CN103167872B - 用于生产l-肉碱酒石酸盐的方法 - Google Patents

用于生产l-肉碱酒石酸盐的方法 Download PDF

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Publication number
CN103167872B
CN103167872B CN201180042646.0A CN201180042646A CN103167872B CN 103167872 B CN103167872 B CN 103167872B CN 201180042646 A CN201180042646 A CN 201180042646A CN 103167872 B CN103167872 B CN 103167872B
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CN
China
Prior art keywords
carnitine
ethanol
reaction mixture
tartaric acid
tartrate
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CN201180042646.0A
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English (en)
Chinese (zh)
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CN103167872A (zh
Inventor
T·布赫纳
U·察赫尔
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Lonza AG
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Lonza AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201180042646.0A 2010-09-06 2011-09-06 用于生产l-肉碱酒石酸盐的方法 Active CN103167872B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10009218A EP2425834A1 (en) 2010-09-06 2010-09-06 Process for the production of l-carnitine tartrate
EP10009218.8 2010-09-06
US38039210P 2010-09-07 2010-09-07
US61/380,392 2010-09-07
PCT/EP2011/004469 WO2012031736A1 (en) 2010-09-06 2011-09-06 Process for the production of l-carnitine tartrate

Publications (2)

Publication Number Publication Date
CN103167872A CN103167872A (zh) 2013-06-19
CN103167872B true CN103167872B (zh) 2016-01-20

Family

ID=43638725

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180042646.0A Active CN103167872B (zh) 2010-09-06 2011-09-06 用于生产l-肉碱酒石酸盐的方法

Country Status (8)

Country Link
US (1) US8779188B2 (enExample)
EP (2) EP2425834A1 (enExample)
JP (1) JP5964831B2 (enExample)
KR (1) KR101899015B1 (enExample)
CN (1) CN103167872B (enExample)
ES (1) ES2531069T3 (enExample)
TW (1) TWI574938B (enExample)
WO (1) WO2012031736A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6421161B2 (ja) * 2015-11-27 2018-11-07 株式会社タムラ製作所 感光性樹脂組成物
WO2017105090A1 (ko) * 2015-12-14 2017-06-22 제이투에이치바이오텍 (주) 오로트산 l-카르니틴의 결정질 다형체, 이의 제조방법 또는 용도
CN109096129B (zh) * 2018-09-30 2021-04-27 东北制药集团股份有限公司 一种左旋肉碱酒石酸盐的制备方法
CN114181101A (zh) * 2021-11-26 2022-03-15 开原亨泰营养科技有限公司 能够控制产品晶型的左旋肉碱酒石酸盐的制备方法
CN115745818B (zh) * 2022-11-22 2024-08-09 安徽泰格生物科技有限公司 一种左旋肉碱盐酸盐的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1212785B (it) * 1983-11-02 1989-11-30 Isom Spa Procedimento industriale per la separazione della d.l. carnitina nei suoi isomeri ottici.
US5073376A (en) 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
IL127266A (en) * 1996-05-31 2002-09-12 Sigma Tau Ind Farmaceuti Stable, non-hygroscopic mucate salts of l(-) carnitine and alkanoyl l(-) carnitines, a process for their preparation and solid, orally administrable compositions containing such salts
IT1289974B1 (it) * 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
IT1291133B1 (it) * 1997-04-07 1998-12-29 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti l-carnitina e alcanoil l-carnitine magnesio tartrato
CN1167669A (zh) 1997-04-09 1997-12-17 周觉民 一种藤皮片材及其制作方法
IT1312018B1 (it) * 1999-03-19 2002-04-04 Fassi Aldo Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina.
IT1317013B1 (it) * 2000-04-12 2003-05-26 Biosalts Srl Sostanze dolcificanti, particolarmente per il caffe' ed il the'.
CN1167669C (zh) * 2000-10-20 2004-09-22 东北制药总厂 制备左旋肉碱酒石酸盐的新方法
WO2006028068A1 (ja) * 2004-09-08 2006-03-16 Wako Pure Chemical Industries, Ltd. Ｌ－カルニチンの精製方法

Also Published As

Publication number Publication date
EP2613778A1 (en) 2013-07-17
HK1186391A1 (zh) 2014-03-14
JP5964831B2 (ja) 2016-08-03
CN103167872A (zh) 2013-06-19
TWI574938B (zh) 2017-03-21
US8779188B2 (en) 2014-07-15
ES2531069T3 (es) 2015-03-10
KR20140019769A (ko) 2014-02-17
EP2613778B1 (en) 2014-12-03
KR101899015B1 (ko) 2018-09-14
EP2425834A1 (en) 2012-03-07
WO2012031736A1 (en) 2012-03-15
TW201217311A (en) 2012-05-01
JP2013536814A (ja) 2013-09-26
US20120059189A1 (en) 2012-03-08

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