and hydraulic pressure valve in the prior art in the present embodiment
Principle it is consistent, just repeat no more here.It should be noted that in other embodiments, it can also be by changing intraocular drainage
The internal diameter of pipe 12 and then control pressure flow, for example, can the tubular body setting of drainage tube 12 within the eye can adjust intraocular drainage
The regulating part of the inner diameter size of the outlet of pipe 12, which adjusts material using light, should when light is irradiated on the material
The surface curvature of regulating part can change, and so as to cause local volume variation, and then the caliber for controlling intraocular drainage tube 12 is big
It is small, during actual use, selectively irradiate regulating part, so that it may adjust the internal diameter of the outlet of intraocular drainage tube 12 to need
The size wanted, and can several time points after surgery repeatedly adjust, such as 1 day after operation, when 1 week, January, the key such as March
Between point, be adjusted in time according to the postoperative intraocular pressure situation of patient.
It should be noted that improving to make the rate holds steady of aqueous humor during transportation because intraocular pressure fluctuation is larger
Damage to the optic nerve of patient the internal diameter of intraocular drainage tube 12, the internal diameter of drainage tube 13 and secondary is drawn in the present embodiment
The internal diameter of flow tube 15 is equal.
Fig. 1 is please referred to, in the present embodiment, the input unit of intraocular drainage tube 12 and the output section of drainage tube 13 are provided with
Tapered opening 121 guarantees the aqueous humor drainage so that intraocular drainage tube 12 and drainage tube 13 be facilitated to be inserted into corresponding tissue regions
The normal operation of device 100.
Embodiment 2
A kind of 100 manufacturing method of aqueous humor drainage device is present embodiments provided, is used to manufacture aqueous humor mentioned above and draws
Device 100 is flowed, 100 manufacturing method of aqueous humor drainage device includes:
The aqueous humor disc of confusion 11 being made of biological collagen material is provided；
The intraocular drainage tube 12 being made of biological collagen material is provided；
The drainage tube 13 being made of biological collagen material is provided；
It connect intraocular drainage tube 12 and drainage tube 13 with aqueous humor disc of confusion 11, makes the output section of intraocular drainage tube 12
It is connected to the input unit of drainage tube 13；
There is provided the method for intraocular drainage tube 12 being made of biological collagen material includes:
The internal diameter of intraocular drainage tube 12 is according to formula F=1.323-2.180d1-0.012·P0It is calculated, wherein F
For the volume flow in aqueous humor within the eye drainage tube 12, d1For the internal diameter of intraocular drainage tube 12, P0For intraocular pressure；
Or, according to formula v=0.609-1.448d2-0.026·P0It is calculated, wherein v is that aqueous humor drains within the eye
Average flow velocity in pipe 12, d2For the internal diameter of intraocular drainage tube 12, P0For intraocular pressure.
It is worth noting that, formula F=1.323-2.180d1-0.012·P0With formula v=0.609-1.448d2-
0.026·P0It is obtained by following steps, comprising:
1. establishing model
It using SolidWorks software, is modeled, simulates eyeball so that radius is the hemisphere of 6mm as an example, it is intraocular to drain
The diameter of pipe 12 be 0.4mm-1.0mm in the form of arithmetic progression, such as by the diameter of intraocular drainage tube 12 be divided into 0.4mm,
0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm, 1.0mm establish several models, and the radius of curvature with intraocular drainage tube 12 is
For 12mm, corresponding angle is 30 degree.
2. dividing network
Established model is imported in ICEM CFD software, grid dividing is carried out.Radius is for 1.5mm and round with bottom surface
It is set as entrance for the region of concentric circles, the rounded face of intraocular drainage tube 12 is set as exporting.Five layers of boundary layer are arranged in hemispherical,
Intraocular drainage tube 12 is two layers of boundary layer.Entrance grid and 12 sizing grid of intraocular drainage tube be hemisphere body region five/
One.Each model is finally about 450,000 grids.
3. flow rate calculation
The model for having divided grid is imported into Fluent software, simulation calculating is carried out.It calculates and uses steady state way, stream
Movable model is laminar flow；Inlet pressure is set to 10-70mmHg etc. respectively, and outlet sets pressure as 0mmHg, and wall surface is without sliding wall
Face；Fluid density is 1006kg/m^3, viscosity 7.5e-4pas, simulation eye aqueous humor attribute；It calculates iteration 1,000 times, it is residual
Difference is less than 1e-7, is analyzed using the result that final step iteration obtains.
4. interpretation of result
Result after calculating is imported into Tecplot360 software, visualization and interpretation of result are carried out.To exit portion
It quadratures, the data on flows in available exit.At the calculated result of different inlet pressure and different models
Reason, obtains a series of rate of discharge data.
5. statistical analysis
Multiple regression analysis, available linear relationship are carried out to data using SPSS software.Above-mentioned calculation can be obtained
Formula F=1.323-2.180d1-0.012·P0With formula v=0.609-1.448d2-0.026·P0。
It should be noted that in the present embodiment, the internal diameter of efferent duct is according to formula F=1.323-2.180d1-
0.012·P0Or formula v=0.609-1.448d2-0.026·P0Be calculated, during practice, will with survey
Measuring appratus tests intraocular pressure, the volume flow of aqueous humor or the flowing velocity of aqueous humor of glaucoma patient, and test value is updated to
In above-mentioned formula, the internal diameter for the intraocular drainage tube 12 being adapted to patient's intraocular pressure is obtained, then uses the corresponding eye of inner diameter values
Inner drainage tube 12, it is to be understood that the intraocular drainage tube 12 being adapted to according to patient's intraocular pressure using internal diameter, different patients,
Intraocular pressure is different, and intraocular drainage tube 12 uses inner diameter values corresponding with intraocular pressure, and the design of this personalization can guarantee aqueous humor in eye
There is stable rate, without making the unstable damage for causing optic nerve of patient's intraocular pressure in inner drainage tube 12.It is noticeable
It is, in the present embodiment, in order to further ensure the stabilization of aqueous humor movement rate, internal diameter, the drainage tube of intraocular drainage tube 12
The internal diameter of 13 internal diameter and secondary drainage tube 15 is equal.
To sum up, which still can effectively carry out aqueous humor in the case where there is fiber package
Drainage, to extend the service life of entire aqueous humor drainage device 100, this is reasonable in design, practical.
It should be noted that in the absence of conflict, the feature in embodiment in the present invention can be combined with each other.
These are only the preferred embodiment of the present invention, is not intended to restrict the invention, for those skilled in the art
For member, the invention may be variously modified and varied.All within the spirits and principles of the present invention, it is made it is any modification,
Equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of aqueous humor drainage device, which is characterized in that including aqueous humor disc of confusion, intraocular drainage tube and drainage tube；
The aqueous humor disc of confusion is for being arranged under the conjunctiva of the eyeball upper half, on sclera in region；
The intraocular drainage tube and the drainage tube are connect with the aqueous humor disc of confusion, the input unit of the intraocular drainage tube
For with intraocular anterior chamber region or back room regional connectivity, the input of the output section of the intraocular drainage tube and the drainage tube
Portion's connection, the output section of the drainage tube is for Tonnon ' the s cystoblast regional connectivity with eyeball lower half.
2. aqueous humor drainage device according to claim 1, which is characterized in that the aqueous humor drainage device further includes liquid storage
Device；
The liquid storage device is connect with the aqueous humor disc of confusion；
The liquid storage apparatus has an accommodating chamber for accommodating aqueous humor, the output section of the intraocular drainage tube and the drainage tube
Input unit is connected to the accommodating chamber；
Multiple first permeability holes are provided on the liquid storage device, first permeability hole is for making the accommodating chamber and the eyeball
Under the conjunctiva of the upper half, regional connectivity on sclera.
3. aqueous humor drainage device according to claim 2, which is characterized in that the aqueous humor drainage device further includes secondary draws
Flow tube；
The secondary drainage tube is connect with the aqueous humor disc of confusion；
The input unit of the secondary drainage tube is connected to the accommodating chamber, and the output section of the secondary drainage tube is used for and the eye
Under the conjunctiva of the ball upper half, regional connectivity on sclera.
4. aqueous humor drainage device according to claim 3, which is characterized in that under the conjunctiva of the eyeball upper half, sclera
Upper region includes the conjunctiva layer of the eyeball upper half and Tonnon ' the s cystoblast of the eyeball upper half, and the liquid storage device, which has, to be combined
Face, the faying face with the conjunctiva layer of the eyeball upper half for being overlapped；
The junction of the output section of the liquid storage device and the intraocular drainage tube is the first connecting pin, the liquid storage device and described outer
The junction of the input unit of drainage tube is second connection end, the junction of the liquid storage device and the input unit of the secondary drainage tube
For third connecting pin, first connecting pin, the second connection end and the third connecting pin be respectively positioned on the faying face with
Between Tonnon ' the s cystoblast of the eyeball upper half, and the distance of first connecting pin to the faying face is greater than described the
Two connecting pins are to the distance of the faying face, and the distance of the second connection end to the faying face is greater than the third connecting pin
To the distance of the faying face；
The liquid storage device is additionally provided with multiple second permeability holes, and second permeability hole can be used for making outside the accommodating chamber and eyeball
Surface region connection.
5. aqueous humor drainage device according to claim 4, which is characterized in that the aqueous humor disc of confusion is arranged in the eyeball
Tonnon ' the s cystoblast of the upper half is provided at least one auxiliary installation through-hole on the aqueous humor disc of confusion.
6. aqueous humor drainage device according to claim 3, which is characterized in that the aqueous humor disc of confusion is provided with the first pipe
Road, second pipe and third pipeline, the first pipe, the second pipe and the third pipeline are from the liquid storage device institute
The edge of the aqueous humor disc of confusion is extended in position, and the first pipe is for making the intraocular drainage tube be arranged in described the
It is connected in one pipeline and with the liquid storage device, the second pipe is for being arranged in the drainage tube in the second pipe
And be connected to the liquid storage device, the third pipeline for make the secondary drainage tube be arranged in the third pipeline and with institute
State liquid storage device connection.
7. according to the described in any item aqueous humor drainage devices of claim 3-6, which is characterized in that the intraocular drainage tube it is interior
The internal diameter of diameter, the internal diameter of the drainage tube and the secondary drainage tube is equal.
8. aqueous humor drainage device according to claim 1-6, which is characterized in that the aqueous humor drainage device also wraps
Include check valve；
The check valve is arranged between the input unit of the drainage tube and the output section of the drainage tube, and described unidirectional
Valve is for making output section one-way flow of the aqueous humor from the input unit of the drainage tube to the drainage tube.
9. aqueous humor drainage device according to claim 1-6, which is characterized in that the aqueous humor drainage device also wraps
Include pressure valve；
The pressure valve is arranged between the input unit of the intraocular drainage tube and the output section of the intraocular drainage tube, and described
Pressure valve be used to make after the aqueous humor pressure in the intraocular drainage tube is more than preset value the aqueous humor in the intraocular drainage tube from
The input unit of the intraocular drainage tube flows to the output section of the intraocular drainage tube.
10. a kind of aqueous humor drainage device manufacturing method, which is characterized in that be used for the described in any item rooms manufacturing claims 1-9
Water drainage device, the aqueous humor drainage device manufacturing method include:
The aqueous humor disc of confusion being made of biological collagen material is provided；
The intraocular drainage tube being made of biological collagen material is provided；
The drainage tube being made of biological collagen material is provided；
It connect the intraocular drainage tube and the drainage tube with the aqueous humor disc of confusion, makes the defeated of the intraocular drainage tube
Portion is connected to the input unit of the drainage tube out；
The method of the intraocular drainage tube being made of biological collagen material that provides includes:
The internal diameter of the intraocular drainage tube is according to formula F=1.323-2.180d1-0.012·P0It is calculated, wherein F is
Volume flow of the aqueous humor in the intraocular drainage tube, d1For the internal diameter of the intraocular drainage tube, P0For intraocular pressure；
Or, according to formula v=0.609-1.448d2-0.026·P0It is calculated, wherein v is aqueous humor in the intraocular drainage
Average flow velocity in pipe, d2For the internal diameter of the intraocular drainage tube, P0For intraocular pressure.
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| CN110037854A (en) * | 2019-03-29 | 2019-07-23 | 温州医科大学附属眼视光医院 | A kind of aqueous humor drainage device for glaucoma and Aqueous Humor of Glaucomas drainage method |
| CN111150546A (en) * | 2020-02-10 | 2020-05-15 | 高莹莹 | Conjunctival sac drainage aqueous humor micro-irrigation device for treating severe xerophthalmia |
| WO2023155565A1 (en) * | 2022-02-16 | 2023-08-24 | 首都医科大学附属北京同仁医院 | Corneal path one-way aqueous humor drainage device |
| WO2024010310A1 (en) * | 2022-07-05 | 2024-01-11 | 서울대학교산학협력단 | Shunt for fibrous encapsulation in glaucoma patients |
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| CN110037854A (en) * | 2019-03-29 | 2019-07-23 | 温州医科大学附属眼视光医院 | A kind of aqueous humor drainage device for glaucoma and Aqueous Humor of Glaucomas drainage method |
| CN110037854B (en) * | 2019-03-29 | 2021-04-20 | 温州医科大学附属眼视光医院 | Glaucoma aqueous humor drainage device |
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| WO2023155565A1 (en) * | 2022-02-16 | 2023-08-24 | 首都医科大学附属北京同仁医院 | Corneal path one-way aqueous humor drainage device |
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| Publication number | Publication date |
|---|---|
| CN109223302B (en) | 2020-12-25 |
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Inventor after: Wang Dajiang Inventor after: Chen Duanduan Inventor after: Huang Yifei Inventor after: Shi Yue Inventor after: Fu Tianxiang Inventor after: Li Xuhui Inventor before: Wang Dajiang Inventor before: Chen Ruirui Inventor before: Huang Yifei Inventor before: Shi Yue Inventor before: Fu Tianxiang Inventor before: Li Xuhui |