CN100415190C - Novel aqueous humor drainage device for glaucoma - Google Patents

Novel aqueous humor drainage device for glaucoma Download PDF

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CN100415190C
CN100415190C CN 200510096186 CN200510096186A CN100415190C CN 100415190 C CN100415190 C CN 100415190C CN 200510096186 CN200510096186 CN 200510096186 CN 200510096186 A CN200510096186 A CN 200510096186A CN 100415190 C CN100415190 C CN 100415190C
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drainage
tube
glaucoma
aqueous
control system
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CN 200510096186
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CN1748661A (en
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孙乃学
崔丽珺
李涤尘
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西安交通大学
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Abstract

本发明涉及一种青光眼房水引流装置,由T型管和引流盘连接组成,引流盘上表面的前端设有固定孔和用于盘绕压力控制系统的沟槽,其后端为储液区,储液区的中央和周边设计有隆起的嵴,其底面有分布均匀的房水交通孔,T型管在沟槽内环绕,T型管有分布均匀的进液孔,另一端与压力控制系统相连通。 The present invention relates to a glaucoma aqueous drainage device, a T-tube drainage plate and connected to form a front end surface of the upper plate is provided with drainage holes for fixing wound pressure control system of the trench, the rear end of the reservoir zone, central and peripheral regions of the reservoir is designed with a raised ridge, which transport aqueous humor bottom surface evenly distributed holes, T-pipe around the trench, T-tube has a uniform distribution of the liquid inlet hole, and the other end of the pressure control system communicating. 本发明采用T型管及其引流盘的结构设计,压力控制系统采用流体力学原理中的哈根一伯箫叶定律。 The present invention uses T-shaped design and the drainage tube plate, the pressure control system using the law of Hagen-primary leaves flute in fluid mechanics. 配合整个ATDS的牵拉、固定,解决引流管移位、退缩、脱出等问题,整个引流盘弯曲呈球面,其底面与巩膜球面相一致,使外植体与眼球紧密贴附,减少活动度,以减轻对眼球及周围眶内组织的刺激。 ATDS with the entire drawing, the fixing solution drainage tube displacement, withdrawal, and other problems emerge, the entire drainage spherical curved disc, which is consistent with the bottom surface of the ball surface of the sclera, explants were closely attached to the eye, reduced activity, to reduce irritation to the eye and surrounding orbital tissues. 储液区周边的嵴呈间断排列,便于房水由嵴间隙向四周扩散。 Ridge region surrounding the reservoir was intermittent arrangement facilitates the diffusion of aqueous humor to the surrounding ridge gap.

Description

一种青光眼房水引流装置技术领域本发明涉及一种眼科医疗器械,具体地说是一种青光眼房水引流装置, 该装置适用于青光眼,尤其是某些难治性青光眼钓治疗。 One kind of glaucoma aqueous drainage TECHNICAL FIELD The present invention relates to an ophthalmic device, in particular a glaucoma aqueous drainage apparatus suitable for glaucoma, particularly glaucoma fishing treating certain refractory. 背景技术青光眼是一种危害性极大的常见致盲性眼病,年龄大于40岁的人群发病率为2%,在我国占致盲性眼病的第二位。 BACKGROUND Glaucoma is a great danger of common blinding eye disease, age greater than 40 years of age the incidence rate of 2%, accounting for blinding eye disease in our country second place. 对于青光眼的治疗,以难治性青光眼最为棘手。 For the treatment of glaucoma, the most difficult to refractory glaucoma. 难治性青光眼,又称为顽固性青光眼或复杂性青光眼,是指最大耐受药物治疗仍不能控制高眼压但又不适合做滤过性手术,或以前曾联合应用抗纤维化药物的滤过性手术失败的青光眼。 Refractory glaucoma, also known as refractory glaucoma or glaucoma complexity, is the maximum tolerated drug therapy can not control ocular hypertension but not suitable for filtering surgery, or had previous combination of anti-fibrosis drugs filter over the failure of glaucoma surgery. 由于其病因多样、眼部情况复杂,施行滤过性手术的成功率仅为11%〜52%。 Because of its diverse etiology, complex eye condition, the implementation of filtration surgery success rate was 11% ~52%. 手术失败的主要原因是术区成纤维细胞的增殖和细胞外间质的合成,导致组织纤维化及瘢痕形成,阻碍了房水的引流和扩散。 Surgery is the main reason for the failure of the surgical proliferation and extracellular matrix synthesis in fibroblasts, leading to fibrosis and scarring, and hinders the diffusion of aqueous humor drainage. 对于某些难治性青光眼,目前临床上推崇的治疗方法是在眼睛前房内弓I入房水引流植入物(Aqueous drainage devices, ADDs)。 For some refractory glaucoma, current treatment of clinically respected before the eye into the room I bow aqueous drainage implants (Aqueous drainage devices, ADDs). 手术适应症通常包括:l.眼部及全身血管性疾病引起的青光眼,如新生血管性青光眼;2.曾联合应用抗纤维化药物的滤过性手术失败的青光眼;3.白内障手术后无晶体眼或人工晶体植入术后的青光眼;4.手术后继发的青光眼,如角膜移植术后、 视网膜^离术后、玻璃体切割术后、硅油注入术后及过氟化碳液体应用后的青光眼等;5.复杂性眼外伤引起的青光眼及因外伤多次手术导致的青光眼; 6.多次小梁切开术失败或晚期先天性青光眼;7.葡萄膜炎继发或伴有葡萄膜炎的青光眼;8.其他复杂的继发性青光眼,如虹膜角膜内皮综合征等。 Indications for surgery generally includes: l glaucoma, ocular and systemic vascular diseases such as neovascular glaucoma; 2 was combined with antifibrotic drugs failed glaucoma filtration surgery; no crystals 3 after cataract surgery... ophthalmic or intraocular lens implantation after glaucoma surgery; 4 secondary glaucoma surgery such as keratoplasty, ^ from retinal surgery, vitrectomy, glaucoma silicone oil injection and after the application of liquid perfluorocarbon and the like; 5. glaucoma ocular trauma caused by the surgery and multiple trauma caused by glaucoma; 6. failure or multiple trabeculotomy late congenital glaucoma; 7 uveitis secondary to or associated with uveitis glaucoma; 8 other complex secondary glaucoma, as iridocorneal endothelial syndrome. 手术原理是借助植入前房的引流物建立房水引流和扩散的人工通路,将房水引流到结膜一Tenon's囊内,从而降低眼内压。 Surgery is the principle means of drainage of anterior chamber aqueous humor was established and artificial diffusion passage, the drainage of aqueous humor into the subconjunctival a Tenon's capsule, thereby reducing the intraocular pressure. 现有的房水引流植入物的结构通常由两部分构成: 一是植入前房内的引流管,负责将房水引流到与其相连的外植体处;二是外植体,为位于眼球赤道部或其后结膜一Tenon's囊内,具有一定形状和表面积的引流盘。 Conventional configuration aqueous drainage implants generally consists of two parts: First, the drainage tube implanted in the anterior chamber, responsible for drainage of aqueous humor into the explants connected thereto; Second explant, located eyeball conjunctiva equatorial portion or a Tenon's capsule, having a shape and a surface area of ​​the drainage disc. 外植体周围将形成一潜在的房水蓄积池,即后部滤过泡。 Explants formed around a water impoundment room potential, i.e., the rear bleb. 根据是否具有限制房水流动的压力敏感性阀单元可将现代房水引流植入物分为非限制性房水引流植入物和限制性房水引流植入物。 According to whether a pressure sensitive valve unit limits the flow of aqueous humor modern aqueous drainage implants may be divided into a non-limiting aqueous drainage implants and restriction aqueous drainage implants. 非限制性房水引流植入物无压力敏感性阀单元设计,如国外的Molteno、Schocket、Baerveldt 浸钡植入物和国产HAD植入物等,这种植入物的引流管直接与后部的外植体相连;而限制性房水引流植入物在引流管与外植体之间具有活门、弹性膜或引流阻抗膜等设计,限制房水在一定压力下单向性外流,使眼内压具有相对的可控制性,因此又被称为青光眼减压阀、青光眼眼压调节器或房水分流泵等。 Non-limiting aqueous humor drainage implant design without a pressure sensitive valve means, such as foreign Molteno, Schocket, Baerveldt implant and domestic immersion barium HAD implants, drainage tubes such implants directly with the rear explants connected; limiting the aqueous drainage implants having a shutter, elastic membrane or film drainage impedance between the draft tube design and the explants, limiting aqueous humor outflow unidirectional under pressure, so that the intraocular having opposite pressure controllability, it is also known AGV, glaucoma or ocular aqueous humor shunt regulator such as a pump. 目前国外常用的限制性房水引流植入物有Ahmed、 Krupin、 Joseph 植入物、White泵分流装置和OpitMed青光眼压力调节器等。 Commonly used in foreign countries, limiting aqueous drainage implants have Ahmed, Krupin, Joseph implant, White shunt means and the pump pressure regulator OpitMed glaucoma and the like. 然而,房水引流植入手术的并发症可多达20余种,以往常用的房水引流装置均为单管引流,临床常见的主要有:前房出血,引流管触及眼内组织, 引流管移位、退縮、脱出,术后低眼压、浅前房或无前房,术后引流管被前房内的血液、炎症碎屑、纤维膜、虹膜、玻璃体等堵塞造成滤过失败,脉络膜渗漏、脱离、出血以及眼压再次升高等。 However, the aqueous humor drainage implant surgery complications can be as many as 20 kinds of commonly used conventional aqueous drainage devices are single-tube drainage, clinical common are: hyphema, internal drainage tube touch the eye tissue, drainage tube shift, back, prolapse, postoperative hypotony, no shallow anterior chamber or anterior chamber, anterior chamber after the drainage tube is blood, inflammatory debris, fiber membrane, iris, vitreous filtration failure caused by clogging, etc., choroid leakage, detachment, hemorrhage, and elevated intraocular pressure and so on again. 虽然限制性房水引流植入物相对于非限制性房水引流植入物能更平稳地降低和维持眼内压,但常用的限制性房水引流植入物仍存在^些结构上的缺陷。 While limiting aqueous drainage implant relative to the non-limiting aqueous drainage implants can sustain more smoothly and reduce intraocular pressure, but the common restriction aqueous drainage implants are still some structural defects ^ . '发明内容鉴于难治性青光眼的临床特点及现有的房水引流物植入手术中存在的诸多并发症,本发明的目的在于,吸收、借鉴国外临床常用房水引流植入装置的先进设计理念,以流体力学原理为基础,提供一种青光眼房水引流装置,或禾尔为人工小梁房水引流系统(artificial trabeculum drainage system, ATDS)。 'In view of the clinical features and the conventional refractory glaucoma aqueous drainage implants of many complications of the surgery exists, object of the present invention is to absorb and learn foreign clinically used implantable device aqueous humor advanced design philosophy, based on the principle of fluid mechanics to provide a glaucoma aqueous drainage device, or Wo Seoul artificial trabecular aqueous drainage systems (artificial trabeculum drainage system, ATDS). 为了实现上述任务,本发明采取如下技术解决方案:一种青光眼房水引流装置,由T形管和引流盘连接组成,其特征在于, 所述的T形管的一端有分布均匀的进液孔,另一端与压力控制系统相连通。 To achieve the above object, the invention adopts the following technical solutions: one kind of glaucoma aqueous drainage device, a drainage tube and a T-shaped connector plate, and is characterized in that the end of the T-shaped pipe has a uniform distribution of the liquid inlet hole , and the other end communicating with the pressure control system. 所述的引流盘前半部分设计有沟槽,T形管的直管延续部分在沟槽内环绕; 后半部分为储液区,底面有分布均匀的房水交通孔,储液区的中央和周边设计有隆起的嵴。 The front half of the disc drainage groove design, the pipe continuation of the straight-tube T around the trench; the latter half region of the reservoir, the hole transport aqueous bottom surface evenly distributed, and the central reservoir region design surrounding a raised ridge. 引流盘上表面的前端设有固定孔。 The front end surface of the fixing hole is provided on the drainage plate. 本发明的其他一些特点是:所述的T形管分为进液管和引流管两部分, 引流管与进液管的外弧中央部相连通。 Other features of the invention are: the T-shaped pipe section is divided into two inlet tubes and draft tube, the draft tube inlet tube and outside the arc central portion communicating. 所述的进液管两端开口圆滑,具有弹性,可弯曲成与前房角弧度相适应的弧形管,曲率半径约6mm左右。 The inlet ends of the tube opening smooth, elastic, bendable into a curved tube adapted to the curvature of the anterior chamber angle, the radius of curvature of about about 6mm. 所述的进液管与眼睛内房水接触的管壁面上有分布均匀进液孔。 The wall surface of the inlet tube in contact with the eye of aqueous humor has a uniform distribution of liquid inlet hole. 所述的引流盘为梨形、圆形、扇形、方形、梯形的盘状结构,底面弯曲呈球面,与人体眼睛的巩膜表面曲率相符。 The drainage disc is pear-shaped, circular, fan-shaped, square, trapezoidal structure discoid, spherical curved bottom surface, consistent with the human eye the curvature of the scleral surface. 所述的压力控制系统依据流体力学原理设计,由盘绕在沟槽内具有一定绕行方式的引流管构成。 The pressure control system based on the principles of fluid mechanics design, a coiled configuration within the groove having a certain way bypass drainage tube. 压力控制系统的两端分别与T形管和储液区相通。 Both ends of the pressure control system are the T-tube and the reservoir in communication area. 所述的T形管由医用硅橡胶制成。 The T-shaped tube made of medical grade silicone rubber. 所述的引流盘由光固化树脂制成。 The drainage disc by a photo-curable resin. 本发明采用不同于以往单管引流的T形管设计,配合整个ATDS的牵拉、固定,解决引流管移位、退縮、脱出等问题;进液管贴紧房角,并与虹膜平行,在眼球运动过程中可防止管道触及眼内组织而导致相应的并发症; 进液管两端开口,其上还有多个进液孔均匀分布,从很大程度上减少了引流管阻塞的发生率。 The present invention is different from the T-tube design uses a conventional single-tube drainage, with pulling the entire ATDS fixed solve drainage tube displacement, withdrawal, and other issues prolapse; snapping corner inlet tube, and parallel to the iris, in eye movement during pipe prevents intraocular tissue complications result in a corresponding hit; liquid inlet tube opening at both ends, that there are more evenly distributed inlet holes, to a large extent reduce the incidence of blocked drainage tube . 引流盘的底面设计为与巩膜球面相一致的弯曲球面,使外植体与眼球紧密贴附,减轻对眼球及周围眶组织的刺激。 The bottom surface of the drainage plate is designed to be a curved spherical surface of the ball and sclera consistent, explants were closely attached to the eye, the eye and reduce irritation of the surrounding orbital tissue. 储液区中央嵴可以5支撑Tenon's囊,扩大滤过区容积,周边嵴呈间断排列,便于房水由嵴间隙向四周扩散。 Central reservoir region may support ridge 5 Tenon's capsule, filtered through a region expansion volume was intermittent peripheral ridge arranged to facilitate the diffusion of aqueous humor to the surrounding ridge gap. 压力控制系统根据流体力学原理而设计,能科学、平稳、有效地控制眼压。 Pressure control system designed in accordance with principles of fluid mechanics, energy science, smooth, effective control of intraocular pressure. 附图说明图1、2、3是人工小梁房水引流系统的结构示意图;其中图1是平面图, 图2、图3是不同角度放置的立体图;图4、 5分别是T形管植入眼球后和未植入时的结构示意图; 图6是人工小梁房水引流系统植入眼球的位置示意图。 BRIEF DESCRIPTION OF FIG. 2, 3 is a schematic view of doing trabecular aqueous drainage system; Figure 1 is a plan view, FIG. 2, FIG. 3 is a perspective view of a different placement angles; FIG. 4, 5 are T-piece implant retrobulbar and non-implanted schematic structural view; FIG. 6 is a schematic view of the position of the artificial aqueous humor drainage system of trabecular implanting into the eyeball. 以下结合附图对人工小梁房水引流系统的工作原理和结构特点作进一步的详细说明。 Working in conjunction with the following drawings principle and structure characteristics of artificial trabecular aqueous drainage system will be further described in detail. 具体实施方式如图1〜3所示,人工小梁房水引流系统由前端植入眼前房的T形管1 和与之相连、位于眼球赤道部巩膜表面的引流盘2构成。 DETAILED DESCRIPTION FIG. 1 ~ 3, the drainage system of artificial aqueous humor by the trabecular distal anterior chamber implant 1 and the T-shaped pipe connected thereto, is located in the equatorial surface of the sclera of the eye drainage disc portion 2 is formed. T形管1又分为进液管(横管)9和引流管(直管)IO两部分。 T-tube 1 is divided into the liquid inlet pipe (horizontal tube) and the drainage tube 9 (straight pipe) the IO two parts. 引流盘2的前半部分设有盘绕于沟槽4中的压力控制系统3;前端的前缘两侧各有一个半圆形固定翼,其上有一个固定孔5。 Drainage plate 2 is provided with a front half portion in the groove 4 of the coiled pressure control system 3; both sides of the front end of the leading edge of each wing a semicircle, which has a fixing hole 5. 引流盘2的后半部分为储液区6,其中央和周边设计有隆起的嵴8,周边嵴呈间断排列,中央嵴与周边嵴之间设计有分布均匀的房水交通孔7。 2 is the second half of the disc drainage reservoir zone 6, which is designed with a raised central and peripheral ridges 8, arranged in the peripheral ridge was intermittent, designed with uniformly distributed traffic aqueous ridge between the central hole 7 and the peripheral ridge. 如图6所示,房水经过植入前房的进液管9、引流管10及压力控制系统3,被引流到储液区6,在此向引流盘2周围扩散,之后逐渐被周围结缔组织所吸收。 6, through the aqueous humor of the anterior chamber implants inlet tube 9, the drainage tube 10 and the pressure control system 3 is drained into the reservoir zone 6, spread around the disc 2 in this drainage, then gradually by the surrounding connective organization absorbed. lT形管的结构与功能特点如图4、 5所示,它们分别是T形管植入眼球后和未植入时的结构示意图;T形管1由水平进液管9和与之垂直的引流管IO两部分组成。 Structural and functional characteristics lT-tubes 4, 5, respectively, and is a schematic view when not implanted after T-tube implanted in the eye; T-tube 1 comprises a horizontal inlet pipe 9 and perpendicular thereto IO drainage tube composed of two parts. 进液管9真有弹性,两端开口圆滑,因引流管直管向后方的拉力,可弯曲成与前房角弧度相适应的弧形管,曲率半径约为6mm左右。 Inlet tube 9 really flexible, open at both ends rounded, straight tube drainage tube due to tension the rear, may be bent in an arc tube and adapted to the curvature of the anterior chamber angle, the radius of curvature is about 6mm. 进液管9的的外弧面与引流管10相连,除该连接面及与房角组织相贴面之外,进液管管壁上分布有均匀的进液孔(微孔)11。 Is connected to the outer arc of the inlet tube 9 and the draft tube 10, and the connecting surface other than the corner with the tissues of veneer, the inlet pipe wall has a uniform distribution of liquid inlet hole (micropore) 11. T形管的进液管9穿过角膜缘手术切口,嵌于前房角,弧平面与虹膜平行;引流管IO在眼球巩膜表面沿子午线方向走行至赤道部。 T-shaped inlet tube passes through the tube 9 limbal incision, embedded in the anterior chamber angle, iris plane parallel arcs; drainage tube IO walk along the scleral surface of the eye in the meridian direction to the equator line. 由于前房内有比较高的压力,房水将在压力差的作用下,通过进液管9上的微孔11进'入引流管,并流向压力控制系统3及储液池6。 Since the anterior chamber has a relatively high pressure, the aqueous humor at a pressure difference, through the inlet tube 911 into the micropores' into the draft tube, and the flow of the pressure control system 3 and the fluid reservoir 6. 本发明的T形管具有以下优点:(1) 柔软而有弹性的进液管可配合角巩缘弧度大小而贴紧房角部位, 配合整个ATDS的牵拉、固定,解决引流管移位、退縮、脱出等问题;(2) 进液管贴紧房角,并与虹膜平行,在眼球运动过程中可防止管道触及眼内组织而导致相应的并发症;(3) 进液管两端开口,其上还有多个进液孔均匀分布,从很大程度上减少了引流管阻塞的发生率。 The T-tube according to the present invention has the following advantages: (1) soft and flexible inlet tube can be used with the curvature of the limbus size snapping corner portion, with the entire drawing ATDS fixed solve drainage tube displacement, withdrawal, and other issues prolapse; (2) the liquid inlet pipe snapping corner, and in parallel with an iris, prevents the pipe touches the intraocular tissue during eye movement caused by respective complications; ends (3) into the liquid pipe opening , on which there are a plurality of uniformly distributed inlet holes, to a large extent reduce the incidence of the drainage tube is blocked. 2.引流盘的结构设计与功能引流盘2为梨形、圆形、扇形、方形、梯形等形状的盘状结构。 2. Drainage disc structure design and function of the drainage plate 2 is pear-shaped, circular, fan-shaped, square, trapezoidal shape or the like disc-shaped structure. 引流盘2的前半部设有沟槽4,用于支撑Tenon's囊和盘绕压力控制系统3,保护压力控制系统不被囊壁压迫;沟槽4的每个侧面设计成凹陷的圆弧,用来嵌和、 固定引流系统3的管道。 Drainage tray 2 front half 4 is provided with a groove for supporting the Tenon's capsule, and wound pressure control system 3, a pressure control system protection wall is not oppressed; arcuate groove on each side of the recess 4 is designed for pipes embedded and fixed drainage system 3. 引流盘的前缘有两个半圆形固定翼,其上有固定孔5,便于将外植体固定于赤道部浅层巩膜上。 The leading edge of the drainage plate has two semi-circular wing, on which the fixing hole 5, to facilitate the explants were fixed to the equatorial portion episcleritis. 整个引流盘2弯曲呈球面(曲率半径12mm),其底面与认膜球面相一致,使外植体与眼球紧密贴附,'减少活动度,以减轻对眼球及周围眶内组织的刺激。 Bending the entire spherical drainage plate 2 (the radius of curvature of 12mm), which recognize membrane bottom surface of the ball surface uniform, explants were closely attached to the eyeball, 'reduced activity, to reduce irritation to the eye and surrounding orbital tissue. 储液区6占据引流盘2的后半部,为引流房水的出口位置。 Drainage reservoir zone 6 occupies the rear half of the disc 2, for the drainage of aqueous humor outlet position. 储液区6 中央和周边有隆起的嵴8,用来支撑四周的Tenon's囊,使房水与Tenon's 囊在引流盘大小、形状不变的情况下具有较大的接触面积,有利于房水的扩散与吸收。 And a reservoir zone 6 surrounding a raised central ridge 8 for supporting around the Tenon's capsule, aqueous humor and Tenon's capsule having a large contact area in the case of drainage disc size, same shape, conducive to aqueous humor diffusion and absorption. 周边的嵴呈间断排列,也是利于房水由嵴间隙向四周扩散。 The peripheral ridge was intermittent arrangement is conducive to the diffusion of aqueous humor to the surrounding ridge gap. 储液区的底部设计有贯通引流盘的房水交通孔7,早期可使引流盘前后巩膜表面的房水贯通,增加吸收;后期如果纤维组织长入,可固定外植体,减少眼部不适感。 Design of the bottom of the reservoir region has a through-hole transport aqueous humor drainage disc 7, scleral surface early allows aqueous humor drainage through the front and rear plates, to increase the absorption; later if fibrous tissue ingrowth, explants may be fixed, to reduce eye discomfort sense. 3.压力控制系统的结构如图1所示,压力控制系统由嵌合于引流盘2前部沟槽4内具有一定绕行方式的引流管构成,其出口位于储液区6的前壁。 3. The structure of the pressure control system shown in Figure 1, the pressure control system is fitted to the drain pan front portion of the draft tube 2 having a certain configuration of the bypass mode within the trench 4, an outlet 6 in the anterior wall of the reservoir region. 引流管是前方的T形管的延续。 Drainage tube is a continuation of the front of the T-tube. 设计压力控制系统的基本理念是流体力学原理中的哈根一伯箫叶定律。 The basic idea of ​​the design pressure control system is a primary law of Hagen flute leaf principles of fluid mechanics in. 即流体在腔道流动的过程中,由于流体与管壁以及流体自身摩擦、变径、弯头处等的能量减损,造成沿程的能量或压强损失,从而在管道入口和出口端形成能量差或压强差。 I.e., the fluid passages of the process chamber, since the energy of the fluid and the tube wall itself and a fluid friction, adjustable, elbow and other impairments cause energy or pressure loss in the process, thereby forming the energy difference between the duct inlet and outlet ends or the pressure difference. 因此,按照固定长度和方向,将硅胶管进行盘绕,借助以上能量减损、局部阻力等原理,便可在硅胶管的进液端和出液端之间形成固定的压强差。 Thus, a fixed length and direction of the coiled silica tube, by means of the above energy impairment, such as the principle of local resistance, can form a fixed pressure differential between the inlet end of the silicone tube and the liquid side. 这一固定的压强差值是控制液体流动的关键。 This pressure difference is the key to the fixed control of the liquid flow. 只有当进液端的压强高于此值时才能引起管道内液体的流动;相反,若进液端的压强低于此值则不引起流动,只有等待进液端的压强逐渐增加,并超过该压强差值时,才引起液体的流动。 In order to induce a flow within the liquid conduit only when the pressure of the liquid inlet end is higher than this value; the contrary, if the inlet-side pressure is below this value is not caused to flow, only to wait for the inlet end of the pressure gradually increases, and exceeds the pressure difference when, due to the flow of liquid only. 这就是压力控制系统控制房水流动的机制。 This is the mechanism of aqueous humor flowing pressure control system. 以下是发明人给出的具体实例,需要说明的是,本发明不限于这些实施例。 The following specific examples are given by the inventors, it is noted that the present invention is not limited to these embodiments. 实施例1:如图1所示,人工小梁房水引流系统由T形管1和与之相连的引流盘2构成。 Example 1: As shown, the drainage of aqueous humor artificial trabecular system consists of a T-shaped drainage tube 1 and the disc 21 connected thereto. T形管1由内径0.3mm、外径0.6mm的医用硅橡胶管'制成。 T-tube 1 having an inner diameter 0.3mm, an outer diameter of 0.6mm medical grade silicon rubber tube 'is made. 进液管9长约8mm、弯曲后的曲率^径约6mm,两端开口圆滑,管壁与房水接触面,每隔0.5mm有一直径为0.25mm的进液孔11,外弧中间部与长约13mm的引流管10相通。 Inlet tube 9 about 8mm, the curvature of the curved ^ diameter of about 6mm, smooth open at both ends, the wall surface in contact with aqueous humor, there is every 0.5mm hole having a diameter of 0.25mm inlet 11, an intermediate portion and an outer arc the drainage tube 10 is about 13mm in communication. 引流盘2为长16 mm宽13mm的梨形盘状结构,高1.7mm,弯曲呈球面(曲率半径12mm),表面积192.2mm2。 Drainage plate 2 is 16 mm wide 13mm long pear-shaped disc-shaped structure, high 1.7mm, spherical bending (radius of curvature of 12mm), the surface area of ​​192.2mm2. 此ATDS的引流盘2以光固化树脂制成。 This ATDS drainage disc 2 to the photo-curable resin. 压力控制系统3嵌合于引流盘28前部高约0.9mm沟槽4中。 The pressure control system 3 is fitted to the front portion 28 of high drainage disc 4 about 0.9mm trench. 如图1所示,此压力控制系统构成的流道长约38.5mm,具有8个弯头,弯头角度有3个大于直角、2个小于直角,3个等于直角。 As shown, the flow path of the pressure control system including about 1 38.5mm, having eight bends, elbows have three angle greater than a right angle, two small right angle, a right angle is equal to three. 实施例2:经过流体动力学测压试验,压力控制系统在空气中的开放压约为7.9〜9.7mmHg (U84士0.119 kPa),关闭压约为:5.0〜7.4 mmHg C0.822士0.159 kPa);在平衡盐溶液中的开放压约为7.9〜9.3 mmHg (1.152±0.094 kPa),关闭压约为:4.9〜6.0 mmHg (0.791 ±0.143 kPa); 当平衡盐溶液以2.5//1 / min的速度流动时,可产生约7.9〜9.0 mmHg U.124士0.075kPa)的压强差。 Example 2: After hydrodynamic load test, the pressure control system opening pressure in the air about 7.9~9.7mmHg (U84 disabilities 0.119 kPa), closing pressure of about: 5.0~7.4 mmHg C0.822 persons 0.159 kPa) ; open pressure balanced salt solution is about 7.9~9.3 mmHg (1.152 ± 0.094 kPa), closing pressure of about: 4.9~6.0 mmHg (0.791 ± 0.143 kPa); balanced salt solution when 2.5 // 1 / min of when the flow velocity, produce about 7.9~9.0 mmHg U.124 persons 0.075kPa) pressure differential. 所以,申请人认为压力控制系统具有单向压力敏感性阀门的作用。 Therefore, Applicants believe that the one-way pressure control system having a pressure-sensitive valve effect. 能有效地将系统两端的压强差控制在要求范围。 Effective to control the pressure difference across the system in the required range. 实施例3:动物实验对15只健康中国长耳白兔施行人工小梁房水引流装置植入术,术后观察眼压和眼前节反应情况。 Example 3: Animal experiments on 15 healthy rabbits were China trabecular on the artificial aqueous humor drainage device implantation, postoperative intraocular pressure and anterior segment reactions. 近期观察结果显示ATDS植入眼的术前眼压为15.380土1.005mmHg,术后7日内平稳下降,术后14日降至最低: 9.080士0.675mmHg,之后眼压逐渐回升,术后28日升至10.470±1.656mmHg, 但仍明显低于术前眼压,差异具有显著性(PO.Ol),术后14、 21、 28天眼压无明显波动。 Recent observations show ATDS implanted in the eye of preoperative IOP was 15.380 soil 1.005mmHg, 7 days after the steady decline after the 14th minimize: 9.080 disabilities 0.675mmHg, after the intraocular pressure to rise gradually after 28 liters to 10.470 ± 1.656mmHg, but still significantly lower than the preoperative intraocular pressure, the difference was significant (PO.Ol), 14, 21, 28 days after no significant fluctuations in intraocular pressure. 少数眼在术后早期出现轻度眼前节反应,如前房闪辉、纤维素渗出,均在术后2〜10天内消失,未发现浅前房、晶体混浊、虹膜后粘连及虹膜表面新生血管等。 Few appeared in the early postoperative ocular anterior segment mild reactions, such as anterior chamber flare, fibrin exudate, disappeared after 2~10 days were not found shallow anterior chamber, lens opacities, posterior synechia and iris newborn blood vessels. 术后角巩缘伤口愈合良好,无引流管退縮、脱出现象。 After limbus wound healed well, no drainage tube back, out phenomenon. 1%荧光素钠眼表染色未发现伤口渗漏。 1% sodium fluorescein staining No ocular wound leakage. 综上所述,通过上述实施方式,'申请人已将本发明的人工小梁房水引流系统的构思和实施例做出了详细说明,在此基础上可作出各种变换和改进, 如材料、结构、规格尺寸、压力控制系统绕流方式等,但这些变化和改进如果没有脱离本发明的基本理念,都应在本发明的权利要求书的保护范围。 In summary, the concept and embodiments of Artificial trabecular aqueous drainage system via the above embodiment, 'the present invention, applicants have made a detailed description on the basis of various changes and modifications can be made, such material , but the scope of such changes and modifications without departing from the basic idea of ​​the invention, as claimed in the present invention should claims configuration, size, flow around the pressure control system like manner.

Claims (8)

1. 一种青光眼房水引流装置,由T形管(1)和引流盘(2)连接组成,其特征在于,所述的引流盘(2)的前半部分设计有用于盘绕压力控制系统的沟槽(4),盘体前端设有固定孔(5);后半部分为储液区(6),储液区(6)的中央和周边设计有隆起的嵴(8),其底面有分布均匀的房水交通孔(7);T形管(1)的直管延续部分在沟槽(4)内环绕,T形管(1)的横管有分布均匀的进液孔(11),直管与压力控制系统(3)相连通。 A glaucoma aqueous drainage device, a T-shaped tube (1) and the drainage plate (2) is connected, and is characterized in that the drainage plate (2) is designed according to the first part of the pressure control system for coiling groove groove (4), the front end of the tray is provided with fixing holes (5); the latter half region of the reservoir (6), a reservoir zone (6) is designed with a central and peripheral ridges (8) raised, its bottom surface distribution homogeneous aqueous transport holes (7); T-tube (1) in a straight continuation of the tube surrounding the inner groove (4), T-shaped tube (1) with a transverse distribution pipe into the liquid inlet (11), straight pipe with a pressure control system (3) in communication.
2. 如权利要求1所述的青光眼房水引流装置,其特征在于,所述的T 形管(1)分为进液管(9)和引流管(10)两部分,引流管(10)连接在进液管(9)的外弧中央。 2. glaucoma aqueous drainage device according to claim 1, characterized in that said T-shaped tube (1) into the liquid inlet pipe (9) and a drainage tube (10) in two parts, the drainage tube (10) connecting the arc center of the outer inlet tube (9).
3. 如权利要求2所述的青光眼房水引流装置,其特征在于,所述的进液管(9)具有弹性,两端开口圆滑,向上弯曲成与前房角弧度相适应的弧形管,曲率半径6mm。 3. glaucoma aqueous drainage device according to claim 2, wherein said inlet tube (9) has an elastic, open at both ends rounded, upwardly curved arcuate curvature of the anterior chamber angle tube adapted the radius of curvature 6mm.
4. 如权利要求2所述的青光眼房水引流装置,其特征在于,所述的进液管(9)与眼睛内房水接触的管壁面上有分布均匀的进液孔(11)。 4. glaucoma aqueous drainage device according to claim 2, wherein said inlet tube (9) in contact with a wall surface of the aqueous humor in the eye with a uniform distribution of the liquid inlet hole (11).
5. 如权利要求1所述的青光眼房水引流装置,其特征在于,所述的引流盘(2)为梨形、圆形、扇形、方形或梯形的盘状结构,底面弯曲呈球面, 与人眼的巩膜表面曲率相符。 5. glaucoma aqueous drainage device according to claim 1, wherein said drainage disc (2) is a disc-like structure pear-shaped, circular, fan-shaped, square or trapezoidal, spherical curved bottom surface, and It matches the curvature of the scleral surface of the eye.
6. 如权利要求1所述的青光眼房水引流装置,其特征在于,所述的压力控制系统(3)由盘绕在沟槽(4)内具有一定绕行方式的引流管构成。 6. glaucoma aqueous drainage device according to claim 1, wherein said pressure control system (3) having a draft tube configuration by way of bypass certain coiled in a groove (4).
7. 如权利要求1所述的青光眼房水引流装置,其特征在于,所述的T 形管(1)由医用硅橡胶制成。 7. glaucoma aqueous drainage device according to claim 1, characterized in that said T-shaped tube (1) made of medical grade silicone rubber.
8. 如权利要求1所述的青光眼房水引流装置,其特征在于,所述的引流盘(2)由光固化树脂制成。 8. glaucoma aqueous drainage device according to claim 1, wherein said drainage disc (2) is made of a light curing resin.
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