CN104083502B - The preparation method of preventing and treating piglet diarrhea medicine - Google Patents

Abstract

The present invention relates to a kind of compound medicine preventing and treating animal diarrhea.This medicine includes by weight: Cortex Fraxini 30 40 parts, flower of poplar 15 20 parts, Herba Pogostemonis 10 20 parts, 10 15 parts of Gypsum Fibrosum, 5 10 parts of Radix Glycyrrhizae, sodium bicarbonate 35 parts, citric acid 6 10 parts, sucrose 10 15 parts, 2%PVP K30 dehydrated alcohol 10 15 parts.Cortex Fraxini heat clearing and damp drying in the present invention, restrains dysentery relieving, for monarch drug；Flower of poplar heat-clearing and toxic substances removing, removing dampness antidiarrheal, for ministerial drug；Herba Pogostemonis removing dampness by means of aromatics, promoting qi circulation, resolving food retention, for adjuvant drug；Gypsum Fibrosum eliminating dampness and diuresis, clearing away heat to stop diarrhea, for adjuvant drug；Radix Glycyrrhizae invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription, for making medicine.All medicines share, and play heat-clearing and toxic substances removing, the merit of removing dampness dysentery relieving altogether.The medicine of the present invention not only determined curative effect, improves drug effect, and significantly reduces medicine cost.Also avoid using the medical materials such as the poor propolis of sick body adaptability.

Description

The preparation method of preventing and treating piglet diarrhea medicine

The application is Application No.: 201310102820.7, and patent name is: " one is used for preventing Control the effervescent granule of piglet diarrhea " the divisional application of patent of invention, the original bill applying date: 2013 On March 27, in.

Technical field

The present invention relates to a kind of compound medicine preventing and treating animal diarrhea.

Background technology

Piglet diarrhea is the aquaculture management difficult problem that numerous raisers are frequently encountered by, current piglet diarrhea stream Row morbidity is in rising trend；Piglet generation viral diarrhea mortality rate within 10 ages in days is the highest, Even up to 100%；After the bigger piglet of part occurs, although there is no death, but late growing stage speed Significantly slower, cause many economic losses to raiser.Owing to piglet diarrhea is systemic disease One of or the symptom of the comprehensive syndrome of gastroenteropathy, often there are antibacterial and the mixed infection of virus.

And according to the Ministry of Agriculture 2006 issue " about checking the antiviral drugs such as amantadine Emergency notice " regulation: except approved production, use vaccine product in addition to, prohibit the use of other The viral blight that the one class pathogenic microorganisms such as medical treatment high pathogenic avian influenza cause.Namely Say and domestic the most substantially prohibit the use of antiviral treatment Animal diseases；And normally used antibiosis Element cure rate is the lowest, and cost is high, and poor prognosis easily causes drug residue, cures the symptoms, not the disease.

Summary of the invention

The present invention is according to Chinese medical theory, and the herbal mixture of deep development preventing and treating piglet diarrhea, for beast Doctor's clinic provides a kind of safety economy, the significant medicine of drug effect.

For achieving the above object, the technical solution adopted in the present invention is: one is used for preventing and treating The medicine of animal diarrhea, it is characterised in that: include by weight: Cortex Fraxini 30-40 part, flower of poplar 15-20 part, Herba Pogostemonis 10-20 part, Gypsum Fibrosum 10-15 part, Radix Glycyrrhizae 5-10 part.

Preferably, described medicine includes sucrose or dextrin or maltose 10-15 part.Increase these Correctives can improve palatability of drugs as adjuvant.

Preferably, described medicine is prepared as effervescent granule.Or can also be prepared as tablet, The dosage forms such as liquid preparation.

Preferably effervescent granule composition is: include by weight: Cortex Fraxini 30-40 part, flower of poplar 15-20 part, Herba Pogostemonis 10-20 part, Gypsum Fibrosum 10-15 part, Radix Glycyrrhizae 5-10 part, sodium bicarbonate 3-5 Part, citric acid 6-10 part, sucrose 10-15 part, 2%PVP-K30 dehydrated alcohol 10-15 part.Carbon Acid hydrogen sodium and citric acid are effervescent intermixture, and sucrose has school taste agent and the function of filler concurrently, 2%PVP-K30 dehydrated alcohol is adhesive.2%PVP-K30 dehydrated alcohol be i.e. solute be PVP-K30, Solvent is dehydrated alcohol, the solution of content 2%.

Preferably, described Cortex Fraxini 35 parts, flower of poplar 17.5 parts, Herba Pogostemonis 15 parts, Gypsum Fibrosum 12.5 Part, 7.5 parts of Radix Glycyrrhizae, sodium bicarbonate 4 parts, citric acid 8 parts, sucrose 12.5 parts, 2%PVP-K30 Dehydrated alcohol 12.5 parts.

Preferably, described Cortex Fraxini 35 parts, flower of poplar 20 parts, each 17 parts of Herba Pogostemonis, Gypsum Fibrosum 10 Part, 10 parts of Radix Glycyrrhizae, sodium bicarbonate 3 parts, citric acid 10 parts, sucrose 12 parts, 2%PVP-K30 Dehydrated alcohol 10 parts.

The preparation method of effervescent granule of the present invention, comprises the steps:

The first step: take the prepared slices of Chinese crude drugs of Cortex Fraxini, flower of poplar, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae, 80 DEG C of bakings Dry 3h, pulverizes, and crosses 50 mesh sieves and obtains A powder；

Second step: pulverize after sodium bicarbonate, citric acid, sucrose are added A powder, cross 50 mesh sieves Obtain B powder；

3rd step: by B powder mixing 30min, adds 2%PVP-K30 dehydrated alcohol and binds granulation, Then it is dried granulate and get final product.

The medicine of the present invention can mix with feedstuff, or drinking-water uses.Effervescent granule is the suitableeest Closing drinking-water to use, dosage is easy to control, medicine absorption easy to digest, rapid-action.Effervescent granule is given Dose is pressed 1-4g/kg regarding state of an illness weight and is used every day.Obviously, the medicine of the present invention is by this consumption also It is applicable to the diarrhoea prevention of other similar animal.

Cortex Fraxini heat clearing and damp drying in the present invention, restrains dysentery relieving, for monarch drug；Flower of poplar heat-clearing and toxic substances removing, changes Wet antidiarrheal, for ministerial drug；Herba Pogostemonis removing dampness by means of aromatics, promoting qi circulation, resolving food retention, for adjuvant drug；Gypsum Fibrosum eliminating dampness and diuresis, Clearing away heat to stop diarrhea, for adjuvant drug；Radix Glycyrrhizae invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription, for making medicine.All medicines share, altogether Play heat-clearing and toxic substances removing, the merit of removing dampness dysentery relieving.

The herbal mixture prescription of the present invention can resisting pathogenic microbes and parasite.Cortex Fraxini has wide spectrum Antibacterial, antivirus action, to staphylococcus aureus, streptococcus, white chain pearl bacterium, suppurative Coccus, dysentery bacterium, escherichia coli, tubercule bacillus and multiple fungus, virus, Mus plasmodium and Schistosoma japonicum has suppression and killing action, and Cortex Fraxini can also strengthen the phagocytic activity of RES, improves machine Body non-specific.Flower of poplar to staphylococcus aureus, hemophilus influenza, streptococcus pneumoniae and Multiple digestive tract pathogen has stronger inhibitory action, to multiple virus, fungus and leptospira Etc. the suppression having in various degree and killing action.The present invention can regulate gastrointestinal function and protection simultaneously Gastrointestinal mucosa, each prescription medicine has certain promotion to intestinal motility, is conducive to a certain extent Promote toxin excretion.Gypsum Fibrosum powder is little due to granule, and the gross area is big, can adsorb a large amount of chemical irritant Or poisonous substance.Remove and be distributed in mucosa or skin ulcer face, overlay film can be formed, reduce chemistry and the mechanical stimulus of local, Simultaneously the most again can absorptive tissue abnormal secretion thing and inflammatory exudate, therefore tissue repair can be promoted.For oral administration After can protect gastrointestinal mucosa, play antiinflammatory, antidiarrheal efficacy.The medicine property of medicine is gentle simultaneously, does not uses Propolis etc. itself are difficult to the crude drug digesting and absorbing, it is easy to animal absorbs.

In prior art: the animal diarrhea formula of application Cortex Fraxini is usually big formula, and join the Radix Pulsatillae, Rhizoma Coptidis；In the diarrhoea formula of application flower of poplar, generally join propolis.The flower of poplar of the present invention, Cortex Fraxini Cost is only used by the formula of commercially available prod 1/5th of the Radix Pulsatillae, for one of the percentage of propolis.Cause The medicine of this present invention not only determined curative effect, improves drug effect, and significantly reduces medicine cost. Also the propolis using sick body adaptability poor is avoided.

On the whole, advantages of the present invention is in particular in:

1, compound compatibility famous-brand and high-quality Chinese crude drug component and ratio, has given full play to Chinese medicine multicomponent, many Position, the comprehensive therapeutic effect of Mutiple Targets.There is resisting pathogenic microbes and parasite, regulate gastrointestinal function With the function of protection gastrointestinal mucosa, control the various complicated state of an illness of piglet diarrhea comprehensively.

2, use advanced effervescent formulation technology, combine with Chinese medicine powder technique, this Bright product dissolves rapidly, absorbs fast, and bioavailability is high, has Comprehensive Treatment effect.Make purposes Footpath is more various, and the most oral, mixed feeding, drinking-water use.

3, natural Chinese medicines preparation toxic and side effects is little, does not has medicine residual, without withdrawal time after medication, also The pathogenic microorganism using chemicals to cause in a large number can be avoided to develop immunity to drugs and environmental pollution etc. Problem.Reasonably preparation process operation is very convenient simply, and Chinese herbal medicine resource enriches, cost control Low, beneficially commercial production needs.

4, the effervescent granule Chinese herbal medicine powder that maturation process is made is sufficiently stable, can be at room temperature Long-time storage.

Detailed description of the invention

In embodiment, the Chinese crude drug Cortex Fraxini of use, flower of poplar, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae are purchased from Chongqing Prepared slices of Chinese crude drugs factory of city.Sodium bicarbonate, citric acid, PVP-K30, dehydrated alcohol are purchased from Tianjin Binhai Guan Lin Science and Technology Ltd., sucrose is purchased from Hebei Sheng Xue glucose company limited.

Embodiment one

1, formula

By weight: Cortex Fraxini 30, flower of poplar 15, Herba Pogostemonis, Gypsum Fibrosum are each 10, Radix Glycyrrhizae 5, carbonic acid Hydrogen sodium 3, citric acid 6, sucrose 10,2%PVP-K30 dehydrated alcohol 10.

2: preparation method

The first step: take the prepared slices of Chinese crude drugs of Cortex Fraxini, flower of poplar, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae, 80 DEG C of bakings Dry 3h, uses beater disintegrating machine chopping after mixing, cross 50 mesh sieve extension sets and obtain A powder.

Second step: use beater disintegrating machine after sodium bicarbonate, citric acid, sucrose are added A powder Chopping, crosses 50 mesh sieve extension sets and obtains B powder.

3rd step: take out after B powder is put into V-Mixer mixing 30min, then put into a step system Grain machine, is simultaneously introduced 2%PVP-K30 dehydrated alcohol and binds granulation, finally use airpillow-dry stove to do Dry granulate and get final product.

Embodiment two

1, formula

By weight: Cortex Fraxini 35, flower of poplar 17.5, Herba Pogostemonis 15, Gypsum Fibrosum 12.5, Radix Glycyrrhizae 7.5, Sodium bicarbonate 4, citric acid 8, sucrose 12.5,2%PVP-K30 dehydrated alcohol 12.5.

2: preparation method: identical with method described in embodiment 1.

Embodiment three

1, formula

By weight: Cortex Fraxini 40, flower of poplar, Herba Pogostemonis each 20, Gypsum Fibrosum 15, Radix Glycyrrhizae 10, carbonic acid Hydrogen sodium 5, citric acid 10, sucrose 15,2%PVP-K30 dehydrated alcohol 15.

2: preparation method: identical with method described in embodiment 1.

Embodiment four

1, formula

By weight: Cortex Fraxini 30, flower of poplar 20, Herba Pogostemonis each 12, Gypsum Fibrosum 12, Radix Glycyrrhizae 8, carbon Acid hydrogen sodium 5, citric acid 7, sucrose 12,2%PVP-K30 dehydrated alcohol 12.

2: preparation method: identical with method described in embodiment 1.

Embodiment five

1, formula

By weight: Cortex Fraxini 40, flower of poplar 20, Herba Pogostemonis each 10, Gypsum Fibrosum 12, Radix Glycyrrhizae 7, carbon Acid hydrogen sodium 4, citric acid 7, sucrose 13,2%PVP-K30 dehydrated alcohol 15.

2: preparation method: identical with method described in embodiment 1.

Embodiment six

1, formula

By weight: Cortex Fraxini 35, flower of poplar 20, Herba Pogostemonis each 17, Gypsum Fibrosum 10, Radix Glycyrrhizae 10, carbon Acid hydrogen sodium 3, citric acid 10, sucrose 12,2%PVP-K30 dehydrated alcohol 10.

2: preparation method: identical with method described in embodiment 1.

One, the accelerated stability test of effervescent granule of the present invention

1, materials and methods: the effervescent granule of Example 1-3, according to " Chinese veterinary pharmacopoeia " One annex medicine stability experimental technique of version in 2010 carries out hot and humid high light Acceleration study, presses Draft commercially available back, at temperature 40 ± 2 DEG C, relative humidity 75 ± 5%, illumination 4500 ± 500LX Medicine stability experimental box (Chongqing immortality experimental apparatus factory) in place 6 months, in experiment periods Between the 1st, 2,3,6 the end of month separately sampled once, to the character of powder, the uniformity, content, Moisture content, granularity are investigated.

2, result: be shown in Table 1.As shown in Table 1, the Chinese herbal medicine effervescent granule dysentery relieving powder of the present invention After accelerated test 6 months, character, the uniformity, dissolubility, moisture content, granularity, each composition contain Amount has no significant change, and has good stability,

Table 1: Chinese herbal medicine effervescent granule dysentery relieving powder

Two, the extracorporeal bacteria inhibitor test of the effervescent granule of the present invention

Sample A1, laboratory homemade embodiment 1 product；

Sample A2, laboratory homemade embodiment 2 product；

Sample A3, laboratory homemade embodiment 3 product；

Escherichia coli (standard), during Salmonella (standard), staphylococcus aureus (standard) are purchased from Veterinary drug supervision institute of state.

1, method: picking escherichia coli (standard), Salmonella (standard), Staphylococcus aureus Bacterium (standard) culture, streak inoculation is on agar plate, by (interior for the circular rustless steel tubule of sterilizing Footpath 6nm, external diameter 8nm, high 10nm) it is positioned on flat board, pressurize gently so that it is with board joint Touching tight, three steel pipes placed by each flat board, respectively in steel pipe dropping for reagent liquid: by A1, A2 and A3 is diluted to 20mg/ml, 10mg/ml, 5mg/ml with water for injection respectively.Addition is supplied Flat board after reagent liquid is cultivated 10-20 hour at 37 DEG C, measures inhibition zone size statistical result.

2, result: be shown in Table 2.As can be seen from Table 2, effervescent granule of the present invention is to causing son The various sensitive organisms of diarrhea of pigs also have stronger in-vitro antibacterial ability at low concentration 10mg/ml.

Table 2: antibacterial experiment in vitro result

Three, the effervescent granule of the present invention is in veterinary clinic application effect

1. materials and methods

1.1 medicine

Effervescent granule, uses the sample of the embodiment of the present invention 2.

1.2 cases sources: technical staff in Hechuan, Guangan, the area such as Tongliang County gather clinical natural Morbidity case, respectively piglet transmissible gastroenteritis 337 example, piglet epidemic diarrhea 142 example, Yellow and white dysentery of piglet 3250 example, piglet parasitic diarrhea 284 example.

1.3 case diagnosis: with natural cases according to epidemiology, clinical symptoms, pathological change, Laboratory Diagnosed.Comprehensive analysis, makes a definite diagnosis.

1.4 implementation processes: carried out case selection and reality by test requirements document by this seminar technical staff Treat treatment, and log.

1.5 results judge

By natural cases according to dosage with the drinking water administration course for the treatment of, dosage presses 2g/kg every day.In one week Observe, pay a return visit and record the state of an illness.Case criterion:

Cure: 3-4 future trouble poultry disease of medication is wholly absent, and spirit, body temperature, appetite are just being recovered Often, urine feces is normal.

Effective: 3-4 future trouble poultry disease of medication disappears substantially, and spirit, body temperature, appetite have changed Kind, urine feces is normal.

Invalid: 4 future trouble poultry diseases of medication do not disappear, and sb.'s illness took a turn for the worse or death, urine feces face Color, character are abnormal.

2. result: be shown in Table 3.The effervescent granule of the present invention has and well controls as can be seen from Table 3 Therapeutic effect, posts piglet transmissible gastroenteritis, piglet epidemic diarrhea, yellow and white dysentery of piglet, piglet The effective percentage such as infested property diarrhoea reach more than 96.0%, and cure rate is all more than 91%.

Table 3: effervescent granule clinical therapeutic efficacy statistical table

Claims (2)

1. one kind for preventing and treating the preparation method of medicine of piglet diarrhea, it is characterised in that: by with The raw material of lower weight ratio is made: Cortex Fraxini 40 parts, flower of poplar 20 parts, Herba Pogostemonis 20 parts, Gypsum Fibrosum 15 Part, 10 parts of Radix Glycyrrhizae, sodium bicarbonate 5 parts, citric acid 10 parts, sucrose 15 parts, 2%PVP-K30 Dehydrated alcohol 15 parts；

Preparation process is:

The first step: take the prepared slices of Chinese crude drugs of Cortex Fraxini, flower of poplar, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae, 80 DEG C of bakings Dry 3h, pulverizes, and crosses 50 mesh sieves and obtains A powder；Second step: by sodium bicarbonate, citric acid, sucrose Pulverize after adding A powder, cross 50 mesh sieves and obtain B powder；3rd step: by B powder mixing 30min, then add Enter 2%PVP-K30 dehydrated alcohol and bind granulation, be then dried granulate and get final product；Prepared by described medicine For effervescent granule.

2. one kind for preventing and treating the preparation method of medicine of piglet diarrhea, it is characterised in that: by with The raw material of lower weight ratio is made: Cortex Fraxini 40 parts, flower of poplar 20 parts, Herba Pogostemonis 10 parts, Gypsum Fibrosum 12 Part, 7 parts of Radix Glycyrrhizae, sodium bicarbonate 4 parts, citric acid 7 parts, sucrose 13 parts, 2%PVP-K30 without Water-ethanol 15 parts；

Preparation process is:

The first step: take the prepared slices of Chinese crude drugs of Cortex Fraxini, flower of poplar, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae, 80 DEG C of bakings Dry 3h, pulverizes, and crosses 50 mesh sieves and obtains A powder；Second step: by sodium bicarbonate, citric acid, sucrose Pulverize after adding A powder, cross 50 mesh sieves and obtain B powder；3rd step: by B powder mixing 30min, then add Enter 2%PVP-K30 dehydrated alcohol and bind granulation, be then dried granulate and get final product；Prepared by described medicine For effervescent granule.