CN103142743B - Preparation method of effervescent granules for preventing and treating piglet diarrhea - Google Patents
Preparation method of effervescent granules for preventing and treating piglet diarrhea Download PDFInfo
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Abstract
The invention relates to a preparation method of a compound medicine for preventing and treating piglet diarrhea, which comprises the following steps: preparing the following raw materials in part by weight: 30-40 parts of Cortex Fraxini, 15-20 parts of poplar flower, 10-20 parts of wrinkled gianthyssop, 10-15 parts of gypsum, 5-10 parts of licorice root, 3-5 parts of sodium bicarbonate, 6-10 parts of citric acid, 10-15 parts of sucrose and 10-15 parts of 2% PVP (polyvinyl pyrrolidone)-K30 anhydrous ethanol; taking traditional Chinese medicine decoction pieces of the Cortex Fraxini, poplar flower, wrinkled gianthyssop, gypsum and licorice root, drying at 80 DEG C for 3 hours, pulverizing, and passing through a 50-mesh sieve to obtain powder A; adding the sodium bicarbonate, citric acid and sucrose into the powder A, pulverizing, and passing through a 50-mesh sieve to obtain powder B; and mixing the powder B for 30 minutes, adding the 2% PVP-K30 anhydrous ethanol for binding, granulating, and drying the whole granules. The medicine provided by the invention has the advantages of definite curative effect, higher drug effect and obviously lower cost. The invention avoids using propolis and other drugs with poor adaptability to a sick body.
Description
Technical field
The present invention relates to a kind of preparation method of the compound medicine of preventing and treating animal diarrhoea.
Background technology
Piglet diarrhea is the aquaculture management difficult problem that numerous raisers often run into, and the popular morbidity of piglet diarrhea is at present in rising trend; 10 ages in days are very high with interior piglet generation viral diarrhea mortality rate, even reach 100%; After the larger piglet of part occurs, although there is no death, late growing stage speed is obviously slower, causes many economic losses to raiser.Be one of symptom of systemic disease or the comprehensive syndrome of gastroenteropathy due to piglet diarrhea, often have antibacterial and viral mixed infection.
And the regulation of " about the emergency notice of checking the antiviral drugs such as amantadine " issued for 2006 according to the Ministry of Agriculture: except the vaccine product of producing, using through approval, ban use of other drug to prevent and treat the viral blight that class pathogenic microorganisms such as high pathogenic avian influenza cause.That is to say the domestic antiviral treatment Animal diseases that substantially banned use of; And normally used cured by antibiotics rate is very low, cost is high, and poor prognosis easily causes drug residue, cures the symptoms, not the disease.
Summary of the invention
The present invention is according to Chinese medical theory, and the preparation method of the herbal mixture of deep development control piglet diarrhea, for veterinary clinic provides a kind of safety economy, the significant medicine of drug effect.
For achieving the above object, the technical solution adopted in the present invention is: a kind of for preventing and treating the preparation method of effervescent granule of animal diarrhoea, step comprises: get the raw materials ready by weight: Cortex Fraxini 30-40 part, flower of poplar 15-20 part, Herba Pogostemonis 10-20 part, Gypsum Fibrosum 10-15 part, Radix Glycyrrhizae 5-10 part, sodium bicarbonate 3-5 part, citric acid 6-10 part, sucrose 10-15 part, 2%PVP-K30 dehydrated alcohol 10-15 part;
The first step: get the prepared slices of Chinese crude drugs of Cortex Fraxini, flower of poplar, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae, dry 3h for 80 DEG C, pulverize, cross 50 mesh sieves and obtain A powder;
Second step: pulverize after sodium bicarbonate, citric acid, sucrose are added to A powder, cross 50 mesh sieves and obtain B powder;
The 3rd step: by B powder mixing 30min, then add 2%PVP-K30 dehydrated alcohol to bind granulation, be then dried granulate and get final product.
Preferably, 35 parts of described Cortex Fraxinis, 17.5 parts of flower of poplar, 15 parts of Herba Pogostemoniss, 12.5 parts, Gypsum Fibrosum, 7.5 parts, Radix Glycyrrhizae, 4 parts of sodium bicarbonate, 8 parts of citric acid, 12.5 parts of sucrose, 12.5 parts of 2%PVP-K30 dehydrated alcohol.
Preferably, 35 parts of described Cortex Fraxinis, 20 parts of flower of poplar, each 17 parts of Herba Pogostemonis, 10 parts, Gypsum Fibrosum, 10 parts, Radix Glycyrrhizae, 3 parts of sodium bicarbonate, 10 parts of citric acid, 12 parts of sucrose, 10 parts of 2%PVP-K30 dehydrated alcohol.
Medicine of the present invention can mix with feedstuff, or drinking-water uses.Effervescent granule is especially applicable to drinking-water and uses, and dosage is easy to control, and medicine absorption easy to digest is rapid-action.Effervescent granule dosage is looked state of an illness weight and is used every day by 1-4g/kg.Obviously, medicine of the present invention is also applicable to the diarrhoea prevention of other similar animal by this consumption.
Cortex Fraxini heat clearing and damp drying in the present invention, convergence dysentery relieving, is monarch drug; Flower of poplar heat-clearing and toxic substances removing, removing dampness antidiarrheal, is ministerial drug; Herba Pogostemonis removing dampness by means of aromatics, promoting qi circulation, resolving food retention are adjuvant drug; Gypsum Fibrosum eliminating dampness and diuresis, clearing away heat to stop diarrhea are adjuvant drug; Radix Glycyrrhizae invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription, for making medicine.All medicines share, and play altogether the merit of heat-clearing and toxic substances removing, removing dampness dysentery relieving.Sodium bicarbonate and citric acid are effervescent intermixture, and sucrose has the function of school taste agent and filler concurrently, and 2%PVP-K30 dehydrated alcohol is adhesive.2%PVP-K30 dehydrated alcohol is that solute is PVP-K30, and solvent is dehydrated alcohol, the solution of content 2%.
Herbal mixture prescription of the present invention can resisting pathogenic microbes and parasite.Cortex Fraxini has broad-spectrum antiseptic, antivirus action, staphylococcus aureus, streptococcus, white chain pearl bacterium, pyococcus, dysentery bacterium, escherichia coli, tubercule bacillus and multiple fungus, virus, Mus plasmodium and Schistosoma japonicum are had and suppressed and killing action, Cortex Fraxini can also strengthen the phagocytic activity of RES, improves the non-specific of body.Flower of poplar has stronger inhibitory action to staphylococcus aureus, hemophilus influenza, streptococcus pneumoniae and multiple digestive tract cause of disease bacterium, and multiple virus, fungus and leptospira etc. are had to inhibition and killing action in various degree.The present invention can regulate gastrointestinal function and protection gastrointestinal mucosa simultaneously, and each prescription medicine has certain promotion to intestinal motility, is conducive to a certain extent promote toxin excretion.Gypsum Fibrosum powder is because granule is little, and the gross area is large, can adsorb a large amount of chemical irritants or poisonous substance.Remove and be distributed in mucosa or skin ulcer face, can form overlay film, reduce local chemistry and mechanical stimulus, simultaneously again can absorptive tissue abnormal secretion thing and inflammatory exudate, therefore can promote tissue repair.After for oral administration, can protect gastrointestinal mucosa, performance antiinflammatory, antidiarrheal efficacy.Simultaneously medicine property of medicine gentleness, the crude drug that does not adopt propolis etc. itself to be difficult to digestion and to absorb, is easy to animal and absorbs.
In prior art: the animal diarrhoea formula of application Cortex Fraxini is generally large formula, and joins the Radix Pulsatillae, Rhizoma Coptidis; In the diarrhoea formula of application flower of poplar, conventionally join propolis.Flower of poplar of the present invention, Cortex Fraxini cost are only commercially available prod 1/5th of the Radix Pulsatillae used of filling a prescription, and are one of percentage of propolis.Therefore not only determined curative effect of medicine of the present invention, improves drug effect, and has significantly reduced medicine cost.Also avoid the propolis that uses sick body adaptability poor.
On the whole, advantage of the present invention is in particular in:
1, the famous-brand and high-quality Chinese crude drug component of compound compatibility and ratio, has given full play to the comprehensive therapeutic effect of Chinese medicine multicomponent, multiple location, many target spots.There is resisting pathogenic microbes and parasite, regulate the function of gastrointestinal function and protection gastrointestinal mucosa, control the various complicated state of an illness of piglet diarrhea comprehensively.
2, use advanced effervescent formulation technology, combine with Chinese medicine powder technique, product of the present invention dissolves rapidly, absorbs soon, and bioavailability is high, has Comprehensive Treatment effect.Use approach is more various, and directly oral, mixed feeding, drinking-water use and all can.
3, natural Chinese medicines preparation toxic and side effects is little, does not have medicine residual, and after medication, without withdrawal time, the pathogenic microorganism that also can avoid using in a large number chemicals to cause develops immunity to drugs and the problem such as environmental pollution.Reasonably preparation process operation is very convenient simple, and Chinese herbal medicine resource is abundant, and cost control is low, is conducive to commercial production needs.
4, the effervescent granule Chinese herbal medicine powder that maturation process is made is very stable, can at room temperature preserve for a long time.
Detailed description of the invention
Chinese crude drug Cortex Fraxini, flower of poplar, Herba Pogostemonis, Gypsum Fibrosum, the Radix Glycyrrhizae using in embodiment is purchased from prepared slices of Chinese crude drugs factory of Chongqing City.Sodium bicarbonate, citric acid, PVP-K30, dehydrated alcohol are purchased from Tianjin Binhai Guan Lin Science and Technology Ltd., and sucrose is purchased from Hebei Sheng Xue glucose company limited.
Embodiment mono-
1, formula
By weight: Cortex Fraxini 30, flower of poplar 15, Herba Pogostemonis, Gypsum Fibrosum are each 10, Radix Glycyrrhizae 5, sodium bicarbonate 3, citric acid 6, sucrose 10,2%PVP-K30 dehydrated alcohol 10.
2: preparation method
The first step: get the prepared slices of Chinese crude drugs of Cortex Fraxini, flower of poplar, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae, dry 3h for 80 DEG C, use beater disintegrating machine chopping after mixing, cross 50 mesh sieve extension sets and obtain A powder.
Second step: use beater disintegrating machine chopping after sodium bicarbonate, citric acid, sucrose are added to A powder, cross 50 mesh sieve extension sets and obtain B powder.
The 3rd step: take out after B powder is dropped into V-Mixer mixing 30min, then drop into one-step-granulating method, add 2%PVP-K30 dehydrated alcohol to bind simultaneously and granulate, finally use the dry granulate of airpillow-dry stove and get final product.
Embodiment bis-
1, formula
By weight: Cortex Fraxini 35, flower of poplar 17.5, Herba Pogostemonis 15, Gypsum Fibrosum 12.5, Radix Glycyrrhizae 7.5, sodium bicarbonate 4, citric acid 8, sucrose 12.5,2%PVP-K30 dehydrated alcohol 12.5.
2: preparation method: identical with method described in embodiment 1.
Embodiment tri-
1, formula
By weight: Cortex Fraxini 40, flower of poplar, Herba Pogostemonis are each 20, Gypsum Fibrosum 15, Radix Glycyrrhizae 10, sodium bicarbonate 5, citric acid 10, sucrose 15,2%PVP-K30 dehydrated alcohol 15.
2: preparation method: identical with method described in embodiment 1.
Embodiment tetra-
1, formula
By weight: Cortex Fraxini 30, flower of poplar 20, Herba Pogostemonis are each 12, Gypsum Fibrosum 12, Radix Glycyrrhizae 8, sodium bicarbonate 5, citric acid 7, sucrose 12,2%PVP-K30 dehydrated alcohol 12.
2: preparation method: identical with method described in embodiment 1.
Embodiment five
1, formula
By weight: Cortex Fraxini 40, flower of poplar 20, Herba Pogostemonis are each 10, Gypsum Fibrosum 12, Radix Glycyrrhizae 7, sodium bicarbonate 4, citric acid 7, sucrose 13,2%PVP-K30 dehydrated alcohol 15.
2: preparation method: identical with method described in embodiment 1.
Embodiment six
1, formula
By weight: Cortex Fraxini 35, flower of poplar 20, Herba Pogostemonis are each 17, Gypsum Fibrosum 10, Radix Glycyrrhizae 10, sodium bicarbonate 3, citric acid 10, sucrose 12,2%PVP-K30 dehydrated alcohol 10.
2: preparation method: identical with method described in embodiment 1.
One, the accelerated stability test of effervescent granule of the present invention
1, materials and methods: the effervescent granule of getting embodiment 1-3, carry out hot and humid high light according to annex medicine stability experimental technique of " Chinese veterinary pharmacopoeia " version in 2010 and accelerate experiment, by drafting commercially available back, in the medicine stability experimental box (Chongqing immortality experimental apparatus factory) of 40 ± 2 DEG C of temperature, relative humidity 75 ± 5%, illumination 4500 ± 500LX, place 6 months, sample respectively once the 1st, 2,3,6 the end of month at experimental session, the character to powder, the uniformity, content, moisture content, granularity are investigated.
2, result: in table 1.As shown in Table 1, Chinese herbal medicine effervescent granule dysentery relieving powder of the present invention is in accelerated test after 6 months, and character, the uniformity, dissolubility, moisture content, granularity, each component content have no significant change, have good stability,
Table 1: Chinese herbal medicine effervescent granule dysentery relieving powder
Two, the extracorporeal bacteria inhibitor test of effervescent granule of the present invention
Sample A1, homemade embodiment 1 product of laboratory;
Sample A2, homemade embodiment 2 products of laboratory;
Sample A3, homemade embodiment 3 products of laboratory;
Escherichia coli (standard), Salmonella (standard), staphylococcus aureus (standard) are purchased from China Veterinary Drugs Supervisory Inst..
1, method: picking escherichia coli (standard), Salmonella (standard), staphylococcus aureus (standard) culture, streak inoculation is on agar plate, the circular rustless steel tubule of sterilizing (internal diameter 6nm, external diameter 8nm, high 10nm) is positioned on flat board, pressurization gently, make itself and the dull and stereotyped tight that contacts, each dull and stereotyped three steel pipes of placing drip for reagent liquid respectively in steel pipe: by A1, A2 and A3 respectively water for injection be diluted to 20mg/ml, 10mg/ml, 5mg/ml.Cultivate 10-20 hour by adding for the flat board after reagent liquid at 37 DEG C, measure inhibition zone size statistical result.
2, result: in table 2.As can be seen from Table 2, effervescent granule of the present invention also has stronger in-vitro antibacterial ability to the various sensitive organisms that cause piglet diarrhea at low concentration 10mg/ml.
Table 2: In Vitro Bacteriostasis experimental result
Three, effervescent granule of the present invention is at veterinary clinic effect
1. materials and methods
1.1 medicine
Effervescent granule, the sample of the employing embodiment of the present invention 2.
1.2 cases sources: technical staff in Hechuan, the area such as Guangan, Tongliang County gathers clinical natural occurrence case, is respectively piglet transmissible gastroenteritis 337 examples, piglet epidemic diarrhea 142 examples, yellow and white dysentery of piglet 3250 examples, piglet parasitic diarrhea 284 examples.
1.3 case diagnosis: with natural cases according to epidemiology, clinical symptoms, pathological change, Laboratory Diagnosed.Comprehensive analysis, makes a definite diagnosis.
1.4 implementation processes: carry out case selection and implement treatment by test requirements document by the technical staff of this seminar, and log.
1.5 results are judged
By natural cases according to dosage with the administration of drinking water the course for the treatment of, dosage is pressed 2g/kg every day.In one week, observe, pay a return visit and record the state of an illness.Case criterion:
Cure: 3-4 future trouble poultry disease of medication disappears completely, and spirit, body temperature, appetite recover normal, and urine feces is normal.
Effective: 3-4 future trouble poultry disease of medication disappears substantially, and spirit, body temperature, appetite make moderate progress, and urine feces is normal.
Invalid: 4 future troubles of medication poultry diseases do not disappear, sb.'s illness took a turn for the worse or dead, and urine stool colour, character are undesired.
2. result: in table 3.Effervescent granule of the present invention has good therapeutic effect as can be seen from Table 3, and the effective percentage such as piglet transmissible gastroenteritis, piglet epidemic diarrhea, yellow and white dysentery of piglet, piglet parasitic diarrhea are reached more than 96.0%, and cure rate is all more than 91%.
Table 3: effervescent granule clinical therapeutic efficacy statistical table
Claims (3)
1. for preventing and treating the preparation method of effervescent granule for piglet diarrhea, step comprises: get the raw materials ready by weight: Cortex Fraxini 30-40 part, flower of poplar 15-20 part, Herba Pogostemonis 10-20 part, Gypsum Fibrosum 10-15 part, Radix Glycyrrhizae 5-10 part, sodium bicarbonate 3-5 part, citric acid 6-10 part, sucrose 10-15 part, 2%PVP-K30 dehydrated alcohol 10-15 part;
The first step: get the prepared slices of Chinese crude drugs of Cortex Fraxini, flower of poplar, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae, dry 3h for 80 DEG C, pulverize, cross 50 mesh sieves and obtain A powder;
Second step: pulverize after sodium bicarbonate, citric acid, sucrose are added to A powder, cross 50 mesh sieves and obtain B powder;
The 3rd step: by B powder mixing 30min, then add 2%PVP-K30 dehydrated alcohol to bind granulation, be then dried granulate and get final product.
2. according to claim 1 for preventing and treating the preparation method of effervescent granule of piglet diarrhea, it is characterized in that: 35 parts of described Cortex Fraxinis, 17.5 parts of flower of poplar, 15 parts of Herba Pogostemoniss, 12.5 parts, Gypsum Fibrosum, 7.5 parts, Radix Glycyrrhizae, 4 parts of sodium bicarbonate, 8 parts of citric acid, 12.5 parts of sucrose, 12.5 parts of 2%PVP-K30 dehydrated alcohol.
3. according to claim 1 for preventing and treating the preparation method of effervescent granule of piglet diarrhea, it is characterized in that: 35 parts of described Cortex Fraxinis, 20 parts of flower of poplar, 17 parts of Herba Pogostemoniss, 10 parts, Gypsum Fibrosum, 10 parts, Radix Glycyrrhizae, 3 parts of sodium bicarbonate, 10 parts of citric acid, 12 parts of sucrose, 10 parts of 2%PVP-K30 dehydrated alcohol.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000025801A1 (en) * | 1998-11-02 | 2000-05-11 | Chinese Medicines Scientific Consultants Pty Ltd. | Herbal compositions for treating gastrointestinal disorders |
| CN101238856A (en) * | 2008-01-28 | 2008-08-13 | 吴忠尚 | Chinese medicinal composition for preventing and controlling virosis of livestock and poultry and preparation thereof |
| CN102764313A (en) * | 2012-08-14 | 2012-11-07 | 天津生机集团股份有限公司 | Drug for preventing swine winter dysentery and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000025801A1 (en) * | 1998-11-02 | 2000-05-11 | Chinese Medicines Scientific Consultants Pty Ltd. | Herbal compositions for treating gastrointestinal disorders |
| CN101238856A (en) * | 2008-01-28 | 2008-08-13 | 吴忠尚 | Chinese medicinal composition for preventing and controlling virosis of livestock and poultry and preparation thereof |
| CN102764313A (en) * | 2012-08-14 | 2012-11-07 | 天津生机集团股份有限公司 | Drug for preventing swine winter dysentery and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 全国中西兽医结合学术研究会华北分会.华北第四次中兽医科研协作会议资料选编.《华北第四次中兽医科研协作会议资料选编》.1979,第95-97页，第95页倒数第3行. * |
| 毛嘉陵.茶饮保健顾问.《茶饮保健顾问》.1996,(第1版),第130页第338节. * |
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Address after: 401519 Hechuan Industrial Park, Chongqing, Chongqing, Chongqing Patentee after: Jin He Xing (Chongqing) Biotechnology Co., Ltd. Address before: 401519 Hechuan Industrial Park, Chongqing, Chongqing, Chongqing Patentee before: Chongqing Jinbang Animal Pharmaceutical Co., Ltd. |
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