CN103113275A - 双苯基硫脲衍生物及应用 - Google Patents

双苯基硫脲衍生物及应用 Download PDF

Info

Publication number
CN103113275A
CN103113275A CN2013100710773A CN201310071077A CN103113275A CN 103113275 A CN103113275 A CN 103113275A CN 2013100710773 A CN2013100710773 A CN 2013100710773A CN 201310071077 A CN201310071077 A CN 201310071077A CN 103113275 A CN103113275 A CN 103113275A
Authority
CN
China
Prior art keywords
double
thiourea derivative
application
phenyl thiourea
phenylthiourea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2013100710773A
Other languages
English (en)
Inventor
丁国华
江道勇
高蕊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guilin University of Technology
Original Assignee
Guilin University of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilin University of Technology filed Critical Guilin University of Technology
Priority to CN2013100710773A priority Critical patent/CN103113275A/zh
Publication of CN103113275A publication Critical patent/CN103113275A/zh
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

本发明公开了一种双苯基硫脲衍生物及应用。双苯基硫脲衍生物的结构式为：

Description

双苯基硫脲衍生物及应用
技术领域
本发明涉及一种双苯基硫脲衍生物及其在抗菌和阴离子识别上的应用。
背景技术
双苯基硫脲衍生物，在抑菌、抗肿瘤、催化、磁性、光学、电化学、非线性光学和化学传感器等领域，有广泛的用途，因此成为当前研究的热点。
发明内容
本发明的目的是提供一种双苯基硫脲衍生物及其应用。
双苯基硫脲衍生物的结构式为：
Figure 2013100710773100002DEST_PATH_IMAGE001
所述双苯基硫脲衍生物应用于抗菌和阴离子识别。
本发明的双苯基硫脲衍生物对欧文氏草生杆菌，枯草芽孢杆菌，大肠杆菌及金黄色葡萄球菌都有不同程度的抗菌效果，对部分阴离子表现出高灵敏识别选择性。
具体实施方式
实施例：
(1)双苯基硫脲衍生物的结构式为：
(2)双苯基硫脲衍生物的制备方法为：
在100毫升的圆底烧瓶里加入10毫摩尔(1.2毫升) 异硫氰酸苯酯和20毫升无水甲醇，在磁力搅拌器上搅拌20分钟，再加入用5毫摩尔(0.33毫升)乙二胺和25毫升无水甲醇制成的混合溶液，加热回流反应3.5小时，过滤并分别用冷的无水乙醇、无水甲醇和无水乙醚洗涤3次，最后用体积比为3:1的无水乙醇和二甲基亚砜(DMF)混合溶剂重结晶，得到黄色晶体，放在真空干燥箱里24小时，即制得双苯基硫脲用衍生物，产量为0.43克(产率为63%)。
(3)双苯基硫脲衍生物的应用：
抗菌：在抗菌实验中，发现本实施例制得的双苯基硫脲衍生物对欧文氏草生杆菌，枯草芽孢杆菌，大肠杆菌及金黄色葡萄球菌都有不同程度的抗菌效果。
阴离子识别：将本实施例制得的双苯基硫脲衍生物溶于二甲基亚砜（DMSO）制得溶液，再向制得的溶液中引入Clˉ、H2PO4ˉ阴离子，溶液颜色及吸收光谱均发生了显著变化，鉴于双苯基硫脲衍生物对这两种阴离子表现出高灵敏识别选择性，用于制作裸眼识别Clˉ、H2PO4ˉ传感器。
实施例中所使用的化学试剂均为分析纯。

Claims (2)

1.一种双苯基硫脲衍生物，其特征在于双苯基硫脲衍生物分子结构式为：
Figure 568295DEST_PATH_IMAGE001
。
2.根据权利要求1所述的双苯基硫脲衍生物的应用，其特征在于所述双苯基硫脲衍生物应用于抗菌和阴离子识别。
CN2013100710773A 2013-03-06 2013-03-06 双苯基硫脲衍生物及应用 Pending CN103113275A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2013100710773A CN103113275A (zh) 2013-03-06 2013-03-06 双苯基硫脲衍生物及应用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2013100710773A CN103113275A (zh) 2013-03-06 2013-03-06 双苯基硫脲衍生物及应用

Publications (1)

Publication Number Publication Date
CN103113275A true CN103113275A (zh) 2013-05-22

Family

ID=48411693

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2013100710773A Pending CN103113275A (zh) 2013-03-06 2013-03-06 双苯基硫脲衍生物及应用

Country Status (1)

Country Link
CN (1) CN103113275A (zh)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3109859A (en) * 1960-10-21 1963-11-05 Monsanto Canada Ltd Disubstituted guanidines
CN101817771A (zh) * 2010-05-18 2010-09-01 桂林理工大学 一种缩氨基硫脲及应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3109859A (en) * 1960-10-21 1963-11-05 Monsanto Canada Ltd Disubstituted guanidines
CN101817771A (zh) * 2010-05-18 2010-09-01 桂林理工大学 一种缩氨基硫脲及应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AI-FANG LI等: "Anion complexation and sensing using modified urea and thiourea-based receptors", 《CHEMICAL SOCIETY REVIEWS》, vol. 39, no. 10, 31 October 2010 (2010-10-31), pages 3729 - 3745 *
PRAMOD B. PANSURIYA等: "1,10-(Ethane-1,2-diyl)bis(3-phenylthiourea)", 《ACTA CRYSTALLOGRAPHICA SECTION E，STRUCTURE REPORTS ONLINE》, vol. 67, no. 11, 31 December 2011 (2011-12-31), pages 2819 *
吴芳英等: "硫脲类阴离子受体的研究进展", 《化学进展》, vol. 16, no. 05, 24 September 2004 (2004-09-24), pages 776 - 784 *

Similar Documents

Publication Publication Date Title
CN103130695B (zh) 一种硫脲席夫碱衍生物及应用
Gowda et al. Synthesis, antimicrobial, DNA-binding and photonuclease studies of Cobalt (III) and Nickel (II) Schiff base complexes
Alaghaz et al. Synthesis, spectroscopic identification, thermal, potentiometric and antibacterial activity studies of 4-amino-5-mercapto-S-triazole Schiff’s base complexes
Langton et al. Halogen bonding in water results in enhanced anion recognition in acyclic and rotaxane hosts
Chandra et al. Syntheses, spectroscopic characterization, thermal study, molecular modeling, and biological evaluation of novel Schiff’s base benzil bis (5-amino-1, 3, 4-thiadiazole-2-thiol) with Ni (II), and Cu (II) metal complexes
Shebl et al. Synthesis, spectroscopic studies, molecular modeling and antimicrobial activity of binuclear Co (II) and Cu (II) complexes of 4, 6-diacetylresorcinol
Soliman et al. Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II) and Zn (II) new complexes of 5-aminosalicylic acid: spectroscopic, thermal characterization and biological activity studies
Jadhav et al. Synthesis, spectral, thermal, potentiometric and antimicrobial studies of transition metal complexes of tridentate ligand
Gaballa et al. Preparation, spectroscopic and antibacterial studies on charge-transfer complexes of 2-hydroxypyridine with picric acid and 7, 7′, 8, 8′-tetracyano-p-quinodimethane
Sönmez et al. Synthesis and biological evaluation of a novel ONS tridentate Schiff base bearing pyrimidine ring and some metal complexes
Sudeepa et al. Synthesis, spectral characterization, antimicrobial, DNA interactions and molecular modeling studies of metal complexes of 1, 3-benzothiazole carbohydrazone
CN103159655B (zh) 一种水杨醛硫脲衍生物及应用
CN103113276B (zh) 一种双硫脲衍生物及应用
CN104557988B (zh) 氮杂环希夫碱银配合物及其制备方法和应用
Nishat et al. Synthesis, spectral characterization and biocidal activity of thermally stable polymeric Schiff base and its polymer metal complexes
El-Sherif et al. Mixed ligand complexes of Cu (II)-2-(2-pyridyl)-benzimidazole and aliphatic or aromatic dicarboxylic acids: synthesis, characterization and biological activity
Kong et al. 2-(4-Formylphenyl) phenanthroimidazole as a colorimetric and fluorometric probe for selective fluoride ion sensing
Soliman et al. Thermal decomposition and biological activity studies of some transition metal complexes derived from mixed ligands sparfloxacin and glycine
CN103159654B (zh) 一种硫脲脲衍生物及应用
Leela et al. Synthesis, characterization, antimicrobial, DNA binding and cleavage studies of mixed ligand Cu (II), Co (II) complexes
CN103145596B (zh) 一种双苯基硫脲衍生物及应用
CN103113275A (zh) 双苯基硫脲衍生物及应用
Aazam et al. Synthesis, characterization, electrochemical behavior, and biological activity of bisazomethine dye derived from 2, 3-diaminomaleonitrile and 2-hydroxy-1-naphthaldehyde and its zinc complex
Aljahdali et al. Synthesis, characterization, equilibrium studies, and biological activity of complexes involving copper (II), 2-aminomethylthiophenyl-4-bromosalicylaldehyde Schiff base, and selected amino acids
Patel et al. Coordination polymers based on bis-ligand-containing indole and 8-hydroxyquinoline moieties

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20130522