CN103932841B - One kind of Schlemm & apos venturi (the Schlemm) expanding stents, and combinations thereof - Google Patents

One kind of Schlemm & apos venturi (the Schlemm) expanding stents, and combinations thereof Download PDF

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CN103932841B
CN103932841B CN201410141744.5A CN201410141744A CN103932841B CN 103932841 B CN103932841 B CN 103932841B CN 201410141744 A CN201410141744 A CN 201410141744A CN 103932841 B CN103932841 B CN 103932841B
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schlemm
alloy wire
stent
apos
venturi
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CN103932841A (en
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王宁利
牟大鹏
王怀洲
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王宁利
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Priority to CN201210198446.02012.06.16 priority
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Abstract

本发明涉及一种施莱姆氏管(Schlemm)扩张支架及其组合体。 The present invention relates to a Schlemm & apos venturi (the Schlemm) expanding stents, and combinations thereof. 所述扩张支架是一个中空的圆柱面壳体,所述圆柱面是由合金丝弯曲回折形成连续的圆形曲线圈构成,所述合金丝表面有涂覆有10微米至50微米厚的涂层,所述涂层包括粘接底层和药物层。 The expandable stent is a hollow, cylindrical surface of the housing, the cylindrical surface is folded back alloy wire bent to form a continuous ring with a circular profile, to the wire surface is coated with 10 to 50 microns thick coating said coating comprises an adhesive layer and drug layer. 本发明管扩张支架能够减小支架壁对Schlemm管壁造成的损害,减小schlemm管腔再狭窄和增殖的发生率,并且具优良的柔顺性能,本发明的Schlemm管扩张支架能够将药物有效、持久地在狭窄病变部位进行释放,在减小支架壁对Schlemm管壁造成的严重损害的同时保证靶病变点局部精确给药,因此能够更有效地减小Schlemm管再狭窄的发生率,从而达到促进房水排除,降低眼压,治疗青光眼的目的。 Expandable tubular stent of the present invention can reduce the damage caused by the wall bracket wall of Schlemm, reducing proliferation and restenosis schlemm lumen of incidence, and is excellent in performance compliant, Schlemm's canal expandable stent of the present invention can be pharmaceutically effective, sustained release in the narrow lesions, severe damage to the stent while reducing the wall of Schlemm wall caused by topical ensure accurate dosing of the target lesion site, can be more effectively reduced Schlemm canal restenosis rate to achieve promote aqueous humor exclusion, reduce intraocular pressure, glaucoma therapeutic purposes.

Description

—种施莱姆氏管(SchIemm)扩张支架及其组合体 - kind of Schlemm & apos venturi (SchIemm) expanding stents, and combinations thereof

技术领域 FIELD

[0001] 本发明涉及一种眼科用支架,尤其是涉及一种用于置入眼内施莱姆氏管(Schlemm)中的施莱姆氏管(Schlemm)扩张支架及其组合体。 [0001] The present invention relates to an ophthalmic stent, particularly, to a venturi tube for insertion into the eye Neishilaimu (the Schlemm) in Schlemm & apos venturi (the Schlemm) expanding stents, and combinations thereof.

背景技术 Background technique

[0002] 青光眼是一种很严重的公众健康疾病,更具体的讲青光眼是一种视觉神经病(视神经疾病),它通常为眼内房水引流不畅,产生眼内压力升高。 [0002] Glaucoma is a very serious public health problems, more specifically speaking Glaucoma is a visual neuropathy (optic nerve disease), it is usually poor drainage of aqueous humor within the eye, resulting in elevated intraocular pressure. 眼睛内的压力升高,使视神经损伤,视野范围缩小。 Increased pressure within the eye, the optic nerve damage, visual field narrowing. 当患者存在持续的高眼压时,可导致患者失明。 When there is sustained high intraocular pressure in patients can lead to blindness.

[0003] 眼睛为空心结构,包含称为“房水”的透明流体。 [0003] The eye is a hollow structure that contains a clear fluid called "aqueous humor" is. 房水通过睫状体以大约2.5微升每分钟的速度形成于眼睛的后房中。 Aqueous humor by the ciliary body at a rate of about 2.5 microliters per minute are formed in the rear chamber of the eye. 以相当恒定速度产生的流体再从晶状体周围经过,并通过虹膜中的瞳孔开口进入眼睛的前房内。 A fairly constant fluid velocity generated around the lens and from passing through the iris and the pupil into the anterior chamber of the eye opening. 一旦到前房内,该流体通过两条不同路线排出眼睛。 Once in the anterior chamber, the fluid is discharged through two different routes eye. 在“眼色素层巩膜(uveoscleral ) ”路线中,流体在睫状体的肌纤维之间滤过。 In the "uveoscleral eye (uveoscleral)" route, the fluid filtration between muscle fibers of the ciliary body. 该路线占流出人体的房水的大约百分之十。 The route accounts for approximately ten percent of the outflow of aqueous humor of the human body. 流出人体的房水的主要通路是通过“小管”路线,该路线涉及小梁网和施莱姆氏管(Schlemm)(施莱姆氏管)。 The main body of the outflow passage of aqueous humor through the "small pipe" route, which involves the trabecular meshwork and Schlemm & apos venturi (the Schlemm) (Schlemm & apos venturi).

[0004] 小梁网和施莱姆氏管(Schlemm)位于虹膜和巩膜之间的连接处。 [0004] The trabecular meshwork and Schlemm & apos venturi (the Schlemm) at the junction between the iris and the sclera. 小梁网是环绕眼睛的外周延伸的楔形结构。 Trabecular meshwork is a wedge-shaped structure extending around the outer periphery of the eye. 它包括布置成三维筛网状结构的胶原质束,该胶原质束与称为小梁细胞的单层细胞对齐。 It comprises collagen bundles arranged in a three-dimensional mesh-like structure, which is aligned with the beam collagen monolayer of cells called trabecular cells. 小梁网的外壁与施莱姆氏管(Schlemm)的内壁重合。 The inner wall of the outer wall of the trabecular meshwork and Schlemm & apos venturi (Schlemm) coincide. Schlemm管是环绕角膜的外周延伸的管状结构。 Schlemm's canal is a tubular structure surrounding the outer periphery of the cornea extends. 在成年人中,认为施莱姆氏管(Schlemm)由中隔分成一系列独立的闭端管。 In adults, Schlemm & apos that the venturi (the Schlemm) Central compartment into a series of separate closed end tube.

[0005] 房水流体通过在小梁束之间的空间,越过施莱姆氏管(Schlemm)的内壁进入该管内,并通过从Schlemm管排出的一系列(大约25个)收集槽道而进入巩膜上静脉系统。 [0005] The aqueous humor fluid through the spaces between the trabecular beams, across the inner wall of Schlemm & apos venturi (Schlemm) enters inside the tube, and collected by a series of channels (about 25) is discharged from the Schlemm's canal into the sclera venous system. 在正常情况下,房水的产生量等于房水的流出量,眼内压力相当恒定地保持在15至21 mmHg的范围内。 Under normal circumstances, produce equal amounts of aqueous humor outflow of aqueous humor, intraocular pressure remains fairly constant in the range of 15 to 21 mmHg. 在青光眼中,通过小管流出系统的阻力异常高。 In glaucoma, the outflow pipe system through a small resistance is abnormally high.

[0006] 在原发开放角性青光眼中(该原发开放角性青光眼是最常见的青光眼形式),认为异常阻力是沿着小梁网的外部和施莱姆氏管(Schlemm)的内壁。 [0006] In primary open angle glaucoma (the primary open-angle glaucoma is the most common form of glaucoma), it is considered abnormal resistance along the inner wall of the trabecular meshwork and Schlemm & apos external venturi (the Schlemm) a. 原发开放角性青光眼占全部青光眼的大约百分之八十五。 Primary open angle glaucoma accounts for approximately eighty-five percent of all glaucoma. 其它形式的青光眼(例如角封闭青光眼和续发性青光眼)也涉及通过schle_管通路的出流减小,但是阻力增加是由于其它原因,例如机械堵塞、炎症残骸、细胞堵塞等。 Other forms of glaucoma (e.g. glaucoma and angle closure glaucoma renewal) also relates to a reducer through schle_ tube passage, but the increased resistance is due to other reasons, such as mechanical blockage, inflammatory debris, cellular blockage.

[0007] 由于增大阻力,将积累房水流体,因为房水不能足够快地排出。 [0007] Due to increased resistance, the aqueous fluid accumulation, because the aqueous humor can not be discharged fast enough. 当流体积累时,眼睛内的眼内压力(1P )升高。 When the fluid accumulation, intraocular pressure (1P) within the eye increases. 升高的1P将压缩视神经中的神经轴突,也可能影响对视神经的血管供给。 1P increased compression axons in the optic nerve, may also affect vascular supply to the optic nerve. 视神经将视觉从眼睛传送给大脑。 Optic visual transmitted from the eye to the brain. 目前可行的青光眼治疗方法只有减小眼内压力。 Currently only viable treatment for glaucoma to reduce intraocular pressure.

[0008] 青光眼的临床治疗采用逐步方式。 [0008] The clinical treatment of glaucoma stepwise manner. 药物治疗通常是第一治疗选择。 Drug therapy is usually the first treatment option. 可以为局部给药或者口服给药,这些药物的作用是减少房水产生量,或者它们用于增加流出量。 It may be topically or orally administered, effects of these drugs is to reduce the amount of aqueous humor production, or for increasing the flow amount thereof. 目前可获得的药物有很多严重的副作用,包括:充血性心脏病、呼吸急促、高血压、抑郁症、肾石、再生障碍性贫血、性功能障碍和死亡。 Currently available drugs have many serious side effects including: congestive heart disease, shortness of breath, high blood pressure, depression, kidney stones, aplastic anemia, sexual dysfunction and death. 药物的顺应性是主要问题,据估计,超过一半的青光眼病人并不遵循他们的正确时间剂量,从而引起眼内压力的波动,造成视神经损伤和视野缺损。 Drug compliance is a major problem, it is estimated that over half of glaucoma patients do not follow their correct time of dose, causing fluctuations in intraocular pressure, optic nerve damage and visual field defects.

[0009] 当用药不足以降低眼球内压力时,通常进行激光小梁成形术。 [0009] When administration is insufficient to reduce intraocular pressure, laser trabeculoplasty is usually carried out. 在激光小梁成形术中,由激光产生的热能施加在小梁网中的多个不连续点上。 In laser trabeculoplasty, a plurality of heat energy generated by the laser is applied in the trabecular meshwork of the discontinuous points. 据认为,激光能量以某种方式刺激小梁细胞的新陈代谢,并改变在小梁网中的细胞外材料。 It is believed that the laser energy somehow stimulate the metabolism of the trabecular cells, and changes the extracellular material in the trabecular meshwork. 在大约百分之八十的病人中,房水流出量增加,1P减小。 About 80 percent of the patients, the aqueous outflow increased, 1P reduced. 不过,该效果通常并不能持续较长时间,百分之五十的病人在五年内发展成高压。 However, this effect does not usually last for a long time, fifty percent of patients develop high pressure within five years. 激光手术通常并不能重复使用。 Laser surgery is usually not reused. 此外,激光小梁移植术不能有效治疗低于50岁的病人的原发开放角性青光眼,也不能有效治疗角封闭青光眼和很多续发性青光眼。 In addition, laser trabeculoplasty transplantation can not be effective in the treatment of patients below 50 years of primary open-angle glaucoma can not be effective in the treatment of glaucoma and angle closure glaucoma lot of renewal. 当激光小梁移植术并不能充分降低压力时,那么将进行过滤手术。 When grafting laser trabeculoplasty does not adequately reduce the pressure, then filtered surgery. 通过过滤手术,在巩膜和角区域形成孔。 By filtration surgery, a hole is formed in the sclera and angle region. 该孔使房水能够通过可选路线离开眼睛。 The aqueous humor to exit the hole through the eye alternative route.

[0010] 青光眼患者最通常进行处理方式是小梁切除术,该术式可以形成人为的房水流出通路。 [0010] The most glaucoma treatment is generally performed trabeculectomy, which may be formed artificially surgical aqueous humor passage. 然而小梁切除术会形成巩膜瓣的瘢痕化,使人工形成的房水流出通道关闭,从而引起眼压再次升高,特别是对于儿童和少年人。 However, trabeculectomy scarring formed scleral flap in the aqueous humor flow out of the artificially created channel is closed, causing the intraocular pressure to rise again, particularly for children and young adults. 在最初成功进行小梁切除术的眼睛中,在手术后三至五年内,百分之八十将由于滤过通道的瘢痕化而失效。 In the eyes of the first successful trabeculectomy, the three to five years after surgery, eighty percent will be due to the scarring filtration channel failure. 小梁切除术产生了使房水出眼睛表面的通路。 Trabeculectomy creates a surface of the eye aqueous humor passage. 同时,它产生了使通常生活在眼睛表面和眼睑上的细菌进入眼睛的通路。 At the same time, it produces the bacteria normally live on the surface of the eye into the eye and eyelid passage. 当发生这种情况时,可能发生称为内眼炎的内眼感染。 When this happens, the eye infection known as endophthalmitis may occur. 眼内炎通常导致永久性和较大的视力损失。 Endophthalmitis often leads to permanent vision loss and larger.

[0011] 此外,现有房水引流装置也可以形成房水流出通路来降低眼压。 [0011] Further, conventional aqueous drainage device may be formed of aqueous humor to lower intraocular pressure passage. 房水引流装置是即硅管,该硅管的一端安装在塑料(聚丙烯或其它合成物)板上。 That device is a drainage of aqueous silicon tube, one end of the silicon tube is mounted on a plastic (polypropylene or other synthetic) plate. 对于房水分流装置,在结膜中形成切口,从而露出巩膜。 For aqueous humor shunt device, an incision in the conjunctiva, exposing the sclera thereby. 塑料板缝在眼睛后部表面上,通常越过赤道线。 Plastic slab on the rear surface of the eye, usually over the equator. 全厚度的孔通常通过针而在缘处形成于眼睛内。 Full thickness hole is generally formed in the eye through the needle edge. 管子通过该孔插入眼睛内。 Tube inserted into the eye through this hole. 管子的外部由供体巩膜或心包膜覆盖。 Outside of the tube is covered by the donor sclera or pericardium. 放回结膜,并紧紧封闭切口。 Replace the conjunctiva, and the incision is closed tightly. 房水分流装置有很多并发症。 Aqueous humor shunt device has many complications. 环绕塑料板形成的疤组织的增厚壁提供了一定流出阻力,在很多眼睛中将限制眼睛压力的减小。 Around the plastic plate forming a wall thickening of scar tissue provide some resistance to the flow, in the eyes of many restrictions reduce eye pressure. 在很多眼睛中,因为流过管子的流体流并不受限制,因此形成张力减退。 In many eyes, because fluid flow through the tube is not restricted, thus forming hypotonia. 很多医师环绕管子系上可吸收的缝合线,并等待该缝合线在手术后溶解,该时间足以环绕板形成疤细胞。 Many physicians absorbable suture around the tube system, and wait for the suture to dissolve post-operatively, the plate is formed around the time enough scar cells. 某些装置包括在管子内的压敏阀,不过这些阀不能够很好地工作。 Some apparatus comprises a pressure-sensitive valve within the tube, although these valves do not work well. 手术在后眼眶中进行,很多病人在手术后形成眼肌不平衡和复视。 In the eyes after surgery, many patients eye muscle imbalance and double vision formation after surgery. 对于现有技术的房水分流装置,产生了使细菌进入眼睛内的通道,并可能产生眼内炎。 For the prior art aqueous shunt devices, the bacteria produced within the eye into the channel, and may produce endophthalmitis.

[0012] 现有的青光眼治疗装置和处理的大部分问题是因为房水从眼睛内部排出到眼睛表面。 [0012] Most of the problems existing glaucoma treatment apparatus and process because the aqueous discharge from the interior of the eye to the surface of the eye. 因此,需要更符合生理学的系统,以便增加从前房向施莱姆氏管(Schlemm)内的房水流体排出。 Therefore, more in line with the physiological system, in order to increase aqueous humor from the anterior chamber to discharge fluid within the Schlemm & apos venturi (Schlemm). 在大部分青光眼病人中,阻力问题是在施莱姆氏管(Schlemm)和前房之间。 In the majority of glaucoma patients, the resistance problem is between Schlemm & apos venturi (the Schlemm) and anterior chamber. 当schlemm管腔出现狭窄或塌陷时,会引起房水引流障碍,从而眼压升高,引起青光眼。 When schlemm luminal narrowing or collapse occurs, it will cause the aqueous humor drainage obstacles and thus increased intraocular pressure, causing glaucoma.

发明内容 SUMMARY

[0013] 本发明是针对房水引流技术而提供的一种置入眼内施莱姆氏管(Schlemm)中的施莱姆氏管(Schlemm)支架及其组合体,以便增加房水从前房向施莱姆氏管(Schlemm)的流出,用于青光眼治疗。 [0013] The present invention is directed to techniques to provide drainage of aqueous humor into a venturi Neishilaimu eye (the Schlemm) in Schlemm & apos venturi (the Schlemm) stent and combinations thereof, in order to increase aqueous humor from the anterior chamber Schlemm & apos outflow to the venturi (the Schlemm) for the treatment of glaucoma. 本发明的技术方案是:一种施莱姆氏管(Schlemm)扩张支架,所述扩张支架是圆柱面或鼓状面的中空壳体,所述壳体上设有通道,壳体的外直径为0.2MM至0.5MM,壳体长度为0.5MM至4MM,壳体的壁厚为0.04MM至0.06MM。 Aspect of the present invention is: A Schlemm & apos's (the Schlemm) expandable stent tube, said expandable stent is a hollow cylindrical or drum-shaped housing surface, said passage is provided on the housing outside of the housing to 0.5MM 0.2MM diameter, the length of the housing to 0.5MM 4MM, shell thickness is 0.04MM to 0.06MM.

[0014] 所述壳体是由金属丝经反复周向弯曲、轴向回折所形成的曲线构成圆柱面或鼓状面,所述构成圆柱面或鼓状面的曲线是由同轴的相间而置的正螺旋环和反螺旋环构成,所述正螺旋环的线性长度和所述反螺旋环的线性长度大于所述圆柱面周长且小于所述圆柱面周长的二倍,各相邻的所述正螺旋环的一端和所述反螺旋环的另一端构成一排回折齿,各相邻的所述正螺旋环的另一端和所述反螺旋环的一端构成另一排回折齿,所述一排回折齿的齿尖与所述另一排回折齿的齿尖相向,每排回折齿之间构成齿槽,其一排的回折齿和齿槽与另一排的齿槽和回折齿相互对应并相互嵌入,所述柱面形曲线的两端光滑圆钝。 [0014] The housing is folded back curve formed by a circumferential metal wires by the repeated bending, or axial cylindrical surface constituting the drum surface, the drum-shaped configuration or a curved surface is a cylindrical surface coaxial interphase and opposing positive and reverse spiral coil loop rings, spiral rings linear length of the positive and the reverse spiral linear length greater than the cylindrical surface of the ring circumference and less than twice the circumference of the cylindrical surface, each adjacent one end of the positive torus and the other end of the reversing helical ring constituting a row of teeth is folded back, the other end of each spiral loop adjacent to said positive and said reverse spiral ring constituting another end is folded back row of teeth, the row of teeth tip is folded back and the other row is folded back toward the tip of teeth, each row of teeth between the gullet folded back configuration, one of the rows of teeth and alveolar folded back and the other row and folded back cogging the teeth engage in each other and correspond to each other, both ends of the cylindrical shaped smooth rounded curve.

[0015] 所述金属丝由钛镁合金或钴铬合金制作而成,其横截面的形状是圆形、半圆形、椭圆形、半椭圆形或者矩形。 [0015] The metal wire made of titanium, cobalt-chromium alloy or a magnesium alloy from which the cross-sectional shapes are circular, semi-circular, elliptical, semi-oval or rectangular.

[0016] 所述壳体为网状结构,该网状结构,包括多个波形环状支撑结构单元,环状支撑结构单元依序左右排列,各排环状支撑结构单元对应的波峰之间相接近,各排环状支撑结构单元对应的波谷之间相远离,相接近的波峰之间通过杆件连接。 [0016] The casing is a mesh structure, the mesh structure comprising a plurality of unit waveforms annular support structure, the support structure annular units arranged sequentially around, with the annular support structure between the rows corresponding peaks unit close, remote from the support ring between the rows of structural units corresponding to the valley between the peaks connected by close lever.

[0017] —种Schlemm管扩张支架,所述扩张支架是一个圆柱面中空壳体,所述圆柱面是由一根合金丝圆弧弯曲360度后然后再回折圆弧弯曲360度形成连续的圆形曲线圈构成,所述合金丝至少有一端是直径大于合金丝直径的膨大末端,所述合金丝表面有涂覆有10微米至50微米厚的涂层,所述涂层包括粘接底层和药物层,所述药物层是丝裂霉素、肝素混、雷帕霉素、紫杉醇、聚乳酸聚乙醇酸共聚物、聚碳酸酯、磷酸胆碱、乙烯基吡咯烷酮共聚物、含氟聚合物、苯乙烯-异丁烯-苯乙烯、聚乙烯乙烯醋酸中的一种。 [0017] - the latter Schlemm's canal expandable stent, the expansion of the stent is a surface of the hollow cylindrical housing, said cylindrical surface is an arcuate alloy wire bent 360 degrees and then return to arcuate bent off to form a continuous 360 degree ring with a circular curve, at least one end to the wire end is enlarged diameter larger than the diameter of the alloy wire, said alloy wire has a surface coated with 10 to 50 microns thick coating, the coating comprises an adhesive bottom layer and the drug layer, the drug layer is mitomycin, mixed with heparin, rapamycin, paclitaxel, polylactic polyglycolic acid copolymers, polycarbonates, phosphorylcholine, vinyl pyrrolidone copolymers, fluoropolymers , styrene - isobutylene - styrene, polyethylene vinyl acetate in one kind.

[0018] 所述粘接底层是将合金丝通过在含有粘接剂的溶液中浸泡、烘干粘附着在合金丝表面,所述粘接底层的厚度是涂层厚度的五分之一至三分之一,所述药物层是通过超声波雾化的方式涂覆在粘接底层之上。 [0018] The wire bonding underlayer is an alloy by immersion in a solution containing an adhesive agent, the adhesion to the drying surface of the alloy wire, the thickness of the bottom layer of the adhesive coating thickness is one-fifth to third, the drug layer is applied by ultrasonic atomization manner on the adhesive layer.

[0019] 所述圆柱面分布的合金丝圈与合金丝圈的间距是20微米至50微米。 Spacing alloy wire ring and the wire ring of the distribution cylindrical surface [0019] 20 to 50 microns.

[0020] 所述合金丝是钛镁合金丝或钴铬合金丝。 [0020] The magnesium alloy wire is a titanium alloy wire or a cobalt-chrome alloy wire.

[0021] —种施莱姆氏管(Schlemm)扩张支架组合体,包括一个圆柱面中空壳体支架和一个支架推进体,所述圆柱面是由一根合金丝圆弧弯曲360度后然后再回折圆弧弯曲360度形成连续的圆形曲线圈构成,所述合金丝至少有一端是直径大于合金丝直径的膨大末端,所述支架推进体托住圆柱面中空壳体支架。 [0021] - the latter Schlemm & apos venturi (the Schlemm) expanding stent assembly, the stent comprising a hollow housing and a bracket body advancing a cylindrical surface, said cylindrical surface is an arcuate alloy wire is then bent 360 degrees return to 360 degrees off the arc bent to form a continuous ring with a circular curve, at least one end of said alloy wire has a diameter greater than a diameter of the enlarged end of the alloy wire, advancing the stent hold the body surface of the hollow cylindrical housing bracket.

[0022] 所述支架推进体是一个圆柱体,圆柱体的一端是锥形头,圆柱体的另一端设有突起的挡环,挡环的直径大于圆柱面中空壳体支架直径20微米,在挡环的外端面上设有连接绳线的凸起,圆柱面中空壳体套入圆柱体直至顶到挡环形成支架组合体。 [0022] The stent pusher member is a cylinder, the head end of the cylinder is tapered, the other end of the cylindrical body is provided with a projecting retaining ring, the retaining ring diameter is greater than the diameter of the cylindrical surface of the hollow shell carrier 20 microns, en strings in the outer end face of the retaining ring projection, the cylindrical surface of the hollow cylinder until the top housing sleeve to form the stent retaining ring assembly.

[0023] 所述支架推进体是一个圆柱套管,圆柱套管的一端封闭,在封闭端面上设有连接绳线的凸起,圆柱面中空壳体插入圆柱套管形成支架组合体。 [0023] The stent pusher member is a cylindrical sleeve, the sleeve cylinder closed end, the closed end face is provided with a projection connected to the strings, the cylindrical surface of the hollow cylindrical sleeves forming the stent is inserted into the housing assembly.

[0024] 本发明与现有技术相比具有如下有益效果: [0024] The present invention and the prior art has the following advantages compared to:

[0025] 本发明的Schlemm管扩张支架能够减小支架壁对Schlemm管壁造成的严重损害,减小再狭窄和增殖的发生率,并且具有较小的预装直径和更优良的柔顺性能,能通过严重狭窄Schlemm管区域并且能到达Schlemm管的远端。 [0025] Schlemm canal expandable stent of the present invention can reduce the severe damage caused by the wall bracket wall of Schlemm, reducing the incidence of restenosis, and proliferation, and has a smaller diameter pre-compliant and better performance, through Schlemm's canal stenosis region and can reach the distal end of the canal of Schlemm. 另外,本发明的Schlemm管扩张支架能够将药物有效、持久地在狭窄病变部位进行释放,在减小支架壁对Schlemm管壁造成的严重损害的同时保证靶病变点局部精确给药,因此能够更有效地减小Schlemm管再狭窄的发生率,从而达到促进房水排除,降低眼压,治疗青光眼的目的。 Further, expansion of the stent tube Schlemm the present invention can be pharmaceutically effective and lasting stenotic lesion to be released at the site, while reducing severe damage to the wall bracket wall of Schlemm caused by topical ensure accurate dosing of the target lesion site, and therefore can be more Schlemm canal object effectively reduced the incidence of restenosis, so as to achieve the promotion of aqueous exclude, reduce intraocular pressure, treating glaucoma.

附图说明 BRIEF DESCRIPTION

[0026] 下面结合附图和本发明的实施例作进一步详细说明: [0026] conjunction with the accompanying drawings and the following embodiments of the present invention are described in further detail:

[0027] 图1是本发明实施例1的结构示意图; [0027] FIG. 1 is a schematic structural diagram of an embodiment of the present invention;

[0028] 图2是本发明实施例2的结构示意图; [0028] FIG. 2 is a schematic structural diagram of embodiment 2 of the present invention;

[0029] 图3是图2的展开图; [0029] FIG. 3 is a developed view of FIG. 2;

[0030] 图4是本发明实施例3的结构示意图; [0030] FIG. 4 is a schematic structural diagram of embodiment 3 of the present invention;

[0031] 图5是本发明实施例4的分解结构示意图; [0031] FIG. 5 is an exploded schematic view of a configuration example 4 of the embodiment of the present invention;

[0032] 图6是本发明实施例4的组合结构示意图; [0032] FIG. 6 is a diagram showing a configuration example 4 of the embodiment compositions of the present invention;

[0033] 图7是本发明实施例5的分解结构示意图; [0033] FIG. 7 is an exploded schematic view of Example 5 of the embodiment of the present invention;

[0034] 图8是本发明实施例5的组合结构示意图; [0034] FIG. 8 is a schematic structural diagram of a combination of the embodiment 5 of the present invention;

[0035] 图9是弹性微导管示意图; [0035] FIG. 9 is a schematic view of an elastic microcatheter;

[0036] 图10是操作本发明施莱姆氏管(Schlemm)扩张支架的示意图。 [0036] FIG. 10 is a schematic diagram of the operation of the present expansion of the stent Mingshilaimu venturi (Schlemm).

具体实施方式 Detailed ways

[0037] 实施例1 ; [0037] Example 1;

[0038] 如图1所示,一种施莱姆氏管(Schlemm)扩张支架,所述扩张支架是圆柱面的中空壳体I,所述壳体上设有通道2,壳体的外直径为0.2MM至0.5MM,壳体长度为0.5MM至4MM,壳体的辟厚为0.04MM至0.06MM,所述壳体也可以是鼓状面。 [0038] 1 A Schlemm & apos's (the Schlemm) expandable tube stent, expandable stent is a cylindrical surface of said hollow casing I, channel 2 is provided with the upper housing, the outer housing to 0.5MM 0.2MM diameter, the length of the housing to 0.5MM 4MM, a thickness of the housing provision is 0.04MM to 0.06MM, the housing may be a drum-shaped surface.

[0039] 所述壳体是由金属丝经反复周向弯曲、轴向回折所形成的曲线构成圆柱面或鼓状面,所述构成圆柱面或鼓状面的曲线是由同轴的相间而置的正螺旋环3和反螺旋环4构成,所述正螺旋环的线性长度和所述反螺旋环的线性长度大于所述圆柱面周长且小于所述圆柱面周长的二倍,各相邻的所述正螺旋环的一端和所述反螺旋环的另一端构成一排回折齿5,各相邻的所述正螺旋环的另一端和所述反螺旋环的一端构成另一排回折齿6,所述一排回折齿的齿尖与所述另一排回折齿的齿尖相向,每排回折齿之间构成齿槽,其一排的回折齿和齿槽与另一排的齿槽和回折齿相互对应并相互嵌入,所述柱面形曲线的两端光滑圆钝。 [0039] The housing is folded back curve formed by a circumferential metal wires by the repeated bending, or axial cylindrical surface constituting the drum surface, the drum-shaped configuration or a curved surface is a cylindrical surface coaxial interphase and opposing positive spiral ring 3 and ring 4 reverse spiral configuration, the length of the linear and positive helix loop helix linear length of the counter-ring is greater than the circumference of the cylindrical surface and less than twice the circumference of the cylindrical surface, each the positive end of the adjacent spiral loop and the other end of the reversing helical ring constituting a row of teeth 5 is folded back, and another end of each of said counter adjacent said positive helix loop helix ring constituting the other row 6 folded back teeth, the row of teeth tip is folded back and the other row is folded back toward the tip of teeth, each row of teeth between the gullet folded back configuration, one of the rows of teeth and is folded back and the other row of the alveolar and folding back the corresponding tooth gullet and mutually fitted, at both ends of said cylindrical smooth rounded curve.

[0040] 所述圆柱面形或鼓状面形曲线的两端向设有圆柱面或鼓状面内弯折成光滑圆钝的小圆环7。 [0040] The ends of the cylindrical surface shape or curved surface shape of the drum to the inner cylindrical surface is provided with bent into a drum-shaped surface is smooth or rounded small ring 7.

[0041] 所述回折齿的齿尖为圆弧形并向圆柱面或鼓状面内弯曲。 [0041] The folded back teeth tips and the inner cylindrical surface of a drum-shaped or arc-shaped curvature.

[0042] 所述金属丝由钛镁合金或钴铬合金制作而成,其横截面的形状是圆形、半圆形、椭圆形、半椭圆形或者矩形。 [0042] The metal wire made of titanium, cobalt-chromium alloy or a magnesium alloy from which the cross-sectional shapes are circular, semi-circular, elliptical, semi-oval or rectangular.

[0043] 实施例2 ; [0043] Example 2;

[0044] 参见图2和图3,本发明另一种结构的所述壳体为网状结构8,该网状结构,包括多个波形环状支撑结构单元9,环状支撑结构单元依序左右排列,各排环状支撑结构单元对应的波峰之间相接近,各排环状支撑结构单元对应的波谷之间相远离,相接近的波峰之间通过杆件10连接,所述杆件的形状为C形或者W形。 [0044] Referring to FIGS. 2 and 3, the housing of another structure of the present invention is a 8 mesh structure, the mesh structure comprising a plurality of ring-shaped support structure unit waveform 9, ring-shaped support structure means sequentially about arranged close to the support ring between the rows of peaks corresponding to the structural unit, remote from the annular support structure between the rows corresponding to the trough unit, connected by a rod 10 between the peaks close to the rod member form C-shaped or W-shaped.

[0045] 实施例1和实施例2中,所述壳体涂覆有由组织生长抑制剂组成的高分子纳米涂层O Example 1 and Example [0045] In Embodiment 2, the housing is coated with a tissue growth inhibitor consisting of a polymer nanocoating O

[0046] 实施例3 ; [0046] Example 3;

[0047] —种施莱姆氏管(Schlemm)扩张支架,如图4所示,所述扩张支架是一个圆柱面中空壳体,所述圆柱面是由一根合金丝11圆弧弯曲360度后然后再回折11-1圆弧弯曲360度形成连续的圆形曲线圈12构成,此种结构相比于单线循环圆弧缠绕形成的圆柱面强度更高;所述合金丝至少有一端是直径大于合金丝直径的膨大末端11-2,此膨大末端可以很方便的固定一个绳索,该绳索用于方便取出支架;为了使支架具有输送药物并缓慢释放的功能,在所述合金丝表面有涂覆有10微米至20微米厚的涂层,所述涂层包括粘接底层和药物层,粘接底层用于将药物粘接在合金丝上,通常粘接底层使用的是非降解聚合物如:氟化物或可降解聚合物如:聚乳酸,上述两种粘接底层除了帮助将药物粘接在合金丝上外,还具有控制药物释放时间,使药物达到缓释的作用;所述药物层是丝裂霉 [0047] - species Schlemm & apos venturi (the Schlemm) expandable stent, shown in Figure 4, the expansion of the stent is a surface of the hollow cylindrical housing, said cylindrical surface is formed by bending a 11 alloy wire arc 360 after then come back off of the arcuate bending 11-1 360 forms a continuous circular ring 12 curved configuration, such a configuration as compared to the circular arc-line winding cylinder is formed of a higher plane intensity; at least one end of said alloy wire is enlarged end diameter larger than the diameter of the alloy wire 11-2, this enlargement can be easily fixed to the end of a rope, the rope for facilitating stent is removed; the stent has a function for delivering a drug and slow release with the surface alloy wire coated with 10 to 20 microns thick coating, the coating comprising an adhesive layer and a drug layer, an adhesive layer for bonding the drug in the alloy wire, non-degradable polymers typically used as an adhesive underlayer : fluoride or degradable polymers such as: polylactic acid, except that the two adhesive underlayer helps the drug bonded to the alloy wire, but also a control drug release time, release of the drug to achieve the effect; the drug layer It is mitomycin 、肝素混、雷帕霉素、紫杉醇、聚乳酸聚乙醇酸共聚物、聚碳酸酯、磷酸胆碱、乙烯基吡咯烷酮共聚物、含氟聚合物、苯乙烯-异丁烯-苯乙烯、聚乙烯乙烯醋酸中的一种。 , Mixed with heparin, rapamycin, paclitaxel, polylactic polyglycolic acid copolymers, polycarbonates, phosphorylcholine, vinyl pyrrolidone copolymers, fluoropolymers, styrene - isobutylene - styrene, polyethylene vinyl acetate in kind.

[0048] 实施例中,所述粘接底层是将合金丝通过在含有粘接剂的溶液中浸泡、烘干附着在合金丝表面,所述粘接底层的厚度是涂层厚度的五分之一至三分之一,所述药物层是通过超声波雾化的方式涂覆在粘接底层之上。 [0048] Example embodiments, the alloy wire is bonded underlayer by immersion in a solution containing the adhesive, the drying wire attached to the surface of the alloy, the thickness of the underlayer is bonded fifth of the thickness of the coating to a third, the drug layer is applied by ultrasonic atomization manner on the adhesive layer.

[0049] 实施例中,所述圆柱面分布的合金丝圈与合金丝圈的间距11-3是20微米至50微米,最佳是30微米。 [0049] In an embodiment, the pitch circle alloy wire and the wire turns of the cylindrical plane distribution is 20 11-3 to 50 microns, most preferably 30 microns.

[0050] 实施例中,所述合金丝是钛镁合金丝或钴铬合金丝。 [0050] Example embodiments, the magnesium alloy wire is a titanium alloy wire or a cobalt-chrome alloy wire.

[0051] 实施例4; [0051] Example 4;

[0052] 如图5和图6所示,一种施莱姆氏管(Schlemm)扩张支架组合体,包括一个圆柱面中空壳体支架和一个支架推进体18,所述圆柱面是由一根合金丝圆弧弯曲360度后然后回折再圆弧弯曲360度形成连续的圆形曲线圈构成,所述合金丝至少有一端是直径大于合金丝直径的膨大末端;本实施例中,所述支架推进体是一个圆柱体,圆柱体的一端是锥形头18-1,圆柱体的另一端设有突起的挡环18-2,挡环的直径大于圆柱面中空壳体支架直径20微米,在挡环的外端面上设有连接绳线的凸起18-3,圆柱面中空壳体套入圆柱体直至顶到挡环形成支架组合体。 [0052] As shown in FIGS. 5 and 6 A Schlemm & apos venturi (the Schlemm) expanding stent assembly, comprising a hollow cylindrical shell surface and a stent pusher holder 18, the cylindrical surface is formed by a after the arc root alloy wire bent 360 degrees and then folded back 360 degrees to form a continuous arcuate curved circular curved ring configuration, said alloy wire has a diameter larger than at least one end of the wire diameter of the enlarged end of the alloy; in the present embodiment, the advancing the stent body is a cylinder, one end of the cylinder is tapered head 18-1, the other end of the cylindrical body is provided with stopper projections 18-2 ring, retaining ring is greater than the diameter of the hollow cylindrical stent diameter surface casing 20 microns with strings connecting the outer end face of the retaining ring projection 18-3, the cylindrical surface of the hollow cylinder until the top housing sleeve to form the stent retaining ring assembly. 此种组合体非常方便放置Schle_管扩张支架,而且在放置后很容易将支架推进体取出,所述的支架推进体可以使用聚四氟棒加工制作,在很小的直径下,聚四氟棒韧性好而且还具有非常好的柔软性。 Such a combination is very convenient expandable stent placed Schle_ tube, and after placing the stent pusher body easily removed, the stent body may be used to promote the manufacture of PTFE rod, at a small diameter, PTFE good bar also has very good toughness and flexibility.

[0053] 实施例5 ; [0053] Example 5;

[0054] 参见图7和图8 ;本实施例中,所述支架推进体是一个圆柱套管19,圆柱套管的一端封闭,在封闭端面上设有连接绳线的凸起19-1,圆柱面中空壳体插入圆柱套管形成支架组合体。 [0054] Referring to FIGS. 7 and 8; in the present embodiment, advancing the stent body is a cylindrical sleeve 19, the sleeve cylinder closed end, the strings are connected with the closed end face of the projection 19-1, cylindrical surface of the hollow cylindrical sleeves forming the stent is inserted into the housing assembly. 此种组合体也非常方便放置Schlemm管扩张支架,放置时现将锥形头植入,而且在放置后抓住连接在圆柱套的绳线很容易将支架推进体取出,所述的支架推进体可以使用聚四氟棒加工制作,在很小的直径下,聚四氟棒韧性好而且还具有非常好的柔软性。 Such a combination is very convenient expandable stent placed in Schlemm's canal, now when the conical head implant is placed, and after placing the catch is connected to a cylindrical sleeve strings easily taken out to promote the stent, the stent pusher member PTFE rod can manufacture, at a very small diameter, PTFE rod toughness but also has very good flexibility.

[0055] 上述实施例的使用如图9和图10所示,手术前,准备好设有锥形头18-1的支架推进体、Schlemm管扩张支架14的Schlemm管扩张支架组合、聚丙烯缝线13和弹性微导管,弹性微导管由聚丙烯材料构成,末端膨大,可以用来固定牵引缝线。 [0055] Examples of the above-described embodiment shown in FIG. 9 and FIG. 10, prior to surgery, provided with a conical head is ready to advance a stent body 18-1, a combination of Schlemm's canal expansion of the stent expandable stent 14 of the Schlemm's canal, polypropylene slit and an elastic cord 13 microcatheter, the microcatheter is made of an elastic material of polypropylene, the end of enlargement may be used to secure a tow suture. 微导管直径lOOum,长度为10cm,主要作用为:微导管先通过schlemm管腔断端进入schlemm管腔,从而对schlemm管腔进行预扩张(即从schlemm管腔的断端进入,绕schlemm管腔360度后,从同一断端穿出),然后将schlemm管扩张支架末端的缝线与微导管膨大末端相连,反向抽出微导管,并将schlemm管扩张支架带入schlemm管腔的合适位置。 Microcatheter diameter lOOum, a length of 10cm, the main role: first into the microcatheter lumen passability schlemm schlemm lumen ends, thereby pre-expanding the lumen schlemm (i.e. stump from entering schlemm lumen, the lumen about schlemm after 360, the same ends from piercing), and then the ends of the stent suture schlemm expandable tube is connected to the enlarged end of the microcatheter, the microcatheter reverse withdrawn and place schlemm expandable stent into the tube lumen schlemm.

[0056] 手术时,用2%利多卡因+ 0.75%布比卡因等量球周麻醉。 [0056] surgery, with 2% lidocaine + equivalent amount of 0.75% bupivacaine peribulbar anesthesia. 作上方以穹隆部为基底结膜瓣。 Above as substrate to fornix conjunctival flap. 作I/ 3厚,5.0X 5.5 mm大小角膜缘基底浅层巩膜瓣。 For I / 3 thick, 5.0X 5.5 mm substrate size limbus episcleritis flap. 前缘达透明角膜内Imm,作3.5 X 4.0mm梯形深层巩膜辧,厚度达到可由巩膜床透见黑色葡萄膜。 Imm, the leading edge of the transparent cornea, as 3.5 X 4.0mm deep scleral vital fixture trapezoid, a thickness of the bed may see through the scleral uvea black. 越过巩膜突同心圆纤维,剖开施莱姆氏管(Schlemm),见外壁突然分离,继续在后弹力膜表面向前分离至透明角膜内0.5 _,剪除深层巩膜瓣,撕除施莱姆氏管(Schlemm)内壁及邻管组织,房水缓慢渗出。 Over the scleral concentric fibers, cut Schlemm & apos venturi (the Schlemm), an outer wall see suddenly separated, separated after continued forward force of the film surface into the transparent cornea _ 0.5, deep scleral flap cut off, tearing Schlemm & apos apos tube (Schlemm) inner wall and adjacent tissue, slowly seeping water room. 在角巩膜缘过度带的后缘做2_长的放射状切口,逐层加深,直至看到清澈的房水从切口侧壁一小黑点处流出,此处即为施莱姆氏管(Schlemm)断端。 After limbal edge band made excessively long 2_ radial incision, layer by layer to deepen until see the clear aqueous humor from the incision sidewall at a black specks, that is where Schlemm & apos venturi (the Schlemm ) stump. 将弹性微导管15的头端插入Schlemm管16断端,在注入粘弹剂同时,从一端进入施莱姆氏管(Schlemm),当弹性微导管头端环绕施莱姆氏管(Schlemm)—周从另一端穿出时,将穿过所述Schlemm管扩张支架缝线的一端拴在弹性微导管膨大头端15_1,随着弹性微导管反向退出施莱姆氏管(Schlemm)时,将拴在弹性微导管头端的缝线带入Schlemm管中,该缝线拉着锥形头,使锥形头推着Schle_管扩张支架将其置入Schle_管腔中,当弹性微导管全部退出Schlemm管,且Schlemm管扩张支架到达预定位置时,拉着锥形卡头顶端的缝线将锥形头拉出Schlemm管,缝线末端打一活结,预埋在深层巩膜瓣下方,最后缝合密闭巩膜瓣。 The head 15 of the elastic micro-catheter end into Schlemm's canal 16 ends, while the viscoelastic agent is injected from one end into the Schlemm & apos venturi (Schlemm), when the elastic around the Schlemm & apos microcatheter tip venturi (Schlemm) - when piercing the other end from the periphery of the end of the tube through the Schlemm expandable stent suture tied in the elastic enlargement of the microcatheter tip 15_1, when the elastic micro-catheter as Schlemm & apos reverse exit venturi (Schlemm), the tied suture head end of the elastic microcatheter into Schlemm's canal in the suture pulling the conical head, the tapered head tube Schle_ pushing it into Schle_ expandable stent lumen, when all of the elastic microcatheter exit Schlemm's canal, and Schlemm's canal when the expandable stent reaches the predetermined position, the tip of the tapered chuck pulling the suture is pulled out of the tapered head Schlemm's canal, suture end play a slipknot, embedded deep scleral flap at the bottom of the last suture closed scleral flap. 当患者眼压情况稳定或者当患者出现对schlemm管扩张支架不适应的症状。 When stable IOP in patients who have symptoms or schlemm inappropriate expansion of the stent tube. 可以重新作上方以穹隆部为基底结膜瓣,打开浅层及深层巩膜瓣,寻找到巩膜瓣下方活结,拉住schle_管扩张支架的牵引线17,将其牵引出schlemm管腔。 To be above the re-fornix base conjunctival flap, shallow and deep scleral flap opens, looking downward into the scleral flap slipknot pulled schle_ expansion of the stent tube puller wire 17, which is pulled out of the lumen schlemm.

Claims (6)

1.一种施莱姆氏管(Schlemm)扩张支架,其特征在于:所述扩张支架是一个圆柱面中空壳体,所述圆柱面是由一根合金丝圆弧弯曲360度后然后再回折圆弧弯曲360度形成连续的圆形曲线圈构成,所述合金丝至少有一端是直径大于合金丝直径的膨大末端,所述合金丝表面有涂覆有10微米至50微米厚的涂层,所述涂层包括粘接底层和药物层,所述药物层是丝裂霉素、肝素混、雷帕霉素、紫杉醇、聚乳酸聚乙醇酸共聚物、聚碳酸酯、磷酸胆碱、乙烯基吡咯烷酮共聚物、含氟聚合物、苯乙烯-异丁烯-苯乙烯、聚乙烯乙烯醋酸中的一种。 A Schlemm & apos venturi (the Schlemm) expanding stent, wherein: said expandable stent is a rear surface of the hollow cylindrical housing, said cylindrical surface is an arcuate alloy wire bent 360 degrees and then folded back 360 degrees to form a continuous arcuate curved circular curved ring configuration, said alloy wire has a diameter larger than at least one end of the enlarged diameter tip alloy wire, said alloy wire has a surface coated with 10 to 50 microns thick coating said coating comprises an adhesive layer and a drug layer, the drug layer is mitomycin, mixed with heparin, rapamycin, paclitaxel, polylactic polyglycolic acid copolymers, polycarbonates, phosphorylcholine, ethylene pyrrolidone copolymers, fluoropolymers, styrene - isobutylene - styrene, polyethylene vinyl acetate in one kind.
2.根据权利要求1所述的一种施莱姆氏管(Schlemm)扩张支架,其特征在于:所述粘接底层是将合金丝通过在含有粘接剂的溶液中浸泡、烘干附着在合金丝表面,所述粘接底层的厚度是涂层厚度的五分之一至三分之一,所述药物层是通过超声波雾化的方式涂覆在粘接底层之上。 2. According to one Schlemm & apos venturi (the Schlemm) expandable stent according to claim 1, characterized in that: said underlayer is an alloy wire bonding by immersion in a solution containing an adhesive agent, adhering to the drying alloy wire surface, the thickness of the bottom layer of the adhesive is one fifth to one third of the thickness of the coating, the drug layer is applied by ultrasonic atomization manner on the adhesive layer.
3.根据权利要求1所述的一种施莱姆氏管(Schlemm)扩张支架,其特征在于:所述合金丝是钛镁合金丝或钴铬合金丝。 3. According to one Schlemm & apos venturi (the Schlemm) expandable stent according to claim 1, wherein: said magnesium alloy wire is a titanium alloy wire or a cobalt-chrome alloy wire.
4.一种施莱姆氏管(Schlemm)扩张支架组合体,其特征在于:所述组合体包括一个圆柱面中空壳体支架和一个支架推进体,所述圆柱面是由一根合金丝圆弧弯曲360度后然后再回折圆弧弯曲360度形成连续的圆形曲线圈构成,所述合金丝至少有一端是直径大于合金丝直径的膨大末端,所述支架推进体托住圆柱面中空壳体支架。 A Schlemm & apos venturi (the Schlemm) expanding stent assembly, wherein: said housing assembly includes a hollow holder and a holder member advancing a cylindrical surface, said cylindrical surface is an alloy wire made after the return arc bent 360 degrees and 360 degrees off the curved arc to form a continuous ring with a circular curve, at least one end of said alloy wire has a diameter greater than a diameter of the enlarged end of the alloy wire, advancing the stent hold the cylindrical surface of the body empty housing bracket.
5.根据权利要求4所述的一种施莱姆氏管(Schlemm)扩张支架组合体,其特征在于:戶斤述支架推进体是一个圆柱体,圆柱体的一端是锥形头,圆柱体的另一端设有突起的挡环,挡环的直径大于圆柱面中空壳体支架直径20微米,在挡环的外端面上设有连接绳线的凸起,圆柱面中空壳体套入圆柱体直至顶到挡环。 5. According to one Schlemm & apos venturi (Schlemm) 4 of the expandable stent assembly as claimed in claim, wherein: said stent pusher household kg body is a cylinder, the head end of the cylinder is tapered, cylindrical the other end is provided with projecting retaining ring, the retaining ring diameter is greater than the diameter of the cylindrical surface of the hollow shell carrier 20 microns, an outer end surface of the retaining ring is provided with a projection connected to the strings, set into the cylindrical surface of the hollow housing the top of the cylinder until the stop ring.
6.根据权利要求4所述的一种施莱姆氏管(Schlemm)扩张支架组合体,其特征在于:戶斤述支架推进体是一个圆柱套管,圆柱套管的一端封闭,在封闭端面上设有连接缝线的凸起,圆柱面中空壳体插入圆柱套管。 6. According to one Schlemm & apos venturi (Schlemm) 4 of the expandable stent assembly as claimed in claim, wherein: said user pounds stent pusher member is a cylindrical sleeve, closed end of the cylindrical sleeve, closed at the end faces projections provided on the connection of the suture is inserted into the cylindrical surface of the hollow cylindrical housing sleeve.
CN201410141744.5A 2011-06-16 2012-06-16 One kind of Schlemm & apos venturi (the Schlemm) expanding stents, and combinations thereof CN103932841B (en)

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