CN103156186A - Calcium tablet using deep-sea fish bone as raw material and preparation method thereof - Google Patents
Calcium tablet using deep-sea fish bone as raw material and preparation method thereof Download PDFInfo
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- CN103156186A CN103156186A CN2011104153981A CN201110415398A CN103156186A CN 103156186 A CN103156186 A CN 103156186A CN 2011104153981 A CN2011104153981 A CN 2011104153981A CN 201110415398 A CN201110415398 A CN 201110415398A CN 103156186 A CN103156186 A CN 103156186A
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Abstract
The present invention relates to a calcium tablet using deep-sea fish bone as a raw material and a preparation method thereof. The calcium tablet is prepared by blending, screening, granulating, and other conventional methods by taking fish bone meal, skim milk powder, lactitol and aspartame as raw materials. The mass ratio of the raw materials is 45-55 parts of the fish bone meal, 40-45 parts of skimm milk powder, 5-10 parts of lactitol and 0.01-0.03 parts of aspartame. The fish bone meal is obtained by processing deep-sea fish bone by an alkali alcohol method. The calcium tablet of the present invention has the characteristics of high solubility and high bioavailability, can promote the body's absorption of calcium, has a good calcium supplement effect, is rich in raw materials, low in cost and simple in production process, and can be widely used for the calcium-deficiency population such as the elderly and children.
Description
Technical field
The invention belongs to field of health care products, relate to a kind of calcium tablet and preparation method thereof, specifically a kind of calcium tablet take the deep-sea fish fish-bone as raw material and preparation method thereof.
Background technology
Calcium is one of necessary mineral element of human body, is the important composition composition of bone.It is very important for safeguarding skeleton normal bone density and health that take in sufficient calcium constituent every day.It is the calcium source mainly with inorganic calcium that tradition changes supplementing preparation, as the calcium carbonate calcium tablet.This type of calcium source alkalescence is strong, stomach is stimulated very large, and human body take in after the calcium constituent absorption rate low; In addition, some is limited due to the solubility of calcium constituent with the calcium supplementing preparation of the animal skeletons such as fish-bone, pig bone exploitation, makes calcium constituent fail to play the effect of effectively replenishing.The exploitation bioavilability is high, calcium supplementing preparation that excitant is little, with low cost becomes the main development direction of calcium supplementing product from now on.
Fish-bone is one of processing of aquatic products important by-products, accounts for output of aquatic products 10% left and right.China's output of aquatic products occupies the first in the world, and the fish-bone annual production reaches millions of tons.Fish-bone calcium belongs to calcium phosphate, solves skeleton on chemical composition, is a kind of high-quality calcium source.Take this type of resource as raw material, exploitation fish-bone calcium product is significant for promoting that people's health and processing of aquatic products industry develop in a healthy way.
Summary of the invention
First technical problem to be solved by this invention is to provide a kind of calcium tablet take the deep-sea fish fish-bone as raw material, has the advantages that solubility is high, bioavilability is high, can be widely used in the calcium deficiency crowds such as old man, children, and effect of supplemented calcium is preferably arranged.
Second technical problem to be solved by this invention is to provide a kind of preparation method of the calcium tablet take the deep-sea fish fish-bone as raw material, and not only production technology is easy, and is with low cost, and the calcium tablet that makes has the advantages that solubility is high, bioavilability is high.
The present invention solves the technical scheme that above-mentioned first technical problem adopts: a kind of calcium tablet take the deep-sea fish fish-bone as raw material, it is characterized in that described calcium tablet be by mass ratio be fishbone dust 45～55, skimmed milk power 40～45, lactitol 5～10, Aspartame 0.01～0.03 raw material through be mixed, sieve, granulation obtains, described fishbone dust be take the deep-sea fish-bone as raw material after alkali alcohol method is processed the fishbone dust of gained.
The present invention solves the technical scheme that above-mentioned second technical problem adopt: a kind of preparation method of the calcium tablet take the deep-sea fish fish-bone as raw material is characterized in that step is followed successively by:
1) with the fish-bone of deep-sea fish through cleaning and degreasing, crushed after being dried to the powder more than granularity 300 orders;
2) fishbone dust after pulverizing and 0.5～1.5mol/L sodium hydroxide solution mix according to 1: 4～6 mass ratio, soaked 24～36 hours, filter, fishbone dust is cleaned after neutral with 50～70% alcohol solution dipping 12～18 hours with distilled water, wherein the mass ratio of fishbone dust and ethanolic solution is 1: 4～6, clean except alcohol with distilled water after filtering, drying to moisture is the fishbone dust of 9～11 (wt) %;
3) with step 2) fishbone dust that makes and distilled water mixes according to 1: 0.5～1.5 mass ratio and is placed in container, the papain and the food flavor enzyme that add fishbone dust quality 2～3%, stir, be heated to 40～45 ℃ of solution central temperatures, be incubated 1～2 hour, filter, clean fishbone dust with distilled water, dry to moisture be 9～11 (wt) %;
4) with step 3) fishbone dust that makes is placed in the mix acid liquor of citric acid and hydrochloric acid, the mass ratio of fishbone dust and mix acid liquor 1: 9～11 soaked 36～60 hours, took out, distilled water cleans to neutral, dries to moisture to be about 9～11 (wt) %;
5) at last with step 4) fishbone dust that obtains and skimmed milk power, lactitol and Aspartame be according to mass ratio 45～55: 40～45: 5～10: 0.01～0.03 ratio, through the calcium tablet that is mixed, sieves, 0.8～1.2g/ grain is made in granulation.
As improvement, described step 1) degreasing in is just fish-bone to be cleaned rear infusion 1～2 hour, described drying be in drying box 140～180 ℃ dry to moisture 9～11 (wt) %, described pulverizing is first to be placed in pulverizer to pulverize, then adopts the ultramicro grinding level to pulverize.
As preferably, described step 2) the Papain Enzymatic Activity 10000IU/g in, food flavor enzyme vigor 20000IU/g, the mass ratio of papain and food flavor enzyme are 1: 1～1.5
At last, the citric acid described step 3) and the mixed solution of hydrochloric acid are by following condition configuration: citric acid solution concentration is 9～11 (wt) %, and concentration of hydrochloric acid solution is 0.04～0.06mol/L, and two kinds of acid solution equal-volumes mix.
Described deep-sea fish is anglerfish or tuna.
Compared with prior art, the invention has the advantages that:
(1) fishbone dust can be removed most of fish oil fat after alkali alcohol method is processed, and can effectively improve the fishbone dust local flavor, plays and takes off the raw meat deodorising effect;
(2) human body is relevant with calcium constituent solubility to the absorption rate of calcium constituent, because hydroxyapatite calcium and collagen in fish-bone combine, externally also has the protection of hydration shell, cause calcium solubility low, adopt the bio-enzyme degradation collagenous fibres can significantly improve the solubility of calcium, and then improve the bioavilability of calcium constituent;
(3) fishbone dust after mix acid liquor is processed, has sterilization and the effect of eliminating histamine in fish-bone, and the reduction of pH simultaneously also helps and suppress the microbial growth growth in following process, storage, and acid treatment also can further improve product special flavour.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1:
(1) take a certain amount of fish-bone, clear water is cleaned to be placed on and was added the water infusion in digester 1 hour, pull fish-bone out and be placed in 160 ℃, drying box and dry to moisture and be about 10 (wt) %, pulverize in pulverizer and be placed on, then adopt more than the ultramicro grinding level is crushed to granularity 300 orders.
(2) fishbone dust mixes (mass ratio) with the 1mol/L sodium hydroxide solution according to 1: 5 ratio, soaked 24 hours, filter, fishbone dust distilled water cleans after neutral with 60 (wt) % alcohol solution dipping (mass ratio 1: 5) 18 hours, filter, fishbone dust is cleaned except alcohol with distilled water, dries to moisture to be about 10 (wt) %.
(3) fishbone dust and distilled water according to 1: 1 ratio (mass ratio) mix and be placed in container, (the enzyme preparation mass ratio is 1: 1 to add the papain of fishbone dust quality 2% and food flavor enzyme, Papain Enzymatic Activity 10000IU/g, food flavor enzyme vigor 20000IU/g), stir, be heated to 40 ℃ of solution central temperatures, be incubated 2 hours, filter, clean fishbone dust with distilled water, dry to moisture and be about 10 (wt) %.
(4) fishbone dust is placed in the mixed solution (mass ratio 1: 10) of citric acid and hydrochloric acid, wherein mix acid liquor is configured by following condition: citric acid solution concentration is 10 (wt) %, concentration of hydrochloric acid solution is 0.04mol/L, and two kinds of acid solution equal-volumes mix.Fishbone dust was soaked in mix acid liquor 48 hours, took out, and distilled water cleans to neutral, dried to moisture to be about 10 (wt) %.
(5) take respectively 45 parts, 45 parts, 10 parts and 0.01 part of fishbone dust, skimmed milk power, lactitol and Aspartames, through the tablet that is mixed, sieves, the conventional method such as granulation is made the lg/ grain.
Embodiment 2:
(1) take a certain amount of fish-bone, clear water is cleaned to be placed on and was added the water infusion in digester 1 hour, pull fish-bone out and be placed in 160 ℃, drying box and dry to moisture and be about 10 (wt) %, pulverize in pulverizer and be placed on, then adopt more than the ultramicro grinding level is crushed to granularity 300 orders.
(2) fishbone dust mixes (mass ratio) with the 1mol/L sodium hydroxide solution according to 1: 5 ratio, soaked 30 hours, filter, fishbone dust distilled water cleans after neutral with 60 (wt) % alcohol solution dipping (mass ratio 1: 5) 15 hours, filter, fishbone dust is cleaned except alcohol with distilled water, dries to moisture to be about 10 (wt) %.
(3) fishbone dust and distilled water according to 1: 1 ratio (mass ratio) mix and be placed in container, (the enzyme preparation mass ratio is 1: 1 to add the papain of fishbone dust quality 2% and food flavor enzyme, Papain Enzymatic Activity 10000IU/g, food flavor enzyme vigor 20000IU/g), stir, be heated to 43 ℃ of solution central temperatures, be incubated 1.5 hours, filter, clean fishbone dust with distilled water, dry to moisture and be about 10 (wt) %.
(4) fishbone dust is placed in the mixed solution (mass ratio 1: 10) of citric acid and hydrochloric acid, wherein mix acid liquor is configured by following condition: citric acid solution concentration is 10 (wt) %, concentration of hydrochloric acid solution is 0.05mol/L, and two kinds of acid solution equal-volumes mix.Fishbone dust was soaked in mix acid liquor 48 hours, took out, and distilled water cleans to neutral, dried to moisture to be about 10 (wt) %.
(5) take respectively 50 parts, 40 parts, 10 parts and 0.02 part of fishbone dust, skimmed milk power, lactitol and Aspartames, through the tablet that is mixed, sieves, the conventional method such as granulation is made the 1g/ grain.
Embodiment 3:
(1) take a certain amount of fish-bone, clear water is cleaned to be placed on and was added the water infusion in digester 1 hour, pull fish-bone out and be placed in 160 ℃, drying box and dry to moisture and be about 10 (wt) %, pulverize in pulverizer and be placed on, then adopt more than the ultramicro grinding level is crushed to granularity 300 orders.
(2) fishbone dust mixes (mass ratio) with the 1mol/L sodium hydroxide solution according to 1: 5 ratio, soaked 36 hours, filter, fishbone dust distilled water cleans after neutral with 60 (wt) % alcohol solution dipping (mass ratio 1: 5) 12 hours, filter, fishbone dust is cleaned except alcohol with distilled water, dries to moisture to be about 10 (wt) %.
(3) fishbone dust and distilled water according to 1: 1 ratio (mass ratio) mix and be placed in container, (the enzyme preparation mass ratio is 1: 1 to add the papain of fishbone dust quality 3% and food flavor enzyme, Papain Enzymatic Activity 10000IU/g, food flavor enzyme vigor 20000IU/g), stir, be heated to 45 ℃ of solution central temperatures, be incubated 1 hour, filter, clean fishbone dust with distilled water, dry to moisture and be about 10 (wt) %.
(4) fishbone dust is placed in the mixed solution (mass ratio 1: 10) of citric acid and hydrochloric acid, wherein mix acid liquor is configured by following condition: citric acid solution concentration is 10 (wt) %, concentration of hydrochloric acid solution is 0.06mol/L, and two kinds of acid solution equal-volumes mix.Fishbone dust was soaked in mix acid liquor 48 hours, took out, and distilled water cleans to neutral, dried to moisture to be about 10 (wt) %.
(5) take respectively 55 parts, 40 parts, 5 parts and 0.03 part of fishbone dust, skimmed milk power, lactitol and Aspartames, through the tablet that is mixed, sieves, the conventional method such as granulation is made the 1g/ grain.
Laboratory report:
Choose 80 of the rats of body weight 180～220g, be divided into 5 groups, 16 every group, male and female half and half are numbered respectively A, B, C, and the A group is control group, gives basal feed; B group gives basal feed+2g calcium tablet/(kgd); C group gives basal feed+4g calcium tablet/(kgd); D group gives basal feed+2g calcium carbonate/(kgd); E family basal feed+4g calcium carbonate/(kgd).Put to death after feeding for 12 weeks, measure rat blood calcium, bone density and calcium absorptivity.Result shows that calcium preparation absorption group blood calcium, bone density all are significantly higher than control group; All higher than the calcium carbonate group, and it is high to present intake, the trend that testing index is high with calcium tablet group under dosage (B, C group) rat blood calcium, calcium density and calcium absorptivity.Wherein C group calcium in rats absorptivity reaches 79.01%, shows that this product can promote rat to the availability of calcium, has effect of supplemented calcium preferably.
Claims (5)
1. calcium tablet take the deep-sea fish fish-bone as raw material, it is characterized in that described calcium tablet be by mass ratio be fishbone dust 45～55, skimmed milk power 40～45, lactitol 5～10, Aspartame 0.01～0.03 raw material through be mixed, sieve, granulation obtains, described fishbone dust be take the deep-sea fish-bone as raw material after alkali alcohol method is processed the fishbone dust of gained.
2. the preparation method of the calcium tablet take the deep-sea fish fish-bone as raw material is characterized in that step is followed successively by:
1) with the fish-bone of deep-sea fish through cleaning and degreasing, crushed after being dried to the powder more than granularity 300 orders;
2) fishbone dust after pulverizing and 0.5～1.5mol/L sodium hydroxide solution mix according to 1: 4～6 mass ratio, soaked 24～36 hours, filter, fishbone dust is cleaned after neutral with 50～70 (wt) % alcohol solution dipping 12～18 hours with distilled water, wherein the mass ratio of fishbone dust and ethanolic solution is 1: 4～6, clean except alcohol with distilled water after filtering, drying to moisture is the fishbone dust of 9～11 (wt) %;
3) with step 2) fishbone dust that makes and distilled water mixes according to 1: 0.5～1.5 mass ratio and is placed in container, the papain and the food flavor enzyme that add fishbone dust quality 2～3%, stir, be heated to 40～45 ℃ of solution central temperatures, be incubated 1～2 hour, filter, clean fishbone dust with distilled water, dry to moisture be 9～11 (wt) %;
4) with step 3) fishbone dust that makes is placed in the mix acid liquor of citric acid and hydrochloric acid, the mass ratio of fishbone dust and mix acid liquor 1: 9～11 soaked 36～60 hours, took out, distilled water cleans to neutral, dries to moisture to be about 9～11 (wt) %;
5) at last with step 4) fishbone dust that obtains and skimmed milk power, lactitol and Aspartame be according to mass ratio 45～55: 40～45: 5～10: 0.01～0.03 ratio, through be mixed, sieve, granulation makes calcium tablet.
3. preparation method according to claim 2, it is characterized in that described step 1) in degreasing be infusion 1～2 hour after just fish-bone being cleaned, described drying be in drying box 140～180 ℃ dry to moisture 9～11 (wt) %, described pulverizing is first to be placed in pulverizer to pulverize, then adopts the ultramicro grinding level to pulverize.
4. preparation method according to claim 2, is characterized in that described step 2) in Papain Enzymatic Activity 10000IU/g, food flavor enzyme vigor 20000IU/g, the mass ratio of papain and food flavor enzyme are 1: 1～1.5.
5. preparation method according to claim 2, it is characterized in that described step 3) in citric acid and the mixed solution of hydrochloric acid be by following condition configuration: citric acid solution concentration is 9～11 (wt) %, concentration of hydrochloric acid solution is 0.04～0.06mol/L, and two kinds of acid solution equal-volumes mix.
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| CN201110415398.1A CN103156186B (en) | 2011-12-14 | 2011-12-14 | Calcium tablet using deep-sea fish bone as raw material and preparation method thereof |
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Cited By (4)
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| WO2017131592A1 (en) | 2016-01-26 | 2017-08-03 | Thai Union Group Public Company Limited | A process for preparing fish bone powder |
| CN107822145A (en) * | 2017-09-27 | 2018-03-23 | 浙江海洋大学 | A kind of preparation method of tuna bone calcium of organic acid chewable tablets |
| CN109350628A (en) * | 2018-07-25 | 2019-02-19 | 深圳先进技术研究院 | Composite calcium preparation |
| CN113952447A (en) * | 2021-10-28 | 2022-01-21 | 国圣制药(上海)有限公司 | Multi-taste calcium chewable tablet and production and manufacturing process thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017131592A1 (en) | 2016-01-26 | 2017-08-03 | Thai Union Group Public Company Limited | A process for preparing fish bone powder |
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| CN107822145A (en) * | 2017-09-27 | 2018-03-23 | 浙江海洋大学 | A kind of preparation method of tuna bone calcium of organic acid chewable tablets |
| CN109350628A (en) * | 2018-07-25 | 2019-02-19 | 深圳先进技术研究院 | Composite calcium preparation |
| CN113952447A (en) * | 2021-10-28 | 2022-01-21 | 国圣制药(上海)有限公司 | Multi-taste calcium chewable tablet and production and manufacturing process thereof |
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| CN103156186B (en) | 2014-11-05 |
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