CN103130695B - 一种硫脲席夫碱衍生物及应用 - Google Patents

一种硫脲席夫碱衍生物及应用 Download PDF

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CN103130695B
CN103130695B CN201310094546.3A CN201310094546A CN103130695B CN 103130695 B CN103130695 B CN 103130695B CN 201310094546 A CN201310094546 A CN 201310094546A CN 103130695 B CN103130695 B CN 103130695B
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schiff base
thiourea
base derivative
thiocarbamide
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CN103130695A (zh
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丁国华
江道勇
高蕊
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Guilin University of Technology
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Abstract

本发明公开了一种硫脲席夫碱衍生物及应用。硫脲席夫碱衍生物的结构式为：

Description

一种硫脲席夫碱衍生物及应用
技术领域
本发明涉及一种硫脲席夫碱衍生物及其在抗菌和阴离子识别上的应用。 
背景技术
硫脲及席夫碱衍生物，在抑菌、抗肿瘤、催化、磁性、光学、电化学、非线性光学和化学传感器等领域，有广泛的用途，因此成为当前研究的热点。 
发明内容
本发明的目的是提供一种硫脲席夫碱衍生物及其应用。 
硫脲席夫碱衍生物的结构式为： 
。
所述硫脲席夫碱衍生物应用在抗菌和阴离子识别上。 
本发明的硫脲席夫碱衍生物对枯草芽孢杆菌，欧文氏草生杆菌，枯草芽孢杆菌，大肠杆菌及金黄色葡萄球菌都有不同程度的抗菌效果，对部分阴离子表现出高灵敏识别选择性。 
具体实施方式
实施例：
(1)    硫脲席夫碱衍生物的结构式为：
Figure 395681DEST_PATH_IMAGE001
。
(2) 硫脲席夫碱衍生物的制备方法为： 
在100毫升的圆底烧瓶里加入10毫摩尔(1.2毫升,1.35克) 异硫氰酸苯酯和15毫升无水甲醇，在磁力搅拌器上搅拌20分钟，再加入10毫摩尔(1.08克)邻苯二胺和15毫升无水甲醇，加热回流反应2小时；冷却，再加入10毫摩尔(2.8克)3,5-二溴水杨醛和15毫升无水甲醇，继续加热回流2.5小时，过滤并分别用冷的无水乙醇、无水甲醇和无水乙醚各洗涤3次，最后用体积比为3:1的无水乙醇和二甲基亚砜(DMF)混合溶剂重结晶，得到橙黄色晶体，放在真空干燥箱里24小时，即制得硫脲席夫碱衍生物，产量为3.5克(产率为66%)。
(3) 硫脲席夫碱衍生物的应用： 
抗菌：在抗菌实验中，发现本实施例制得的硫脲席夫碱衍生物对枯草芽孢杆菌，欧文氏草生杆菌，枯草芽孢杆菌，大肠杆菌及金黄色葡萄球菌都有不同程度的抗菌效果。
阴离子识别：将本实施例制得的硫脲席夫碱衍生物溶于二甲基亚砜（DMSO）制得溶液，再向制得的溶液中引入Fˉ、Clˉ和H2PO4ˉ阴离子，溶液颜色及吸收光谱均发生了显著变化，鉴于硫脲席夫碱衍生物对这三种阴离子表现出高灵敏识别选择性，用于制作裸眼识别Fˉ、Clˉ和H2PO4ˉ传感器。 
实施例中所使用的化学试剂均为分析纯 。

Claims (1)

1.一种硫脲席夫碱衍生物在阴离子识别的应用，其特征在于所述硫脲席夫碱衍生物分子结构式为：
；
所述硫脲席夫碱衍生物应用于F—、Cl—和H2PO4 —这三种阴离子识别。
CN201310094546.3A 2013-03-24 2013-03-24 一种硫脲席夫碱衍生物及应用 Expired - Fee Related CN103130695B (zh)

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CN103709063A (zh) * 2014-01-20 2014-04-09 桂林理工大学 一种苯甲醛缩氨基苯甲酸衍生物及应用
CN103709062A (zh) * 2014-01-20 2014-04-09 桂林理工大学 一种苯甲醛缩甘氨酸衍生物及应用
CN103709064A (zh) * 2014-01-21 2014-04-09 桂林理工大学 一种苯甲二醛缩氨基苯甲酸衍生物及应用
CN103819376A (zh) * 2014-02-20 2014-05-28 桂林理工大学 一种二氯水杨醛硫脲衍生物及其应用
CN103787940A (zh) * 2014-02-20 2014-05-14 桂林理工大学 一种二甲氨基苯甲醛硫脲衍生物及其应用
CN104557645A (zh) * 2014-12-28 2015-04-29 桂林理工大学 一种二溴水杨醛硫脲衍生物及其应用
CN104610116A (zh) * 2015-02-21 2015-05-13 桂林理工大学 一种双苯基硫脲衍生物及其应用
CN105175279A (zh) * 2015-09-30 2015-12-23 西北师范大学 一种高效单一选择识别氟离子的希夫碱化合物及其合成和应用
CN114057628B (zh) * 2021-11-10 2023-04-18 河西学院 吡啶季铵盐类阴离子识别受体及其制备方法和应用

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