CN103181556A - Health food having effects of life cultivation and health preservation in spring and preparation method thereof - Google Patents
Health food having effects of life cultivation and health preservation in spring and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a health food, particularly to a health food for anti-fatigue and liver protection and nourishing in spring and a preparation method of the health food, and also relates to new application of the composition. The health food comprises radix astragali, Chinese wolfberry, spina date seed, upripe malt, Chinese date, ginger and rose. The health food formula not only has the traditional functions of regulating vital energy and blood of viscera of a human body and promoting the human body to conform to change rule of yin and yang in spring, but also has the modern effects of anti-fatigue, liver protection and immunity enhancement.
Description
Invention field
The present invention relates to a kind of health food that is specially adapted to antifatigue in spring, protecting and nourishing liver and preparation method thereof, relate to the new purposes of said composition simultaneously.
Background technology
The present invention relates to modern health care and traditional Chinese medical science four seasons diet regimen field.
Spring, " qi and blood is treated freely for all things on earth recovery, yang-energy hair tonic " and " spring is answered liver " and human body were easily sent out characteristics such as hepatopathy, epidemic disease; Spring, nourishment maintenance should be principle with " liver is protected in invigorating the spleen for benefiting qi and raising yang, happy qi and blood ", namely escorted gas admittedly, improved immunity of organisms to prevent the generation of many diseases; Happy qi and blood strengthens fatigue resistance; Protecting and nourishing liver prevents hepatopathy recurrence etc.
Fatigue claims tired again, is a kind of subjective uncomfortable sensation.But objectively can under equal conditions lose it and finish normal activity or the ability to work of originally being engaged in.Physiological variation: because the accumulation of lactic acid and other metabolites, muscle tone descends, and the motion durability reduces; Because the accumulation of carbon dioxide stimulates respiratory center, also can cause yawning.Every disease progression all can occur tired to certain phase, so can cause that tired disease is a lot.Fatigue claims that again tired is the discomfort of subjective a kind of fatigue and weak, feel fatigue and be not special symptom, a lot of diseases all can cause fatigue, anti-fatigue medicament mainly contains genseng, wilsonii, glossy ganoderma, royal jelly, atriphos (apt, vitamins etc. at present, wherein vitamin also is to have roborant more representational medicine to the body nutrient that is absolutely necessary.As adopt vitamin b1 and vitamin b6 to treat athletic fatigue state and electrocardiographic abnormality, received effect preferably.Vitamin b12 is used also very general in the sportsman as a kind of reinforcement medicine, and strengthens physical measure as pre-games, can keep muscle power, improve a poor appetite and sleep, and prevent jerk.Take after the exercise and then can accelerate to eliminate fatigue.Vitamin c also is that a kind of elimination is tired, strengthens the standing medicine of muscle power.The elderly uses the recovery for muscle power, and the improvement of whole physiological function has a lot of benefit.
Hepatic injury is the disease of clinical common harm humans health.Hepatic injury is exactly the invasion that liver is subjected to extraneous factor, thus the liver damage that causes.Hepatic injury generally is divided into infectious hepatic injury and chemical damage.Clinical and experiment proves that all traditional Chinese medicine has certain short regeneration and repair to hepatic injury.Use the experience of Chinese medicine compound prescription compatibility, preventing and treating the hepatic injury that some cause of disease causes is a kind of both effective and practicable treatment thinking.
Immunity is the defense mechanism of human body self, is human body identification and any foreign matter (virus, bacterium etc.) of eliminating external intrusion; Handle the ability of self cell and identification and processing vivo mutations cell and the virus infected cell of old and feeble, damage, dead, sex change.Immunity still is human body identification and gets rid of " dissident ", safeguards the critical function of homeostasis.Many studies show that, many Chinese medicines have good regulating action to immunity of organism.
4 o'clock diet regimens
Health in 4 o'clock is exactly the principle according to the traditional Chinese medical science " correspondence between man and universe ", adapt to the rule that the nature YIN YANG in four seasons changes according to Human Physiology, initiatively take to comprise multiple proper method such as rule of life, diet, motion, spirit, to improve the physiological fitness of body, farthest bringing into play treating naturally of human body can, go after profits and advoid disadvantages the purpose of reach illness prevention and fitness, promoting longevity.Wherein according to the 4 o'clock suitable food of apolegamy, to reach salubrious method, i.e. four seasons dietary regimen.
In the clinical practice of the traditional Chinese medical science, the division of medicine and food is relative, because most of Chinese medicine can eat, medicine and the difference of food are different on the consumption, and the amount that toxic action is big is little, and the little amount of toxic action is big.Have medicine for the food of eating double function for some simultaneously, the difference of its medicine and food also only is the various objectives of its utilization.Its side effect of food on the ordinary meaning is little, and very big amount ranges is arranged, and is mainly used in strengthening by means of tonics; And medicine has certain side effect, and amount ranges is smaller, is mainly used in treating disease.Some of them had both been had the food effect of allaying one's hunger by empirical evidence, had the Chinese medicine of strong treatment disease effect again, because it has medicine food dual-use function, and had good security, and what become diet regimen mainly selects object for use always.Diet regimen then was the principle according to the traditional Chinese medical science " integration of drinking and medicinal herbs " and " correspondence between man and universe " in 4 o'clock, drew the experience of the traditional Chinese medical science " four seasons health ", namely should " difference in season 4 o'clock spring, summer, autumn and winter changes the seasonal medicine food that nourishes of feed, is referred to as four seasons diet and mends strong.
Four seasons diet regimen relates to " being benefit with the food ", " food De Qifa " and reach empirical contents such as " eat reach Time ".But a large amount of experiences of relevant 4 o'clock diet regimens only sporadically appear in the successive dynasties medical book, and content is mainly concerned with the compatibility and incompatibility of drugs food record of four seasons use, and health theory and medicine feeding habits energy and compound compatibility characteristics thereof propose for the prescription that is specifically designed to health in 4 o'clock then seldom during wherein according to the traditional Chinese medical science four.Modern market has many nominals various tea beverage with health role, between can see the Chinese medicine class tea beverage (four seasons tea) that uses specialized designs to go out for the four seasons, but its prescription still lacks necessary traditional Chinese medicine scientific principle and the support of experiential basis, especially can not provide it to have the evidence of four seasons health care effectiveness.This series products also more belongs to the bagged instant preparation that crude drug that suitable boiling water brews slightly looses, exist effective components utilising degree not high, use problems such as inconvenience and mouthfeel be not good.
The traditional Chinese medical science is thought, as medicine, food also has its performance separately, comprise nature and flavor (fever and chills and warm and cool four gas and the salty five tastes of bitter sweet suffering), return through contents such as, lifting sink-float, reinforcing and reducing methods, the food of different performance can produce different functions by different compatibilities, can correct the imbalance of body internal organs yang blood and qi, play health care (prevention, body-building, rehabilitation etc.) effect.
Summary of the invention
One object of the present invention is to disclose a kind of new antifatigue, is particularly useful for the food that health care in spring, protecting and nourishing liver are used; Another object of the present invention is to disclose a kind of new antifatigue and the preparation method who is applicable to the food that spring, health care was used; One object of the present invention also is to disclose a kind of new antifatigue and the new purposes that is applicable to the food that spring, health care was used.
The bulk drug of health food of the present invention is formed and proportioning following (by weight):
Health food preferred feedstock medicine proportioning of the present invention can for:
Health food preferred feedstock medicine proportioning of the present invention can also for:
Health food preferred feedstock medicine proportioning of the present invention can also for:
Press practice of pharmacy, the invention described above health-care food composition can be added conventional auxiliary material and be prepared into the various clinical formulation according to conventional method, comprise the formulation of oral formulations or parenterai administration.Said oral formulations is selected from a kind of in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, the bag infusion agent.
Health food of the present invention also can add conventional health food excipient, as solvent, disintegrant, flavouring, anticorrisive agent, colouring agent etc.
Health food preparation method of extract of the present invention is following method:
Get ginger and rose and add 2-5 times of water gaging, the water distillating extracting oil is collected volatile oil, and is standby; Getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extracts 1-3 time, each 0.5-1.5 hour, amount of water is respectively 6-10 doubly, filter, relative density was 1～1.5 when merging filtrate, filtrate decompression were concentrated into 60 ℃, added ginger and rose volatile oil and mixed, drying under reduced pressure, dried cream powder is broken into fine powder.
Health food preparation method of extract of the present invention is preferably following method:
Get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extracts 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, merging filtrate, relative density was 1.25～1.30 when filtrate decompression was concentrated into 60 ℃, adding ginger and rose volatile oil mixes, drying under reduced pressure, temperature≤70 ℃, dried cream powder is broken into fine powder.
The preparation method of health food of the present invention is following method:
Get ginger and rose and add 2-5 times of water gaging, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 1-3 time, each 0.5-1.5 hour, amount of water was respectively 6-10 doubly, filter, merging filtrate, relative density was 1～1.5 when filtrate decompression was concentrated into 60 ℃, the dextrin that adds the 50-100 weight portion mixes, drying under reduced pressure, temperature≤70 ℃, dried cream powder is broken into fine powder, adds 95% ethanol and makes softwood, and 14 mesh sieves are granulated, dry, temperature≤70 ℃, the whole grain of 12 mesh sieves gets particle; Getting ginger and rose volatile oil adds 1-3 and doubly measures ethanol and mix, add in the particle, the dolomol that adds the 0.3-1 weight portion mixes, placed 1-4 hour, and added conventional auxiliary material and be prepared into a kind of in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, the bag infusion agent according to conventional method.
The preparation method of health food of the present invention is preferably following method:
Get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water was respectively 10 times, 8 times, filter, merging filtrate, relative density was 1.25～1.30 when filtrate decompression was concentrated into 60 ℃, the dextrin that adds 72.4 weight portions mixes, drying under reduced pressure, temperature≤70 ℃, dried cream powder is broken into fine powder, adds 95% ethanol and makes softwood, and 14 mesh sieves are granulated, dry, temperature≤70 ℃, the whole grain of 12 mesh sieves gets particle; Get ginger and rose volatile oil add 1 times the amount ethanol mix, add in the particle, the dolomol that adds 0.5 weight portion mixes, placed 2 hours, and added conventional auxiliary material and be prepared into a kind of in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, the bag infusion agent according to conventional method.
The present invention relates to a kind of health food, particularly a kind of health food and preparation method for spring antifatigue, protecting and nourishing liver relate to the new purposes of said composition simultaneously.This health food is made up of northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus, date, ginger and rose.Health food of the present invention has antifatigue, protecting and nourishing liver and strengthens the effect of immunity.
Following experimental example and embodiment are used for further specifying but are not limited to the present invention.
Following material is all adopted in experiment of the present invention.
Medicine: health in spring tea (by the extract of preparation among the embodiment 11), 10g particle/sky provides lot number by Beijing University of Chinese Medicine's state key prescription subject: 20100305.DDB, Zhejiang Medicine Co produces, lot number: 20090303; Domperidone Tablets, the prompt many biochemistry corporation,Ltd.s in Jiangxi produce lot number: 200808006275; Bolus for reinforcing middle-jiao and replenishing qi, the Henan Province Wanxi Pharmacy Stock Co., Ltd produces, lot number: 080905; Content of Tablet of Levamisole Hydrochloride, Shandong Kernel and Hall Pharmaceutical Industry Co., Ltd., lot number: 100105.
Reagent: barium sulphide, Shanghai Zhuo Rui chemical industry Co., Ltd; DNCB, the emerging good fortune fine chemistry in Beijing research institute, lot number: 20091102; Sheep blood, suitable animal-breeding center, the Xiushan Mountain, capital, Beijing, SRBC (face the time spent with physiological saline washing 3 times, got packed red cells in 10 minutes through 2000rpm, press the desired concn dilution again); Complement: at least 3 pooled serums of fresh cavy absorb below 30 minutes postposition-20 ℃ standby through SRBC (10: 1) in 4 ℃; Dou Shi reagent, Nanjing build up bio-engineering research institute.Incomplete 1640 (Sigma); Hyclone (Hyclone), ConA (Sigma); LPS (Sigma), MTT (Sigma); 0.01NHCL-10%SDS, two anti-, Tris-NH4Cl, PBS, 75% ethanol.
Animal: Kunming mouse, 20-24g, male and female dual-purpose; The Balb/c mouse, 18-22g, female.Cavy, 200 ± 20g, female.
Instrument: 754-spectrophotometer; Olympus-400 type automatic clinical chemistry analyzer; High speed freezing centrifuge; ELIASA; Microscope; The CO2 constant incubator.
Experimental example 1Health in spring tea is to mouse endurance and anti-stress effect
1 gets above-mentioned experiment material
2 methods
2.1 the influence to the mouse swimming time
Temperature 18-25 ℃; Humidity: 55-65% (back together).Getting body weight is 50 of 18-22g mouse, male and female half and half, be divided at random normal group, bolus for reinforcing middle-jiao and replenishing qi group (positive group 4.68g/kg), health tea little, in, heavy dose of group (1.30,2.60,5.20g particle/kg, press body surface area calculating, be equivalent to 1,2,4 times of people's consumption 10g particle/sky).Each organizes gastric infusion according to dosage, and continuous 7 days, normal group gave isometric(al) distilled water, and after the last administration 30 minutes, mouse tail heavy burden 2g (be about body weight 7%) put in the water and swims, and observes mouse and swims to power and exhaust the dead time, is the mouse swimming time.
2.2 the mouse normal pressure anti-anoxic time-to-live is influenced
Getting body weight is 50 of 18-22g mouse, be divided at random normal group, bolus for reinforcing middle-jiao and replenishing qi group, health tea little, in, heavy dose of group, each organizes gastric infusion according to dosage, continuous 7 days, normal group gives isometric(al) distilled water, after the last administration 30 minutes, each group mouse is put into the 200ml wide-mouth bottle that fills soda lime respectively, the mouse time-to-live is observed in timing immediately.
2.3 statistical procedures: data all adopt
One-way analysis of variance (one-way ANOVA) is relatively adopted in expression between the group between a plurality of samples, carry out the SNK-Q check and carry out Chi-square Test.Total data adopts SPSS13.0 software to handle.
3 results
3.1 health in spring tea endurance and anti-stress effect
3.1.1 the influence to the mouse swimming time
The results are shown in Table 1.
Table 1 health in spring tea influences the mouse swimming time
With normal group ratio, * P＜0.05.
By table 1 as seen, behind the successive administration 7 days, in positive group, health in the spring tea, a large amount of group can obviously increase the mouse swimming with a load attached to the body time, wherein positive group and a large amount of group have the conspicuousness meaning with normal group than difference, health in spring tea presses 1.30,2.60, (press body surface area calculates 5.20g particle/kg, be equivalent to 1,2,4 times of people's consumption 10g particle/sky) gave the mouse stomach administration 7 days, can significantly increase the mouse swimming with a load attached to the body time, the trend that prolongs mouse normal pressure hypoxia endurance time is arranged.
3.1.2 the influence to mouse normal pressure hypoxia endurance time
The results are shown in Table 2.
Table 2 health in spring tea influences mouse normal pressure hypoxia endurance time
By table 2 as seen, than the normal control group, successive administration is after 7 days, and the normal pressure hypoxia endurance time of each administration group mouse is all seen increase in various degree, but difference does not have conspicuousness meaning (P＞0.05).
Experimental example 2Health in spring tea is to the protective effect of acute liver damage
1 gets above-mentioned experiment material
2 methods
Getting body weight is 60 of 18-22g mouse, male and female half and half, be divided at random normal group, model group, positive group (DDB group), health tea little, in, heavy dose of group, each organizes gastric infusion according to dosage, normal group gives isometric(al) distilled water, continuous 7 days.After the last administration 30 minutes, the carbon tetrachloride peanut oil solution 0.1ml/10g body weight of each mouse lumbar injection 0.2% except normal group, fasting be can't help water after 18 hours, plucked eyeball and got blood, adopted Olympus-400 type automatic clinical chemistry analyzer to measure AST, ALT content.
Statistical procedures: data all adopt
One-way analysis of variance (one-way ANOVA) is relatively adopted in expression between the group between a plurality of samples, carry out the SNK-Q check and carry out Chi-square Test.Total data adopts SPSS13.0 software to handle.
3 results
The results are shown in Table 3.
Table 3 health in spring tea is to the protective effect of chmice acute hepatic injury
With normal group ratio, * P＜0.05; With model group ratio, Δ P＜0.05.
By table 3 as seen, behind the carbon tetrachloride peanut oil solution of lumbar injection 0.2%, AST, the ALT of each group of modeling obviously increase, and than difference the conspicuousness meaning are arranged with normal group, and the model success is described.Serum AST, the ALT of each administration group mouse that successive administration 7 prevents all obviously reduces, and wherein the positive is organized, organized in a large number and the model group ratio, and difference has the conspicuousness meaning.Illustrate that health in spring tea has the certain protection effect to acute liver damage.
Experimental example health in 3 spring tea is to effect of immunologic function
1 gets above-mentioned experiment material
2 methods
2.1 serum hemolysin determination method
The Balb/c mouse is divided into small dose group (1.55g/kg), middle dosage group (3.1g/kg) and left-handed group (5mg/kg), 10 every group at random.Each only organizes mouse peritoneal injection 20%SRBC 0.2ml/, behind the immune 1h, gives corresponding medicine through irritating stomach, every every day each administration 0.4ml, once a day, blank group is irritated equivalent distilled water.Administration after 7 days mouse pluck eyeball and get blood, separation of serum, with serum with after 500 times of the SPSS dilutions for measuring.
Hemolytic reaction: add diluted serum 1ml, 5%SRBC 0.5ml, 10% complement 1ml in the reaction tube successively, put in 37 ℃ of waters bath with thermostatic control and be incubated 30 minutes, move to cessation reaction in the ice bath then, centrifugal 5 minutes of 1500rpm, get supernatant 1ml and add Dou Shi reagent 3ml, shake up and placed 10 minutes.Get each sample and add in 96 orifice plates, every hole 200ul.Survey absorbance with ELIASA in the 540nm wavelength.
SRBC HD50 value: get 5%SRBC 0.25ml and add Dou Shi liquid to 4ml, add in 96 orifice plates and survey absorbance, the absorbance when being used SRBC HD50 in the experiment.Sample cell HD50 value HC50 is calculated as follows: absorbance * extension rate during the serum HC50=sample absorbance of every mouse/SRBC HD50.
2.2 lymphocyte proliferation assay
The Balb/c mouse is divided into small dose group (1.55g/kg), middle dosage group (3.1g/kg) and left-handed group (5mg/kg), 10 every group at random.4 groups of mouse in preceding 1 day of experiment with the barium sulphide starch mixture at mouse web portion fixed position 3cm * 1cm area depilation, warm water cleaning.Testing the 1st, 2 day (sensitization phase) is coated with 1%DNCB in mouse web portion depilation position, every day 1 time, each 20ul, the 3rd, 4,5 day coating not, the 6th day (sending out quick the phase) brings out dermatitis in the hard of hearing 20ul of the being coated with 0.5%DNCB in a mouse left side, and the auris dextra back of the body is coated with 1: 1 acetone glycerol 20ul and compares.2h begins to gavage relative medicine before the 1st coating, every mouse each administration 0.4ml every day, and every day 1 time, continuous use 5 days brought out preceding 2h on the 6th day and brought out back each gastric infusion of 4h 1 time.After bringing out 24h, after each is organized mouse and plucks eyeball and put to death, get spleen immediately and prepare splenocyte suspension.
Preparation splenocyte suspension: in ice bath, spleen is placed on 200 eye mesh screens, add a little complete 1640 liquid, squeeze out splenocyte gently.Through the Tris-NH4Cl lysed erythrocyte, after PBS washes twice, carry out cell count.Observing living cells with the dyeing of 0.4% trypan blue during cell count should be more than 90%.Splenocyte suspension is made into 107/ml concentration.
Splenocyte is added in 96 orifice plates, every hole 100ul, each sample repeats the 3-4 hole.Add ConA (5ug/ml) when stimulating T cell proliferation, add LPS (10ug/mI) when stimulating B cell proliferation.Put into 37 ℃ of 5%CO2 incubators, cultivated 72 hours.Stop cultivating preceding 6 hours, every hole adds 5mg/ml MTT solution, adds 0.01NHCL-10%SDS when stopping cultivating, and puts 37 ℃ and spends the night.Survey absorbance with ELIASA in the 570nm wavelength.
2.3 statistical procedures: data all adopt
One-way analysis of variance (one-way ANOVA) is relatively adopted in expression between the group between a plurality of samples, carry out the SNK-Q check and carry out Chi-square Test.Total data adopts SPSS13.0 software to handle.
3 results
3.3 health in spring tea is to effect of immunologic function
3.3.1 health in spring tea is to the influence of mouse humoral immune function
The results are shown in Table 4.
Table 4 health in spring tea is to the influence of mice serum hemolysin
With normal group ratio, * P＜0.05.
By table 4 as seen, compare to the normal control group, the HD50 value of the low dose of and heavy dose of group of health in spring tea and levamisol group mouse is all seen rising in various degree, and wherein small dose group does not have significant difference, and levamisol and heavy dose of group difference all have conspicuousness meaning (P＜0.05).
3.3.2 health in spring tea is to the mouse cell Immune Effects
The results are shown in Table 5.
Table 5 health in spring tea is to the influence of mouse T, B cell proliferation
With normal control group ratio, * P＜0.05, * * P＜0.01.
As shown in Table 5, compare with the normal control group, the spleen T lymphopoiesis that health in spring tea small dose group and heavy dose of group rat stimulate through ConA all is increase in various degree, and wherein heavy dose of group difference has conspicuousness meaning (P＜0.05); Health in spring tea small dose group and levamisol group rat increase in various degree through the propagation the monarch and his subjects of the spleen bone-marrow-derived lymphocyte that LPS stimulates, and its difference all has conspicuousness meaning (P＜0.01 or P＜0.05).Health in spring tea mouse is by 1.55 and 3.11 particles/kg mouse stomach administration, can significantly improve through sheep red blood cell mice immunized serum hemolysin level and the delayed allergy mice spleen T that induces through dinitrofluorobenzene, bone-marrow-derived lymphocyte propagation.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1Granule
North stilbene 3kg fruit of Chinese wolfberry 2kg spina date seed 1.33kg Fructus Hordei Germinatus 2kg
Date 0.67kg ginger 0.67kg rose 0.33kg
More than seven flavors, get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water was respectively 10 times, 8 times, filter, merging filtrate, it is 1.25～1.30 (60 ℃ of surveys) that filtrate decompression concentrates (temperature≤70 ℃) to relative density, adding dextrin 7.24kg mixes, drying under reduced pressure (temperature≤70 ℃), dried cream powder is broken into fine powder, adds 95% ethanol and makes softwood, 14 mesh sieves are granulated, dry (temperature≤70 ℃), the whole grain of 12 mesh sieves gets particle; Get ginger and rose volatile oil and add 1 times of amount ethanol and mix, add in the particle, add the 0.05kg dolomol and mix, placed 2 hours, pack, the 5g/ bag, namely.
Embodiment 2Capsule
North stilbene 1500g fruit of Chinese wolfberry 1000g spina date seed 665g Fructus Hordei Germinatus 1000g
Date 335g ginger 335g rose 165g
More than seven flavors, get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extracts 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, it is 1.25～1.30 (60 ℃ of surveys) that merging filtrate, filtrate decompression concentrate (temperature≤70 ℃) to relative density, after getting ginger and rose volatile oil and adding 1 times of amount ethanol and mix, encapsulated, every contains extract 0.5g.It is directly encapsulated perhaps to be ground into fine powder with crude drug.
Embodiment 3 tablets
North stilbene 22kg fruit of Chinese wolfberry 28kg spina date seed 18kg Fructus Hordei Germinatus 12kg date
4kg ginger 9kg rose 4kg dextrin 90kg stearic acid
Magnesium 0.4kg
More than seven flavors, get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene; the fruit of Chinese wolfberry; spina date seed; Fructus Hordei Germinatus and date boiling are extracted 2 times, and each 1 hour, amount of water was respectively 10 times; 8 times; filter; it is 1.25～1.30 (60 ℃ of surveys) that merging filtrate, filtrate decompression concentrate (temperature≤70 ℃) to relative density, adds dextrin and mixes; drying under reduced pressure (temperature≤70 ℃); dried cream powder is broken into fine powder, adds 95% ethanol and makes softwood, granulates with the 16-20 mesh sieve; after waiting to fling to the alcohol flavor; in 60 ℃ of oven dryings, after the drying, the whole grain of 14 mesh sieves; adding dolomol mixes; particle is crossed 60 mesh sieves, in fine powder, add ginger and rose volatile oil (dissolving of 1 times of amount ethanol) and mix, again this fine powder is added former particle mixing; in closed container, placed 24 hours; after volatile oil was evenly distributed, it was heavy to calculate sheet, compressing tablet; or dressing, namely.
Embodiment 4Tablet
North stilbene 22kg fruit of Chinese wolfberry 28kg spina date seed 18kg Fructus Hordei Germinatus 12kg date
4kg ginger 9kg rose 4kg
More than seven flavors, get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extract after routinely technology make tablet.
Embodiment 5Capsule
North stilbene 1500g fruit of Chinese wolfberry 1000g spina date seed 665g Fructus Hordei Germinatus 1000g date 335g ginger 335g rose 165g
More than seven flavors, get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extract after routinely technology make capsule.
Embodiment 6Pill
North stilbene 1500g fruit of Chinese wolfberry 1000g spina date seed 665g Fructus Hordei Germinatus 1000g date 335g ginger 335g rose 165g
More than seven flavors, get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extract after routinely technology make pill.
Embodiment 7Granule
North stilbene 3kg fruit of Chinese wolfberry 2kg spina date seed 1.33kg Fructus Hordei Germinatus 2kg
Date 0.67kg ginger 0.67kg rose 0.33kg
More than seven flavors, get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extract after routinely technology make granule.
Embodiment 8Supensoid agent
North stilbene 3kg fruit of Chinese wolfberry 2kg spina date seed 1.33kg Fructus Hordei Germinatus 2kg
Date 0.67kg ginger 0.67kg rose 0.33kg
More than seven flavors, get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extract after routinely technology make supensoid agent.
Embodiment 9Dripping pill
North stilbene 22kg fruit of Chinese wolfberry 28kg spina date seed 18kg Fructus Hordei Germinatus 12kg date
4kg ginger 9kg rose 4kg
More than seven flavors, get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extract after routinely technology make dripping pill.
Embodiment 10Oral liquid
North stilbene 38kg fruit of Chinese wolfberry 12kg spina date seed 12kg Fructus Hordei Germinatus 28kg
Date 9kg ginger 4kg rose 2kg.
More than seven flavors, get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extract after routinely technology make oral liquid.
The preparation of embodiment 11 present composition extracts
Get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extracts 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, relative density was 1.25～1.30 when merging filtrate, filtrate decompression were concentrated into 60 ℃, added ginger and rose volatile oil and mixed, drying under reduced pressure, dried cream powder is broken into fine powder.
The preparation of embodiment 12 present composition extracts
North stilbene 22kg fruit of Chinese wolfberry 28kg spina date seed 18kg Fructus Hordei Germinatus 12kg date
4kg ginger 9kg rose 4kg
Get ginger and rose and add 4 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extracts 3 times, each 1.2 hours, amount of water is 7 times respectively respectively, filter, it is 1.4 that merging filtrate, filtrate decompression are concentrated into relative density, adds ginger and rose volatile oil and mixes, drying under reduced pressure, dried cream powder is broken into fine powder.
The preparation of embodiment 13 present composition extracts
North stilbene 38kg fruit of Chinese wolfberry 12kg spina date seed 12kg Fructus Hordei Germinatus 28kg
Date 9kg ginger 4kg rose 2kg.
Get ginger and rose and add 5 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extracts 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filter, it is 1.45 that merging filtrate, filtrate decompression are concentrated into relative density, adds ginger and rose volatile oil and mixes, drying under reduced pressure, dried cream powder is broken into fine powder.
Embodiment 14Granule
North stilbene 3kg fruit of Chinese wolfberry 2kg spina date seed 1.33kg Fructus Hordei Germinatus 2kg
Date 0.67kg ginger 0.67kg rose 0.33kg
Get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extracts 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filters merging filtrate, relative density was 1.25～1.30 when filtrate decompression was concentrated into 60 ℃, add ginger and rose volatile oil and mix, drying under reduced pressure, temperature≤70 ℃, dried cream powder is broken into fine powder, adds conventional auxiliary material and makes granule.
Embodiment 15Granule
North stilbene 38kg fruit of Chinese wolfberry 12kg spina date seed 12kg Fructus Hordei Germinatus 28kg
Date 9kg ginger 4kg rose 2kg.
Get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extracts 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filters merging filtrate, relative density was 1.25～1.30 when filtrate decompression was concentrated into 60 ℃, add ginger and rose volatile oil and mix, drying under reduced pressure, temperature≤70 ℃, dried cream powder is broken into fine powder, adds conventional auxiliary material and makes granule.
Embodiment 16Granule
North stilbene 22kg fruit of Chinese wolfberry 28kg spina date seed 18kg Fructus Hordei Germinatus 12kg date
4kg ginger 9kg rose 4kg
More than seven flavors, get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water was respectively 10 times, 8 times, filter, merging filtrate, it is 1.25～1.30 (60 ℃ of surveys) that filtrate decompression concentrates (temperature≤70 ℃) to relative density, adding dextrin 7.24kg mixes, drying under reduced pressure (temperature≤70 ℃), dried cream powder is broken into fine powder, adds 95% ethanol and makes softwood, 14 mesh sieves are granulated, dry (temperature≤70 ℃), the whole grain of 12 mesh sieves gets particle; Get ginger and rose volatile oil and add 1 times of amount ethanol and mix, add in the particle, add the 0.05kg dolomol and mix, placed 2 hours, pack, the 5g/ bag, namely.
Claims (10)
1. health food that is used for anti-disease labor in spring, protecting and nourishing liver is characterized in that this food made by following raw material medicaments:
2. health food as claimed in claim 1 is characterized in that this food made by following raw material medicaments:
3. health food as claimed in claim 1 is characterized in that this food made by following raw material medicaments:
4. health food as claimed in claim 1 is characterized in that this food made by following raw material medicaments:
5. as the arbitrary described health food of claim 1-4, it is characterized in that getting this healthy food material medicine and add conventional auxiliary material and prepare a kind of in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, the bag infusion agent according to conventional method.
6. as the arbitrary described health food preparation method of extract of claim 1-4, it is characterized in that this method is following method:
Get ginger and rose and add 2-5 times of water gaging, the water distillating extracting oil is collected volatile oil, and is standby; Getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extracts 1-3 time, each 0.5-1.5 hour, amount of water is respectively 6-10 doubly, filter, relative density was 1～1.5 when merging filtrate, filtrate decompression were concentrated into 60 ℃, added ginger and rose volatile oil and mixed, drying under reduced pressure, dried cream powder is broken into fine powder.
7. health food preparation method of extract as claimed in claim 6 is characterized in that this method is following method:
Get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extracts 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, merging filtrate, relative density was 1.25～1.30 when filtrate decompression was concentrated into 60 ℃, adding ginger and rose volatile oil mixes, drying under reduced pressure, temperature≤70 ℃, dried cream powder is broken into fine powder.
8. as the preparation method of the arbitrary described health food of claim 1-4, it is characterized in that this method is following method:
Get ginger and rose and add 2-5 times of water gaging, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 1-3 time, each 0.5-1.5 hour, amount of water was respectively 6-10 doubly, filter, merging filtrate, relative density was 1～1.5 when filtrate decompression was concentrated into 60 ℃, the dextrin that adds the 50-100 weight portion mixes, drying under reduced pressure, temperature≤70 ℃, dried cream powder is broken into fine powder, adds 95% ethanol and makes softwood, and 14 mesh sieves are granulated, dry, temperature≤70 ℃, the whole grain of 12 mesh sieves gets particle; Getting ginger and rose volatile oil adds 1-3 and doubly measures ethanol and mix, add in the particle, the dolomol that adds the 0.3-1 weight portion mixes, placed 1-4 hour, and added conventional auxiliary material and be prepared into a kind of in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, the bag infusion agent according to conventional method.
9. the preparation method of health food as claimed in claim 8 is characterized in that this method is following method:
Get ginger and rose and add 3 times of water gagings, the water distillating extracting oil is collected volatile oil, and is standby; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water was respectively 10 times, 8 times, filter, merging filtrate, relative density was 1.25～1.30 when filtrate decompression was concentrated into 60 ℃, the dextrin that adds 72.4 weight portions mixes, drying under reduced pressure, temperature≤70 ℃, dried cream powder is broken into fine powder, adds 95% ethanol and makes softwood, and 14 mesh sieves are granulated, dry, temperature≤70 ℃, the whole grain of 12 mesh sieves gets particle; Get ginger and rose volatile oil add 1 times the amount ethanol mix, add in the particle, the dolomol that adds 0.5 weight portion mixes, placed 2 hours, and added conventional auxiliary material and be prepared into a kind of in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, the bag infusion agent according to conventional method.
As the arbitrary described health food of claim 1-4 for the preparation of spring antifatigue, protecting and nourishing liver or strengthen application in the health food of immunity.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112544896A (en) * | 2020-12-04 | 2021-03-26 | 李�杰 | Making method of air-dried chicken |
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| CN101822746A (en) * | 2009-03-04 | 2010-09-08 | 北京因科瑞斯医药科技有限公司 | Chinese medicinal composition with function of enhancing immunity and preparation method thereof |
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| JPH069417A (en) * | 1992-03-27 | 1994-01-18 | Taisho Pharmaceut Co Ltd | Solution for internal use |
| CN1074616A (en) * | 1993-02-12 | 1993-07-28 | 北京康力天然保健品研究所 | The health nutrient composition and method of making the same that helps sleeping |
| US20030031732A1 (en) * | 2001-05-15 | 2003-02-13 | Kim Won Kyu | Anti-fatigue and tonic agent containing wild ginseng |
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