CN103130695B - 一种硫脲席夫碱衍生物及应用 - Google Patents

一种硫脲席夫碱衍生物及应用 Download PDF

Info

Publication number
CN103130695B
CN103130695B CN201310094546.3A CN201310094546A CN103130695B CN 103130695 B CN103130695 B CN 103130695B CN 201310094546 A CN201310094546 A CN 201310094546A CN 103130695 B CN103130695 B CN 103130695B
Authority
CN
China
Prior art keywords
schiff base
thiourea
base derivative
thiocarbamide
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201310094546.3A
Other languages
English (en)
Other versions
CN103130695A (zh
Inventor
丁国华
江道勇
高蕊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guilin University of Technology
Original Assignee
Guilin University of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilin University of Technology filed Critical Guilin University of Technology
Priority to CN201310094546.3A priority Critical patent/CN103130695B/zh
Publication of CN103130695A publication Critical patent/CN103130695A/zh
Application granted granted Critical
Publication of CN103130695B publication Critical patent/CN103130695B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

本发明公开了一种硫脲席夫碱衍生物及应用。硫脲席夫碱衍生物的结构式为:

Description

一种硫脲席夫碱衍生物及应用
技术领域
本发明涉及一种硫脲席夫碱衍生物及其在抗菌和阴离子识别上的应用。 
背景技术
硫脲及席夫碱衍生物,在抑菌、抗肿瘤、催化、磁性、光学、电化学、非线性光学和化学传感器等领域,有广泛的用途,因此成为当前研究的热点。 
发明内容
本发明的目的是提供一种硫脲席夫碱衍生物及其应用。 
硫脲席夫碱衍生物的结构式为: 
所述硫脲席夫碱衍生物应用在抗菌和阴离子识别上。 
本发明的硫脲席夫碱衍生物对枯草芽孢杆菌,欧文氏草生杆菌,枯草芽孢杆菌,大肠杆菌及金黄色葡萄球菌都有不同程度的抗菌效果,对部分阴离子表现出高灵敏识别选择性。 
具体实施方式
实施例:
(1)    硫脲席夫碱衍生物的结构式为:
Figure 395681DEST_PATH_IMAGE001
(2) 硫脲席夫碱衍生物的制备方法为: 
在100毫升的圆底烧瓶里加入10毫摩尔(1.2毫升,1.35克) 异硫氰酸苯酯和15毫升无水甲醇,在磁力搅拌器上搅拌20分钟,再加入10毫摩尔(1.08克)邻苯二胺和15毫升无水甲醇,加热回流反应2小时;冷却,再加入10毫摩尔(2.8克)3,5-二溴水杨醛和15毫升无水甲醇,继续加热回流2.5小时,过滤并分别用冷的无水乙醇、无水甲醇和无水乙醚各洗涤3次,最后用体积比为3:1的无水乙醇和二甲基亚砜(DMF)混合溶剂重结晶,得到橙黄色晶体,放在真空干燥箱里24小时,即制得硫脲席夫碱衍生物,产量为3.5克(产率为66%)。
(3) 硫脲席夫碱衍生物的应用: 
抗菌:在抗菌实验中,发现本实施例制得的硫脲席夫碱衍生物对枯草芽孢杆菌,欧文氏草生杆菌,枯草芽孢杆菌,大肠杆菌及金黄色葡萄球菌都有不同程度的抗菌效果。
阴离子识别:将本实施例制得的硫脲席夫碱衍生物溶于二甲基亚砜(DMSO)制得溶液,再向制得的溶液中引入Fˉ、Clˉ和H2PO4ˉ阴离子,溶液颜色及吸收光谱均发生了显著变化,鉴于硫脲席夫碱衍生物对这三种阴离子表现出高灵敏识别选择性,用于制作裸眼识别Fˉ、Clˉ和H2PO4ˉ传感器。 
实施例中所使用的化学试剂均为分析纯 。

Claims (1)

1.一种硫脲席夫碱衍生物在阴离子识别的应用,其特征在于所述硫脲席夫碱衍生物分子结构式为:
所述硫脲席夫碱衍生物应用于F、Cl和H2PO4 这三种阴离子识别。
CN201310094546.3A 2013-03-24 2013-03-24 一种硫脲席夫碱衍生物及应用 Expired - Fee Related CN103130695B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310094546.3A CN103130695B (zh) 2013-03-24 2013-03-24 一种硫脲席夫碱衍生物及应用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310094546.3A CN103130695B (zh) 2013-03-24 2013-03-24 一种硫脲席夫碱衍生物及应用

Publications (2)

Publication Number Publication Date
CN103130695A CN103130695A (zh) 2013-06-05
CN103130695B true CN103130695B (zh) 2014-05-14

Family

ID=48491200

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310094546.3A Expired - Fee Related CN103130695B (zh) 2013-03-24 2013-03-24 一种硫脲席夫碱衍生物及应用

Country Status (1)

Country Link
CN (1) CN103130695B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103709063A (zh) * 2014-01-20 2014-04-09 桂林理工大学 一种苯甲醛缩氨基苯甲酸衍生物及应用
CN103709062A (zh) * 2014-01-20 2014-04-09 桂林理工大学 一种苯甲醛缩甘氨酸衍生物及应用
CN103709064A (zh) * 2014-01-21 2014-04-09 桂林理工大学 一种苯甲二醛缩氨基苯甲酸衍生物及应用
CN103819376A (zh) * 2014-02-20 2014-05-28 桂林理工大学 一种二氯水杨醛硫脲衍生物及其应用
CN103787940A (zh) * 2014-02-20 2014-05-14 桂林理工大学 一种二甲氨基苯甲醛硫脲衍生物及其应用
CN104557645A (zh) * 2014-12-28 2015-04-29 桂林理工大学 一种二溴水杨醛硫脲衍生物及其应用
CN104610116A (zh) * 2015-02-21 2015-05-13 桂林理工大学 一种双苯基硫脲衍生物及其应用
CN105175279A (zh) * 2015-09-30 2015-12-23 西北师范大学 一种高效单一选择识别氟离子的希夫碱化合物及其合成和应用
CN114057628B (zh) * 2021-11-10 2023-04-18 河西学院 吡啶季铵盐类阴离子识别受体及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2251687A1 (en) * 2009-05-11 2010-11-17 The Provost Fellows And Scholars Of The College Of The Holy and Undivided Trinity Of Queen Elizabeth Near Dublin Colorimetric anion sensor element
CN101817771B (zh) * 2010-05-18 2012-12-19 桂林理工大学 一种缩氨基硫脲及应用

Also Published As

Publication number Publication date
CN103130695A (zh) 2013-06-05

Similar Documents

Publication Publication Date Title
CN103130695B (zh) 一种硫脲席夫碱衍生物及应用
Gowda et al. Synthesis, antimicrobial, DNA-binding and photonuclease studies of Cobalt (III) and Nickel (II) Schiff base complexes
Alaghaz et al. Synthesis, spectroscopic identification, thermal, potentiometric and antibacterial activity studies of 4-amino-5-mercapto-S-triazole Schiff’s base complexes
Shebl et al. Synthesis, spectroscopic studies, molecular modeling and antimicrobial activity of binuclear Co (II) and Cu (II) complexes of 4, 6-diacetylresorcinol
El-Sonbati et al. Thermal, spectroscopic studies and hydrogen bonding in supramolecular assembly of azo rhodanine complexes
Jadhav et al. Synthesis, spectral, thermal, potentiometric and antimicrobial studies of transition metal complexes of tridentate ligand
Sudeepa et al. Synthesis, spectral characterization, antimicrobial, DNA interactions and molecular modeling studies of metal complexes of 1, 3-benzothiazole carbohydrazone
CN103159655B (zh) 一种水杨醛硫脲衍生物及应用
CN103113276B (zh) 一种双硫脲衍生物及应用
CN103159654B (zh) 一种硫脲脲衍生物及应用
Nishat et al. Synthesis, spectral characterization and biocidal activity of thermally stable polymeric Schiff base and its polymer metal complexes
Kopchuk et al. Preparation of pyridyl-substituted monoazatriphenylenes
CN104557988B (zh) 氮杂环希夫碱银配合物及其制备方法和应用
El-Sherif et al. Mixed ligand complexes of Cu (II)-2-(2-pyridyl)-benzimidazole and aliphatic or aromatic dicarboxylic acids: synthesis, characterization and biological activity
Yang et al. Ln (III)-MOFs (Ln= Tb, Eu, Dy, and Sm) based on triazole carboxylic ligand with carboxylate and nitrogen donors with applications as chemical sensors and magnetic materials
Leela et al. Synthesis, characterization, antimicrobial, DNA binding and cleavage studies of mixed ligand Cu (II), Co (II) complexes
Soliman et al. Thermal decomposition and biological activity studies of some transition metal complexes derived from mixed ligands sparfloxacin and glycine
CN103145596B (zh) 一种双苯基硫脲衍生物及应用
Kharadi et al. In‐vitro antimicrobial, thermal and spectral studies of mixed ligand Cu (II) heterochelates of clioquinol and coumarin derivatives
CN103113275A (zh) 双苯基硫脲衍生物及应用
Salehi et al. Synthesis, antibacterial studies and crystal structures of tridentate schiff base ligand and it’s cobalt (III) complex
He et al. Terpyridine functionalized α-cyanostilbene derivative as excellent fluorescence and naked eyes Fe 2+ probe in aqueous environment
Čermáková et al. Syntheses and magnetic properties of trinuclear trithiocyanurato-bridged manganese (II) complexes involving bidentate aromatic N-donor heterocycles
Jin et al. Structure, luminescent and thermal properties of two novel lanthanide complexes with 3, 4-diethoxybenzoic acid and 5, 5′-dimethy-2, 2′-bipyridine
Refat et al. Spectroscopic studies and biological evaluation of some transition metal complexes of a novel Schiff base ligands derived from 5-arylazo-salicyladehyde and o-amino phenol

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20140514

Termination date: 20210324

CF01 Termination of patent right due to non-payment of annual fee